Güncel Peri-İmplantitis Tedavileri ve Antibiyotiklerin Yeri
Özet
Referanslar
Heitz-Mayfield LJA. Peri-implant mucositis and peri-implantitis: key features and differences. Br Dent J. 2024 May 24;236(10):791–4. doi:10.1038/s41415-024-7402-z
Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. J Periodontol. 2018 Jun 21;89(S1). doi:10.1002/JPER.17-0721
Moraschini V, Poubel LA da C, Ferreira VF, Barboza E dos SP. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015 Mar;44(3):377–88. doi:10.1016/j.ijom.2014.10.023
Galarraga‐Vinueza ME, Pagni S, Finkelman M, Schoenbaum T, Chambrone L. Prevalence, incidence, systemic, behavioral, and patient‐related risk factors and indicators for peri‐implant diseases: An AO/AAP systematic review and meta‐analysis. J Periodontol. 2025 Jun 9;96(6):587–633. doi:10.1002/JPER.24-0154
Berglundh T, Mombelli A, Schwarz F, Derks J. Etiology, pathogenesis and treatment of peri-implantitis: A European perspective. Periodontology 2000. John Wiley and Sons Inc; 2024. doi:10.1111/prd.12549
Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Clin Periodontol. 2018 Jun 1;45:S246–66. doi:10.1111/jcpe.12954 PubMed PMID: 29926484.
Fu J, Wang H. Breaking the wave of peri‐implantitis. Periodontol 2000. 2020 Oct 25;84(1):145–60. doi:10.1111/prd.12335
Donos N, Calciolari E, Ghuman M, Baccini M, Sousa V, Nibali L. The efficacy of bone reconstructive therapies in the management of peri‐implantitis. A systematic review and meta‐analysis. J Clin Periodontol. 2023 Jun 13;50(S26):285–316. doi:10.1111/jcpe.13775
Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A, et al. Prevention and treatment of peri-implant diseases—The EFP S3 level clinical practice guideline. J Clin Periodontol. 2023 Jun 1;50(S26):4–76. doi:10.1111/jcpe.13823 PubMed PMID: 37271498.
Blanco C, Pico A, Dopico J, Gándara P, Blanco J, Liñares A. Adjunctive benefits of systemic metronidazole on non‐surgical treatment of peri‐implantitis. A randomized placebo‐controlled clinical trial. J Clin Periodontol. 2022 Jan 28;49(1):15–27. doi:10.1111/jcpe.13564
Liñares A, Sanz‐Sánchez I, Dopico J, Molina A, Blanco J, Montero E. Efficacy of adjunctive measures in the non‐surgical treatment of peri‐implantitis: A systematic review. J Clin Periodontol. 2023 Jun 4;50(S26):224–43. doi:10.1111/jcpe.13821
Araujo MG, Lindhe J. Peri‐implant health. J Clin Periodontol. 2018 Jun 20;45(S20). doi:10.1111/jcpe.12952
Pontoriero R, Tonelli MP, Carnevale G, Mombelli A, Nyman SR, Lang NP. Experimentally induced peri‐implant mucositis. A clinical study in humans. Clin Oral Implants Res. 1994 Dec 27;5(4):254–9. doi:10.1034/j.1600-0501.1994.050409.x
Zitzmann NU, Berglundh T, Marinello CP, Lindhe J. Experimental peri‐implant mucositis in man. J Clin Periodontol. 2001 Jun 12;28(6):517–23. doi:10.1034/j.1600-051x.2001.028006517.x
Zitzmann NU, Abrahamsson I, Berglundh T, Lindhe J. Soft tissue reactions to plaque formation at implant abutments with different surface topography. J Clin Periodontol. 2002 May 6;29(5):456–61. doi:10.1034/j.1600-051X.2002.290511.x
Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP, Ramseier CA. Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012 Feb 2;23(2):182–90. doi:10.1111/j.1600-0501.2011.02220.x
Heitz‐Mayfield LJA, Salvi GE. Peri‐implant mucositis. J Clin Periodontol. 2018 Jun 20;45(S20). doi:10.1111/jcpe.12953
Ivanovski S, Lee R. Comparison of peri‐implant and periodontal marginal soft tissues in health and disease. Periodontol 2000. 2018 Feb 30;76(1):116–30. doi:10.1111/prd.12150
Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun 1;89:S313–8. doi:10.1002/JPER.17-0739 PubMed PMID: 29926955.
