Florür Alternatifi Remineralizasyon Ajanlarına Güncel Bir Bakış

Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, et al. Demineralization–remineralization dynamics in teeth and bone. International journal of nanomedicine. 2016:4743-63.

Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, et al. Dental caries. Nature reviews Disease primers. 2017;3(1):1-16.

Mull GP, Shanbhog R, Bhojraj N, Singh J, Katariya M, Bandyopadhyay P. Evaluation of the Remineralization Potential of an Herbal Non-fluoridated Dentifrice on Carious Lesions: An In Vitro Study. 2024.

Grohe B, Mittler S. Advanced non-fluoride approaches to dental enamel remineralization: The next level in enamel repair management. Biomaterials and Biosystems. 2021;4:100029.

Cate JMt. Current concepts on the theories of the mechanism of action of fluoride. Acta Odontologica Scandinavica. 1999;57(6):325-9.

Dentistry AAoP. Caries-risk assessment and management for infants, children, and adolescents. The reference manual of pediatric dentistry. 2020;2:66-72.

Enax J, Epple M. Synthetic hydroxyapatite as a biomimetic oral care agent. Oral health & preventive dentistry. 2018;16(1).

Philip N. State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management. Caries Res. 2019;53:284-95.

Bordea IR, Candrea S, Alexescu GT, Bran S, Băciuț M, Băciuț G, et al. Nano-hydroxyapatite use in dentistry: a systematic review. Drug Metabolism Reviews. 2020;52(2):319-32.

Meyer F, Amaechi BT, Fabritius H-O, Enax J. Overview of Calcium Phosphates used in Biomimetic Oral Care. The Open Dentistry Journal. 2018;12.

Juntavee N, Juntavee A, Plongniras P. Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. International journal of nanomedicine. 2018:2755-65.

Pushpalatha C, Gayathri V, Sowmya S, Augustine D, Alamoudi A, Zidane B, et al. Nanohydroxyapatite in dentistry: A comprehensive review. The Saudi Dental Journal. 2023;35(6):741-52.

Juntavee A, Juntavee N, Hirunmoon P. Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions. International Journal of Dentistry. 2021;2021(1):5588832.

Najibfard K, Ramalingam K, Chedjieu I, Amaechi BT. Remineralization of early caries by a nano-hydroxyapatite dentifrice. J Clin Dent. 2011;22(5):139-43.

Wierichs RJ, Wolf TG, Campus G, Carvalho TS. Efficacy of nano-hydroxyapatite on caries prevention—a systematic review and meta-analysis. Clinical oral investigations. 2022;26(4):3373-81.

Harman EB, Akleyin E. Preventive and remineralization agents in pediatric dentistry: Review of the literature. J Dent Sci Educ. 2024;2:18-23.

Arifa MK, Ephraim R, Rajamani T. Recent advances in dental hard tissue remineralization: a review of literature. International journal of clinical pediatric dentistry. 2019;12(2):139.

Shihabi S, Alnesser S, Comisi JC. NovaMin versus Fluoride Shihabi et al. Comparative Remineralization Efficacy of Topical NovaMin and Fluoride on Incipient Enamel Lesions in Primary Teeth: Scanning Electron Microscope and Vickers Microhardness Evaluation. 2020.

Haghgoo R, Ahmadvand M, Moshaverinia S. Remineralizing effect of topical novamin and nanohydroxyapatite on caries-like lesions in primary teeth. The Journal of Contemporary Dental Practice. 2016;17(8):645-9.

Hsu SM, Alsafadi M, Vasconez C, Fares C, Craciun V, O’neill E, et al. Qualitative Analysis of Remineralization Capabilities of Bioactive Glass (NovaMin) and Fluoride on Hydroxyapatite (HA) Discs: An In Vitro Study. Materials. 2021;14(14):3813-.

Rai JJ, Chaturvedi S, Gokhale ST, Nagate RR, Al-Qahtani SM, Magbol MA, et al. Effectiveness of a Single Chair Side Application of NovaMin® [Calcium Sodium Phosphosilicate] in the Treatment of Dentine Hypersensitivity following Ultrasonic Scaling—A Randomized Controlled Trial. Materials. 2023;16(4):1329-.

Meyer-Lueckel H, Wierichs RJ, Schellwien T, Paris S. Remineralizing Efficacy of a CPP-ACP Cream on Enamel Caries Lesions in situ. Caries Research. 2015;49(1):56-62.

