Düşük Over Rezervinde Yenilikçi Tedaviler

Hansen KR, Craig LB, Zavy MT, Klein NA, Soules MR. Ovarian primordial and nongrowing follicle counts according to the Stages of Reproductive Aging Workshop (STRAW) staging system. Menopause. 2012;19(2):164-171. doi:10.1097/gme.0b013e31823b0b2e

Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23(3):699-708. doi:10.1093/humrep/dem408

Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org; Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2020;114(6):1151-1157. doi:10.1016/j.fertnstert.2020.09.134

Papathanasiou A. Implementing the ESHRE 'poor responder' criteria in research studies: methodological implications. Hum Reprod. 2014;29(9):1835-1838. doi:10.1093/humrep/deu135

Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26(7):1616-1624. doi:10.1093/humrep/der092

Poseidon Group (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number), Alviggi C, Andersen CY, et al. A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept. Fertil Steril. 2016;105(6):1452-1453. doi:10.1016/j.fertnstert.2016.02.005

Zhu Q, Du J, Li Y, et al. Downregulation of glucose-energy metabolism via AMPK signaling pathway in granulosa cells of diminished ovarian reserve patients. Gene. 2025;933:148979. doi:10.1016/j.gene.2024.148979

Zhu Q, Li Y, Ma J, Ma H, Liang X. Potential factors result in diminished ovarian reserve: a comprehensive review. J Ovarian Res. 2023;16(1):208.doi:10.1186/s13048-023-01296-x

Lee DY. Diminished Ovarian Reserve: A Narrative Review of Etiologies and Possible Therapeutic Approaches. J Menopausal Med. 2025;31(2):85-94. doi:10.6118/jmm.25109

An Z, Xie C, Lu H, et al. Mitochondrial Morphology and Function Abnormality in Ovarian Granulosa Cells of Patients with Diminished Ovarian Reserve. Reprod Sci. 2024;31(7):2009-2020. doi:10.1007/s43032-024-01459-1

Monniaux D. Factors influencing establishment of the ovarian reserve and their effects on fertility. Anim Reprod.2018;15(Suppl 1):635-647.doi:10.21451/1984-3143-AR2018-0011

Tsoulis MW, Chang PE, Moore CJ, et al. Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring. Biol Reprod. 2016;94(4):94. doi:10.1095/biolreprod.115.135004

Bleil ME, English P, Valle J, et al. Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?. Womens Midlife Health. 2018;4:5.doi:10.1186/s40695-018-0033-2

Priya K, Setty M, Babu UV, Pai KSR. Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility?. Environ Sci Pollut Res Int. 2021;28(48):67925-67939. doi:10.1007/s11356-021-16489-4

Collodel G, Gambera L, Stendardi A, et al. Follicular Fluid Components in Reduced Ovarian Reserve, Endometriosis, and Idiopathic Infertility. Int J Mol Sci. 2023;24(3):2589. doi:10.3390/ijms24032589

Li J, Zhang Z, Wei Y, Zhu P, Yin T, Wan Q. Metabonomic analysis of follicular fluid in patients with diminished ovarian reserve. Front Endocrinol (Lausanne). 2023;14:1132621. doi:10.3389/fendo.2023.1132621

Wen J, Feng Y, Yan W, et al. Vaginal Microbiota Changes in Patients With Premature Ovarian Insufficiency and Its Correlation With Ovarian Function. Front Endocrinol (Lausanne). 2022;13:824282.doi:10.3389/fendo.2022.824282

Lourenço DMR, Araújo DB, Aikawa NE, Yamakami LYS, Borba EF, Maciel GAR, Soares-Junior JM, Baracat EC, Pereira RMR, Bonfa E, Silva CA. Adrenal steroidogenesis and ovarian reserve in adult childhood-onset systemic lupus erytematosus patients. Clin Rheumatol. 2021;40:3651–8. doi: 10.1007/s10067-021-05677-9.

