Biyolojik Risk Etmenleri

Yazarlar

Sedat Per

Özet

Biyolojik risk etmenleri, birçok iş yerinde çalışan sağlığını tehdit eden önemli mesleki tehlikeler arasında yer almaktadır. Bakteriler, virüsler, mantarlar ve parazitlerden oluşan biyolojik etkenler; sağlık hizmetleri, laboratuvarlar, gıda üretimi, tarım ve hayvancılık ile atık yönetimi gibi çeşitli sektörlerde enfeksiyonlar, alerjik hastalıklar ve toksik etkiler dahil olmak üzere ciddi ve çok boyutlu sağlık sorunlarına yol açabilmektedir. Bu bölümde, biyolojik etkenlerin tanımı, özellikleri ve yasal çerçevesi açıklanmakta ve mikroorganizma türlerine ve risk gruplarına göre gerçekleştirilen sınıflandırmalar ayrıntılı biçimde incelenmektedir. Ayrıca biyolojik etkenlerin yayılım mekanizmalarının anlaşılmasında temel bir yaklaşım olan enfeksiyon zinciri ile maruziyetin önlenmesine yönelik kontrol hiyerarşisi ilkeleri ele alınmaktadır. Biyolojik risklerin yönetiminde mühendislik ve idari kontrol önlemlerinin, kişisel koruyucu donanımların, sağlık gözetimi uygulamalarının ve çalışan eğitimlerinin önemi vurgulanmaktadır.

Referanslar

Aggarwal, N., Kitano, S., Puah G. R. Y., Kittelmann, S., Hwang I. Y., & Chang M. W. (2023). Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies. Chemical Reviews, 123(1):31-72. https://doi.org/10.1021/acs.chemrev.2c00431

Ağar, A. (2021). Çalışma Hayatında Biyolojik Risk Faktörleri ve Covid-19. Halk Sağlığı Hemşireliği Dergisi, 3(2), 133-140. https://izlik.org/JA65JU39XR

Amoah, I. D., Adegoke, A. A., & Stenström, T. A. (2018). Soil-transmitted helminth infections associated with wastewater and sludge reuse: a review of current evidence. Tropical Medicine & International Health, 23(7):692-703.https://doi.org/10.1111/tmi.13076

Anandadurai, D., Praisie, R., Venkateshvaran, S., Nelson, S. B., & Thulasiram, M. (2024). Awareness, perception, and practice regarding needle-stick injury and its prevention among healthcare workers in a tertiary care hospital in Southern India. Cureus, 16(3), e55820. https://doi.org/10.7759/cureus.55820

Bartram, J., Chartier, Y., Lee, J. V., Pond, K., & Surman-Lee, S. (Eds.). (2007). Legionella and the prevention of legionellosis. World Health Organization. https://www.who.int/publications/i/item/9241562978

Beckett, W., Kallay, M., Sood, A., Zuo, Z., & Milton, D. (2005). Hypersensitivity pneumonitis associated with environmental mycobacteria. Environmental Health Perspectives, 113(6):767-70.

Bento, D., & Tobin, E. H. (2026). Listeria monocytogenes Infection (Listeriosis) [Updated 2026 Apr 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 02 Haziran 2026 tarihinde https://www.ncbi.nlm.nih.gov/books/NBK534838/ adresinden erişildi.

Bilir, N. (2016). İş sağlığı ve güvenliği, Güneş Tıp Kitap Evleri. Ankara, 146

Bosch, A., Guix, S., Sano, D., & Pintó, R. M. (2008). New tools for the study and direct surveillance of viral pathogens in water. Current Opinion in Biotechnology, 19(3), 295–301. https://doi.org/10.1016/j.copbio.2008.04.006

Bramley, T.J., Lerner, D., & Sames, M. (2002a). Productivity losses related to the common cold. Journal of Occupational and Environmental Medicine, 44(9):822-9.

Bramley, T. J., & Lerner, D. (2002b). Sarnes, Matthew PharmD. Productivity Losses Related to the Common Cold. Journal of Occupational and Environmental Medicine, 44(9): 822-829.

