Çocuklarda Kabızlık Nedeni Olan Gastrointestinal Sistem Hastalıkları

Harvey S, Matthai S, King DA. How to use the Bristol Stool Chart in childhood constipation.

Arch Dis Child Educ Pract Ed. 2023;108(5):335-339. doi:10.1136/archdischild-2022-324513

Mulhem E, Khondoker F, Kandiah S. Constipation in Children and Adolescents: Evaluation and Treatment. Am Fam Physician. 2022;105(5):469-478.

Nurko S, Zimmerman LA. Evaluation and treatment of constipation in children and adoles- cents. Am Fam Physician. 2014;90(2):82-90.

Tabbers MM, DiLorenzo C, Berger MY. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258-274. doi:10.1097/MPG.0000000000000266

Small Intestinal Bacterial Overgrowth Classic Articles in Colonic and Rectal Surgery. Constipa- tion in the newborn as a result of dilation and hypertrophy of the colon: Harald Hirschsprung, Jahrbuch für Kinderheilkunde, 1888. Dis Colon Rectum. 1981;24(5):408-410.

SWENSON O, BILL AHJ. Resection of rectum and rectosigmoid with preservation of the sphincter for benign spastic lesions producing megacolon; an experimental study. Surgery. 1948;24(2):212-220.

Amiel J, Sproat-Emison E, Garcia-Barcelo M. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet. 2008;45(1):1-14. doi:10.1136/jmg.2007.053959

Pashankar DS. Childhood constipation: evaluation and management. Clin Colon Rectal Surg. 2005;18(2):120-127. doi:10.1055/s-2005-870894

Kessmann J. Hirschsprung’s disease: diagnosis and management. Am Fam Physician. 2006;74(8):1319-1322.

Moore SW. Total colonic aganglionosis in Hirschsprung disease. Semin Pediatr Surg. 2012;21(4):302-309. doi:10.1053/j.sempedsurg.2012.07.004

McCallion AS. Phenotype variation in two-locus mouse models of Hirschsprung disease: tis- sue-specific interaction between Ret and Ednrb. Proc Natl Acad Sci U S A. 2003;100(4):1826- 1831. doi:10.1073/pnas.0337540100

Gfroerer S, Rolle U. Pediatric intestinal motility disorders. World J Gastroenterol. 2015;21(33):9683-9687. doi:10.3748/wjg.v21.i33.9683

Gershon EM. Hirschsprung’s disease associated enterocolitis: A comprehensive review. World J Clin Pediatr. 2023;12(3):68-76. doi:10.5409/wjcp.v12.i3.68

Musa ZA. Diagnostic roles of calretinin in hirschsprung disease: A comparison to neuron-spe- cific enolase. Saudi J Gastroenterol. 2017;23(1):60-66. doi:10.4103/1319-3767.199118

Tou JF, Li MJ. Mutation of RET proto-oncogene in Hirschsprung’s disease and intestinal neuro- nal dysplasia. World J Gastroenterol. 2006;12(7):1136-1139. doi:10.3748/wjg.v12.i7.1136

Terra SA. A critical appraisal of the morphological criteria for diagnosing intestinal neuronal dysplasia type B. Modern Pathology. 2017;30(7):978-985.

Kapur RP, Reyes-Mugica M. Intestinal Neuronal Dysplasia Type B: An Updated Review of a Problematic Diagnosis. Arch Pathol Lab Med. 2019;143(2):235-243. doi:10.5858/arpa.2017- 0524-RA

Thapar N. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Re- commendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018;66(6):991-1019. doi:10.1097/MPG.0000000000001982

Wood RJ, Levitt MA. Anorectal Malformations. Clin Colon Rectal Surg. 2018;31(2):61-70. do- i:10.1055/s-0037-1609020

Smith CA, Avansino J. Anorectal Malformations. In: StatPearls [Internet]. StatPearls Publis- hing; 2023.