An L, Huang Y, Wang Y, et al. Assessment of ovarian dysfunction induced by environmental toxins: a systematic review. Front Public Health. 2025;13:1575418. doi:10.3389/fpubh.2025.1575418

Cizmeli C, Lobel M, Franasiak J, Pastore LM. Levels and associations among self-esteem, fertility distress, coping, and reaction to potentially being a genetic carrier in women with diminished ovarian reserve. Fertil Steril. 2013;99(7):2037-44.e3. doi:10.1016/j.fertnstert.2013.02.033

Birch Petersen K, Hvidman HW, Forman JL, et al. Ovarian reserve assessment in users of oral contraception seeking fertility advice on their reproductive lifespan. Hum Reprod. 2015;30(10):2364-2375. doi:10.1093/humrep/dev197

Gasparri ML, Di Micco R, Zuber V, et al. Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis. Breast. 2021;60:155-162. doi:10.1016/j.breast.2021.09.006

Greene AD, Patounakis G, Segars JH. Genetic associations with diminished ovarian reserve: a systematic review of the literature. J Assist Reprod Genet. 2014;31(8):935-946. doi:10.1007/s10815-014-0257-5

Xu Q, Ding H, Liu Y, et al. Genetic variants in diminished ovarian reserve and premature ovarian insufficiency: implications for assisted reproductive outcomes. J Assist Reprod Genet. 2025;42(11):3791-3807. doi:10.1007/s10815-025-03663-7

Yılmaz Hanege B, Güler Çekıç S, Ata B. Endometrioma and ovarian reserve: effects of endometriomata per se and its surgical treatment on the ovarian reserve. Facts Views Vis Obgyn. 2019;11(2):151-157.

Weidlinger S, Weidlinger M, Schramm RM, et al. High impact of chemotherapy on ovarian reserve in breast cancer survivors of reproductive age: A systematic review and meta-analysis. Breast. 2025;82:104514. doi:10.1016/j.breast.2025.104514

Wallace WH, Thomson AB, Saran F, Kelsey TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys. 2005;62(3):738-744. doi:10.1016/j.ijrobp.2004.11.038

Younis JS, Shapso N, Ben-Sira Y, Nelson SM, Izhaki I. Endometrioma surgery-a systematic review and meta-analysis of the effect on antral follicle count and anti-Müllerian hormone. Am J Obstet Gynecol. 2022;226(1):33-51.e7. doi:10.1016/j.ajog.2021.06.102

Arı SA, Şahin Ç, Akdemir A, et al. Effects of ovarian cyst types on ovarian reserve after three-dimensional laparoscopic cystectomy. Turk J Obstet Gynecol. 2025;22(2):134-140. doi:10.4274/tjod.galenos.2025.38259

Amable PR, Carias RB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. doi:10.1186/scrt218

Ramos-Torrecillas J, De Luna-Bertos E, García-Martínez O, Ruiz C. Clinical utility of growth factors and platelet-rich plasma in tissue regeneration: a review. Wounds. 2014;26(7):207-213.

Melo P, Navarro C, Jones C, Coward K, Coleman L. The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study. J Assist Reprod Genet. 2020;37(4):855-863. doi:10.1007/s10815-020-01710-z

Cakiroglu Y, Yuceturk A, Karaosmanoglu O, et al. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging (Albany NY). 2022;14(6):2513-2523. doi:10.18632/aging.203972

Sabouni R, Tarrab R, Kalaji D, Abbassi H. A new approach of using platelet-rich autologous plasma to increase the ovarian reservoir in a Syrian patient with ovarian insufficiency: A case report. Ann Med Surg (Lond). 2021;73:103149. doi:10.1016/j.amsu.2021.103149

Tülek F, Kahraman A. The effects of intra-ovarian autologous platelet rich plasma injection on IVF outcomes of poor responder women and women with premature ovarian insufficiency. J Turk Ger Gynecol Assoc. 2022;23(1):14-21. doi:10.4274/jtgga.galenos.2021.2021.0134

Pantos K, Simopoulou M, Pantou A, et al. A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment. Cell Transplant. 2019;28(9-10):1333-1340. doi:10.1177/0963689719859539