Bridges, C. B., Lim, W., Hu-Primmer, J., Sims, L., Fukuda, K., Mak, K. H., Rowe, T., Thompson, W. W., Conn, L., Wells, K., Cox, N. J., & Katz, J. M. (2002). Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997–1998. Journal of Infectious Diseases, 185(8), 1005–1010. https://doi.org/10.1086/340044

Brooker, S., Clements, A. C. A., & Bundy, D. A. P. (2006). Global epidemiology, ecology and control of soil-transmitted helminth infections. Advances in Parasitology, 62, 221–261. https://doi.org/10.1016/S0065-308X(05)62007-6

Burzoni, S., Duquenne, P., Mater, G., & Ferrari, L. (2020). Workplace biological risk assessment: Review of existing and description of a comprehensive approach. Atmosphere, 11(7), 741. https://doi.org/10.3390/atmos11070741

Budke, C. M., Deplazes, P., & Torgerson, P. R. (2006). Global Socioeconomic Impact of Cystic Echinococcosis. Emerging Infectious Diseases, 12(2), 296-303. https://doi.org/10.3201/eid1202.050499

Carvalhais, C., Querido, M., Pereira, C. C., & Santos, J. (2021). Biological risk assessment: A challenge for occupational safety and health practitioners during the COVID-19 (SARS-CoV-2) pandemic. WORK: A Journal of Prevention, Assessment & Rehabilitation, 69(1):3-13. https://doi.org/10.3233/WOR-205302

Centers for Disease Control and Prevention. (2022). Chain of infection components. National Institute for Occupational Safety and Health. Erişim adresi: https://www.cdc.gov/niosh/learning/safetyculturehc/module-2/3.html

Centers for Disease Control and Prevention. (2024a). About Brucellosis. Erişim adresi: https://www.cdc.gov/brucellosis/about/

Centers for Disease Control and Prevention. (2024b). Preventing toxoplasmosis. https://www.cdc.gov/toxoplasmosis/prevention/index.html

Centers for Disease Control and Prevention. 2026. Biosafety in Microbiological and Biomedical Laboratories, 6th Edition. 2026) Erişim adresi: https://www.cdc.gov/labs/bmbl/index.html

Cook, A. J., Gilbert, R. E., Buffolano, W., Zufferey, J., Petersen, E., Jenum, P. A., Foulon, W., Semprini, A. E., & Dunn D.T. (2000). Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. BMJ. 15;321(7254):142-7. https://doi.org/10.1136/bmj.321.7254.1422

Corbel, M. J. (2006). Food and Agriculture Organization of the United Nations, World Health Organization & World Organisation for Animal Health. Brucellosis in humans and animals. World Health Organization. Erişim adresi: https://iris.who.int/handle/10665/43597

Craig, P. S., McManus, D. P., Lightowlers, M. W., Chabalgoity, J. A., Garcia, H. H., Gavidia, C. M., Gilman, R. H., Gonzalez, A. E., Lorca, M., Naquira, C., Nieto, A., & Schantz, P. M. (2007). Prevention and control of cystic echinococcosis. Lancet Infectious Diseases, 7(6), 385–394. https://doi.org/10.1016/S1473-3099(07)70134-2

Dangi, T., Jain, A. Dangi, T., & Jain, A. (2012). Influenza Virus: A Brief Overview. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 82, 111–121. https://doi.org/10.1007/s40011-011-0009-6

Davis, C. P., Woods, G., & Niesel, D. (1996). Introduction to Bacteriology. In: Baron, S. (editör) Medical Microbiology. 4th edition. University of Texas Medical Branch at Galveston, Texas. USA.

