Karaciğer Hastalıklarında Minimal İnvaziv Cerrahi

Authors

Alpen Yahya Gümüşoğlu
https://orcid.org/0000-0001-5378-9074

Synopsis

Karaciğer hastalıklarında minimal invaziv cerrahi, son yıllarda teknolojik gelişmeler ve artan cerrahi deneyim sayesinde hepatobiliyer cerrahinin temel uygulama alanlarından biri haline gelmiştir. Laparoskopik ve robotik yaklaşımlar; daha az postoperatif ağrı, kısa hastanede kalış süresi, düşük kan kaybı ve daha hızlı iyileşme gibi önemli perioperatif avantajlar sağlamaktadır. Günümüzde majör hepatektomiler, kompleks anatomik rezeksiyonlar, canlı donör hepatektomileri ve seçilmiş karaciğer transplantasyonu olguları minimal invaziv yöntemlerle güvenli şekilde uygulanabilmektedir. Robotik cerrahi sistemleri; üç boyutlu görüntüleme, gelişmiş enstrüman hareket kabiliyeti ve ergonomik avantajlar sayesinde cerrahi hassasiyeti artırmaktadır. Bunun yanında yapay zekâ destekli görüntüleme sistemleri ve navigasyon teknolojileri, gelecekte minimal invaziv karaciğer cerrahisinin daha da yaygınlaşmasına katkı sağlayacaktır. Bu bölümde laparoskopik ve robotik karaciğer cerrahisinin güncel endikasyonları, onkolojik sonuçları, transplantasyon uygulamaları, ALPPS yaklaşımı ve öğrenme eğrisi ile ilgili güncel literatür eşliğinde kapsamlı bir değerlendirme sunulmaktadır.

Minimally invasive liver surgery has become one of the major fields of hepatobiliary surgery owing to significant technological advances and increasing surgical experience over the past decades. Laparoscopic and robotic approaches provide important perioperative advantages, including reduced postoperative pain, shorter hospital stay, lower blood loss, and faster recovery. Today, major hepatectomies, complex anatomical resections, living donor hepatectomies, and selected liver transplantation procedures can be safely performed using minimally invasive techniques. Robotic surgical systems enhance surgical precision through high-definition three-dimensional visualization, improved instrument dexterity, and ergonomic advantages. Furthermore, the integration of artificial intelligence–based navigation and imaging technologies is expected to further expand the role of minimally invasive liver surgery in the future. This chapter provides a comprehensive overview of current laparoscopic and robotic liver surgery, including oncological outcomes, minimally invasive transplantation, ALPPS procedures, and learning curve assessment in light of the contemporary literature.

References

Tanaka S, Kubo S, Kanazawa A, et al. Validation of a difficulty scoring system for laparoscopic liver resection: a multicenter analysis by the Endoscopic Liver Surgery Study Group in Japan. J Am Coll Surg. 2017;225(2):249-58.e1.

Dincer HA, Dogrul AB. Advances in minimally invasive liver surgery. North Clin Istanb. 2024 Nov 20;11(6):586-592. doi: 10.14744/nci.2024.42744. PMID: 39650315; PMCID: PMC11622747.

Zwart MJW, Görgec B, Arabiyat A, Nota CLM, van der Poel MJ, Fichtinger RS, Berrevoet F, van Dam RM, Aldrighetti L, Fuks D, Hoti E, Edwin B, Besselink MG, Abu Hilal M, Hagendoorn J, Swijnenburg RJ; Dutch Liver Collaborative Group and E-AHPBA Innovation & Development Committee. Pan-European survey on the implementation of robotic and laparoscopic minimally invasive liver surgery. HPB (Oxford). 2022 Mar;24(3):322-331. doi: 10.1016/j.hpb.2021.08.939. Epub 2021 Aug 21. PMID: 34772622.

Abu Hilal M, Aldrighetti L, Dagher I, et al. The Southampton Consensus Guidelines for Laparoscopic Liver Surgery. Ann Surg. 2018;268(1):11-18.

Morise Z. Current status of minimally invasive liver surgery for cancers. World J Gastroenterol. 2022 Nov 21;28(43):6090-6098. doi: 10.3748/wjg.v28.i43.6090. PMID: 36483154; PMCID: PMC9724486.