Sfakianoudis K, Simopoulou M, Grigoriadis S, et al. Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women. J Clin Med. 2020;9(6):1809. doi:10.3390/jcm9061809

Devenutto LM, Valzacchi GR, Ercolano M, Etchegoyen O. Intraovarian platelet-rich plasma injection in poor responders. JBRA Assist Reprod. 2024;28(3):450-456. doi:10.5935/1518-0557.20240031

Éliás M, Kónya M, Kekk Z, et al. Platelet-rich plasma (PRP) treatment of the ovaries significantly improves fertility parameters and reproductive outcomes in diminished ovarian reserve patients: a systematic review and meta-analysis. J Ovarian Res. 2024;17(1):104. doi:10.1186/s13048-024-01423-2

Herlihy NS, Cakiroglu Y, Whitehead C, et al. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Hum Reprod. 2024; doi:10.1093/humrep/deae093

Zhang X, Wang S. Current status and future prospects of mesenchymal stem cell-derived exosomes therapy for premature ovarian insufficiency. J Ovarian Res. 2025;18(1):231. doi:10.1186/s13048-025-01813-0

Lu Y, Wei Y, Shen X, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles improve ovarian function in rats with primary ovarian insufficiency by carrying miR-145-5p. J Reprod Immunol. 2023;158:103971. doi:10.1016/j.jri.2023.103971

Geng Z, Chen H, Zou G, et al. Human Amniotic Fluid Mesenchymal Stem Cell-Derived Exosomes Inhibit Apoptosis in Ovarian Granulosa Cell via miR-369-3p/YAF2/PDCD5/p53 Pathway. Oxid Med Cell Longev. 2022;2022:3695848. doi:10.1155/2022/3695848

Zhang S, Huang B, Su P, et al. Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency. Stem Cell Res Ther. 2021;12(1):178. doi:10.1186/s13287-021-02255-3

Gabryś J, Kij-Mitka B, Sawicki S, et al. Extracellular vesicles from follicular fluid may improve the nuclear maturation rate of in vitro matured mare oocytes. Theriogenology. 2022;188:116-124. doi:10.1016/j.theriogenology.2022.05.022

Feng X, Ling L, Zhang W, Liu X, Wang Y, Luo Y, et al. Effects of human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation in situ on primary ovarian insufficiency in SD rats. Reprod Sci. 2020;27:1502–1512. doi: 10.1007/s43032-020-00147-0.

Wang Z, Wang Y, Yang T, Li J, Yang X. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice. Stem Cell Res Ther. 2017;8:11. doi: 10.1186/s13287-016-0458-1.

Chen L, Guo S, Wei C, Li H, Wang H, Xu Y. Effect of stem cell transplantation of premature ovarian failure in animal models and patients: A meta-analysis and case report. Exp Ther Med. 2018;15(5):4105-4118. doi:10.3892/etm.2018.5970

Martirosyan YO, Silachev DN, Nazarenko TA, Birukova AM, Vishnyakova PA, Sukhikh GT. Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency. Life (Basel). 2023;13(12):2247. doi:10.3390/life13122247

Herraiz S, Buigues A, Díaz-García C, et al. Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion. Fertil Steril. 2018;109(5):908-918.e2. doi:10.1016/j.fertnstert.2018.01.004

Herraiz S, Pellicer N, Romeu M, Pellicer A. Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure. Curr Opin Obstet Gynecol. 2019;31(3):156-162. doi:10.1097/GCO.0000000000000531

Salvatore G, De Felici M, Dolci S, et al. Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency. Stem Cell Res Ther. 2021;12(1):537. doi:10.1186/s13287-021-02590-5

Navarro C, Torrecillas Cabrera P, Teppa Garrán A. Comparative analysis of the use of autologous exosomes and platelet-derived growth factors in women with premature ovarian insufficiency and infertility: A prospective, randomized, observational, analytical study. Regen Ther. 2025;30:309-320. doi:10.1016/j.reth.2025.06.007