Demicheli, V., Jefferson, T., Ferroni, E., Rivetti, A., & Di Pietrantonj, C. (2018). Vaccines for preventing influenza in healthy adults. Cochrane Database of Systematic Reviews, (2): CD001269. https://doi.org/10.1002/14651858.CD001269.pub6

Descatha, A., Hamzaoui, H., & Takala, J. (2023). A Systematized Overview of Published Reviews on Biological Hazards, Occupational Health, and Safety. Safety and Health at Work, 14(4), 347–357. https://doi.org/10.1016/j.shaw.2023.10.008

Diggle, S. P., & Whiteley, M. (2021). Microbe Profile: Pseudomonas aeruginosa: opportunistic pathogen and lab rat. Microbiology (Reading). 2020 Jan;166(1):30-33. doi: 10.1099/mic.0.000860. Erratum in: Microbiology (Reading). 167(8). https://doi.org/10.1099/mic.0.000860

Dutkiewicz, J., Śpiewak, R., Podgórski, C., & Szymańska, J. (2011). Biological agents as occupational hazards. Annals of Agricultural and Environmental Medicine, 18(1), 23–33.

Eckert, J., & Deplazes, P. (2004). Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern. Clinical Microbiology Reviews, 17. https://doi.org/10.1128/cmr.17.1.107-135.2004

Enning, D., & Garrelfs, J. (2014). Corrosion of iron by sulfate-reducing bacteria: new views of an old problem. Applied and Environmental Microbiology, 80(4):1226-36. https://doi.org/10.1128/AEM.02848-13

Ergönül, Ö. (2006). Crimean-Congo haemorrhagic fever. Lancet Infectious Diseases, 6(4), 203–214. https://doi.org/10.1016/S1473-3099(06)70435-2

European Agency for Safety and Health at Work. (2019). Biological agents and work-related diseases: A review of the evidence. Publications Office of the European Union. Erişim adresi: https://osha.europa.eu/en/themes/work-related-diseases/biological-agents

Ferris, M., Ferris, R., Workman, C., O'Connor, E., Enoch, D. A., Goldesgeyme, E., Quinnell, N., Patel, P., Wright, J., Martell, G., Moody, C., Shaw, A., Illingworth, C. J., Matheson, N. J., & Weekes M. P. (2021). Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers. Elife. https://doi.org/10.7554/eLife.71131

Franc, K. A., Krecek, R. C., Häsler, B. N., & Arenas-Gamboa, A. M. (2018). Brucellosis remains a neglected disease in the developing world: a call for interdisciplinary action. BMC Public Health. 18(1):125. https://doi.org/10.1186/s12889-017-5016-y

Gralton, J., Tovey, E., McLaws, M. L., & Rawlinson, W. D. (2011). The role of particle size in aerosolised pathogen transmission: A review. Journal of Infection, 62(1), 1–13. https://doi.org/10.1016/j.jinf.2010.11.010

Garus-Pakowska, A. (2022). Biological Factors in the Workplace-Current Threats to Employees, the Effects of Infections, Prevention Options. International Journal of Environmental Research and Public Health, 19(9):5592. https://doi.org/10.3390/ijerph19095592

Gaviola, G. C., McCarville, M., Shendale, S., Goodman, T., Lomazzi, M., & Desai, S. (2023). A review of health worker vaccination programs in low, middle and upper middle-income countries. Public Health in Practice, 6:100415.

https://doi.org/10.1016/j.puhip.2023.100415

Gómez-Ochoa, S. A., Franco, OH., Rojas, LZ., Raguindin, PF., Roa-Díaz, ZM., Wyssmann, BM., Guevara, SLR., Echeverría, LE., Glisic, M., Muka, T. (2021). COVID-19 in health-care workers: A living systematic review and meta-analysis of prevalence, risk factors, clinical characteristics, and outcomes. American Journal of Epidemiology, 190(1), 161–175.

https://doi.org/10.1093/aje/kwaa191

Górny, R. L., Reponen, T., Willeke, K., Schmechel, D., Robine, E., Boissier, M., & Grinshpun, S. A. (2002). Fungal fragments as indoor air biocontaminants. Applied and Environmental Microbiology, 68(7), 3522–3531. https://doi.org/10.1128/AEM.68.7.3522-3531.2002

Gupta, A. K., Wang, T., Susmita, Talukder, M., & Bakotic, W. L. (2025). Global Dermatophyte Infections Linked to Human and Animal Health: A Scoping Review. Microorganisms, 13(3), 575. https://doi.org/10.3390/microorganisms13030575

Haagsma, J. A., Polinderr, S., Claudia, E., & Havelaar, A. H. (2013).

