Çocuklarda Kabızlığın Tıbbi Beslenme Tedavisi ve Yönetimi

Yazarlar

Meryem Gözde Koçak
https://orcid.org/0000-0002-4599-7831

Özet

Kabızlık, çocukluk çağında en sık görülen fonksiyonel gastrointestinal hastalıklardan biri olup, yaşam kalitesini olumsuz etkileyen ve sağlık hizmeti kullanımını artıran önemli bir halk sağlığı sorunudur. Tedavide temel amaç, bağırsak alışkanlığının yeniden düzenlenmesi, semptomların giderilmesi ve nükslerin önlenmesidir. Bu doğrultuda tıbbi beslenme tedavisi, farmakolojik tedaviyi destekleyen temel yaklaşımlardan biridir. Bu bölümde çocuklarda kabızlığın tıbbi beslenme tedavisine ilişkin güncel kanıtlar değerlendirilmiştir. Diyet lifi ve sıvı alımının yeterli düzeyde sağlanmasının bağırsak fonksiyonlarının düzenlenmesindeki rolü, probiyotik, prebiyotik ve sinbiyotiklerin olası etkileri ile mevcut kanıtların sınırlılıkları ele alınmıştır. Anne sütüyle beslenmenin bağırsak mikrobiyotası ve dışkılama düzeni üzerindeki olumlu etkileri, formül mamaların özellikleri ve mikrobiyota odaklı beslenme yaklaşımları değerlendirilmiştir. Sonuç olarak, çocuklarda kabızlığın tıbbi beslenme tedavisi; güncel kanıtlar doğrultusunda, çocuğun yaşı, beslenme durumu, klinik özellikleri ve yaşam

Referanslar

Xinias I, Mavroudi A. Constipation in childhood: an update on evaluation and management. Hippokratia. 2015;19(1):11-19.

Gordon M, Geus A, Banasiuk M, Benninga MA, et al. ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure). BMJ Paediatr Open. 2025;9(1).

Benzamin M, Karim AB, Rukunuzzaman M, et al. Functional constipation in Bangladeshi school aged children: a hidden misty at community. World J Clin Pediatr. 2022;11(2):160-172.

Geus A, Koppen IJ, Flint R, Benninga MA, Tabbers MM. An update of pharmacological management in children with functional constipation. Paediatr Drugs. 2023;25(3):343-358.

Rajindrajith S, Devanarayana NM, Benninga MA. Childhood constipation: current status, challenges, and future perspectives. World J Clin Pediatr. 2022;11(5):385-404.

Baysal A. Beslenme. 13. baskı. Hatiboğlu Yayınları; 2011.

Velez A, Kaul A, El-Chammas KI, et al. Safety and effectiveness of prucalopride in children with functional constipation with and without upper symptoms. Paediatr Drugs. 2024;26(2):187-195.

Selimoğlu MA. Sağlıkta ve Hastalıkta Çocuk Beslenmesi. Akademi Yayınevi; 2014.

Koppen IJN, Benninga MA. Functional constipation and dyssynergic defecation in children. Front Pediatr. 2022;10:832877.

Santucci NR, Chogle A, Leiby A, et al. Non-pharmacologic approach to pediatric constipation. Complement Ther Med. 2021;59:102769.

Alshehri DB, Sindi HH, AlMusalami IM, et al. Saudi experts consensus on diagnosis and management of pediatric functional constipation. Pediatr Gastroenterol Hepatol Nutr. 2022;25(3):163-179.

Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66.

Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, et al. Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods. 2019;8:92. doi: 10.3390/foods8030092.

Tunc V.T., Camurdan A.D., Ilhan M.N., Sahin F., Beyazova U. Factors associated with defecation patterns in 0–24 month-old children. Eur. J. Pediatr. 2008;167:1357–1362. doi: 10.1007/s00431-008-0669-2.