Gualini F, Berglundh T. Immunohistochemical characteristics of inflammatory lesions at implants. J Clin Periodontol. 2003 Jan 3;30(1):14–8. doi:10.1034/j.1600-051X.2003.300103.x
Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification. J Periodontol. 2018 Jun 21;89(S1). doi:10.1002/JPER.18-0157
Berglundh T, Lindhe J. Dimension of the periimplant mucosa. J Clin Periodontol. 1996 Oct 13;23(10):971–3. doi:10.1111/j.1600-051X.1996.tb00520.x
Moon I ‐S., Berglundh T, Abrahamsson I, Linder E, Lindhe J. The barrier between the keratinized mucosa and the dental implant. J Clin Periodontol. 1999 Oct 9;26(10):658–63. doi:10.1034/j.1600-051X.1999.261005.x
Heitz-Mayfield LJA, Lang NP. Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis. Periodontol 2000. 2010 Jun;53(1):167–81. doi:10.1111/j.1600-0757.2010.00348.x
Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP, Ramseier CA. Reversibility of experimental peri‐implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012 Feb 2;23(2):182–90. doi:10.1111/j.1600-0501.2011.02220.x
Meyer S, Giannopoulou C, Courvoisier D, Schimmel M, Müller F, Mombelli A. Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses. Clin Oral Implants Res. 2017 Aug 23;28(8):1005–12. doi:10.1111/clr.12912
Carcuac O, Abrahamsson I, Derks J, Petzold M, Berglundh T. Spontaneous progression of experimental peri‐implantitis in augmented and pristine bone: A pre‐clinical in vivo study. Clin Oral Implants Res. 2020 Feb 3;31(2):192–200. doi:10.1111/clr.13564
Serroni M, Borgnakke WS, Romano L, Balice G, Paolantonio M, Saleh MHA, et al. History of periodontitis as a risk factor for implant failure and incidence of peri-implantitis: A systematic review, meta-analysis, and trial sequential analysis of prospective cohort studies. Clinical Implant Dentistry and Related Research. John Wiley and Sons Inc; 2024. p. 482–508. doi:10.1111/cid.13330 PubMed PMID: 38720611.
Serino G, Ström C. Peri‐implantitis in partially edentulous patients: association with inadequate plaque control. Clin Oral Implants Res. 2009 Feb 21;20(2):169–74. doi:10.1111/j.1600-0501.2008.01627.x
Archana, Bagewadi A, Keluskar V. Assessment and comparison of phagocytic function and viability of polymorphonuclear leukocytes in saliva of smokers and non-smokers. Arch Oral Biol. 2015 Feb;60(2):229–33. doi:10.1016/j.archoralbio.2014.09.018
Cyprus GN, Overlin JW, Hotchkiss KM, Kandalam S, Olivares-Navarrete R. Cigarette smoke increases pro-inflammatory markers and inhibits osteogenic differentiation in experimental exposure model. Acta Biomater. 2018 Aug;76:308–18. doi:10.1016/j.actbio.2018.06.018
Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011 Dec 28;7(12):738–48. doi:10.1038/nrendo.2011.106
Monje A, Catena A, Borgnakke WS. Association between diabetes mellitus/hyperglycaemia and peri‐implant diseases: Systematic review and meta‐analysis. J Clin Periodontol. 2017 Jun 5;44(6):636–48. doi:10.1111/jcpe.12724
Renvert Stefan, Giovannoli JLouis, Lang NPeter. Peri-implantitis. Quintessence Pub.; 2012. 259 p.