Systematic review of foodborne burden of disease studies: quality assessment of data and methodology. International Journal of Food Microbiology, 166(1), 34–47.

https://doi.org/10.1016/j.ijfoodmicro.2013.05.029

Haig, D. M., & Mercer, A. A. (1998). Ovine diseases: Orf. Veterinary Research, 29(3–4), 311–326.

Halstensen, A. S., Nordby, K. C., Klemsdal, S. S., Elen, O., Clasen, P. E., & Eduard, W. (2006). Toxigenic Fusarium spp. as Determinants of Trichothecene Mycotoxins in Settled Grain Dust. Journal of Occupational and Environmental Hygiene, 3(12), 651–659. https://doi.org/10.1080/15459620600987431

Heikkinen, T., & Järvinen, A. (2003). The common cold. The Lancet, 361(9351), 51–59. https://doi.org/10.1016/S0140-6736(03)12162-9.

Hoogstraal, H. (1979). The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. Journal of Medical Entomology, 15(4), 307–417. https://doi.org/10.1093/jmedent/15.4.307

Iannone, P., Castellini, G., Coclite, D., Napoletano, A., Fauci, A. J., Iacorossi, L., D'Angelo, D., Renzi, C., La Torre, G., Mastroianni, C. M., & Gianola, S. (2020). The need of health policy perspective to protect Healthcare Workers during COVID-19 pandemic. A GRADE rapid review on the N95 respirators effectiveness. PLoS One, 3;15(6):e0234025. https://doi.org/10.1371/journal.pone.0234025

International Labour Organization. (2020). COVID-19 and the world of work: Impact and policy responses. International Labour Organization. 03 Haziran 2026 tarihinde https://www.ilo.org/sites/default/files/wcmsp5/groups/public/@dgreports/@dcomm/documents/briefingnote/wcms_738753.pdf adresinden erişildi.

International Labour Organization. (2023). Safety and health at work. 06 Haziran 2026 tarihinde https://www.ilo.org/topics-and-sectors/safety-and-health-work adresinden erişildi.

Jefferson, T., Del Mar, C. B., Dooley, L., Ferroni, E., Al‐Ansary, L. A., Bawazeer, G. A., van Driel, M. L., Nair, N. S., Jones, M. A., Thorning, S., & Conly, J. M. (2011). Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database of Systematic Reviews, (7): CD006207. https://doi.org/10.1002/14651858.CD006207.pub4

Jeffery-Smith, A., Taori, S. K., Schelenz, S., Jeffery, K., Johnson, E. M., Borman, A., Manuel, R., & Brown C. S. (2018). Candida auris: A review of the literature. Clinical Microbiology Reviews, 31(1), e00029-17. https://doi.org/10.1128/cmr.00029-17

Jensen, P. A., Lambert, L. A., Iademarco, M. F., & Ridzon, R. (2005). Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings. MMWR Recommendations and Reports, 54(RR-17), 1–141.

Karwowska, E. (2005). Microbiological air contamination in farming environment. Polish Journal of Environmental Studies, 14(4), 445–449

Knecht, H., Balanay, J. A. G., Langley, R., Marcom, R. T., & Richards, S. L. (2024). Systematic review of biological, chemical, ergonomic, physical, and psychosocial hazards impacting occupational health of United States forestry workers. Journal of Forestry, 122(2), 159–170. https://doi.org/10.1093/jofore/fvad052

Konstantinidis, K. T., Ramette, A., Tiedje, J. M. (2006). The bacterial species definition in the genomic era. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 29;361(1475):1929-40. https://doi.org/10.1098/rstb.2006.1920

Koonin, E. V., Dolja, V. V., Krupovic, M., Kuhn, J. H. (2021). Viruses Defined by the Position of the Virosphere within the Replicator Space. Microbiology and Molecular Biology Reviews, 15;85(4):e0019320. https://doi.org/10.1128/MMBR.00193-20

Kosmidis, C., & Denning, D. W. (2015). The clinical spectrum of pulmonary aspergillosis. Thorax,70(3):270-7. https://doi.org/10.1136/thoraxjnl-2014-206291

Kravetz, J. D., & Federman, D. G. (2005). Toxoplasmosis in pregnancy. The American Journal of Medicine, 118 (3), 212–216. https://doi.org/10.1016/j.amjmed.2004.08.0233

Larone, D. H. (2011). Medically important fungi: A guide to identification (5th ed.). ASM Press.

