Kronik Gastrointestinal Hastalıklarda Tedavi Uyumu, İzlem ve Yaşam Tarzı Eğitimi

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Özet

Kronik gastrointestinal hastalıklarda inflamatuvar bağırsak hastalığı (İBH), kronik viral hepatitler, metabolik disfonksiyon ilişkili steatotik karaciğer hastalığı (MASLD), siroz, çölyak hastalığı, gastroözofageal reflü hastalığı (GÖRH), irritabl bağırsak sendromu (İBS) ve Helicobacter pylori eradikasyonu sonrası izlem dahil tedavinin uzun dönem başarısını belirleyen en kritik faktörlerden biri hastaların tedaviye uyumudur. Kronik hastalıklarda tedaviye uyum oranları ortalama %50 civarında seyreder; uyumsuzluk hastalık alevlenmelerine, hastane yatışlarına, komplikasyonlara ve sağlık harcamalarının artışına yol açar. Bu bölümde tedaviye uyumu belirleyen hasta, hekim ve sistem kaynaklı faktörler; uyum ölçüm yöntemleri; hastalığa özgü izlem parametreleri; yaşam tarzı eğitiminin kanıta dayalı bileşenleri ve etkili hasta-hekim iletişim stratejileri ele alınır. Motivasyonel görüşme, paylaşımlı karar alma, dijital sağlık araçları ve multidisipliner ekip yaklaşımı güncel kılavuzlar eşliğinde sunulur. 

In chronic gastrointestinal diseases — including inflammatory bowel disease (IBD), chronic viral hepatitis, metabolic dysfunction-associated steatotic liver disease (MASLD), cirrhosis, coeliac disease, gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS) and post-Helicobacter pylori eradication follow-up — treatment adherence is one of the most critical determinants of long-term therapeutic success. Adherence rates in chronic diseases average around 50%; non-adherence leads to disease flares, hospital admissions, complications and increased healthcare costs. This chapter addresses patient-, physician- and system-related factors influencing adherence; adherence measurement tools; disease-specific monitoring parameters; evidence-based components of lifestyle education; and effective patient-physician communication strategies, including motivational interviewing, shared decision-making and digital health tools, in line with current ACG, AGA, ECCO, EASL, ESPEN, NICE and WHO guidelines.  

Referanslar

World Health Organization. Adherence to Long-term Thera¬pies: Evidence for Action. Geneva: WHO; 2003.

Jackson CA, Clatworthy J, Robinson A, Horne R. Factors as¬sociated with non-adherence to oral medication for inflam¬matory bowel disease: a systematic review. Am J Gastroente¬rol. 2010;105(3):525-539.

Sewitch MJ, Abrahamowicz M, Bitton A, et al. Psychologi¬cal distress, social support, and disease activity in patients with inflammatory bowel disease. Am J Gastroenterol. 2003;98(7):1535-1544.

Hommel KA, Davis CM, Baldassano RN. Medication adhe¬rence and quality of life in pediatric inflammatory bowel dise¬ase. J Pediatr Psychol. 2008;33(8):867-874.

Rubin DT, Ananthakrishnan AN, Siegel CA, et al. ACG Clini¬cal Guideline: Ulcerative Colitis in Adults. Am J Gastroente¬rol. 2019;114(3):384-413.

Turner D, Ricciuto A, Lewis A, et al. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the IOIBD: Determining The¬rapeutic Goals for Treat-to-Target Strategies in IBD. Gastro¬enterology. 2021;160(5):1570-1583.

European Association for the Study of the Liver (EASL), EASD, EASO. EASL-EASD-EASO Clinical Practice Guideli¬nes on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). J Hepatol. 2024;81(3):492- 542.

Husby S, Koletzko S, Korponay-Szabó I, et al. ESPGHAN Gu-idelines for Diagnosing Coeliac Disease 2020. J Pediatr Gast-roenterol Nutr. 2020;70(1):141-156.

Drossman DA, Hasler WL. Rome IV — Functional GI Disor¬ders: Disorders of Gut-Brain Interaction. Gastroenterology. 2016;150(6):1257-1261.

Miller WR, Rollnick S. Motivational Interviewing: Helping People Change. 3rd ed. New York: Guilford Press; 2013.

Elwyn G, Frosch D, Thomson R, et al. Shared Decision Making: A Model for Clinical Practice. J Gen Intern Med. 2012;27(10):1361-1367.

Siegel CA, Lofland JH, Naim A, et al. Gastroenterologists’ Views of Shared Decision Making for Patients with Inflam¬matory Bowel Disease. Dig Dis Sci. 2015;60(9):2636-2645.

Reigada LC, Satybaldiyeva G, Bhatt B. Mobile Health Tech¬nology Interventions in IBD. Dig Dis Sci. 2020;65(10):2716- 2733.

NICE. Coeliac Disease: Recognition, Assessment and Mana¬gement. NICE Guideline NG20. London: NICE; 2015.

Staudacher HM, Irving PM, Lomer MC, Whelan K. Mecha¬nisms and Efficacy of Dietary FODMAP Restriction in IBS. Nat Rev Gastroenterol Hepatol. 2014;11(4):256-266.

Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, et al. Weight Loss Through Lifestyle Modification Significantly Re¬duces Features of Nonalcoholic Steatohepatitis. Gastroentero¬logy. 2015;149(2):367-378.e5.

Ford AC, Moayyedi P, Lacy BE, et al. American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation. Am J Gastroenterol. 2014;109(Suppl 1):S2-S26.

Sandborn WJ, Su C, Sands BE, et al. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis (OCTAVE). N Engl J Med. 2017;376(18):1723-1736.

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18 Ağustos 2026

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