İnfantil Hipertrofik Pilor Stenozu
Özet
İnfantil hipertrofik pilor stenozunun (IHPS) etiyolojisi kesin olarak aydınlatılamamış olmakla birlikte, hastalığın ortaya çıkışında genetik yatkınlık ile çevresel faktörlerin birlikte rol oynadığı düşünülmektedir. Pilor stenozu, çocuk cerrahisi pratiğinde sık karşılaşılan bir durum olup, ultrasonografinin yaygın kullanımı sayesinde kolaylıkla tanı konulabilmektedir. Uygun sıvı ve elektrolit replasmanı ile gerçekleştirilen yeterli preoperatif resüsitasyon sonrasında, postoperatif süreç genellikle sorunsuz ilerlemektedir. Ameliyat sonrası uygun izlem ve erken başlanan beslenme, çoğu hastada 24–48 saat içerisinde güvenli ve zamanında taburculuğa olanak tanımaktadır. Dehidratasyon ve elektrolit dengesizlikleri düzeltildikten sonra gerçekleştirilen Ramstedt piloromiyotomisinin prognozu oldukça iyidir ve zamanında müdahale edilen olgularda sonuçlar genellikle mükemmeldir. Cerrahi sırasında perforasyonun önlenmesi ve yeterli miyotominin sağlanması, başarılı ve tutarlı sonuçlar elde edilmesinde temel unsurlardır. IHPS cerrahisi acil bir girişim olarak değerlendirilmemeli; operasyon, serum elektrolit düzeyleri ve asit-baz dengesi normale getirildikten sonra planlanmalıdır.
Referanslar
Pokhrel B, Bhatta A, Basnet A, et al. Hypertrophic Pyloric Stenosis in a Four-Week-Old Infant: Radiological Diagnosis and Pitfalls. Cureus. 2025; 17(12):e98606. doi: 10.7759/cureus.98606.
Garfield K, Sergent SR. Pyloric Stenosis. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 32310391.
Jobson M, Hall NJ. Contemporary management of pyloric stenosis. Seminars in Pediatric Surgery. 2016; 25(4):219-224. doi:10.1053/j.sempedsurg.2016.05.004.
Pandya S, Heiss K. Pyloric stenosis in pediatric surgery: an evidence-based review. Surgical Clinics of North America. 2012; 92(3):527-539, vii-viii. doi: 10.1016/j.suc.2012.03.006.
Serra A, Schuchardt K, Genuneit J, et al. Genomic variants in the coding region of neuronal nitric oxide synthase (NOS1) in infantile hypertrophic pyloric stenosis. Journal of Pediatric Surgery. 2011; 46(10):1903-1908. doi: 10.1016/j.jpedsurg.2011.05.021.
Boybeyi O, Soyer T, Atasoy P, et al. Investigation of the effects of enteral hormones on the pyloric muscle in newborn rats. Journal of Pediatric Surgery. 2015; 50(3):408-12. doi:10.1016/j.jpedsurg.2014.05.036.
Galea R, Said E. Infantile Hypertrophic Pyloric Stenosis: An Epidemiological Review. Neonatal Network. 2018; 37(4):197-204. doi: 10.1891/0730-0832.37.4.197.
Rich BS, Dolgin SE. Hypertrophic Pyloric Stenosis. Pediatrics in Review. 2021; 42(10):539-545. doi: 10.1542/pir.2020-003277.
Abdellatif M, Ghozy S, Kamel MG, et al. Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. European Journal of Pediatrics. 2019; 178(3):301-314. doi:10.1007/s00431-018-3287-7.
Georgoula C, Gardiner M. Pyloric stenosis a 100 years after Ramstedt. Archives of Disease in Childhood. 2012; 97(8):741-745. doi: 10.1136/archdischild-2011-301526.
Zhu J, Zhu T, Lin Zet al. Perinatal risk factors for infantile hypertrophic pyloric stenosis: A meta-analysis. Journal of Pediatric Surgery. 2017; 52(9):1389-1397. doi: 10.1016/j.jpedsurg.2017.02.017.
Wayne C, Hung JH, Chan E, et al. Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. Journal of Pediatric Surgery. 2016 ;51(5):779-782. doi: 10.1016/j.jpedsurg.2016.02.021.
Rosenthal YS, Chodick G, Grossman Z,et al. The incidence of infantile hypertrophic pyloric stenosis and its association with folic acid supplementation during pregnancy: A nested case-control study. Journal of Pediatric Surgery. 2019; 54(4):701-706. doi:10.1016/j.jpedsurg.2018.05.005.
Mason PF. Increasing infantile hypertrophic pyloric stenosis? Experience in a military hospital abroad. Journal of the Royal College of Surgeons of Edinburgh. 1991; 36:293–294.
O'Donoghue JM, Connolly KD, Gallagher MM et al. The increasing incidence of hypertrophic pyloric stenosis in infants. Irish Journal of Medical Science. 1993; 162:175–176. doi:10.1007/BF02945178.
Hedback G. The epidemiology of infantile hypertrophic pyloric stenosis in Sweden 1987–96. Archives of Disease in Childhood. 2001; 85:379–381. doi: 10.1136/adc.85.5.379.
Sommerfield T, Chalmers J, Youngson G et al. The changing epidemiology of infantile hypertrophic pyloric stenosis in Scotland. Archives of Disease in Childhood. 2008; 93:1007–1011. doi: 10.1136/adc.2007.128090.