Latgé J. P. (1999). Aspergillus fumigatus and aspergillosis. Clinical Microbiology Reviews, 12(2):310-50. https://doi.org/10.1128/cmr.12.2.310

Lavoie, M. C., Verbeek, J. H., & Pahwa, M. (2014). Devices for preventing percutaneous exposure injuries caused by needles in healthcare personnel. Cochrane Database of Systematic Reviews, 3, CD009740. https://doi.org/10.1002/14651858.CD009740.pub2

Lele D. V. (2018). Occupational Health Surveillance. Indian Journal of Occupational and Environmental Medicine, 22(3):117-120.

Leveson, N. (2011). Applying systems thinking to analyze and learn from events. Safety Science, 49(1), 55–64. https://doi.org/10.1016/j.ssci.2009.12.021

Levy, S. B., & Marshall, B. (2004). Antibacterial resistance worldwide: causes, challenges and responses. Nature Medicine, 10(12 Suppl):S122-9. https://doi.org/10.1038/nm1145

Li, Y., Leung, G. M., Tang, J. W., Yang, X., Chao, C. Y., Lin, J. Z., Lu, J. W, Nielsen, P. V., Niu, J., Qian, H., Sleigh, A. C., Su, H. J., Sundell, J., Wong, T. W., & Yuen, P. L. (2007). Role of ventilation in airborne transmission of infectious agents in the built environment - a multidisciplinary systematic review. Indoor Air, 17(1), 2-18. https://doi.org/10.1111/j.1600-0668.2006.00445.x

Lone, S. A., & Ahmad, A. (2019). Candida auris — the growing menace to global health. Mycoses, 62(8), 620–637. https://doi.org/10.1111/myc.12904

Lustig, A., & Levine, A. J. (1992). One hundred years of virology. Journal of Virol, 66(8):4629-31. https://doi.org/10.1128/jvi.66.8.4629-4631.1992

Maltezou, H. C., Panagopoulos, P., Sourri, F., Giannouchos, T. V., Raftopoulos, V., Gamaletsou, M. N., Karapanou, A., Koukou, D. M., Koutsidou, A., Peskelidou, E., Papanastasiou, K., Souliotis, K., Lourida, A., Sipsas, N. V., Hatzigeorgiou, D. (2021). COVID-19 vaccination significantly reduces morbidity and absenteeism among healthcare personnel: A prospective multicenter study. Vaccine, 26;39(48):7021-7027. https://doi.org/10.1016/j.vaccine.2021.10.054

Manuele, F. A. (2005). Risk assessment and hierarchies of control. Professional Safety, 50(5), 33–39.

McFall-Ngai, M., Hadfield, M. G., Bosch, T. C., Carey, H. V., Domazet-Lošo, T., Douglas, A. E., Dubilier, N., Eberl, G., Fukami, T., Gilbert, S. F., Hentschel, U., King, N., Kjelleberg, S., Knoll, A. H., Kremer, N., Mazmanian, S. K., Metcalf, J. L., Nealson, K., Pierce, N. E., Rawls, J. F., Reid, A., Ruby, E. G., Rumpho, M., Sanders, J. G., Tautz, D., & Wernegreen, J. J. (2013). Animals in a bacterial world, a new imperative for the life sciences. Proceedings of the National Academy of Sciences of the United States of America, 26;110(9):3229-36. https://doi.org/10.1073/pnas.1218525110

Mengistu, D. A., Tolera, S. T., & Demmu, Y. M. (2021). Worldwide prevalence of occupational exposure to needle stick injury among healthcare workers: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 2021, 9019534. https://doi.org/10.1155/2021/9019534

Mohammed, A., Ahmed, M., & Ibrahim, N. (2024).