Doornewaard R, Christiaens V, De Bruyn H, Jacobsson M, Cosyn J, Vervaeke S, et al. Long‐Term Effect of Surface Roughness and Patients’ Factors on Crestal Bone Loss at Dental Implants. A Systematic Review and Meta‐Analysis. Clin Implant Dent Relat Res. 2017 Apr 15;19(2):372–99. doi:10.1111/cid.12457
Wilson Jr. TG. The Positive Relationship Between Excess Cement and Peri‐Implant Disease: A Prospective Clinical Endoscopic Study. J Periodontol. 2009 Sep;80(9):1388–92. doi:10.1902/jop.2009.090115
Linkevicius T, Vindasiute E, Puisys A, Peciuliene V. The influence of margin location on the amount of undetected cement excess after delivery of cement‐retained implant restorations. Clin Oral Implants Res. 2011 Dec 8;22(12):1379–84. doi:10.1111/j.1600-0501.2010.02119.x
Katafuchi M, Weinstein BF, Leroux BG, Chen Y, Daubert DM. Restoration contour is a risk indicator for peri‐implantitis: A cross‐sectional radiographic analysis. J Clin Periodontol. 2018 Feb 5;45(2):225–32. doi:10.1111/jcpe.12829
Heitz‐Mayfield LJ, Schmid B, Weigel C, Gerber S, Bosshardt DD, Jönsson J, et al. Does excessive occlusal load affect osseointegration? An experimental study in the dog. Clin Oral Implants Res. 2004 Jun 13;15(3):259–68. doi:10.1111/j.1600-0501.2004.01019.x
Di Spirito F, Giordano F, Di Palo MP, D’Ambrosio F, Scognamiglio B, Sangiovanni G, et al. Microbiota of Peri-Implant Healthy Tissues, Peri-Implant Mucositis, and Peri-Implantitis: A Comprehensive Review. Microorganisms. 2024 Jun 2;12(6):1137. doi:10.3390/microorganisms12061137
Mombelli A, Van Oosten MAC, Schiirch E, Lang NP. The microbiota associated with successfuiorfaiiing osseointegrated titanium impiants. Oral Microbiol Immunol. 1987. Report.
Yan X, Lu H, Zhang L, Zhu B, Piao M, Huang B, et al. A three-year study on periodontal microorganisms of short locking-taper implants and adjacent teeth in patients with history of periodontitis. J Dent. 2020 Apr;95:103299. doi:10.1016/j.jdent.2020.103299
Carvalho ÉBS, Romandini M, Sadilina S, Sant’Ana ACP, Sanz M. Microbiota associated with peri-implantitis—A systematic review with meta-analyses. Clinical Oral Implants Research. John Wiley and Sons Inc; 2023. p. 1176–87. doi:10.1111/clr.14153 PubMed PMID: 37523470.
Carcuac O, Abrahamsson I, Albouy J, Linder E, Larsson L, Berglundh T. Experimental periodontitis and peri‐implantitis in dogs. Clin Oral Implants Res. 2013 Apr 26;24(4):363–71. doi:10.1111/clr.12067
Renvert S, Polyzois I, Claffey N. Surgical therapy for the control of peri‐implantitis. Clin Oral Implants Res. 2012 Oct 12;23(s6):84–94. doi:10.1111/j.1600-0501.2012.02554.x
De Waal YCM, Vangsted TE, Van Winkelhoff AJ. Systemic antibiotic therapy as an adjunct to non‐surgical peri‐implantitis treatment: A single‐blind RCT. J Clin Periodontol. 2021 Jul 3;48(7):996–1006. doi:10.1111/jcpe.13464
SHIBLI JA, FERRARI DS, SIROMA RS, FIGUEIREDO LC de, FAVERI M de, FERES M. Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up. Braz Oral Res. 2019;33(suppl 1). doi:10.1590/1807-3107bor-2019.vol33.0080
Barbato L, Cavalcanti R, Rupe C, Scartabelli D, Serni L, Chambrone L, et al. Clinical efficacy of adjunctive methods for the non-surgical treatment of peri-implantitis: a systematic review and meta-analysis. BMC Oral Health. 2023 Jun 9;23(1):375. doi:10.1186/s12903-023-03058-z
Cosgarea R, Roccuzzo A, Jepsen K, Sculean A, Jepsen S, Salvi GE. Efficacy of mechanical/physical approaches for implant surface decontamination in non‐surgical submarginal instrumentation of peri‐implantitis. A systematic review. J Clin Periodontol. 2023 Jun 23;50(S26):188–211. doi:10.1111/jcpe.13762
de Waal YCM, Winning L, Stavropoulos A, Polyzois I. Efficacy of chemical approaches for implant surface decontamination in conjunction with sub‐marginal instrumentation, in the non‐surgical treatment of peri‐implantitis: A systematic review. J Clin Periodontol. 2023 Jun 25;50(S26):212–23. doi:10.1111/jcpe.13749
Luo R, Li L, Wang W. Efficacy of systemic use of antibiotics as an adjunct to nonsurgical treatment of peri-implantitis: a meta-analysis of randomized controlled trials. Quintessence Int. 2024 Feb 28;55(2):120–8. doi:10.3290/j.qi.b4551761 PubMed PMID: 37870595.
