Dudak Damak Yarıkları ve Etiyolojisi

Mossey PA, Little J, Munger RG, et al. Cleft lip and palate. The Lancet. 2009 Nov;374(9703):1773–1785. doi:10.1016/S0140-6736(09)60695-4

Saleem K, Zaib T, Sun W, et al. Assessment of candidate genes and genetic heterogeneity in human non syndromic orofacial clefts specifically non syndromic cleft lip with or without palate. Heliyon. 2019;5:e01700. doi:10.1016/j.heliyon.2019.e01700

Kaul B, Mahajan N, Gupta R, et al. The syndrome of pit of the lower lip and its association with cleft palate. Contemp Clin Dent. 2014 Jul;5(3):383–385. doi:10.4103/0976-237X.137935

Luzzi V, Zumbo G, Guaragna M, et al. The role of the pediatric dentist in the multidisciplinary management of the cleft lip palate patient. Int J Environ Res Public Health. 2021;18:1234. doi:10.3390/ijerph18031234

Prabhu S, Krishnapillai R, Jose M, et al. Etiopathogenesis of orofacial clefting revisited. J Oral Maxillofac Pathol. 2012 May;16(2):228–232. doi:10.4103/0973-029X.99093

Conway JC, Taub PJ, Kling R, et al. Ten-year experience of more than 35,000 orofacial clefts in Africa. BMC Pediatr. 2015 Feb 14;15(1):12. doi:10.1186/s12887-015-0335-1

Sadler TW. Langman’s Medical Embryology. 14th ed. Philadelphia: Wolters Kluwer; 2019. p.284–312

Hammond NL, Dixon MJ. Revisiting the embryogenesis of lip and palate development. Oral Dis. 2022 Jul;28(5):1306–1326. doi:10.1111/odi.14090

Smarius B, Loozen C, Manten W, et al. Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology. World J Methodol. 2017 Sep 26;7(3):93–100. doi:10.5662/wjm.v7.i3.93

Brăila AD, Damian CM, Albu CC, et al. Prenatal Diagnosis of Cleft Lip and Palate: A Retrospective Study. J Clin Med. 2024 Aug 1;13(16):3200. doi:10.3390/jcm13163200

Allori AC, Mulliken JB, Meara JG, Shusterman S, Marcus JR. Classification of cleft lip/palate: Then and now. In: Cleft Palate-Craniofacial Journal. American Cleft Palate Craniofacial Association; 2017. p.175–188

Vyas T, Gupta P, Kumar S, et al. Cleft of lip and palate: A review. J Family Med Prim Care. 2020 Jun;9(6):2621–2625. doi:10.4103/jfmpc.jfmpc_1152_20

Reynolds K, Zhang S, Sun B, et al. Genetics and signaling mechanisms of orofacial clefts. Birth Defects Res. 2020 Nov;112(19):1588–1634. doi:10.1002/bdr2.1786

Franco B, Bruel AL, Thauvin-Robinet C. Oral-Facial-Digital Syndrome Type I. 1993

Zajac DJ, Vallino-Napoli LD. Evaluation and Management of Cleft Lip and Palate A Developmental Perspective. 1st ed. San Diego; 2017. p.24–31

Cheng L, Jiangyue W, Zhonglin J. Environmental factors of non-syndromic cleft lip and palate. Hua Xi Kou Qiang Yi Xue Za Zhi / West China J Stomatol. 2019;37:547–550

Shaw GM, Wasserman CR, Lammer EJ, et al. Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants. Am J Hum Genet. 1996 Mar;58(3):551–561. doi:10.1016/S0002-9297(07)60035-3

Romitti PA, Lidral AC, Munger RG, et al. Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts. Teratology. 1999 Jan;59(1):39–50. doi:10.1002/(SICI)1096-9926(199901)59:1<39::AID-TERA3>3.0.CO;2-T

Beaty TH, Hetmanski JB, Zeiger JS, et al. Testing candidate genes for non-syndromic oral clefts using a case-parent trio design. Genet Epidemiol. 2002 Jan;22(1):1–11. doi:10.1002/gepi.1017

Wu T, Liang KY, Hetmanski JB, et al. Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate. Hum Genet. 2010 Oct;128(4):401–410. doi:10.1007/s00439-010-0876-9

Kummet CM, Moreno LM, Wilcox AJ, et al. Passive Smoke Exposure as a Risk Factor for Oral Clefts-A Large International Population-Based Study. Am J Epidemiol. 2016 May 1;183(9):834–841. doi:10.1093/aje/kww007

Munger RG, Romitti PA, Daack-Hirsch S, et al. Maternal alcohol use and risk of orofacial cleft birth defects. Teratology. 1996 Jul;54(1):27–33. doi:10.1002/(SICI)1096-9926(199607)54:1<27::AID-TERA5>3.0.CO;2-B

Bell JC, Raynes-Greenow C, Turner RM, et al. Maternal alcohol consumption during pregnancy and the risk of orofacial clefts in infants: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2014 Jul;28(4):322–332. doi:10.1111/ppe.12119

Jayarajan R, Natarajan A, Nagamuttu R. Efficacy of Periconceptional High-Dose Folic Acid in Isolated Orofacial Cleft Prevention: A Systematic Review. Indian J Plast Surg. 2019 May;52(2):153–159. doi:10.1055/s-0039-1688820

Millacura N, Pardo R, Cifuentes L, et al. Effects of folic acid fortification on orofacial clefts prevalence: a meta-analysis. Public Health Nutr. 2017 Aug;20(12):2260–2268. doi:10.1017/S1368980017000880