The global seroprevalence of Toxoplasma gondii infection in workers occupationally exposed to animals (1972–2023): A systematic review and meta-analysis. The Veterinary Quarterly, 44(1), 1–18. https://doi.org/10.1080/01652176.2024.2396577

Mol, M. P. G., Gonçalves, J. P., Silva, E. A., Scarponi, C. F. O., Greco, D. B., Cairncross, S., & Heller, L. (2016). Seroprevalence of hepatitis B and C among domestic and healthcare waste handlers in Belo Horizonte, Brazil. Waste Management & Research, 34(9), 875–883. https://doi.org/10.1177/0734242X16649686

Montano, D. (2014). Chemical and biological work-related risks across occupations in Europe: a review. Journal of Occupational Medicine and Toxicology, (9):28. https://doi.org/10.1186/1745-6673-9-28

Mourya, D. T., Yadav, P. D., Majumdar, T. D., Chauhan, D. S., Katoch, V. M. (2014). Establishment of Biosafety Level-3 (BSL-3) laboratory: important criteria to consider while designing, constructing, commissioning & operating the facility in Indian setting. Indian Journal of Medical Research, 140(2):171-83.

Murray, P. R., Rosenthal, K. S., & Pfaller, M. A. (2021) Medical microbiology. 9th edn. London: Elsevier.

National Institute for Occupational Safety and Health. (2024). Hierarchy of controls. Centers for Disease Control and Prevention. Erişim adresi: https://www.cdc.gov/niosh/hierarchy-of-controls/index.html

OpenStax. (2024). Infection cycle. In Clinical Nursing Skills. LibreTexts. Erişim adresi: https://med.libretexts.org/Bookshelves/Nursing/Clinical_Nursing_Skills_(OpenStax)/06%3A_Infection_Prevention_Techniques_and_Safety_in_the_Clinical_Setting/6.01%3A_Infection_Cycle

Parashar, U. D., Gibson, C. J., Bresee, J. S., & Glass, R. I. (2006). Rotavirus and severe childhood diarrhea. Emerging Infectious Diseases, 12(2), 304–306. https://doi.org/10.3201/eid1202.050006

Paris, C., Tadié, E., Heslan, C., Gary-Bobo, P., Oumari, S., Saade, A., Sitruk, A., Wild, P., Thibault, V., Tattevin, P., Garlantezec, R. (2022). Risk factors for SARS-CoV-2 infection among health care workers. American Journal of Infection Control, 50(4):375-382. https://doi.org/10.1016/j.ajic.2021.11.001

Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J.A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. H. & Bennett, J. E. (2016). Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, 63(4): e1–e60. https://doi.org/10.1093/cid/ciw326

Payne S. (2017). Introduction to Animal Viruses. Viruses. 2017:1–11. https://doi.org/10.1016/B978-0-12-803109-4.00001-5

Pereira, C. R., Cotrim de Almeida, J. V. F., Cardoso de Oliveira, I. R., Faria de Oliveira, L., Pereira, L. J., Zangerônimo, M. G., Lage, A. P., & Dorneles, E. M. S. (2020) Occupational exposure to Brucella spp.: A systematic review and meta-analysis. PLOS Neglected Tropical Diseases, 14(5):e0008164. https://doi.org/10.1371/journal.pntd.000816444

Pike R. M. (1979). Laboratory-associated infections: incidence, fatalities, causes, and prevention. Annual Review of Microbiology, 33:41-66. https://doi.org/10.1146/annurev.mi.33.100179.000353

Popa G. L., & Papa M. I. (2021). Salmonella spp. infection - a continuous threat worldwide. Germs. 11(1):88-96. https://doi.org/10.18683/germs.2021.1244

Poulsen, O. M., Breum, N. O., Ebbehøj, N., Hansen, A. M., Ivens, U. I., van Lelieveld, D., Malmros, P., Matthiasen, L., Nielsen, B. H., Nielsen, E.M, Schibye, B., Skov, T., Stenbaek, E. I., & Wilkins, C. K. (1995). Collection of domestic waste. Review of occupational health problems and their possible causes. Science of the Total Environment, 170(1-2):1-19. https://doi.org/10.1016/0048-9697(95)04524-5