Wang H, Li W, Zhang D, Li W, Wang Z. Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial. Aust Dent J. 2019 Sep 21;64(3):256–62. doi:10.1111/adj.12705
Karlsson K, Trullenque‐Eriksson A, Tomasi C, Derks J. Efficacy of access flap and pocket elimination procedures in the management of peri‐implantitis: A systematic review and meta‐analysis. J Clin Periodontol. 2023 Jun 3;50(S26):244–84. doi:10.1111/jcpe.13732
Derks J, Ortiz‐Vigón A, Guerrero A, Donati M, Bressan E, Ghensi P, et al. Reconstructive surgical therapy of peri‐implantitis: A multicenter randomized controlled clinical trial. Clin Oral Implants Res. 2022 Sep 26;33(9):921–44. doi:10.1111/clr.13972
Roccuzzo M, Mirra D, Roccuzzo A. Surgical treatment of peri-implantitis. Br Dent J. 2024 May 24;236(10):803–8. doi:10.1038/s41415-024-7405-9
Hallström H, Persson GR, Lindgren S, Renvert S. Open flap debridement of peri‐implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial. J Clin Periodontol. 2017 Dec 4;44(12):1285–93. doi:10.1111/jcpe.12805
Schwarz F, Jepsen S, Obreja K, Galarraga‐Vinueza ME, Ramanauskaite A. Surgical therapy of peri‐implantitis. Periodontol 2000. 2022 Feb;88(1):145–81. doi:10.1111/prd.12417
Chan H, Lin G, Suarez F, MacEachern M, Wang H. Surgical Management of Peri‐Implantitis: A Systematic Review and Meta‐Analysis of Treatment Outcomes. J Periodontol. 2014 Aug;85(8):1027–41. doi:10.1902/jop.2013.130563
Stavropoulos A, Bertl K, Eren S, Gotfredsen K. Mechanical and biological complications after implantoplasty—A systematic review. Clin Oral Implants Res. 2019 Sep 17;30(9):833–48. doi:10.1111/clr.13499
Ramanauskaite A, Sculean A, Cafferata EA, Schwarz F. Biomaterials for Reconstructive Treatment of Peri‐Implantitis. J Periodontal Res. 2025 May 9. doi:10.1111/jre.13414
Monje A, Pons R, Insua A, Nart J, Wang H, Schwarz F. Morphology and severity of peri‐implantitis bone defects. Clin Implant Dent Relat Res. 2019 Aug 14;21(4):635–43. doi:10.1111/cid.12791
Tomasi C, Regidor E, Ortiz‐Vigón A, Derks J. Efficacy of reconstructive surgical therapy at peri‐implantitis‐related bone defects. A systematic review and meta‐analysis. J Clin Periodontol. 2019 Jun 18;46(S21):340–56. doi:10.1111/jcpe.13070
Øen M, Leknes KN, Lund B, Bunæs DF. The efficacy of systemic antibiotics as an adjunct to surgical treatment of peri-implantitis: a systematic review. BMC Oral Health. 2021 Dec 27;21(1):666. doi:10.1186/s12903-021-02020-1
Heitz‐Mayfield LJA, Salvi GE, Mombelli A, Loup P, Heitz F, Kruger E, et al. Supportive peri‐implant therapy following anti‐infective surgical peri‐implantitis treatment: 5‐year survival and success. Clin Oral Implants Res. 2018 Jan 23;29(1):1–6. doi:10.1111/clr.12910
Teughels W, Seyssens L, Christiaens V, Temmerman A, Castro AB, Cosyn J. Adjunctive locally and systemically delivered antimicrobials during surgical treatment of peri‐implantitis: A systematic review. J Clin Periodontol. 2023 Jun 27;50(S26):359–72. doi:10.1111/jcpe.13773
Belibasakis GN, Charalampakis G, Bostanci N, Stadlinger B. Peri-Implant Infections of Oral Biofilm Etiology. In. 2015. p. 69–84. doi:10.1007/978-3-319-11038-7_4
Derks J, Tomasi C. Peri‐implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015 Apr 31;42(S16). doi:10.1111/jcpe.12334
Heitz-Mayfield LJA, Salvi GE, Botticelli D, Mombelli A, Faddy M, Lang NP. Anti-infective treatment of peri-implant mucositis: a randomised controlled clinical trial. Clin Oral Implants Res. 2011 Mar;22(3):237–41. doi:10.1111/j.1600-0501.2010.02078.x
Riben Grundström C, Lund B, Kämpe J, Belibasakis GN, Hultin M. Systemic antibiotics in the surgical treatment of peri‐implantitis: A randomized placebo‐controlled trial. J Clin Periodontol. 2024 Aug 3;51(8):981–96. doi:10.1111/jcpe.13994
