Derinin Bakteriyel Enfeksiyonları

Yazarlar

Melike Güven
https://orcid.org/0000-0002-2620-615X

Özet

Bakteriyel deri enfeksiyonları, birinci basamak sağlık hizmetlerinde sık karşılaşılan ve yüzeyel, kendini sınırlayan enfeksiyonlardan yaşamı tehdit eden invaziv tablolara kadar geniş bir klinik spektrum gösteren hastalıklardır. Bu bölümde başlıca gram-pozitif ve gram-negatif bakterilerin neden olduğu deri enfeksiyonları; epidemiyoloji, klinik bulgular, tanı, ayırıcı tanı ve tedavi yaklaşımları açısından ele alınmıştır. İmpetigo, ektima, bakteriyel folikülit, furonkül, karbonkül, apse, selülit ve erizipel gibi sık görülen enfeksiyonların yanı sıra stafilokokkal haşlanmış deri sendromu, toksik şok sendromu, nekrotizan fasiit ve gazlı gangren gibi hızlı tanı ve acil sevk gerektiren tablolar üzerinde durulmuştur. Ayrıca korinebakteriyel enfeksiyonlar, erizipeloid, aktinomikoz ve Pseudomonas ilişkili deri enfeksiyonlarının klinik özellikleri ve tedavi seçenekleri özetlenmiştir. Birinci basamakta doğru klinik tanının konulması, uygun antimikrobiyal tedavinin seçilmesi ve ciddi enfeksiyonu düşündüren kırmızı bayrak bulgularının erken tanınması, komplikasyonların ve mortalitenin azaltılması açısından önem taşımaktadır.

Referanslar

Szabó K, Bolla BS, Erdei L, et al. Are the Cutaneous Microbiota a Guardian of the Skin’s Physical Barrier? The Intricate Relationship between Skin Microbes and Barrier Integrity. International Journal of Molecular Sciences. 2023 Nov 4;24(21):15962. doi:10.3390/ijms242115962

Matthew McLarney R, Sommer LL, Reboli AC, et al. Bacterial Diseases. In: Dermatology. Fifth Edition. Netherlands: Elsevier; 2024. p. 1273–309.

Trang DT, Buck EC, Schoenherr DT. Impetigo: Rapid Evidence Review. American Family Physician. 2026 Feb;113(2):175–80. PubMed PMID: 41839109.

Hartman-Adams H, Banvard C, Juckett G. Impetigo: diagnosis and treatment. American Family Physician. 2014 Aug 15;90(4):229–35. PubMed PMID: 25250996.

Johnson MK. Impetigo. Advanced Emergency Nursing Journal. 2020 Oct;42(4):262–9. doi:10.1097/TME.0000000000000320

Brown J, Shriner DL, Schwartz RA, et al. Impetigo: an update. International Journal of Dermatology. 2003 Apr 11;42(4):251–5. doi:10.1046/j.1365-4362.2003.01647.x

Bolognia Jean, Schaffer JV., Cerroni Lorenzo, et al. Dermatology. Fifth edition. Elsevier; 2024. 1273–1307 p.

Preda-Naumescu A, Elewski B, Mayo TT. Common Cutaneous Infections. Medical Clinics of North America. 2021 Jul;105(4):783–97. doi:10.1016/j.mcna.2021.04.012

Lamand V, Dauwalder O, Tristan A, et al. Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains. Clinical Microbiology and Infection. 2012 Dec;18(12):E514–21. doi:10.1111/1469-0691.12053

Baddour LM. Impetigo - UpToDate [Internet]. 2025 [cited 2026 May 17]. Available from: https://www.uptodate.com/contents/impetigo?search=impetigo&source=search_result&selectedTitle=1~86&usage_type=default&display_rank=1&searchCorrelationId=f1b10867-a194-4a3b-960a-98bfbbc89cde&searchCorrelationTerm=impetigo

Stevens DL, Bisno AL, Chambers HF, et al. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2014 Jul 15;59(2):e10–52. doi:10.1093/cid/ciu296