Jahanbin A, Shadkam E, Miri HH, et al. Maternal Folic Acid Supplementation and the Risk of Oral Clefts in Offspring. J Craniofac Surg. 2018 Sep;29(6):e534–541. doi:10.1097/SCS.0000000000004886

Johansen AMW, Lie RT, Wilcox AJ, et al. Maternal dietary intake of vitamin A and risk of orofacial clefts: a population-based case-control study in Norway. Am J Epidemiol. 2008 May 15;167(10):1164–1170. doi:10.1093/aje/kwn050

Alade A, Ismail W, Nair R, et al. Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis. Birth Defects Res. 2022 Jun;114(10):467–477. doi:10.1002/bdr2.1966

van Rooij IALM, Swinkels DW, Blom HJ, et al. Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol. 2003 Oct;189(4):1155–1160. doi:10.1067/S0002-9378(03)00969-7

Munger RG, Sauberlich HE, Corcoran C, et al. Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Res A Clin Mol Teratol. 2004 Jul;70(7):464–471. doi:10.1002/bdra.20053

Wallenstein MB, Shaw GM, Yang W, et al. Periconceptional nutrient intakes and risks of orofacial clefts in California. Pediatr Res. 2013 Oct;74(4):457–465. doi:10.1038/pr.2013.154

Tamura T, Munger RG, Corcoran C, et al. Plasma zinc concentrations of mothers and the risk of nonsyndromic oral clefts in their children: a case-control study in the Philippines. Birth Defects Res A Clin Mol Teratol. 2005 Sep;73(9):612–616. doi:10.1002/bdra.20141

Hozyasz KK, Kaczmarczyk M, Dudzik J, et al. Relation between the concentration of zinc in maternal whole blood and the risk of an infant being born with an orofacial cleft. Br J Oral Maxillofac Surg. 2009 Sep;47(6):466–469. doi:10.1016/j.bjoms.2008.08.002

Kutbi H, Wehby GL, Moreno Uribe LM, et al. Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies. Int J Epidemiol. 2017 Feb 1;46(1):190–199. doi:10.1093/ije/dyw285

Blanco R, Colombo A, Suazo J. Maternal obesity is a risk factor for orofacial clefts: a meta-analysis. Br J Oral Maxillofac Surg. 2015 Oct;53(8):699–704. doi:10.1016/j.bjoms.2015.05.013

Shi FP, Huang YY, Dai QQ, et al. Maternal Common Cold or Fever During Pregnancy and the Risk of Orofacial Clefts in the Offspring: A Systematic Review and Meta-analysis. Cleft Palate Craniofac J. 2023 Apr;60(4):446–453. doi:10.1177/10556656221150621

Abd-El-Ghafour M. Association between human cytomegalovirus infection and incidence of severe orofacial clefts: a series of rare cases. BMC Oral Health. 2025 May 23;25(1):773. doi:10.1186/s12903-025-01234-5

Saarti M, Mahmood M, Alchalaby L. Overview of drug-induced orofacial cleft. Georgian Med News. 2024 Mar;(348):128–131

Xiao WL, Liu XY, Liu YS, et al. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017 Apr;69:99–105. doi:10.1016/j.reprotox.2017.01.001

Veroniki AA, Cogo E, Rios P, et al. Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. BMC Med. 2017 May 5;15(1):95. doi:10.1186/s12916-017-0866-0

Mølgaard-Nielsen D, Hviid A. Maternal use of antibiotics and the risk of orofacial clefts: a nationwide cohort study. Pharmacoepidemiol Drug Saf. 2012 Mar;21(3):246–253. doi:10.1002/pds.2240

Leslie EJ, Marazita ML. Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):246–258. doi:10.1002/ajmg.c.31381

Schutte BC, Saal HM, Goudy S, et al. IRF6-Related Disorders. 1993

Sunumu O, Köse R, Burçe A, Tuna K. Van der Woude Sendromu: 2 Olgu Sunumu. Fırat Tıp Dergisi [Internet]. 2012;17:58–60. Available from: www.firattipdergisi.com

Karempelis P, Hagen M, Morrell N, et al. Associated syndromes in patients with Pierre Robin Sequence. Int J Pediatr Otorhinolaryngol. 2020 Apr;131:109842. doi:10.1016/j.ijporl.2020.109842

Meurice T, Barry F, Touzet-Roumazeille S, et al. The oral and maxillofacial manifestations of Stickler syndrome: A systematic review. J Stomatol Oral Maxillofac Surg. 2025 Oct;126(5):102261. doi:10.1016/j.jormas.2025.102261

Cárdenas-Nieto D, Forero-Castro M, Esteban-Pérez C, et al. The 22q11.2 Microdeletion in Pediatric Patients with Cleft Lip, Palate, or Both and Congenital Heart Disease: A Systematic Review. J Pediatr Genet. 2020 Mar;9(1):1–8. doi:10.1055/s-0040-1701503

Im H, Song Y, Kim JK, Park DK, Kim DS, Kim H, et al. Molecular Regulation of Palatogenesis and Clefting: An Integrative Analysis of Genetic, Epigenetic Networks, and Environmental Interactions. Int J Mol Sci. 2025 Feb 6;26(3). doi:10.3390/ijms26031382

Sharp GC, Ho K, Davies A, Stergiakouli E, Humphries K, McArdle W, et al. Distinct DNA methylation profiles in subtypes of orofacial cleft. Clin Epigenetics. 2017;9:63. doi:10.1186/s13148-017-0362-2

Petrin AL, Machado-Paula LA, Romanowska J, Lie RT, Hovey L, Doolittle B, et al. Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology. medRxiv. 2025 Sep 17. doi:10.1101/2025.02.09.25321494