Hansen KR, Craig LB, Zavy MT, Klein NA, Soules MR. Ovarian primordial and nongrowing follicle counts according to the Stages of Reproductive Aging Workshop (STRAW) staging system. Menopause. 2012;19(2):164-171. doi:10.1097/gme.0b013e31823b0b2e

Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23(3):699-708. doi:10.1093/humrep/dem408

Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org; Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2020;114(6):1151-1157. doi:10.1016/j.fertnstert.2020.09.134

Papathanasiou A. Implementing the ESHRE 'poor responder' criteria in research studies: methodological implications. Hum Reprod. 2014;29(9):1835-1838. doi:10.1093/humrep/deu135

Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26(7):1616-1624. doi:10.1093/humrep/der092

Poseidon Group (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number), Alviggi C, Andersen CY, et al. A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept. Fertil Steril. 2016;105(6):1452-1453. doi:10.1016/j.fertnstert.2016.02.005

Zhu Q, Du J, Li Y, et al. Downregulation of glucose-energy metabolism via AMPK signaling pathway in granulosa cells of diminished ovarian reserve patients. Gene. 2025;933:148979. doi:10.1016/j.gene.2024.148979

Zhu Q, Li Y, Ma J, Ma H, Liang X. Potential factors result in diminished ovarian reserve: a comprehensive review. J Ovarian Res. 2023;16(1):208.doi:10.1186/s13048-023-01296-x

Lee DY. Diminished Ovarian Reserve: A Narrative Review of Etiologies and Possible Therapeutic Approaches. J Menopausal Med. 2025;31(2):85-94. doi:10.6118/jmm.25109

An Z, Xie C, Lu H, et al. Mitochondrial Morphology and Function Abnormality in Ovarian Granulosa Cells of Patients with Diminished Ovarian Reserve. Reprod Sci. 2024;31(7):2009-2020. doi:10.1007/s43032-024-01459-1

Monniaux D. Factors influencing establishment of the ovarian reserve and their effects on fertility. Anim Reprod.2018;15(Suppl 1):635-647.doi:10.21451/1984-3143-AR2018-0011

Tsoulis MW, Chang PE, Moore CJ, et al. Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring. Biol Reprod. 2016;94(4):94. doi:10.1095/biolreprod.115.135004

Bleil ME, English P, Valle J, et al. Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?. Womens Midlife Health. 2018;4:5.doi:10.1186/s40695-018-0033-2

Priya K, Setty M, Babu UV, Pai KSR. Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility?. Environ Sci Pollut Res Int. 2021;28(48):67925-67939. doi:10.1007/s11356-021-16489-4

Collodel G, Gambera L, Stendardi A, et al. Follicular Fluid Components in Reduced Ovarian Reserve, Endometriosis, and Idiopathic Infertility. Int J Mol Sci. 2023;24(3):2589. doi:10.3390/ijms24032589

Li J, Zhang Z, Wei Y, Zhu P, Yin T, Wan Q. Metabonomic analysis of follicular fluid in patients with diminished ovarian reserve. Front Endocrinol (Lausanne). 2023;14:1132621. doi:10.3389/fendo.2023.1132621

Wen J, Feng Y, Yan W, et al. Vaginal Microbiota Changes in Patients With Premature Ovarian Insufficiency and Its Correlation With Ovarian Function. Front Endocrinol (Lausanne). 2022;13:824282.doi:10.3389/fendo.2022.824282

Lourenço DMR, Araújo DB, Aikawa NE, Yamakami LYS, Borba EF, Maciel GAR, Soares-Junior JM, Baracat EC, Pereira RMR, Bonfa E, Silva CA. Adrenal steroidogenesis and ovarian reserve in adult childhood-onset systemic lupus erytematosus patients. Clin Rheumatol. 2021;40:3651–8. doi: 10.1007/s10067-021-05677-9.

