Uterin Atoni Algoritmaları
Özet
Uterin atoni, doğum sonrasında uterusun yeterince kasılamamasıyla ortaya çıkan ve anne hayatını tehdit eden ciddi bir postpartum kanama nedenidir. Postpartum kanamaların en yaygın sebebi uterin atoni olup, anne ölümlerinin de başlıca nedenlerinden biridir. Normal şartlarda, doğumdan hemen sonra uterus kontrakte olarak plasental yataktan oluşan kanamayı durdurur; ancak atoni durumunda bu hayati kontraksiyon mekanizması yetersiz kalır. Atoni risk faktörleri arasında, uterusun aşırı gerilmesine yol açan durumlar, myometriyal disfonksiyon, oksitosin reseptörlerinin duyarsızlaşması, enfeksiyonlar ve bazı anestezik ilaçlar yer alır. Uterin atoninin önlenmesi için doğumun üçüncü evresinde aktif yönetim ve profilaktik oksitosin kullanımı kritik önem taşır. Atoni tanısı, klinik muayenede uterusun gevşek ve yumuşak olarak palpe edilmesiyle konulur. Tedavide ilk adım, kanama durana kadar uygulanan bimanual uterin masaj, kavitedeki pıhtıların temizlenmesi ve oksitosin gibi uterotonik ilaçlardır. Eğer bu tedaviler yetersiz kalırsa, balon tamponad veya cerrahi müdahaleler uygulanabilir. Tüm hastalar için risk değerlendirmesi antenatal dönemde, doğum için başvuruda ve her yeni gelişen durumda yapılmalıdır. Her doğum kliniği oluşabilecek uterin atoni ve postpartum kanama durumunu yönetebilecek donanıma, ekipmana ve eğitimli personele sahip olmalıdır. Uterin atoniye yönelik hazırlıklı olmak, acil durumlarda hızlı ve etkili müdahale edebilmek için hayati önem taşır.
Referanslar
Cunningham FG, Leveno KJ, Bloom SL. Williams Obstetrics. 26th ed. ed. New York, NY: McGraw-Hill Education; 2022.
Practice Bulletin No. 183: Postpartum Hemorrhage. Obstetrics and gynecology. 2017;130(4):e168-e86.
Sheldon WR, Blum J, Vogel JP, Souza JP, Gülmezoglu AM, Winikoff B. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG : an international journal of obstetrics and gynaecology. 2014;121 Suppl 1:5-13.
Li S, Gao J, Liu J, Hu J, Chen X, He J, et al. Incidence and Risk Factors of Postpartum Hemorrhage in China: A Multicenter Retrospective Study. Frontiers in medicine. 2021;8:673500.
Corbetta-Rastelli CM, Friedman AM, Sobhani NC, Arditi B, Goffman D, Wen T. Postpartum Hemorrhage Trends and Outcomes in the United States, 2000-2019. Obstetrics and gynecology. 2023;141(1):152-61.
Bateman BT, Berman MF, Riley LE, Leffert LR. The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesthesia and analgesia. 2010;110(5):1368-73.
Yunas I, Islam MA, Sindhu KN, Devall AJ, Podesek M, Alam SS, et al. Causes of and risk factors for postpartum haemorrhage: a systematic review and meta-analysis. Lancet (London, England). 2025;405(10488):1468-80.
van den Akker T, Brobbel C, Dekkers OM, Bloemenkamp KWM. Prevalence, Indications, Risk Indicators, and Outcomes of Emergency Peripartum Hysterectomy Worldwide: A Systematic Review and Meta-analysis. Obstetrics and gynecology. 2016;128(6):1281-94.
Walls R, Hockberger R, Gausche-Hill M, Erickson TB, Wilcox SR. Rosen's Emergency Medicine-Concepts and Clinical Practice E-Book: 2-Volume Set: Elsevier Health Sciences; 2022.
Gill P, Patel A, Van Hook JW. Uterine Atony. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Anjali Patel declares no relevant financial relationships with ineligible companies. Disclosure: James Van Hook declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC.; 2025.
Yi C, Li K, Shi Q. Meta-analysis of the effect of duration of labour on postpartum haemorrhage. Ginekologia polska. 2024;95(5):391-7.
Rubio Álvarez A, Hernández Martínez A, Molina Alarcón M. [Factors associated with blood loss during precipitate labor]. Anales del sistema sanitario de Navarra. 2017;40(2):237-45.
Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y, Balki M. Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reproductive sciences (Thousand Oaks, Calif). 2009;16(5):501-8.
Khireddine I, Le Ray C, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C. Induction of labor and risk of postpartum hemorrhage in low risk parturients. PloS one. 2013;8(1):e54858.