Chen X. Human milk oligosaccharides (HMOS): Structure, function, and enzyme-catalyzed synthesis. Adv. Carbohydr. Chem. Biochem. 2015;72:1013–1090. doi: 10.1016/bs.accb.2015.08.002.

Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, Double-Blind, Placebo-Controlled Parallel Clinical Trial Assessing the Effect of Fructooligosaccharides in Infants with Constipation. Nutrients. 2018;10(11):1602. Published 2018 Nov 1. doi:10.3390/nu10111602.

Bongers ME, de Lorijn F, Reitsma JB, Groeneweg M, Taminiau JA, Benninga MA. The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. Nutr J. 2007;6:8. doi: 10.1186/1475-2891-6-8.

Benninga MA MENA Infant Constipation Study Group. Vandenplas Y. The magnesium-rich formula for functional constipation in infants: a randomized comparator-controlled study. Pediatr Gastroenterol Hepatol Nutr. 2019;22:270–281. doi: 10.5223/pghn.2019.22.3.270.

Bae SH. Diets for constipation. Pediatr Gastroenterol Hepatol Nutr. 2014;17(4):203-208.

Wegh CAM, Baaleman DF, Tabbers MM, Smidt H, Benninga MA. Nonpharmacologic treatment for children with functional constipation: a systematic review and meta-analysis. J Pediatr. 2022;240:136-149.e5.

Fabbrini M, D'Amico F, Barone M, et al. Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties. Biomolecules. 2022;12(7):875. doi:10.3390/biom12070875.

Speridião PG, Tahan S, Fagundes-Neto U, Morais MB. Dietary fiber, energy intake and nutritional status during the treatment of children with chronic constipation. Braz J Med Biol Res. 2003;36(6):753-759.

Xiao P, Song T, Li XL, et al. Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites. Front Nutr. 2025;12:1579668.

Hill C, Guarner F, Reid G, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-514. doi:10.1038/nrgastro.2014.66

de Meij TG, de Groot EF, Eck A, et al. Characterization of microbiota in children with chronic functional constipation. PLoS One. 2016;11(10). doi:10.1371/journal.pone.0164731

Vandeputte D, Falony G, Vieira-Silva S, et al. Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates. Gut. 2016;65(1):57-62. doi:10.1136/gutjnl-2015-309618

Dimidi E, Christodoulides S, Scott SM, Whelan K. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Adv Nutr. 2017;8(3):484-494. doi:10.3945/an.116.014407

Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502. doi:10.1038/nrgastro.2017.75

Wegh CA, Schoterman MHC, Vaughan EE, Belzer C, Benninga MA. The effect of fiber and prebiotics on children's gastrointestinal disorders and microbiome. Expert Rev Gastroenterol Hepatol. 2017;11(11):1031-1045. doi:10.1080/17474124.2017.1372196

Swanson KS, Gibson GR, Hutkins R, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687-701. doi:10.1038/s41575-020-0344-2

Chen K, Zhou Z, Nie Y, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55(2):1317-1330.

Mohammadi Bourkheili A, Mehrabani S, Esmaeili Dooki M, Haji Ahmadi M, Moslemi L. Effect of Cow's-milk-free diet on chronic constipation in children; A randomized clinical trial. Caspian J Intern Med. 2021;12(1):91-96. doi:10.22088/cjim.12.1.91

Guthold R, Stevens GA, Riley LM, et al. Global trends in insufficient physical activity among adolescents: a pooled analysis of 298 population-based surveys with 1·6 million participants. Lancet Child Adolesc Health. 2020;4:23–35. doi: 10.1016/S2352-4642(19)30323-2.

Adil S, Gordon M, Hathagoda W, Kuruppu C, Benninga MA, Rajindrajith S. Impact of physical inactivity and sedentary behaviour on functional constipation in children and adolescents: a systematic review. BMJ Paediatr Open. 2024;8(1):e003069. Published 2024 Dec 5. doi:10.1136/bmjpo-2024-003069

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6 Ekim 2026

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