Pinto F, Pangrazio MD, Martinino A, Todeschini L, Toti F, Cristin L, Caimano M, Mattia A, Bianco G, Spoletini G, Giovinazzo F. Laparoscopic versus open liver resection for colorectal liver metastasis: an umbrella review. Front Oncol. 2024 Jul 15;14:1340430. doi: 10.3389/fonc.2024.1340430. PMID: 39077468; PMCID: PMC11284054

Fichtinger RS, Aldrighetti LA, Abu Hilal M, Troisi RI, Sutcliffe RP, Besselink MG, Aroori S, Menon KV, Edwin B, D'Hondt M, Lucidi V, Ulmer TF, Díaz-Nieto R, Soonawalla Z, White S, Sergeant G, Olij B, Ratti F, Kuemmerli C, Scuderi V, Berrevoet F, Vanlander A, Marudanayagam R, Tanis P, Dewulf MJL, Dejong CHC, Eminton Z, Kimman ML, Brandts L, Neumann UP, Fretland ÅA, Pugh SA, van Breukelen GJP, Primrose JN, van Dam RM; ORANGE II PLUS Collaborative. Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial. J Clin Oncol. 2024 May 20;42(15):1799-1809. doi: 10.1200/JCO.23.01019. Epub 2024 Apr 19. PMID: 38640453; PMCID: PMC11107897.

Ziogas IA, Evangeliou AP, Mylonas KS, Athanasiadis DI, Cherouveim P, Geller DA, Schulick RD, Alexopoulos SP, Tsoulfas G. Economic analysis of open versus laparoscopic versus robotic hepatectomy: a systematic review and meta-analysis. Eur J Health Econ. 2021 Jun;22(4):585-604. doi: 10.1007/s10198-021-01277-1. Epub 2021 Mar 19. PMID: 33740153.

Liu R, Abu Hilal M, Wakabayashi G, et al. International experts consensus guidelines on robotic liver resection in 2023. World J Gastroenterol. 2023 Aug 28;29(32):4815-4830. doi: 10.3748/wjg.v29.i32.4815.

Chua D, Syn N, Koh YX, Goh BKP. Learning curves in minimally invasive hepatectomy: systematic review and meta-regression analysis. Br J Surg. 2021 Apr 30;108(4):351-358. doi: 10.1093/bjs/znaa118. PMID: 33779690.

Sijberden JP, Hoogteijling TJ, Aghayan D, et al; International consortium on Minimally Invasive Liver Surgery (I-MILS). Robotic Versus Laparoscopic Liver Resection in Various Settings: An International Multicenter Propensity Score Matched Study of 10.075 Patients. Ann Surg. 2024 Jul 1;280(1):108-117. doi: 10.1097/SLA.0000000000006267. Epub 2024 Mar 14. PMID: 38482665; PMCID: PMC11161239.

Di Benedetto F, Magistri P, Di Sandro S, Sposito C, Oberkofler C, Brandon E, Samstein B, Guidetti C, Papageorgiou A, Frassoni S, Bagnardi V, Clavien PA, Citterio D, Kato T, Petrowsky H, Halazun KJ, Mazzaferro V; Robotic HPB Study Group. Safety and Efficacy of Robotic vs Open Liver Resection for Hepatocellular Carcinoma. JAMA Surg. 2023 Jan 1;158(1):46-54. doi: 10.1001/jamasurg.2022.5697. PMID: 36416833; PMCID: PMC9685546.

Safiejko K, Pedziwiatr M, Pruc M, Tarkowski R, Juchimiuk M, Domurat M, Smereka J, Anvarov K, Sielicki P, Kurek K, Szarpak L. Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis. Cancers (Basel). 2024 Apr 22;16(8):1596. doi: 10.3390/cancers16081596. PMID: 38672678; PMCID: PMC11048946.

Hamad A, Ansari A, Li Y, Shen C, Cloyd J, Pawlik TM, Ejaz A. Short- and long-term outcomes following robotic and open resection for intrahepatic cholangiocarcinoma: A national cohort study. Surg Oncol. 2022 Aug;43:101790. doi: 10.1016/j.suronc.2022.101790. Epub 2022 Jun 9. PMID: 35717859.