Kelly AJ, Kavanagh J, Thomas J. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. The Cochrane database of systematic reviews. 2003(4):Cd003101.
Chang CC, Wang IT, Chen YH, Lin HC. Anesthetic management as a risk factor for postpartum hemorrhage after cesarean deliveries. American journal of obstetrics and gynecology. 2011;205(5):462.e1-7.
Gallo DM, Romero R, Bosco M, Chaiworapongsa T, Gomez-Lopez N, Arenas-Hernandez M, et al. Maternal plasma cytokines and the subsequent risk of uterine atony and postpartum hemorrhage. Journal of perinatal medicine. 2023;51(2):219-32.
Anderson JM, Etches D. Prevention and management of postpartum hemorrhage. American family physician. 2007;75(6):875-82.
FIGO. Uterine atony and uterotonics in postpartum haemorrhage (FIGO Statement). September 2023.
Guidelines for oxytocin administration after birth: AWHONN practice brief number 2. Nursing for women's health. 2015;19(1):99-101.
Evensen A, Anderson JM, Fontaine P. Postpartum Hemorrhage: Prevention and Treatment. American family physician. 2017;95(7):442-9.
World Health Organization. WHO recommendations for the prevention and treatment of postpartum haemorrhage. Geneva: 2012.
Begley CM, Gyte GM, Devane D, McGuire W, Weeks A. Active versus expectant management for women in the third stage of labour. The Cochrane database of systematic reviews. 2011(11):Cd007412.
Gallos I, Devall A, Martin J, Middleton L, Beeson L, Galadanci H, et al. Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage. 2023;389(1):11-21.
Gallos ID, Papadopoulou A, Man R, Athanasopoulos N, Tobias A, Price MJ, et al. Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis. The Cochrane database of systematic reviews. 2018;12(12):Cd011689.
Escobar MF, Nassar AH, Theron G, Barnea ER, Nicholson W, Ramasauskaite D, et al. FIGO recommendations on the management of postpartum hemorrhage 2022. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2022;157 Suppl 1(Suppl 1):3-50.
World Health Organization. WHO recommendations for the prevention and treatment of postpartum haemorrhage. Geneva: 2021.
T.C. Sağlık Bakanlığı. Doğum Sonu Bakım Yönetim Rehberi. Ankara, Türkiye: 2020.
Likis FE, Sathe NA, Morgans AK, Hartmann KE, Young JL, Carlson-Bremer D, et al. AHRQ Comparative Effectiveness Reviews. Management of Postpartum Hemorrhage. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015.
Patacchiola F, D'Alfonso A, Di Fonso A, Di Febbo G, Kaliakoudas D, Carta G. Intrauterine balloon tamponade as management of postpartum haemorrhage and prevention of haemorrhage related to low-lying placenta. Clin Exp Obstet Gynecol. 2012;39(4):498-9.
C BL, Coker A, Lawal AH, Abu J, Cowen MJ. The B-Lynch surgical technique for the control of massive postpartum haemorrhage: an alternative to hysterectomy? Five cases reported. British journal of obstetrics and gynaecology. 1997;104(3):372-5.
Panda B, Laifer S, Stiller R, Kleinman G. Primary atony of the lower uterine segment as a distinct cause of early postpartum haemorrhage: a case series and management recommendations. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2009;29(7):628-32.
Main EK, Goffman D, Scavone BM, Low LK, Bingham D, Fontaine PL, et al. National Partnership for Maternal Safety: Consensus Bundle on Obstetric Hemorrhage. Obstetrics and gynecology. 2015;126(1):155-62.
Dilla AJ, Waters JH, Yazer MH. Clinical validation of risk stratification criteria for peripartum hemorrhage. Obstetrics and gynecology. 2013;122(1):120-6.
Kramer MS, Berg C, Abenhaim H, Dahhou M, Rouleau J, Mehrabadi A, et al. Incidence, risk factors, and temporal trends in severe postpartum hemorrhage. American journal of obstetrics and gynecology. 2013;209(5):449.e1-7.
Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, et al. Risk Factors for Atonic Postpartum Hemorrhage: A Systematic Review and Meta-analysis. Obstetrics and gynecology. 2021;137(2):305-23.
Brynolf A, Sandström A. Risk of recurrent red-cell transfusion in delivery: A nationwide longitudinal study. 2024;131(4):455-62.
Westergaard D, Steinthorsdottir V. Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage. 2024;56(8):1597-603.
Cianci V, Mondello C, Sapienza D, Genazzani AD, Tornese L, Cianci A, et al. Uterine atony and postpartum haemorrhage: predisposing genetic factors and postmortem findings. La Clinica terapeutica. 2025;176(4):468-77.