Oetzmann von Sochaczewski C, Muensterer OJ. The incidence of infantile hypertrophic pyloric stenosis nearly halved from 2005 to 2017: analysis of German administrative data. Pediatric Surgery International. 2021; 37(5):579-585. doi: 10.1007/s00383-020-04810-0.
Donda K, Asare-Afriyie B, Ayensu M et al. Pyloric Stenosis: National Trends in Incidence and Resource Utilization in the United States From 2012 to 2016. Hospital Pediatrics. 2019; 9:923–932. doi:10.1542/hpeds.2019-0112.
Kapoor R, Kancherla V, Cao Y, et al. Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multi-state, population-based retrospective study, 1999–2010. Birth Defects Research. 2019; 111:159–169. doi: 10.1002/bdr2.1439.
Bakir N, Lapidus-Krol E, Hossain A, et al. Population-based Study of Hypertrophic Pyloric Stenosis in Canada: Investigating the National Changes in Surgical Practice and Outcomes From 2004 to 2021. Journal of Pediatric Surgery. 2025; 60(4):162221. doi:10.1016/j.jpedsurg.2025.162221.
Leong MM, Chen SC-C, Hsieh CS et al. Epidemiological Features of Infantile Hypertrophic Pyloric Stenosis in Taiwanese Children: A Nationwide Analysis of Cases from 1997 to 2007. PLoS ONE. 2011; 6:e19404. doi: 10.1371/journal.pone.0019404.
Yau A, Cha R, Jayaratnam S et al. Decreasing incidence of pyloric stenosis in New Zealand. ANZ Journal of Surgery. 2019; 89:1242–1245. doi: 10.1111/ans.15377.
Kaye P. Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. BMJ Case Reports. 2018; 2018:bcr2017222800. doi: 10.1136/bcr-2017-222800.
O'Toole S, Marven S. Infantile hypertrophic pyloric stenosis. Paediatrics and Child Health. 2025; 35(11). doi:10.1016/j.paed.2025.001838.
Peters B, Oomen MW, Bakx R, et al. Advances in infantile hypertrophic pyloric stenosis. Expert Review of Gastroenterology & Hepatology. 2014; 8(5):533–541. doi: 10.1586/17474124.2014.903154.
Puri P, Kutasy B, Lakshmanadass G. Hypertrophic pyloric stenosis. Puri P (ed.) Newborn surgery içinde. London: Hodder Arnold; 2011. p. 433–442.
Sobrino JA, Wulkan M. Stomach lesions. St. Peter SD, Snyder CL (ed.) Holcomb and Ashcraft's pediatric surgery. 8th ed. London: Elsevier; 2026. p. 412–424.
Piotto L, Gent R, Taranath A, et al. Ultrasound diagnosis of hypertrophic pyloric stenosis - Time to change the criteria. Australasian Journal of Ultrasound in Medicine. 2022; 25(3):116-126. doi:10.1002/ajum.12305.
Ranells JD, Carver JD, Kirby RS. Infantile hypertrophic pyloric stenosis: epidemiology, genetics, and clinical update. Advances in Pediatrics. 2011; 58:195–206. doi: 10.1016/j.yapd.2011.03.005.31.
Lauriti G, Cascini V, Chiesa PL,et al. Atropine Treatment for Hypertrophic Pyloric Stenosis: A Systematic Review and Meta-Analysis. European Journal of Pediatric Surgery. 2018; 28(5): 393-399. doi:10.1055/s-0037-1604116.
Elnahas A, Pemberton J, Yousef Y, et al. Investigating the use of preoperative nasogastric tubes and postoperative outcomes for infants with pyloric stenosis: a retrospective cohort study. Journal of Pediatric Surgery. 2010; 45(5): 1020-1023. doi: 10.1016/j.jpedsurg.2010.02.026.
Mandell GA, Wolfson PJ, Schidlow DV,et al. Balloon catheter dilatation for hypertrophic pyloric stenosis. Journal of Pediatric Surgery. 1990; 25(11):1119-21. doi: 10.1016/0022-3468(90)90744-t.
Fourie N, Arnold M, Banieghbal B, Marchant SL. Is there any benefit with pantoprazole treatment in infantile hypertrophic pyloric stenosis? African Journal of Paediatric Surgery. 2022; 19(1): 52-55. doi: 10.4103/ajps.AJPS_9_21.
Griffin KL, Rodgers B, Rinehardt H, et al. The Utility of Prophylactic Antibiotics for Laparoscopic Pyloromyotomy. Journal of Surgical Research. 2024; 299: 298-302. doi: 10.1016/j.jss.2024.04.049.
Al-Ansari AN, Ahammed S, Sofy AA, et al. Minimally Invasive Versus Open Pyloromyotomy for Infantile Hypertrophic Pyloric Stenosis: Insights from an Updated Systematic Review and Meta-Analysis. Pediatric Reports. 2025; 17(6): 124. doi: 10.3390/pediatric17060124.
Graham KA, Laituri CA, Markel TA, et al. A review of postoperative feeding regimens in infantile hypertrophic pyloric stenosis. Journal of Pediatric Surgery. 2013; 48(10): 2175-9. doi: 10.1016/j.jpedsurg.2013.04.023.
Chuang YH, Chao HC, Yeh HY, et al. Factors associated with pyloric hypertrophy severity and post-operative feeding and nutritional recovery in infantile hypertrophic pyloric stenosis. Biomedical Journal. 2022; 45(6): 948-956. doi: 10.1016/j.bj.2021.12.011.