Koning S, van der Sande R, Verhagen AP, et al. Interventions for impetigo. Cochrane Database of Systematic Reviews. 2012 Jan 18;2015(6). doi:10.1002/14651858.CD003261.pub3

Stevens DL et al (Clin Infect Dis 2014; 59:147–59). Clinical Infectious Diseases. 2015 May 1;60(9):1448–1448. doi:10.1093/cid/civ114

Almquist E. Pemphigus neonatorum, bacteriologisch und epidemiologisch beleuchtet. Zeitschrift für Hygiene. 1891 Dec;10(1):253–66. doi:10.1007/BF02188520

Handler MZ, Schwartz RA. Staphylococcal scalded skin syndrome: diagnosis and management in children and adults. Journal of the European Academy of Dermatology and Venereology. 2014 Nov 20;28(11):1418–23. doi:10.1111/jdv.12541

Leung AKC, Barankin B, Leong KF. Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management. World Journal of Pediatrics. 2018 Apr 5;14(2):116–20. doi:10.1007/s12519-018-0150-x

Saleh HM, Ross A, Sathe NC. Staphylococcal Scalded Skin Syndrome. 2026. PubMed PMID: 28846262.

Braunstein I, Wanat KA, Abuabara K, et al. Treat JR. Antibiotic Sensitivity and Resistance Patterns in Pediatric Staphylococcal Scalded Skin Syndrome. Pediatric Dermatology. 2014 May 23;31(3):305–8. doi:10.1111/pde.12195

Schmitz M, Roux X, Huttner B, et al. Streptococcal toxic shock syndrome in the intensive care unit. Annals of Intensive Care. 2018;8(1):88. doi:10.1186/s13613-018-0438-y

Lappin E, Ferguson AJ. Gram-positive toxic shock syndromes. The Lancet Infectious Diseases. 2009 May;9(5):281–90. doi:10.1016/S1473-3099(09)70066-0

DeVries AS, Lesher L, Schlievert PM, et al. Staphylococcal Toxic Shock Syndrome 2000–2006: Epidemiology, Clinical Features, and Molecular Characteristics. PLoS One. 2011 Aug 10;6(8):e22997. doi:10.1371/journal.pone.0022997

MURRAY RJ. Recognition and management of Staphylococcus aureus toxin‐mediated disease. The Internal Medicine Journal. 2005 Dec 4;35(s2). doi:10.1111/j.1444-0903.2005.00984.x

Wharton M, Chorba TL, Vogt RL, et al. Case definitions for public health surveillance. The Morbidity and Mortality Weekly Report. 1990 Oct 19;39(RR-13):1–43. PubMed PMID: 2122225.

Laureano AC, Schwartz RA, Cohen PJ. Facial bacterial infections: Folliculitis. Clinical Dermatology. 2014 Nov;32(6):711–4. doi:10.1016/j.clindermatol.2014.02.009

Natsis NE, Cohen PR. Coagulase-Negative Staphylococcus Skin and Soft Tissue Infections. American Journal of Clinical Dermatology. 2018 Oct 7;19(5):671–7. doi:10.1007/s40257-018-0362-9

Luelmo-Aguilar J, S??bat Santandreu M. Folliculitis. American Journal of Clinical Dermatology. 2004;5(5):301–10. doi:10.2165/00128071-200405050-00003

Lin HS, Lin PT, Tsai YS, et al. Interventions for bacterial folliculitis and boils (furuncles and carbuncles). Cochrane Database of Systematic Reviews. 2021 Feb 26;2021(3). doi:10.1002/14651858.CD013099.pub2

Baddour LM. Cellulitis and skin abscess: Epidemiology, microbiology, clinical manifestations, and diagnosis [Internet]. 2026 [cited 2026 May 15]. Available from: https://www.uptodate.com/contents/cellulitis-and-skin-abscess-epidemiology-microbiology-clinical-manifestations-and-diagnosis?search=cellulitis%20and%20skin%20abscess&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1&searchCorrelationId=721a3646-b73f-4bc8-9092-38232ae2f6b9&searchCorrelationTerm=cellulitis%20and%20skin%20abscess

Bolognia Jean, Schaffer JV., Cerroni Lorenzo. Dermatology. Fourth edition. Elsevier; 2018. 1259–1293 p.

