Endocrin System Diseases in Children
Özet
The endocrine system is one of the physiological systems that plays a fundamental role in growth, development, metabolism, and the maintenance of homeostasis. The healthy functioning of endocrine systems during childhood is crucial for physical growth, neurodevelopment, pubertal maturation, and the maintenance of metabolic balance. Disorders in the synthesis, secretion, or mechanisms of action of hormones secreted by endocrine glands lead to various clinical presentations in children. The primary endocrine system disorders observed in childhood include growth hormone disorders, diabetes insipidus, inappropriate antidiuretic hormone secretion syndrome, thyroid disorders, and parathyroid and calcium metabolism disorders. These disorders are associated with growth retardation, developmental delay, fluid-electrolyte imbalance, and metabolic problems. Early diagnosis, regular clinical evaluation, laboratory monitoring, and appropriate treatment are crucial for preventing complications. In nursing care, monitoring growth and development, supporting treatment adherence, medication management, early detection of complications, and educating the child and family constitute the core components of care.
Referanslar
Acerini, C. L., Wac, K., Bang, P., & Lehwalder, D. (2017). Optimizing patient management and adherence for children receiving growth hormone. Frontiers in Endocrinology, 8, 313. https://doi.org/10.3389/fendo.2017.00313
Alharbi, S., Meshari, A., Henawi, Z., Alsaadi, R., Alqarni, S., Hani, A., Alhamrani, O., Saptan, L., Hamoud, Z., Alshanbri, N., Jafar, Z., & Farag, A. (2023). Management of diabetic ketoacidosis in internal medicine: insulin protocols, electrolyte balance, and clinical outcomes. International Journal Of Community Medicine And Public Health. https://doi.org/10.18203/2394-6040.ijcmph20233833.
Arslan, Z., & Yaşar, H. (2025). Çevrimiçi çocukluk: Zihin, kimlik ve ruh sağlığı. In F. Toper & E. Ağyar (Eds.), Çocuklukta ruh sağlığı: Sosyal, dijital ve travmatik bağlamlar (1. bs., ss. 157-189). Vize Akademik.
Atila, C., Loughrey, P. B., Garrahy, A., Winzeler, B., Refardt, J., Gildroy, P., Hamza, M., Pal, A., Verbalis, J. G., Thompson, C. J., Hemkens, L. G., Hunter, S. J., Sherlock, M., Levy, M. J., Karavitaki, N., Newell-Price, J., Wass, J. A. H., & Christ-Crain, M. (2022). Central diabetes insipidus from a patient's perspective: Management, psychological co-morbidities, and renaming of the condition: Results from an international web-based survey. The Lancet Diabetes & Endocrinology, 10(10), 700-709. https://doi.org/10.1016/S2213-8587(22)00219-4
Bholah, R., & Bunchman, T. E. (2017). Review of Pediatric Pheochromocytoma and Paraganglioma. Frontiers in pediatrics, 5, 155. https://doi.org/10.3389/fped.2017.00155
Birol, L., Olgun, N., & Çelik, S. (2020). Pankreas hastalıkları ve hemşirelik bakımı.
Bizzarri, C., Capalbo, D., Wasniewska, M. G., Baronio, F., Grandone, A., & Cappa, M. (2023). Adrenal crisis in infants and young children with adrenal insufficiency: Management and prevention. Frontiers in Endocrinology, 14, 1133376. https://doi.org/10.3389/fendo.2023.1133376
Boro, H., Khatiwada, S., Alam, S., Kubihal, S., Dogra, V., Malla, S., & Kumar, C. (2022). The spectrum of manifestations of primary hyperparathyroidism in children and adolescents. Pediatric Endocrinology, Diabetes, and Metabolism, 28(3), 178-187. https://doi.org/10.5114/pedm.2022.118315
Caruso, M., Mazzatenta, D., Asioli, S., Costanza, G., Trivellin, G., Franke, M., Abboud, D., Hanson, J., Raverot, V., Pétrossians, P., Beckers, A., Cappa, M., & Daly, A. F. (2024). Case report: Management of pediatric gigantism caused by the TADopathy, X-linked acrogigantism. Frontiers in Endocrinology, 15, 1345363. https://doi.org/10.3389/fendo.2024.1345363
Christ-Crain, M., Hoorn, E. J., Sherlock, M., Thompson, C. J., & Wass, J. A. H. (2020). Endocrinology in the time of COVID-19: Management of diabetes insipidus and hyponatraemia. European Journal of Endocrinology, 183(1), G9-G15. https://doi.org/10.1530/EJE-20-0338
Claahsen-van der Grinten, H. L., Speiser, P. W., Ahmed, S. F., Arlt, W., Auchus, R. J., Falhammar, H., Flück, C. E., Guasti, L., Huebner, A., Kortmann, B. B. M., Krone, N., Merke, D. P., Miller, W. L., Nordenström, A., Reisch, N., Sandberg, D. E., Stikkelbroeck, N. M. M. L., Touraine, P., Utari, A., Wudy, S. A., … White, P. C. (2022). Congenital adrenal hyperplasia: Current insights in pathophysiology, diagnostics, and management. Endocrine Reviews, 43(1), 91-159. https://doi.org/10.1210/endrev/bnab016
Dineen, R., Thompson, C. J., & Sherlock, M. (2019). Adrenal crisis: Prevention and management in adult patients. Therapeutic Advances in Endocrinology and Metabolism, 10, 2042018819848218. https://doi.org/10.1177/2042018819848218
Erk, O. (2014). Diyabetik ketoasidoz. İçinde H. Erk (Ed.), Vaka sunumları ile acil metabolik hastalıklar: Asit-baz, elektrolit denge bozuklukları, hematolojik parametreler, şoklar, bazı onkolojik aciller, akut faz reaktanları (ss. 1-40). Nobel Tıp Kitabevleri.