An L, Huang Y, Wang Y, et al. Assessment of ovarian dysfunction induced by environmental toxins: a systematic review. Front Public Health. 2025;13:1575418. doi:10.3389/fpubh.2025.1575418

Cizmeli C, Lobel M, Franasiak J, Pastore LM. Levels and associations among self-esteem, fertility distress, coping, and reaction to potentially being a genetic carrier in women with diminished ovarian reserve. Fertil Steril. 2013;99(7):2037-44.e3. doi:10.1016/j.fertnstert.2013.02.033

Birch Petersen K, Hvidman HW, Forman JL, et al. Ovarian reserve assessment in users of oral contraception seeking fertility advice on their reproductive lifespan. Hum Reprod. 2015;30(10):2364-2375. doi:10.1093/humrep/dev197

Gasparri ML, Di Micco R, Zuber V, et al. Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis. Breast. 2021;60:155-162. doi:10.1016/j.breast.2021.09.006

Greene AD, Patounakis G, Segars JH. Genetic associations with diminished ovarian reserve: a systematic review of the literature. J Assist Reprod Genet. 2014;31(8):935-946. doi:10.1007/s10815-014-0257-5

Xu Q, Ding H, Liu Y, et al. Genetic variants in diminished ovarian reserve and premature ovarian insufficiency: implications for assisted reproductive outcomes. J Assist Reprod Genet. 2025;42(11):3791-3807. doi:10.1007/s10815-025-03663-7

Yılmaz Hanege B, Güler Çekıç S, Ata B. Endometrioma and ovarian reserve: effects of endometriomata per se and its surgical treatment on the ovarian reserve. Facts Views Vis Obgyn. 2019;11(2):151-157.

Weidlinger S, Weidlinger M, Schramm RM, et al. High impact of chemotherapy on ovarian reserve in breast cancer survivors of reproductive age: A systematic review and meta-analysis. Breast. 2025;82:104514. doi:10.1016/j.breast.2025.104514

Wallace WH, Thomson AB, Saran F, Kelsey TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys. 2005;62(3):738-744. doi:10.1016/j.ijrobp.2004.11.038

Younis JS, Shapso N, Ben-Sira Y, Nelson SM, Izhaki I. Endometrioma surgery-a systematic review and meta-analysis of the effect on antral follicle count and anti-Müllerian hormone. Am J Obstet Gynecol. 2022;226(1):33-51.e7. doi:10.1016/j.ajog.2021.06.102

Arı SA, Şahin Ç, Akdemir A, et al. Effects of ovarian cyst types on ovarian reserve after three-dimensional laparoscopic cystectomy. Turk J Obstet Gynecol. 2025;22(2):134-140. doi:10.4274/tjod.galenos.2025.38259

Amable PR, Carias RB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. doi:10.1186/scrt218

Ramos-Torrecillas J, De Luna-Bertos E, García-Martínez O, Ruiz C. Clinical utility of growth factors and platelet-rich plasma in tissue regeneration: a review. Wounds. 2014;26(7):207-213.

Melo P, Navarro C, Jones C, Coward K, Coleman L. The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study. J Assist Reprod Genet. 2020;37(4):855-863. doi:10.1007/s10815-020-01710-z

Cakiroglu Y, Yuceturk A, Karaosmanoglu O, et al. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging (Albany NY). 2022;14(6):2513-2523. doi:10.18632/aging.203972

Sabouni R, Tarrab R, Kalaji D, Abbassi H. A new approach of using platelet-rich autologous plasma to increase the ovarian reservoir in a Syrian patient with ovarian insufficiency: A case report. Ann Med Surg (Lond). 2021;73:103149. doi:10.1016/j.amsu.2021.103149

Tülek F, Kahraman A. The effects of intra-ovarian autologous platelet rich plasma injection on IVF outcomes of poor responder women and women with premature ovarian insufficiency. J Turk Ger Gynecol Assoc. 2022;23(1):14-21. doi:10.4274/jtgga.galenos.2021.2021.0134

Pantos K, Simopoulou M, Pantou A, et al. A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment. Cell Transplant. 2019;28(9-10):1333-1340. doi:10.1177/0963689719859539