Quirke M, Ayoub F, McCabe A, et al. Risk factors for nonpurulent leg cellulitis: a systematic review and meta-analysis. British Journal of Dermatology. 2017 Aug;177(2):382–94. doi:10.1111/bjd.15186

Boettler MA, Kaffenberger BH, Chung CG. Cellulitis: A Review of Current Practice Guidelines and Differentiation from Pseudocellulitis. American Journal of Clinical Dermatology. 2022 Mar 13;23(2):153–65. doi:10.1007/s40257-021-00659-8

Bystritsky RJ. Cellulitis. Infectious Disease Clinics of North America. 2021 Mar;35(1):49–60. doi:10.1016/j.idc.2020.10.002

Fisher RG, Benjamin DK. Facial cellulitis in childhood: a changing spectrum. Southern Medical Journal. 2002 Jul;95(7):672–4. PubMed PMID: 12144069.

Singer S, Li DG, Gunasekera N, et al. The ALT-70 cellulitis model maintains predictive value at 24 and 48 hours after presentation. Journal of the American Academy of Dermatology. 2019 Dec;81(6):1252–6. doi:10.1016/j.jaad.2019.03.050

Baddour LM. Acute cellulitis and erysipelas in adults: Treatment [Internet]. 2025 [cited 2026 Apr 25]. Available from: https://www.uptodate.com/contents/acute-cellulitis-and-erysipelas-in-adults-treatment?sectionName=DETERMINING%20THE%20SITE%20OF%20CARE&topicRef=144515&anchor=H2126273051&source=bqp#H2126273051

Bonnetblanc JM, B??dane C. Erysipelas. American Journal of Clinical Dermatology. 2003;4(3):157–63. doi:10.2165/00128071-200304030-00002

Long B, Gottlieb M. Diagnosis and Management of Cellulitis and Abscess in the Emergency Department Setting: An Evidence-Based Review. The Journal of Emergency Medicine. 2022 Jan;62(1):16–27. doi:10.1016/j.jemermed.2021.09.015

Facinelli B, Spinaci C, Magi G, et al. Association between erythromycin resistance and ability to enter human respiratory cells in group A streptococci. The Lancet. 2001 Jul;358(9275):30–3. doi:10.1016/S0140-6736(00)05253-3

Atchade E, De Tymowski C, Grall N, et al. Toxic Shock Syndrome: A Literature Review. Antibiotics. 2024 Jan 18;13(1):96. doi:10.3390/antibiotics13010096

Lappin E, Ferguson AJ. Gram-positive toxic shock syndromes. Lancet Infectious Diseases. 2009 May;9(5):281–90. doi:10.1016/S1473-3099(09)70066-0

Defining the group A streptococcal toxic shock syndrome. Rationale and consensus definition. The Working Group on Severe Streptococcal Infections. JAMA. 1993 Jan 20;269(3):390–1. PubMed PMID: 8418347.

Goldstein EJC, Anaya DA, Dellinger EP. Necrotizing Soft-Tissue Infection: Diagnosis and Management. Clinical Infectious Diseases. 2007 Mar 1;44(5):705–10. doi:10.1086/511638

Stevens DL, Bryant AE. Necrotizing Soft-Tissue Infections. New England Journal of Medicine. 2017 Dec 7;377(23):2253–65. doi:10.1056/NEJMra1600673

Ahmed S, Ali SR, Samani ZA. Pseudomonas Necrotizing Fasciitis in an Otherwise Healthy Infant. Case Reports in Infectious Diseases. 2012;2012:1–3. doi:10.1155/2012/517135

Eke N. Fournier’s gangrene: a review of 1726 cases. Journal of British Surgery. 2000 Jun 1;87(6):718–28. doi:10.1046/j.1365-2168.2000.01497.x

Sabir S, Nguyen AD. Scarlet Fever. 2026. PubMed PMID: 29939666.