Hakalmaz AE, Topuzlu Tekant G. Anorectal Malformations and Late-Term Problems. Turk Arch Pediatr. 2023;58(6):572-579. doi:10.5152/TurkArchPediatr.2023.23090

Connor F. Cows’ Milk Allergy-Associated Constipation: When to Look for It? A Narrative Re- view. Nutrients. 2022;14(6):1317. doi:10.3390/nu14061317

Isa HM. Assessing indicators and clinical differences between functional and organic childho- od constipation: a retrospective study in pediatric gastroenterology clinics. Clin Exp Pediatr. 2023;66(7):296-306. doi:10.3345/cep.2022.01298

Dehghani SM. The Role of Cow’s Milk Allergy in Pediatric Chronic Constipation: A Randomi- zed Clinical Trial. Iran J Pediatr. 2012;22(4):468-474.

Chugh AA. Celiac Disease. In: Kliegman RM, St. Geme JW, eds. Nelson Textbook of Pediatrics. Elsevier; 2024.

Pelleboer RAA. Celiac disease is overrepresented in patients with constipation. J Pediatr (Rio J). 2012;88(2):173-176.

Leung AK, Hon KL. Paediatrics: how to manage functional constipation. Drugs Context. 2021;10. doi:10.7573/dic.2020-11-2

Meena M. Prevalence and Predictors of Celiac Disease in Children With Constipation. Indian Pediatr. 2024;61(4):331-336.

Lebwohl B, Green PHR. Celiac Disease. In: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. Elsevier; 2021.

De Giorgio R. Chronic intestinal pseudo-obstruction: clinical features, diagnosis, and therapy.

Gastroenterol Clin North Am. Published online 2011.

Tang X. Pathophysiological mechanisms, diagnostic innovations, and multimodal therapeu- tic strategies for slow transit constipation. BMC Gastroenterol. 2025;25(1):810. doi:10.1186/ s12876-025-04387-9

Husby S. ESPGHAN Guidelines for Diagnosing Coeliac Disease. J Pediatr Gastroenterol Nutr. 2020;70(1):141-156.

Leffler DA. Celiac Disease. In: Yamada’s Textbook of Gastroenterology. Wiley-Blackwell; 2022.

Cil O. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mou- se model of constipation. Cell Mol Gastroenterol Hepatol. 2016;2(3):317-327. doi:10.1016/j.jcm- gh.2015.12.010

Adeyemo-Salami OA. Cystic fibrosis in the intestine and the influence on digestion. J Immunol Sci. Published online 2020. doi:10.29245/2578-3009/2020/3.1187

De Lisle RC, Borowitz D. The cystic fibrosis intestine. Cold Spring Harb Perspect Med. 2013;3(9). doi:10.1101/cshperspect.a009753

Fernández-Ibieta M. Treatment options of distal intestinal obstruction syndrome: And if the ene- mas fail? An Pediatr (Barc). 2016;84(1):54-55. doi:10.1016/j.anpede.2015.05.021

Anton-Păduraru DT. Diagnosis and Management of Gastrointestinal Manifestations in Child- ren with Cystic Fibrosis. Diagnostics. 2024;14(2):228. doi:10.3390/diagnostics14020228

Miles C. Presentation, characteristics and management of obstructive intestinal conditions in cystic fibrosis. Frontline Gastroenterol. 2024;15(3):222-227. doi:10.1136/flgastro-2023-102533

van der Doef HP. Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal in- testinal obstruction syndrome, and constipation. Curr Gastroenterol Rep. 2011;13(3):265-270. doi:10.1007/s11894-011-0185-9

Adu Y. Adult intussusception of the small intestine caused by cystic fibrosis: a case report, re- view of the literature, and guide for management. J Surg Case Rep. 2023;(10). doi:10.1093/jscr/ rjad574

Somaraju URR. Pancreatic enzyme replacement therapy for people with cystic fibrosis. Cochra- ne Database Syst Rev. 2020;8(8). doi:10.1002/14651858.CD008227.pub4

Houwen RH. Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS. J Pediatr Gastroenterol Nutr. 2010;50(1).