Principe, L., Tomao, P., & Visca, P. (2017). Legionellosis in the occupational setting. Environmental Research, 152, 485–495. https://doi.org/10.1016/j.envres.2016.09.018

Prüss-Üstün A., & Corvalán C. (2006). World Health Organization. Preventing disease through healthy environments: towards an estimate of the environmental burden of disease. Erişim adresi: https://iris.who.int/handle/10665/43457

Rawson, A. M., Dempster, A. W., Humphreys, C. M., & Minton, N.P. (2023). Pathogenicity and virulence of Clostridium botulinum. Virulence. 14(1):2205251. https://doi.org/10.1080/21505594.2023.2205251

Rim, K. T., & Lim, C. H. (2014). Biologically hazardous agents at work and efforts to protect workers' health: A review of recent reports. Safety and Health at Work, 5(2), 43–52. https://doi.org/10.1016/j.shaw.2014.03.006

Ruiz, C., von Känel, G., Burkard, S., & Küenzi, P. (2024). Fusarium spp. in Metalworking Fluid Systems: Companions Forever. Pathogens, 13(11), 990. https://doi.org/10.3390/pathogens13110990

Santos, J., Ramos, C., Vaz-Velho, M., Vasconcelos Pinto, M. (2020). Occupational Exposure to Biological Agents. Advances in Safety Management and Human Performance, 28;1204:61–7. https://doi.org/10.1007/978-3-030-50946-0_9

Scallan, E., Hoekstra, R. M., Angulo, F. J., Tauxe, R. V., Widdowson, M. A., Roy, S. L., Jones, J. L., & Griffin, P. M. (2011). Foodborne illness acquired in the United States — major pathogens. Emerging Infectious Diseases, 17(1), 7–15. https://doi.org/10.3201/eid1701.P11101

Schelenz, S., Hagen, F., Rhodes, J.L., Abdolrasouli, A., Chowdhary, A., Hall, A., Ryan, L., Shackleton, J., Meis, J. F., Armstrong-James, D., & Fisher, M. C. (2016). First hospital outbreak of the globally emerging Candida auris in a European hospital. Antimicrobial Resistance & Infection Control, 5:35. https://doi.org/10.1186/s13756-016-0132-5

Schillie, S., Vellozzi, C., Reingold, A., Harris, A., Haber, P., Ward, J. W., & Nelson, N. P. (2018). Prevention of hepatitis B virus infection in the United States: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recommendations and Reports, 67(1), 1–31. https://doi.org/10.15585/mmwr.rr6701a1

Segeritz, C. P., & Vallier, L. (2017). Cell Culture: Growing Cells as Model Systems In Vitro. Basic Science Methods for Clinical Researchers, 2017:151–72. https://doi.org/10.1016/B978-0-12-803077-6.00009-6

Siegel, J. D., Rhinehart, E., Jackson, M., & Chiarello, L. (2007). 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings. American Journal of Infection Control, 35(10Suppl2):65-164 https://doi.org/10.1016/j.ajic.2007.10.007

Souza-Silva, G., Zolnikov, T. R., Ortolani, P. L., Cruvinel, V. R. N., Dias, S. M., & Mol, M. P. G. (2022). Hepatitis B and C prevalence in waste pickers: a global meta-analysis. Journal of Public Health, 44(4), 761–769. https://doi.org/10.1093/pubmed/fdab285

Talapko, J., Frauenheim, E., Juzbašić, M, Tomas, M., Matić, S., Jukić, M., Samardžić, M., & Škrlec, I. (20202). Legionella pneumophila-Virulence Factors and the Possibility of Infection in Dental Practice. Microorganisms. 10(2):255. https://doi.org/10.3390/microorganisms10020255

Tarekegn, A. A., Mitiku, B. A., Alemu, Y. F. (2023). Escherichia coli O157:H7 beef carcass contamination and its antibiotic resistance in Awi Zone, Northwest Ethiopia. Food Science & Nutrition, 11(10):6140-6150. https://doi.org/10.1002/fsn3.3550