Pennycook KM, McCready TA. Perianal Streptococcal Dermatitis. 2026. PubMed PMID: 31613443.

Palha MJ, Limão S, Santos MC, et al. Perianal streptococcal dermatitis. Pediatric Neonatology. 2019 Dec;60(6):691–2. doi:10.1016/j.pedneo.2019.04.001

Groves JB, Nassereddin A, Syed HA. Erythrasma. 2026. PubMed PMID: 30020724.

Wang X. Inguinal Erythrasma. New England Journal of Medicine. 2023 Jul 13;389(2). doi:10.1056/NEJMicm2215982

Palaniappan V, Murthy AB, Karthikeyan K. Pitted keratolysis. Clinical and Experimental Dermatology. 2023 Aug 25;48(9):978–83. doi:10.1093/ced/llad175

Bian K, Ma Y, Hu W. Trichomycosis axillaris. Canadian Medical Association Journal. 2024 Oct 15;196(34):E1170–E1170. doi:10.1503/cmaj.240723

Makhecha M, Dass S, Singh T, et al. Pitted keratolysis – a study of various clinical manifestations. International Journal of Dermatology. 2017 Nov 18;56(11):1154–60. doi:10.1111/ijd.13744

Veraldi S, Girgenti V, Dassoni F, et al. Erysipeloid: a review. Clinical Experimental Dermatology. 2009 Dec;34(8):859–62. doi:10.1111/j.1365-2230.2009.03444.x

Weenink RP, Giannakopoulos GF, van Hulst RA. Clostridial Myonecrosis (Gas Gangrene). Undersea Hyperbaric Medicine. 2025;52(2):203–9. PubMed PMID: 40819362.

Buboltz JB, Murphy-Lavoie HM. Gas Gangrene(Archived). 2026. PubMed PMID: 30725715.

Wong VK, Turmezei TD, Weston VC. Actinomycosis. BMJ. 2011 Oct 11;343(oct11 3):d6099–d6099. doi:10.1136/bmj.d6099

Fronek L, Brazen B, Ross R, et al. Cervicofacial actinomycosis: a unique diagnostic challenge. Dermatology Online Journal. 2021 Aug 11;27(7). doi:10.5070/D327754367

Matsuura H, Senoo A, Saito M, et al. Green nail syndrome. QJM: An International Journal of Medicine. 2017 Jun 13. doi:10.1093/qjmed/hcx114

Lee H, Mun J, Cho S, et al. Clinical analysis of Pseudomonas aeruginosa ‐positive and ‐negative green nail syndrome cases: A single center retrospective analysis. Journal of Dermatology. 2021 Jul 23;48(7):1073–6. doi:10.1111/1346-8138.15832

Korte AKM, Vos JM. Ecthyma Gangrenosum. New England Journal of Medicine. 2017 Dec 7;377(23):e32. doi:10.1056/NEJMicm1702302

Shah M, Crane JS. Ecthyma Gangrenosum. 2026. PubMed PMID: 30521198.

Spernovasilis N, Psichogiou M, Poulakou G. Skin manifestations of Pseudomonas aeruginosa infections. Current Opinion in Infectious Diseases. 2021 Apr;34(2):72–9. doi:10.1097/QCO.0000000000000717

Jackson JD. Infectious Folliculitis [Internet]. 2025 [cited 2026 May 17]. Available from: https://www.uptodate.com/contents/infectious-folliculitis?search=infectious%20folliculitis&source=search_result&selectedTitle=1~111&usage_type=default&display_rank=1&searchCorrelationId=43c5bbca-477d-4fa3-b36e-16d0709933ea&searchCorrelationTerm=infectious%20folliculitis

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25 Eylül 2026

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