Baccolini V, da Silva LP, Teixeira L, de Sousa RT, Manarte-Monteiro P. The Role of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in White Spot Lesion Remineralization—A Systematic Review. Journal of Functional Biomaterials 2025, Vol 16, Page 272. 2025;16(8):272-.

Mottaghi M, Bagheri H, Majidinia S, Rangrazi A, Garmroodi AF, Montazeri AH. Casein Phosphopeptide-Amorphous Calcium Phosphate and Gallic Acid as a Complementary Approach for the Treatment of Early Enamel Lesions. International Journal of Biomaterials. 2025;2025(1):5536375-.

Rahmath Meeral P, Doraikannan S, Indiran MA. Efficiency of casein phosphopeptide amorphous calcium phosphate versus topical fluorides on remineralizing early enamel carious lesions – A systematic review and meta analysis. The Saudi Dental Journal. 2024;36(4):521-7.

Memarpour M, Fakhraei E, Dadaein S, Vossoughi M. Efficacy of Fluoride Varnish and Casein Phosphopeptide-Amorphous Calcium Phosphate for Remineralization of Primary Teeth: A Randomized Clinical Trial. Medical Principles and Practice. 2015;24(3):231-.

Li J, Xie X, Wang Y, Yin W, Antoun JS, Farella M, Mei L. Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review. Journal of Dentistry. 2014;42(7):769-77.

Del Rey YC, Rikvold PD, Lund MB, Raittio EJ, Schramm A, Meyer RL, Schlafer S. Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science 2025 17:1. 2025;17(1):70.

Bramhecha A, Krithikadatta J. Role of Arginine in Caries Prevention. Int J Dentistry Oral Sci. 2021;8(7):3230-4.

Kraivaphan P, Amornchat C, Triratana T, Mateo LR, Ellwood R, Cummins D, et al. Two-year caries clinical study of the efficacy of novel dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride. Caries research. 2013;47(6):582-90.

Yin W, Zhou Z, Huang R-Z, Sun G, Zhong Y, Yang Z, et al. Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial. JDR Clinical & Translational Research.23800844251361471.

Alblooshi NA, Naseer TK, Bijle MN. Caries preventive potential of professionally deliverable fluoride-containing agents with incorporated arginine: A scoping review. Japanese Dental Science Review. 2024;60:154-62.

Ru J, Xu X, Cheng Y, Luo N, Tan S, Chen X, et al. Influence of Polyphosphate on the Mineralization Balance of Tooth Enamel. 2025;10:10162-72.

Alshehri A, Almutairi B, Jurado CA, Afrashtehfar KI, Albarrak S, Alharbi A, et al. Biomimetic Whitening Effect of Polyphosphate-Bleaching Agents on Dental Enamel. Biomimetics 2022, Vol 7, Page 183. 2022;7(4):183-.

Liu Y, Li N, Qi Y, Niu LN, Elshafiy S, Mao J, et al. The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin. Dental Materials. 2011;27(5):465-77.

Shehata MA, Khattab NM, Kamal Yassa M. Orthodontics, Pediatric and Preventive Dentistry EVALUATION OF THE REMINERALIZING EFFECT OF FLUORIDATED TOOTHPASTE WITH SODIUM HEXAMETAPHOSPHATE ON DEMINERALIZED PRIMARY TEETH ENAMEL. DENTAL JOURNAL. 2021;67:130-.

Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH. Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel. Journal of Dental Research. 2017;97(2):148-.

Mohamed RN, Basha S, Al-Thomali Y, Saleh Alshamrani A, Salem Alzahrani F, Tawfik Enan E. Self-assembling peptide P11-4 in remineralization of enamel caries - a systematic review of in-vitro studies. Acta odontologica Scandinavica. 2021;79(2):139-46.

Doberdoli D, Bommer C, Begzati A, Haliti F, Heinzel-Gutenbrunner M, Juric H. Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Scientific reports. 2020;10(1).

Keeper JH, Kibbe LJ, Thakkar-Samtani M, Heaton LJ, Desrosiers C, Vela K, et al. Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions. The Journal of the American Dental Association. 2023;154(7):580-91.e11.

Wierichs RJ, Carvalho TS, Wolf TG. Efficacy of a self-assembling peptide to remineralize initial caries lesions - A systematic review and meta-analysis. Journal of Dentistry. 2021;109.

Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, et al. Demineralization–remineralization dynamics in teeth and bone. International journal of nanomedicine. 2016:4743-63.

Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, et al. Dental caries. Nature reviews Disease primers. 2017;3(1):1-16.

Mull GP, Shanbhog R, Bhojraj N, Singh J, Katariya M, Bandyopadhyay P. Evaluation of the Remineralization Potential of an Herbal Non-fluoridated Dentifrice on Carious Lesions: An In Vitro Study. 2024.

Grohe B, Mittler S. Advanced non-fluoride approaches to dental enamel remineralization: The next level in enamel repair management. Biomaterials and Biosystems. 2021;4:100029.

Cate JMt. Current concepts on the theories of the mechanism of action of fluoride. Acta Odontologica Scandinavica. 1999;57(6):325-9.

Dentistry AAoP. Caries-risk assessment and management for infants, children, and adolescents. The reference manual of pediatric dentistry. 2020;2:66-72.

Enax J, Epple M. Synthetic hydroxyapatite as a biomimetic oral care agent. Oral health & preventive dentistry. 2018;16(1).

Philip N. State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management. Caries Res. 2019;53:284-95.

Bordea IR, Candrea S, Alexescu GT, Bran S, Băciuț M, Băciuț G, et al. Nano-hydroxyapatite use in dentistry: a systematic review. Drug Metabolism Reviews. 2020;52(2):319-32.

Meyer F, Amaechi BT, Fabritius H-O, Enax J. Overview of Calcium Phosphates used in Biomimetic Oral Care. The Open Dentistry Journal. 2018;12.

Juntavee N, Juntavee A, Plongniras P. Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. International journal of nanomedicine. 2018:2755-65.

Pushpalatha C, Gayathri V, Sowmya S, Augustine D, Alamoudi A, Zidane B, et al. Nanohydroxyapatite in dentistry: A comprehensive review. The Saudi Dental Journal. 2023;35(6):741-52.

Juntavee A, Juntavee N, Hirunmoon P. Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions. International Journal of Dentistry. 2021;2021(1):5588832.

Najibfard K, Ramalingam K, Chedjieu I, Amaechi BT. Remineralization of early caries by a nano-hydroxyapatite dentifrice. J Clin Dent. 2011;22(5):139-43.

Wierichs RJ, Wolf TG, Campus G, Carvalho TS. Efficacy of nano-hydroxyapatite on caries prevention—a systematic review and meta-analysis. Clinical oral investigations. 2022;26(4):3373-81.

Harman EB, Akleyin E. Preventive and remineralization agents in pediatric dentistry: Review of the literature. J Dent Sci Educ. 2024;2:18-23.

Arifa MK, Ephraim R, Rajamani T. Recent advances in dental hard tissue remineralization: a review of literature. International journal of clinical pediatric dentistry. 2019;12(2):139.

Shihabi S, Alnesser S, Comisi JC. NovaMin versus Fluoride Shihabi et al. Comparative Remineralization Efficacy of Topical NovaMin and Fluoride on Incipient Enamel Lesions in Primary Teeth: Scanning Electron Microscope and Vickers Microhardness Evaluation. 2020.

Haghgoo R, Ahmadvand M, Moshaverinia S. Remineralizing effect of topical novamin and nanohydroxyapatite on caries-like lesions in primary teeth. The Journal of Contemporary Dental Practice. 2016;17(8):645-9.

Hsu SM, Alsafadi M, Vasconez C, Fares C, Craciun V, O’neill E, et al. Qualitative Analysis of Remineralization Capabilities of Bioactive Glass (NovaMin) and Fluoride on Hydroxyapatite (HA) Discs: An In Vitro Study. Materials. 2021;14(14):3813-.

Rai JJ, Chaturvedi S, Gokhale ST, Nagate RR, Al-Qahtani SM, Magbol MA, et al. Effectiveness of a Single Chair Side Application of NovaMin® [Calcium Sodium Phosphosilicate] in the Treatment of Dentine Hypersensitivity following Ultrasonic Scaling—A Randomized Controlled Trial. Materials. 2023;16(4):1329-.

Meyer-Lueckel H, Wierichs RJ, Schellwien T, Paris S. Remineralizing Efficacy of a CPP-ACP Cream on Enamel Caries Lesions in situ. Caries Research. 2015;49(1):56-62.

