Fonksiyonel Yem Kaynaklarının In Vivo Sindirim Kinetiği, Metabolik Profil ve Hayvan Sağlığı Üzerine Etkileri
Özet
Dünya nüfusundaki hızlı artış, doğal kaynaklar üzerindeki baskıyı artırmakta ve gelecekte yeterli gıdaya erişimi önemli bir sorun hâline getirmektedir. Birleşmiş Milletler verilerine göre dünya nüfusunun 2050 yılında 9,8 milyarı aşması beklenirken, hayvansal kökenli gıdalara olan talebin de önemli ölçüde artacağı öngörülmektedir. Bunun yanında, insan ve hayvan beslenmesinde kullanılan mısır, buğday ve soya gibi temel yem hammaddelerine yönelik rekabet sürdürülebilir hayvansal üretim açısından yeni yaklaşımlara duyulan ihtiyacı artırmaktadır. Bu gelişmeler doğrultusunda hayvan besleme bilimi, yalnızca hayvanların besin maddesi gereksinimlerinin karşılanmasına değil, aynı zamanda sağlık, bağışıklık, sindirim sistemi ve verim özelliklerinin desteklenmesine yönelik fonksiyonel besleme uygulamalarına da yönelmiştir. Yem katkı maddeleri ve fonksiyonel yem bileşenleri, bu amaçlarla uzun yıllardır kullanılmakta ve hayvansal üretimde önemli bir yer tutmaktadır. Özellikle antibiyotik direncinin artmasıyla birlikte, hayvan sağlığını ve performansını destekleyen alternatif katkı maddelerine yönelik araştırmalar hız kazanmıştır. Ancak bu maddelerin etkinliği, katkının türü ve düzeyi, hayvan türü ve besleme koşullarına bağlı olarak değişebildiğinden, güvenli ve etkin kullanım düzeylerinin belirlenmesine yönelik bilimsel çalışmalara ihtiyaç devam etmektedir.
Referanslar
Kholıf, Ahmed E.; Anele, Anuoluwapo; Anele, Uchenna Y. Microbial feed additives in rumi- nant feeding. AIMS microbiology, 2024, doi: 10.3: 542. 10.3934/microbiol.2024026
Park, Sang-O., et al. Application strategy for sustainable livestock production with farm animal algorithms in response to climate change up to 2050: A review. Czech Journal of Animal Science, 2022, 67.11: 425-441.doi: 10.17221/172/2022-CJAS
European Commission. Feed additives. (07/08/2026 tarihinde https://food.ec.europa.eu/fo- od-safety/animal-feed/feed-additives_en adresinden ulaşılmıştır).
FAO. Environmental performance of feed additives in livestock supply chains: Guidelines for assessment. (07/08/2026 tarihinde https://doi.org/10.4060/ca9744en adresinden ulaşılmıştır).
Perera, W. Nipuna U.; Ravındran, Velmurugu. Role of feed additives in poultry nutrition: Historical, current and future perspectives. Animal Feed Science and Technology, 2025, 326: 116371.doi: 10.1016/j.anifeedsci.2025.116371
Gıda, Tarım ve Hayvancılık Bakanlığı. (2013). Hayvan Beslemede Kullanılan Yem Katkı Mad- deleri Hakkında Yönetmelik. Resmî Gazete (Sayı: 28711, 18 Temmuz 2013).
Dell’Anno, M. (2023). Functional feed additives for animal health.