T.C. Çalışma ve Sosyal Güvenlik Bakanlığı. (2012). 6331 sayılı İş Sağlığı ve Güvenliği Kanunu. Resmî Gazete, 28339. Erişim adresi: https://www.resmigazete.gov.tr/eskiler/2012/06/20120630-1.htm

T.C. Çalışma ve Sosyal Güvenlik Bakanlığı. (2013). Biyolojik Etkenlere Maruziyet Risklerinin Önlenmesi Hakkında Yönetmelik. Resmî Gazete, 28678. Erişim adresi: https://www.mevzuat.gov.tr/File/GeneratePdf?mevzuatNo=18485&mevzuatTur=KurumVeKurulusYonetmeligi&mevzuatTertip=5

Tikhomirova, A., McNabb, E. R., Petterlin, L., Bellamy, G. L., Lin, K. H., Santoso, C. A., Daye, E. S., Alhaddad, F. M., Lee, K. P., & Anna Roujeinikova, A. (2024). Campylobacter jejuni virulence factors: update on emerging issues and trends. Journal of Biomedical Science, 31:45. https://doi.org/10.1186/s12929-024-01033-6

Torgerson, P. R., & Macpherson, C. N. L. (2011). The socioeconomic burden of parasitic zoonoses: Global trends. Veterinary Parasitology, 182(1), 79–95. https://doi.org/10.1016/j.vetpar.2011.07.017

Tournier, J. N., Ulrich, R. G., Quesnel-Hellmann, A., Mohamadzadeh, M., & Stiles, B. G. (2009). Anthrax, toxins and vaccines: a 125-year journey targeting Bacillus anthracis. Expert Review of Anti-Infective Therapy, 7(2):219-36. https://doi.org/10.1586/14787210.7.2.219

Trafny, E. A. (2013). Microorganisms in metalworking fluids: Current issues in research and management. International Journal of Occupational Medicine and Environmental Health, 26(1), 4–15. https://doi.org/10.2478/S13382-013-0075-5

Ueki, T., & Lovley, D. R. (2022). Desulfovibrio vulgaris as a model microbe for the study of corrosion under sulfate-reducing conditions. mLife, 1(1):13-20. https://doi.org/10.1002/mlf2.12018

Vonberg, R. P., & Gastmeier, P. (2006). Nosocomial aspergillosis in outbreak settings. Journal of Hospital Infection, 63(3):246-54. https://doi.org/10.1016/j.jhin.2006.02.014

Walton, S. F., & Currie, B. J. (2007). Problems in diagnosing scabies, a global disease in human and animal populations. Clinical Microbiology Reviews, 20(2), 268–279. https://doi.org/10.1128/CMR.00042-06

Wheeler, C., Vogt, T. M., Armstrong, G. L., Vaughan, G., Weltman, A., Nainan, O. V., Dato, V., Xia, G., Waller, K., Amon, J., Lee, T. M., Highbaugh-Battle, A., Hembree, C., Evenson, S., Ruta, M. A., Williams, I. T., Fiore, A. E., & Bell, B. P. (2005). An outbreak of hepatitis A associated with green onions. New England Journal of Medicine, 353(9), 890–897. https://doi.org/10.1056/NEJMoa050855

World Health Organization. (2020). Laboratory Biosafety Manual, 4th ed., 2020) 04 Haziran 2026 tarihinde https://www.who.int/publications/i/item/9789240011311 adresinden erişildi.

World Health Organization. (2018). E. coli. 02 Haziran 2026 tarihinde https://www.who.int/news-room/fact-sheets/detail/e-coli adresinden erişildi.

World Health Organization. (2019). Tuberculosis infection prevention and control guidelines. World Health Organization. 04 Haziran 2026 tarihinde https://iris.who.int/bitstream/handle/10665/311259/9789241550512-eng.pdf adresinden erişildi.

World Health Organization. (2024). Vaccination of health workers. World Health Organization. 04 Haziran 2026 tarihinde https://www.who.int/teams/immunization-vaccines-and-biologicals/essential-programme-on-immunization/integration/health-worker-vaccination adresinden erişildi.

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