Bozkurt E, Sijberden JP, Hilal MA. What Is the Current Role and What Are the Prospects of the Robotic Approach in Liver Surgery? Cancers (Basel). 2022 Aug 31;14(17):4268. doi: 10.3390/cancers14174268. PMID: 36077803; PMCID: PMC9454668.

Xu X, Lv T, Xu G, Wei Q, Ling Q, Wei L, Li J, Zhang J, Cai Y, Cai J, Chen G, Chen Z, Chen Z, Cheng Y, Dou J, Du S, Du C, Fu Z, Guo Z, Gao L, He X, He Q, Huang L, Huang J, Huo F, Jia C, Jin C, Jiang W, Jiang J, Jiao Z, Jing HE, Lang R, Li B, Li L, Li N, Li Q, Li W, Li Y, Li G, Liu J, Liu L, Liu J, Liu L, Liu Z, Lu S, Lu Q, Lv L, Lv Y, Lv G, Liang T, Ming Y, Peng Z, Ran J, Shi J, Sun B, Sun C, Sun X, Sun Y, Si Z, Shao Y, Song J, Tao K, Teng M, Wan Y, Wan X, Wang L, Wen H, Wu G, Wu J, Wu X, Wu Z, Wei L, Xu J, Xu J, Yang Y, Yang H, Yang Z, Yang Z, Yang J, Ye Q, Yi S, Zhou J, Zhang F, Zhang L, Zhang M, Zhang W, Zhang L, Zhang S, Zhao S, Zheng H, Zhong L, Zhu H, Zhu J, Zhu X, Zhu Z, Wu H, Guo W, Wang Z, Xu X, Yang J; Branch of Organ Transplant Physicians of Chinese Medical Doctor Association; Branch of Organ Transplant of Chinese Medical Association. Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition). Hepatobiliary Surg Nutr. 2024 Dec 1;13(6):919-936. doi: 10.21037/hbsn-24-329. Epub 2024 Nov 20. PMID: 39669074; PMCID: PMC11634423.

Troisi RI, Giglio MC, Kim J, Broering D, Cherqui D, Wakabayashi G, Teh C, Abu-Hilal M, Lee KW, Soin A, Lerut J, Tang CN, Aldrighetti L, Hermann P, Asbun H, Rela M, Kim KH, Eguchi S, Han HS, Suh KS, Kasahara M, Olthoff K, Geller D, Egawa H; World Survey on Minimally Invasive Donor Hepatectomy Collaboration Group. Current Status of Minimally Invasive Surgery for Donor Hepatectomy: A Worldwide Survey (A Joint Initiative of the International Laparoscopic Liver Society and the International Living Donor Liver Transplantation Group). Transplantation. 2025 Jun 9. doi: 10.1097/TP.0000000000005423. Epub ahead of print. PMID: 40484991.

Rajalingam R, Rammohan A, Cherukuru R, Rela M. Minimally Invasive Liver Transplantation: The Recipient Operation. J Clin Exp Hepatol. 2025 Jul-Aug;15(4):102532. doi: 10.1016/j.jceh.2025.102532. Epub 2025 Feb 21. PMID: 40177171; PMCID: PMC11960625.

Loke S, Ong BDC, Ng J, Kow AWC. Safety and efficacy of minimally invasive associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): a systematic review and meta-analysis. Int J Surg. 2025 Feb 1;111(2):2283-2290. doi: 10.1097/JS9.0000000000002240. PMID: 39869398.

Kuemmerli C, Toti JMA, Haak F, Billeter AT, Nickel F, Guidetti C, Santibanes M, Vigano L, Lavanchy JL, Kollmar O, Seehofer D, Abu Hilal M, Di Benedetto F, Clavien PA, Dutkowski P, Müller BP, Müller PC. Towards a Standardization of Learning Curve Assessment in Minimally Invasive Liver Surgery. Ann Surg. 2024 Jun 26;281(2):252–64. doi: 10.1097/SLA.0000000000006417. Epub ahead of print. PMID: 38920042; PMCID: PMC11723502.

Published

July 9, 2026

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