Edhi MM, Aslam HM, Naqvi Z, Hashmi H. "Post partum hemorrhage: causes and management". BMC research notes. 2013;6:236.
Nyfløt LT, Sandven I, Stray-Pedersen B, Pettersen S, Al-Zirqi I, Rosenberg M, et al. Risk factors for severe postpartum hemorrhage: a case-control study. BMC pregnancy and childbirth. 2017;17(1):17.
Smith J, Johnson A. Parity with Risk and Increased Incidence of Postpartum Hemorrhage. Journal of Medical Health Science. 2022;15(3):45-52.
Zackler A, Flood P, Dajao R, Maramara L, Goetzl L. Suspected Chorioamnionitis and Myometrial Contractility: Mechanisms for Increased Risk of Cesarean Delivery and Postpartum Hemorrhage. 2019;26(2):178-83.
Lodato RF, Khan AR, Zembowicz MJ, Weisbrodt NW, Pressley TA, Li YF, et al. Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide. The American journal of physiology. 1999;276(6):G1356-62.
Rauk PN, Friebe-Hoffmann U. Interleukin-1 beta down-regulates the oxytocin receptor in cultured uterine smooth muscle cells. American journal of reproductive immunology (New York, NY : 1989). 2000;43(2):85-91.
Rauk PN, Chiao JP. Oxytocin signaling in human myometrium is impaired by prolonged exposure to interleukin-1. Biology of reproduction. 2000;63(3):846-50.
Jena BH, Biks GA, Gete YK, Gelaye KA. Determinants of postpartum uterine atony in urban South Ethiopia: a community-based unmatched nested case-control study. BMC pregnancy and childbirth. 2023;23(1):499.
Robinson C, Schumann R, Zhang P, Young RC. Oxytocin-induced desensitization of the oxytocin receptor. American journal of obstetrics and gynecology. 2003;188(2):497-502.
Belghiti J, Kayem G, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C. Oxytocin during labour and risk of severe postpartum haemorrhage: a population-based, cohort-nested case-control study. BMJ open. 2011;1(2):e000514.
Grotegut CA, Paglia MJ, Johnson LN, Thames B, James AH. Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. American journal of obstetrics and gynecology. 2011;204(1):56.e1-6.
Lam SJ, Best S, Kumar S. The impact of fibroid characteristics on pregnancy outcome. American journal of obstetrics and gynecology. 2014;211(4):395.e1-5.
Shavell VI, Thakur M, Sawant A, Kruger ML, Jones TB, Singh M, et al. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertility and sterility. 2012;97(1):107-10.
Karsli B, Kaya T, Cetin A. Effects of intravenous anesthetic agents on pregnant myometrium. Polish journal of pharmacology. 1999;51(6):505-10.
Thind AS, Turner RJ. In vitro effects of propofol on gravid human myometrium. Anaesthesia and intensive care. 2008;36(6):802-6.
Gultekin H, Yildiz K, Sezer Z, Dogru K. Comparing the relaxing effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated myometrium in both pregnant and nonpregnant rats. Advances in therapy. 2006;23(1):39-46.
Yoo KY, Lee JC, Yoon MH, Shin MH, Kim SJ, Kim YH, et al. The effects of volatile anesthetics on spontaneous contractility of isolated human pregnant uterine muscle: a comparison among sevoflurane, desflurane, isoflurane, and halothane. Anesthesia and analgesia. 2006;103(2):443-7, table of contents.
Berlet T, Krah A, Börner U, Gathof BS. Desflurane inhibits platelet function in vitro similar to halothane. European journal of anaesthesiology. 2003;20(11):878-83.
Hirakata H, Ushikubi F, Toda H, Nakamura K, Sai S, Urabe N, et al. Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. Anesthesiology. 1996;85(6):1447-53.
Fauza DO, Kohane DS, Beeuwkes EB, Clayton N, Maher TJ. Local anesthetics inhibit uterine activity in vitro. Possible application on preterm labor prevention and treatment. Fetal diagnosis and therapy. 2003;18(5):292-6.
Lo B, Hönemann CW, Kohrs R, Hollmann MW, Polanowska-Grabowska RK, Gear AR, et al. Local anesthetic actions on thromboxane-induced platelet aggregation. Anesthesia and analgesia. 2001;93(5):1240-5.
Wendel MP, Shnaekel KL, Magann EF. Uterine Inversion: A Review of a Life-Threatening Obstetrical Emergency. Obstetrical & gynecological survey. 2018;73(7):411-7.