Fedorczak, A., Lewiński, A., & Stawerska, R. (2024). Comparison of the clinical picture and hormonal test results in children with growth hormone deficiency and idiopathic short stature-Diagnostic difficulties and brief overview. Pediatria i Medycyna Rodzinna. https://doi.org/10.15557/pimr.2024.0006
Goldberg, M., Ciesielski Jones, A. J., McGrath, J. A., Barker-Cummings, C., Cousins, D. S., Kipling, L. M., Meadows, J. W., Kesner, J. S., Marcus, M., Monteilh, C., & Sandler, D. P. (2021). Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development. PloS one, 16(5), e0251598. https://doi.org/10.1371/journal.pone.0251598
Hockenberry, M. J., Wilson, D., & Rodgers, C. C. (2019). Wong’s nursing care of infants and children (11th ed.). Elsevier.
İçinde N. Akdemir & L. Birol (Ed.), İç hastalıkları ve hemşirelik bakımı (Güncellenmiş 5. bs., ss. 937-968). Akademisyen Kitabevi.
İlarslan, N., Şıklar, Z., & Berberoğlu, M. (2017). Childhood sustained hypercalcemia: A diagnostic challenge. Journal of Clinical Research in Pediatric Endocrinology, 9, 315-322. https://doi.org/10.4274/jcrpe.4247
Khan, A. A., Ali, D. S., Bilezikian, J. P., Björnsdottir, S., Collins, M. T., Cusano, N. E., Ebeling, P. R., Fuleihan, G. E. H., Fukumoto, S., Giustina, A., Kaiser, S. M., Koch, C. A., Khan, T., Keating, P., Liu, J. M., Mantzoros, C. S., Mannstadt, M., Mithal, A., Perrier, N. D., Rayes, M., … Brandi, M. L. (2025). Best practice recommendations for the diagnosis and management of hypoparathyroidism. Metabolism: Clinical and Experimental, 171, 156335. https://doi.org/10.1016/j.metabol.2025.156335
Khan, A. A., Bilezikian, J. P., Brandi, M. L., Clarke, B. L., Gittoes, N. J., Pasieka, J. L., Rejnmark, L., Shoback, D. M., Potts, J. T., Guyatt, G. H., & Mannstadt, M. (2022). Evaluation and management of hypoparathyroidism: Summary statement and guidelines from the second international workshop. Journal of Bone and Mineral Research, 37(12), 2568-2585. https://doi.org/10.1002/jbmr.4691
Khonsary, S. A. (2017). Guyton and Hall: Textbook of medical physiology. Surgical Neurology International, 8, 275. https://doi.org/10.4103/sni.sni_327_17
Korbonits, M., Blair, J. C., Boguslawska, A., Ayuk, J., Davies, J. H., Druce, M. R., Evanson, J., Flanagan, D., Glynn, N., Higham, C. E., Jacques, T. S., Sinha, S., Simmons, I., Thorp, N., Swords, F. M., Storr, H. L., & Spoudeas, H. A. (2024). Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases. Nature Reviews Endocrinology, 20(5), 290-309. https://doi.org/10.1038/s41574-023-00949-7
Landis, S. C. (2014). Nursing assessment: Endocrine system. In S. L. Lewis, S. R. Dirksen, M. M. Heitkemper, L. Bucher, & M. M. Harding (Eds.), Medical-surgical nursing: Assessment and management of clinical problems (9th ed., pp. 1134-1151). Elsevier Mosby.
Lazear, J. (2014). Nursing management: Diabetes mellitus. İçinde S. L. Lewis, S. R. Dirksen, M. M. Heitkemper, L. Bucher, & M. M. Harding (Eds.), Medical-surgical nursing:Assessment and management of clinical problems (9th ed., ss. 1153-1187). Elsevier Mosby.