Kruger Howard A. Evaluation of Polyethylene Glycol Dosing for Functional Constipation in Children. Hosp Pharm. 2024;59(6):645-649. doi:10.1177/00185787241257390

O’Brien CE. Lubiprostone for constipation in adults with cystic fibrosis: a pilot study. Ann Pharmacother. 2011;45(9):1061-1066. doi:10.1345/aph.1Q219

Velez A. Safety and effectiveness of prucalopride in children with functional constipation with and without upper symptoms. Pediatr Drugs. Published online 2024. doi:10.1007/s40272-023- 00612-8

Cruz Mosquera FE. Effectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas). 2025;61(3):489. doi:10.3390/medicina61030489

Schwarzenberg SJ. Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI. J Cyst Fibros. 2023;22(2):282-289. doi:10.1016/j.jcf.2022.10.003

Odofin A. Intestinal obstruction in cystic fibrosis: a surgeon’s perspective. International Surgery Journal. 2018;5(9):2948-2951. doi:10.18203/2349-2902.isj20183712

Miller C. Constipation in ulcerative colitis: pathophysiology and practical management. Front- line Gastroenterol. 2021;12:493-499.

Cenni S, Colucci A, Salomone S, et al. The prevalence of constipation in children with new diagnosis of inflammatory bowel disease: A retrospective study. J Pediatr Gastroenterol Nutr. 2025;80(5):799-806. doi:10.1002/jpn3.70005

D’Aleo CM. Childhood Crohn’s disease presenting as chronic constipation. Pediatr Med Chir. 2009;31(4):168-171.

Goday PS. Gastrointestinal disorders: red flags and best treatments. Contemporary PEDS Jour- nal. 2021;38(7).

Al-Beltagi M. Fecal calprotectin in pediatric gastrointestinal diseases: Pros and cons. World J Clin Pediatr. 2024;13(2). doi:10.5409/wjcp.v13.i2.93341

Diefenbach KA. Pediatric inflammatory bowel disease. World J Gastroenterol. 2006;12(20):3204- 3212. doi:10.3748/wjg.v12.i20.3204

Miller C. Constipation in ulcerative colitis: pathophysiology and practical management. Colo- rectal Dis. 2023;25(8). doi:10.1136/flgastro-2020-101566

Neville JJ. Therapeutic strategies for stricturing Crohn’s disease in childhood: a systematic re- view. Pediatr Surg Int. 2021;37(5):569-577. doi:10.1007/s00383-020-04848-0

Sandhu BK. Irritable bowel syndrome in children: pathogenesis, diagnosis and evidence-based treatment. World J Gastroenterol. 2014;20(20):6013-6023. doi:10.3748/wjg.v20.i20.6013

Hawa K. Pediatric irritable bowel syndrome: current understanding and future directions. Curr Treat Options Peds. 2025;11:24. doi:10.1007/s40746-025-00339-3

Karabulut GS. The incidence of irritable bowel syndrome in children using the Rome III cri- teria and the effect of trimebutine treatment. J Neurogastroenterol Motil. 2013;19(1):90-93. doi:10.5056/jnm.2013.19.1.90

Self MM. Subtypes of irritable bowel syndrome in children and adolescents. Clin Gastroenterol Hepatol. 2014;12(9):1468-1473. doi:10.1016/j.cgh.2014.01.031

Reynolds KH. Small intestinal bacterial overgrowth: a case-based review. J Patient Cent Res Rev. 2015;2(4):165-173. doi:10.17294/2330-0698.1209

Ahmed JF. Aetiology, diagnosis and management of small intestinal bacterial overgrowth.

Frontline Gastroenterol. 2023;14(2):149-154. doi:10.1136/flgastro-2022-102163