Sfakianoudis K, Simopoulou M, Grigoriadis S, et al. Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women. J Clin Med. 2020;9(6):1809. doi:10.3390/jcm9061809

Devenutto LM, Valzacchi GR, Ercolano M, Etchegoyen O. Intraovarian platelet-rich plasma injection in poor responders. JBRA Assist Reprod. 2024;28(3):450-456. doi:10.5935/1518-0557.20240031

Éliás M, Kónya M, Kekk Z, et al. Platelet-rich plasma (PRP) treatment of the ovaries significantly improves fertility parameters and reproductive outcomes in diminished ovarian reserve patients: a systematic review and meta-analysis. J Ovarian Res. 2024;17(1):104. doi:10.1186/s13048-024-01423-2

Herlihy NS, Cakiroglu Y, Whitehead C, et al. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Hum Reprod. 2024; doi:10.1093/humrep/deae093

Zhang X, Wang S. Current status and future prospects of mesenchymal stem cell-derived exosomes therapy for premature ovarian insufficiency. J Ovarian Res. 2025;18(1):231. doi:10.1186/s13048-025-01813-0

Lu Y, Wei Y, Shen X, et al. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles improve ovarian function in rats with primary ovarian insufficiency by carrying miR-145-5p. J Reprod Immunol. 2023;158:103971. doi:10.1016/j.jri.2023.103971

Geng Z, Chen H, Zou G, et al. Human Amniotic Fluid Mesenchymal Stem Cell-Derived Exosomes Inhibit Apoptosis in Ovarian Granulosa Cell via miR-369-3p/YAF2/PDCD5/p53 Pathway. Oxid Med Cell Longev. 2022;2022:3695848. doi:10.1155/2022/3695848

Zhang S, Huang B, Su P, et al. Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency. Stem Cell Res Ther. 2021;12(1):178. doi:10.1186/s13287-021-02255-3

Gabryś J, Kij-Mitka B, Sawicki S, et al. Extracellular vesicles from follicular fluid may improve the nuclear maturation rate of in vitro matured mare oocytes. Theriogenology. 2022;188:116-124. doi:10.1016/j.theriogenology.2022.05.022

Feng X, Ling L, Zhang W, Liu X, Wang Y, Luo Y, et al. Effects of human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation in situ on primary ovarian insufficiency in SD rats. Reprod Sci. 2020;27:1502–1512. doi: 10.1007/s43032-020-00147-0.

Wang Z, Wang Y, Yang T, Li J, Yang X. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice. Stem Cell Res Ther. 2017;8:11. doi: 10.1186/s13287-016-0458-1.

Chen L, Guo S, Wei C, Li H, Wang H, Xu Y. Effect of stem cell transplantation of premature ovarian failure in animal models and patients: A meta-analysis and case report. Exp Ther Med. 2018;15(5):4105-4118. doi:10.3892/etm.2018.5970

Martirosyan YO, Silachev DN, Nazarenko TA, Birukova AM, Vishnyakova PA, Sukhikh GT. Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency. Life (Basel). 2023;13(12):2247. doi:10.3390/life13122247

Herraiz S, Buigues A, Díaz-García C, et al. Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion. Fertil Steril. 2018;109(5):908-918.e2. doi:10.1016/j.fertnstert.2018.01.004

Herraiz S, Pellicer N, Romeu M, Pellicer A. Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure. Curr Opin Obstet Gynecol. 2019;31(3):156-162. doi:10.1097/GCO.0000000000000531

Salvatore G, De Felici M, Dolci S, et al. Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency. Stem Cell Res Ther. 2021;12(1):537. doi:10.1186/s13287-021-02590-5

Navarro C, Torrecillas Cabrera P, Teppa Garrán A. Comparative analysis of the use of autologous exosomes and platelet-derived growth factors in women with premature ovarian insufficiency and infertility: A prospective, randomized, observational, analytical study. Regen Ther. 2025;30:309-320. doi:10.1016/j.reth.2025.06.007