Erickson PS, Kalscheur KF (2020). Nutrition and feeding of dairy cattle. Animal Agriculture 9:157-180. doi.org/10.1016/B978-0- 12-817052-6.00009-4
Ndudzo, A., Pullen, J., Magwaba, T., Ndlovu, S., Moyo, M., Sibanda, S., ... & Mugoti, A. (2023). Incorporation of functional feed ingredients to substitute antimicrobials in animal nutrition: Opportunities for livestock production in developing countries. International Journal of Lives- tock Production, 14(2), 44-57. doi: 10.5897/IJLP2023.0820
Buonaiuto, G., Danese, T., El-Sabrout, K., & Yıldırım, A. (2025). Bioactive feed additives in ani- mal nutrition: bridging innovation, health, and sustainability. Frontiers in Veterinary Science, 12, 1727126. doi.org/10.3389/fvets.2025.1727126
Nagpal, R., Shrivastava, B., Kumar, N., Dhewa, T., Sahay, H. (2015). Microbial Feed Additives. In: Puniya, A., Singh, R., Kamra, D. (eds) Rumen Microbiology: From Evolution to Revolution. Springer, New Delhi. Doi: 10.1007/978-81-322-2401-3_12
Anee, I.J., Alam, S., Begum, R.A. et al. The role of probiotics on animal health and nutrition. JoBAZ 82, 52 (2021). Doi:10.1186/s41936-021-00250-x
Moritz, J. S., Wilson, K. J., Cramer, K. R., Beyer, R. S., McKinney, L. J., Cavalcanti, W. B., & Mo,
X. (2002). Effect of formulation density, moisture, and surfactant on feed manufacturing, pellet quality, and broiler performance. Journal of Applied Poultry Research, 11(2), 155-163. Doi; org/10.1093/japr/11.2.155
Hasan, K.N., Banerjee, G. Recent studies on probiotics as beneficial mediator in aquaculture: a review. JoBAZ 81, 53 (2020). doi.org/10.1186/s41936-020-00190-y
Bhogoju, S., & Nahashon, S. (2022). Recent advances in probiotic application in animal health and nutrition: A review. Agriculture, 12(2), 304. doi: 10.3390/agriculture12020304
Akdemir Evrendilek G. Postbiotics and Phytogenics as Functional Feed Additives: Impact on Gut Health and Growth Performance. Applied Sciences. 2026; 16(3):1518. Doi: 10.3390/ app16031518
Patra, A.K., Saxena, J. Dietary phytochemicals as rumen modifiers: a review of the effects on microbial populations. Antonie van Leeuwenhoek 96, 363–375 (2009). Doi:10.1007/s10482-009-9364-1
Thi, H. H. P., Thi, T. V. P., Huynh, N. P., Doan, V., Onoda, S., & Nguyen, T. L. (2022). Therapeu- tic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers. Acta tropica, 232, 106537. doi: 10.1016/j.actatropica.2022.106537
Greathead H. Plants and plant extracts for improving animal productivity. Proceedings of the Nutrition Society. 2003;62(2):279-290. doi:10.1079/PNS2002197
Abdelli N, Solà-Oriol D, Pérez JF. Phytogenic Feed Additives in Poultry: Achievements, Pros- pective and Challenges. Animals. 2021; 11(12):3471. Doi: 10.3390/ani11123471
W. Windisch, K. Schedle, C. Plitzner, A. Kroismayr, Use of phytogenic products as feed additi- ves for swine and poultry, Journal of Animal Science, Volume 86, Issue suppl_14, April 2008, Pages E140–E148, doi:10.2527/jas.2007-0459
Wang, J., Deng, L., Chen, M., Che, Y., Li, L., Zhu, L., ... & Feng, T. (2024). Phytogenic feed additives as natural antibiotic alternatives in animal health and production: A review of the literature of the last decade. Animal Nutrition, 17, 244-264. doi: 10.1016/j.aninu.2024.01.012
Budiastuti, B., Khairullah, A. R., Moses, I. B., Effendi, M. H., Pratama, B. P., Tyasningsih, W., ... & Yuri, A. J. B. (2026). Potential use of phytobiotics as an alternative to antibiotics in livestock. Journal of Advanced Veterinary Research, 16(2), 301-312.
Aminullah, N., Mostamand, A., Zahir, A., Mahaq, O., & Azizi, M. N. (2025). Phytogenic feed additives as alternatives to antibiotics in poultry production: A review. Veterinary World, 18(1), 141.doi: 10.14202/vetworld.2025.141-154
Dong Z, Liu Z, Xu Y, Tan B, Sun W, Ai Q, Yang Z and Zeng J (2024) Potential for the develop- ment of Taraxacum mongolicum aqueous extract as a phytogenic feed additive for poultry. Front. Immunol. 15:1354040. doi: 10.3389/fimmu.2024.1354040
Mnisi, C. M., Mlambo, V., Gila, A., Matabane, A. N., Mthiyane, D. M., Kumanda, C., ... & Ga- jana, C. S. (2022). Antioxidant and antimicrobial properties of selected phytogenics for sustai- nable poultry production. Applied Sciences, 13(1), 99. Doi: 10.3390/app13010099
Abou-Elkhair, R., Selim, S., & Hussein, E. (2018). Effect of supplementing layer hen diet with phytogenic feed additives on laying performance, egg quality, egg lipid peroxidation and blood biochemical constituents. Animal nutrition, 4(4), 394-400.doi:10.1016/j.aninu.2018.05.009
Abdelli, N., Solà-Oriol, D., & Pérez, J. F. (2021). Phytogenic feed additives in poultry: achieve- ments, prospective and challenges. Animals, 11(12), 3471. Doi: 0.3390/ani11123471
Cristea, V., Antache, A., Grecu, I., Docan, A., Dediu, L., & Mocanu, M. (2012). The use of phy- tobiotics in aquaculture.