Baccolini V, da Silva LP, Teixeira L, de Sousa RT, Manarte-Monteiro P. The Role of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in White Spot Lesion Remineralization—A Systematic Review. Journal of Functional Biomaterials 2025, Vol 16, Page 272. 2025;16(8):272-.

Mottaghi M, Bagheri H, Majidinia S, Rangrazi A, Garmroodi AF, Montazeri AH. Casein Phosphopeptide-Amorphous Calcium Phosphate and Gallic Acid as a Complementary Approach for the Treatment of Early Enamel Lesions. International Journal of Biomaterials. 2025;2025(1):5536375-.

Rahmath Meeral P, Doraikannan S, Indiran MA. Efficiency of casein phosphopeptide amorphous calcium phosphate versus topical fluorides on remineralizing early enamel carious lesions – A systematic review and meta analysis. The Saudi Dental Journal. 2024;36(4):521-7.

Memarpour M, Fakhraei E, Dadaein S, Vossoughi M. Efficacy of Fluoride Varnish and Casein Phosphopeptide-Amorphous Calcium Phosphate for Remineralization of Primary Teeth: A Randomized Clinical Trial. Medical Principles and Practice. 2015;24(3):231-.

Li J, Xie X, Wang Y, Yin W, Antoun JS, Farella M, Mei L. Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review. Journal of Dentistry. 2014;42(7):769-77.

Del Rey YC, Rikvold PD, Lund MB, Raittio EJ, Schramm A, Meyer RL, Schlafer S. Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science 2025 17:1. 2025;17(1):70.

Bramhecha A, Krithikadatta J. Role of Arginine in Caries Prevention. Int J Dentistry Oral Sci. 2021;8(7):3230-4.

Kraivaphan P, Amornchat C, Triratana T, Mateo LR, Ellwood R, Cummins D, et al. Two-year caries clinical study of the efficacy of novel dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride. Caries research. 2013;47(6):582-90.

Yin W, Zhou Z, Huang R-Z, Sun G, Zhong Y, Yang Z, et al. Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial. JDR Clinical & Translational Research.23800844251361471.

Alblooshi NA, Naseer TK, Bijle MN. Caries preventive potential of professionally deliverable fluoride-containing agents with incorporated arginine: A scoping review. Japanese Dental Science Review. 2024;60:154-62.

Ru J, Xu X, Cheng Y, Luo N, Tan S, Chen X, et al. Influence of Polyphosphate on the Mineralization Balance of Tooth Enamel. 2025;10:10162-72.

Alshehri A, Almutairi B, Jurado CA, Afrashtehfar KI, Albarrak S, Alharbi A, et al. Biomimetic Whitening Effect of Polyphosphate-Bleaching Agents on Dental Enamel. Biomimetics 2022, Vol 7, Page 183. 2022;7(4):183-.

Liu Y, Li N, Qi Y, Niu LN, Elshafiy S, Mao J, et al. The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin. Dental Materials. 2011;27(5):465-77.

Shehata MA, Khattab NM, Kamal Yassa M. Orthodontics, Pediatric and Preventive Dentistry EVALUATION OF THE REMINERALIZING EFFECT OF FLUORIDATED TOOTHPASTE WITH SODIUM HEXAMETAPHOSPHATE ON DEMINERALIZED PRIMARY TEETH ENAMEL. DENTAL JOURNAL. 2021;67:130-.

Alkilzy M, Tarabaih A, Santamaria RM, Splieth CH. Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel. Journal of Dental Research. 2017;97(2):148-.

Mohamed RN, Basha S, Al-Thomali Y, Saleh Alshamrani A, Salem Alzahrani F, Tawfik Enan E. Self-assembling peptide P11-4 in remineralization of enamel caries - a systematic review of in-vitro studies. Acta odontologica Scandinavica. 2021;79(2):139-46.

Doberdoli D, Bommer C, Begzati A, Haliti F, Heinzel-Gutenbrunner M, Juric H. Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. Scientific reports. 2020;10(1).

Keeper JH, Kibbe LJ, Thakkar-Samtani M, Heaton LJ, Desrosiers C, Vela K, et al. Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest, cavitation, and progression of initial caries lesions. The Journal of the American Dental Association. 2023;154(7):580-91.e11.

Wierichs RJ, Carvalho TS, Wolf TG. Efficacy of a self-assembling peptide to remineralize initial caries lesions - A systematic review and meta-analysis. Journal of Dentistry. 2021;109.