Lodish, M. B., Keil, M. F., & Stratakis, C. A. (2018). Cushing's Syndrome in Pediatrics: An Update. Endocrinology and metabolism clinics of North America, 47(2), 451-462. https://doi.org/10.1016/j.ecl.2018.02.008
Mentrasti, G., Scortichini, L., Torniai, M., Giampieri, R., Morgese, F., Rinaldi, S., & Berardi, R. (2020). Syndrome of inappropriate antidiuretic hormone secretion (SIADH): Optimal management. Therapeutics and Clinical Risk Management, 16, 663-672. https://doi.org/10.2147/TCRM.S206066
Michalczewska, A., Ambroziak, U., & Skrzypczyk, P. (2025). Current Strategies for Managing Pheochromocytoma and Paraganglioma in Children and Adolescents. Medical science monitor: international medical journal of experimental and clinical research, 31, e947277. https://doi.org/10.12659/MSM.947277
Moog, N. K., Entringer, S., Heim, C., Wadhwa, P. D., Kathmann, N., & Buss, C. (2017). Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience, 342, 68-100. https://doi.org/10.1016/j.neuroscience.2015.09.070
Nokoff, N. J., Buchanan, C., & Barker, J. M. (2025). Clinical manifestations and treatment challenges in infants and children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. The Journal of Clinical Endocrinology & Metabolism, 110(Supplement_1), S13-S24. https://doi.org/10.1210/clinem/dgae563
Nordenström, A., Ahmed, S. F., van den Akker, E., Blair, J., Bonomi, M., Brachet, C., Broersen, L. H. A., Claahsen-van der Grinten, H. L., Dessens, A. B., Gawlik, A., Gravholt, C. H., Juul, A., Krausz, C., Raivio, T., Smyth, A., Touraine, P., Vitali, D., & Dekkers, O. M. (2022). Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: An Endo-ERN clinical practice guideline. European Journal of Endocrinology, 186(6), G9-G49. https://doi.org/10.1530/EJE-22-0073
Olgun, N., & Çelik, S. (2021). Endokrin sistem ve metabolizma hastalıkları ve hemşirelik bakımı. In N. Olgun & S. Çelik (Eds.), Tüm yönleriyle iç hastalıkları hemşireliği (ss. 295-362). Ankara Nobel Tıp Kitabevleri.
Palma Sisto, P., & Heneghan, M. K. (2019). Endocrinology. In K. J. Marcdante & R. M. Kliegman (Eds.), Nelson essentials of pediatrics (8th ed., pp. 637-680). Elsevier.
Pearlstein, H., Dayno, A., Zook, J., Crowley, J., Alter, C., Gutmark-Little, I., & McCormack, S. E. (2025). Management of arginine vasopressin deficiency (central diabetes insipidus) in neonates and infants. Hormone Research in Paediatrics, 1-11. Advance online publication. https://doi.org/10.1159/000547155
Reddy, P. (2023). Clinical approach to euvolemic hyponatremia. Cureus, 15(2), e35574. https://doi.org/10.7759/cureus.35574
Sandy, J. L., Titmuss, A., Hameed, S., Cho, Y. H., Sandler, G., & Benitez-Aguirre, P. (2022). Thyroid nodules in children and adolescents: Investigation and management. Journal of Paediatrics and Child Health, 58(12), 2163-2168. https://doi.org/10.1111/jpc.16257
Smyczyńska, J. (2022). Inclusion and withdrawal criteria for growth hormone (GH) therapy in children with idiopathic GH deficiency-Towards following the evidence but still with unresolved problems. Endocrines, 3(1), 55-75. https://doi.org/10.3390/endocrines3010006
Sperling, M. A. (2021). Overview and principles of pediatric endocrinology. In M. A. Sperling (Ed.), Sperling pediatric endocrinology (5th ed., pp. 1-8). Elsevier. https://doi.org/10.1016/B978-0-323-62520-3.00001-4
Tatsi, C., Kamilaris, C., Keil, M., Saidkhodjaeva, L., Faucz, F. R., Chittiboina, P., & Stratakis, C. A. (2024). Paediatric Cushing syndrome: a prospective, multisite, observational cohort study. The Lancet. Child & adolescent health, 8(1), 51-62. https://doi.org/10.1016/S2352-4642(23)00264-X
Warren, A. M., Grossmann, M., Christ-Crain, M., & Russell, N. (2023). Syndrome of inappropriate antidiuresis: From pathophysiology to management. Endocrine Reviews, 44(5), 819-861. https://doi.org/10.1210/endrev/bnad010
Wilson, J. D., & Foster, D. W. (1992). Williams textbook of endocrinology (8th ed.). WB Saunders.
Wydra, A., Czajka-Oraniec, I., Wydra, J., & Zgliczyński, W. (2023). The influence of growth hormone deficiency on bone health and metabolism. Reumatologia, 61(4), 239-247. https://doi.org/10.5114/reum/170244
Yaşar, H., & Arslan, Z. (2025). Çocuk sağlığını koruyucu ve önleyici tedbirler. In F. Toper & E. Ağyar (Eds.), Çocuk sağlığı (ss. 55-80). Vize Akademik.