Caipang, C. M. A. (2020). Phytogenics in aquaculture: a short review of their effects on gut health and microflora in fish. The Philippine Journal of Fisheries, 27(2), 11-22.doi: 10.31398/ tpjf/27.2.2020-0006
Zaynab, M., Fatima, M., Abbas, S., Sharif, Y., Umair, M., Zafar, M. H., & Bahadar, K. (2018). Role of secondary metabolites in plant defense against pathogens. Microbial pathogenesis, 124, 198-202. doi:10.1016/j.micpath.2018.08.034
Rahul Sandeep, T., Sravya, M.V.N. & Simhachalam, G. Phytobiotics in finfish and shellfish: a systematic review. Discov Anim 2, 74 (2025). Doi:10.1007/s44338-025-00098-3
Zaikina, A. S., Buryakov, N. P., Buryakova, M. A., Zagarin, A. Y., Razhev, A. A., & Aleshin, D.
E. (2022). Impact of supplementing phytobiotics as a substitute for antibiotics in broiler chic- ken feed on growth performance, nutrient digestibility, and biochemical parameters. Veterinary Sciences, 9(12), 672. doi: 10.3390/vetsci9120672
Hashemi, S.R., Davoodi, H. Herbal plants and their derivatives as growth and health promoters in animal nutrition. Vet Res Commun 35, 169–180 (2011). https://doi.org/10.1007/s11259- 010-9458-2
Lin, Z. N., Ye, L., Li, Z. W., Huang, X. S., Lu, Z., Yang, Y. Q., ... & Ying, Z. Y. (2020). Chinese herb feed additives improved the growth performance, meat quality, and nutrient digestibility parameters of pigs. Animal models and experimental medicine, 3(1), 47-54. Doi: 10.1002/ ame2.12104
Kuralkar, P., & Kuralkar, S. V. (2021). Role of herbal products in animal production–An updated review. Journal of Ethnopharmacology, 278, 114246. Doi: 10.1016/j.jep.2021.114246
Palangi, V., & Lackner, M. (2022). Management of enteric methane emissions in ruminants using feed additives: A review. Animals, 12(24), 3452. doi: 10.3390/ani12243452
Desnoyers, M., Giger-Reverdin, S., Bertin, G., Duvaux-Ponter, C., & Sauvant, D. (2009). Me- ta-analysis of the influence of Saccharomyces cerevisiae supplementation on ruminal para- meters and milk production of ruminants. Journal of Dairy Science, 92(4), 1620-1632. Doi: 10.3168/jds.2008-1414
Ricke, S. C., Dittoe, D. K., & Richardson, K. E. (2020). Formic acid as an antimicrobial for poultry production: A review. Frontiers in Veterinary Science, 7, 563. Doi: 10.3389/fvets.2020.00563
Zhang Q, Guo S, Yi D, Hou Y. Impact of functional lipids on intestinal health in swine and poultry. Animal Nutriomics. 2025;2:e21. doi:10.1017/anr.2025.10012
Zeng, X., Li, S., Liu, L. et al. Role of functional fatty acids in modulation of reproductive poten- tial in livestock. J Animal Sci Biotechnol 14, 24 (2023). Doi:10.1186/s40104-022-00818-9
Moreno, AA, Parker, VJ, Winston, JA, & Rudinsky, AJ (2022). Dietary fiber aids in the manage- ment of canine and feline gastrointestinal diseases. Journal of the American Veterinary Medical Association, 260 (S3), pp. 33-pp. 45.doi: 10.2460/javma.22.08.0351
Margerison, J. (2026). Macronutrients. In J. M. Brameld, S. Athanasiadou, D. A. Kenny, & S. A. Lanham (Eds.), Animal Nutrition (1). Wiley and Sons, Ltd ISBN: 9781119852728
Kazemi, M. Algae as a sustainable feed resource: revolutionizing animal nutrition. Aquacult Int 33, 535 (2025). Doi: 10.1007/s10499-025-02195-2
Kholif, A. E., Gouda, G. A., Olafadehan, O. A., Sallam, S. M., & Anele, U. Y. (2025). Acidifiers and organic acids in livestock nutrition and health. In Organic Feed Additives for Livestock (pp. 43-56). Academic Press. doi: 10.1016/B978-0-443-13510-1.00003-7
Amaro, H. M., Guedes, A. C., & Malcata, F. X. (2011). Antimicrobial activities of microalgae: An invited review. Science against microbial pathogens: communicating current research and te- chnological advances, 2, 1272-1284.
Michalak, M., Wojnarowski, K., Cholewińska, P., Szeligowska, N., Bawej, M., & Pacoń, J. (2021). Selected alternative feed additives used to manipulate the rumen microbiome. Animals, 11(6), 1542. doi: 10.3390/ani11061542
Ferreira, M., Teixeira, C., Abreu, H. et al. Nutritional value, antimicrobial and antioxidant acti- vities of micro- and macroalgae, single or blended, unravel their potential use for aquafeeds. J Appl Phycol 33, 3507–3518 (2021). doi:10.1007/s10811-021-02549-2
