Gebede Tekrarlayan Akut Pankreatit
Özet
Genç yaşta tekrarlayan akut pankreatit olgularında ayırıcı tanı önemlidir. Bu olguda, gebeliğin 31. haftasında iki ay içinde altı kez akut pankreatit atağı geçiren genç bir hasta sunulmaktadır. Etiyolojide alkol, ilaç kullanımı ve hiperlipidemi dışlanmıştır. IgG4 düzeyleri normal bulunmuş, görüntülemede otoimmün pankreatit veya pankreatik divisum lehine bulgu saptanmamıştır. Bulgular, akut biliyer pankreatit ile uyumlu değerlendirilmiş ve atakların stabilize olmasının ardından kolesistektomi planlanmıştır. Bu vaka, gebelikte tekrarlayan akut biliyer pankreatit ile karakterize nadir bir klinik tabloyu ortaya koymaktadır.
Referanslar
Clinical manifestations, diagnosis, and natural history of acute pancreatitis - UpToDate. Accessed August 27, 2025. https://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-natural-history-of-acute-pancreatitis?search=pankreatit&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1
Gardner, T. B. (2022). Acute pancreatitis. In T. C. Wang, M. Camilleri, B. Lebwohl, A. S. Lok, W. J. Sandborn, K. K. Wang, & G. W. Wu (Eds.), Yamada’s textbook of gastroenterology (7th ed., Chapter 74). John Wiley & Sons Ltd.
Magudapathi C, Shanthi S, Palanisamy R. Pancreatitis in Pregnancy: Case Series for 5 Years. J Obstet Gynaecol India. 2020;70(2):169-172. doi:10.1007/s13224-019-01267-7
Luo L, Zen H, Xu H, et al. Clinical characteristics of acute pancreatitis in pregnancy: experience based on 121 cases. Arch Gynecol Obstet. 2018;297(2):333-339. doi:10.1007/s00404-017-4558-7
Eddy JJ, Gideonsen MD, Song JY, Grobman WA, O’Halloran P. Pancreatitis in pregnancy. Obstet Gynecol. 2008;112(5):1075-1081. doi:10.1097/AOG.0b013e318185a032
Pitchumoni CS, Yegneswaran B. Acute pancreatitis in pregnancy. World J Gastroenterol. 2009;15(45):5641-5646. doi:10.3748/wjg.15.5641
Vege SS. Acute Pancreatitis. In: Mark F, Lawrence SF, Lawrence JB (Eds). Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 11th Edition. Canada: Elsevier; 2021: 893-916.
De Chalain TM, Michell WL, Berger GM. Hyperlipidemia, pregnancy and pancreatitis. Surg Gynecol Obstet. 1988;167(6):469-473.
Wilkinson EJ. Acute pancreatitis in pregnancy: a review of 98 cases and a report of 8 new cases. Obstet Gynecol Surv. 1973;28(5):281-303.
Hughes DL, Hughes A, White PB, Silva MA. Acute pancreatitis in pregnancy: meta-analysis of maternal and fetal outcomes. Br J Surg. 2021;109(1):12-14. doi:10.1093/bjs/znab221
Tobola J, Němec M, Bieliková P. Acute recurrent pancreatitis during 3rd trimester of pregnancy. Ceska Gynekol. 2023;88(1):17-19. doi:10.48095/cccg202317
Vilallonga R, Calero-Lillo A, Charco R, Balsells J. Acute pancreatitis during pregnancy, 7-year experience of a tertiary referral center. Cirugia Espanola. 2014;92(7):468-471. doi:10.1016/j.ciresp.2013.12.016
Xu Q, Wang S, Zhang Z. A 23-year, single-center, retrospective analysis of 36 cases of acute pancreatitis in pregnancy. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2015;130(2):123-126. doi:10.1016/j.ijgo.2015.02.034
Turhan AN, Gönenç M, Kapan S, et al. Acute biliary pancreatitis related with pregnancy: a 5-year single center experience. Ulus Travma Ve Acil Cerrahi Derg Turk J Trauma Emerg Surg TJTES. 2010;16(2):160-164.
Sumbizi C, Obwar A, Rofaeil B, Fidaali Z, Ali A, Mwanga A. Simultaneous endoscopic and laparoscopic management of acute biliary pancreatitis in the second trimester of pregnancy: A case report. Int J Surg Case Rep. 2025;133:111589. doi:10.1016/j.ijscr.2025.111589
Charlet P, Lambert V, Carles G. [Acute pancreatitis and pregnancy: Cases study and literature review]. J Gynecol Obstet Biol Reprod (Paris). 2015;44(6):541-549. doi:10.1016/j.jgyn.2014.08.002
Shimosegawa T, Chari ST, Frulloni L, et al. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas. 2011;40(3):352–358.
Bertin C, Pelletier AL, Vullierme MP, et al. Pancreas divisum is not a cause of pancreatitis by itself but acts as a partner of genetic mutations. Am J Gastroenterol. 2012;107(2):311–317.