Restoratif Diş Hekimliğine Biyomimetik Bakış
Özet
Bu bölüm, restoratif diş hekimliğinde giderek önem kazanan biyomimetik yaklaşımın temel prensiplerini ve klinik uygulamalarını ele almaktadır. Biyomimetik diş hekimliği, doğal diş dokularının biyolojik, mekanik ve fonksiyonel özelliklerini taklit ederek restorasyonların uzun dönem başarısını artırmayı amaçlayan bir tedavi felsefesidir. Bu kapsamda diş anatomisi, mine–dentin birleşimi ve diş dokularının biyomekanik özellikleri incelenerek restoratif tedavilerde bu yapıların nasıl taklit edilebileceği açıklanmaktadır. Ayrıca kompozit rezinler, adeziv sistemler, cam iyonomer simanlar, seramik sistemler ve biyoaktif materyaller gibi modern restoratif materyaller biyomimetik prensipler açısından değerlendirilmektedir. Bölümde minimal invaziv tedavi yaklaşımları kapsamında Immediate Dentin Sealing (IDS), Deep Margin Elevation (DME), selektif çürük uzaklaştırma ve adeziv restorasyon teknikleri gibi güncel uygulamalara da yer verilmiştir. Bunun yanı sıra rejeneratif diş hekimliği, dentin remineralizasyonu ve dentin-pulpa kompleksinin biyomimetik yöntemlerle yeniden yapılandırılması gibi yenilikçi yaklaşımlar ele alınmıştır. Sonuç olarak biyomimetik restoratif diş hekimliği, doğal diş dokusunun korunmasını ve fonksiyonunun en iyi şekilde taklit edilmesini hedefleyen modern ve multidisipliner bir tedavi yaklaşımı olarak değerlendirilmektedir.
This chapter discusses the fundamental principles and clinical applications of the biomimetic approach in restorative dentistry. Biomimetic dentistry aims to improve the longevity and performance of restorations by mimicking the biological, mechanical, and functional properties of natural dental tissues. Within this framework, the anatomical structure of teeth, the dentin–enamel junction, and the biomechanical behavior of dental tissues are examined to explain how restorative procedures can replicate natural tooth structures. Contemporary restorative materials—including composite resins, adhesive systems, glass ionomer cements, ceramic systems, and bioactive materials—are evaluated from a biomimetic perspective. The chapter also presents current minimally invasive restorative strategies such as Immediate Dentin Sealing (IDS), Deep Margin Elevation (DME), selective caries removal, and adhesive restoration techniques. Furthermore, regenerative dentistry concepts, dentin remineralization processes, and biomimetic approaches for dentin–pulp complex regeneration are discussed. Overall, biomimetic restorative dentistry represents a modern and multidisciplinary treatment philosophy that prioritizes the preservation of natural tooth structure while restoring function and esthetics through biologically inspired restorative techniques.
Referanslar
Singer, L., A. Fouda, and C. Bourauel, Biomimetic approaches and materials in restorative and regenerative dentistry. BMC oral health, 2023. 23(1): p. 105.
Paryani, M., et al., Evolution of Biomimetic Approaches for Regenerative and Restorative Dentistry. Cureus, 2023. 15(1).
Reis, A., et al., Biomimetic Restorative Dentistry: an evidence-based discussion of common myths. Journal of Applied Oral Science, 2024. 32: p. e20240271.
Attik, N., R. Richert, and S. Garoushi, Biomechanics, Bioactive and Biomimetic philosophy in restorative dentistry ̶ Quo vadis? Journal of Dentistry, 2024. 148: p. 105036.
Jadhav, G.R., et al., Biomimetic approach to strengthen the incisal fracture composite build-up: an in vitro study. BMC Oral Health, 2024. 24(1): p. 42.
Goswami, S., Biomimetic dentistry. Journal of Oral Research and Review, 2018. 10(1): p. 28-32.
Kimble, P., et al., Decision making in the restoration of endodontically treated teeth: effect of biomimetic dentistry training. Dentistry Journal, 2023. 11(7): p. 159.
Luo, X., et al., Research progress of biomimetic materials in oral medicine. Journal of biological engineering, 2023. 17(1): p. 72.
Yu, W., X. Wang, and H. Yang, Clinically oriented automatic three-dimensional enamel segmentation via deep learning. BMC Oral Health, 2025. 25(1): p. 133.
Collart-Dutilleul, P.-Y., et al., Raman confocal microscopy atlas of human tooth. Archives of Oral Biology, 2025. 173: p. 106189.
Beniash, E., et al., The hidden structure of human enamel. Nature communications, 2019. 10(1): p. 4383.
West, N.X. and A. Joiner, Enamel mineral loss. Journal of dentistry, 2014. 42: p. S2-S11.
Robinson, C., J. Weatherell, and A. Hallsworth, Variation in composition of dental enamel within thin ground tooth sections. Caries research, 1971. 5(1): p. 44-57.
Monteiro, N. and P.C. Yelick, Advances and perspectives in tooth tissue engineering. Journal of tissue engineering and regenerative medicine, 2017. 11(9): p. 2443-2461.
Marshall, S.J., et al., The dentin–enamel junction—a natural, multilevel interface. Journal of the European Ceramic Society, 2003. 23(15): p. 2897-2904.
Dong, X. and N. Ruse, Fatigue crack propagation path across the dentinoenamel junction complex in human teeth. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 2003. 66(1): p. 103-109.
Xu, C., et al., Chemical/molecular structure of the dentin–enamel junction is dependent on the intratooth location. Calcified tissue international, 2009. 84: p. 221-228.
Demarco, F.F., et al., Dental pulp tissue engineering. Brazilian dental journal, 2011. 22: p. 3-13.
Mjör, I.A., Pulp-dentin biology in restorative dentistry. (No Title), 2002.
Diekwisch, T., The developmental biology of cementum. The International journal of developmental biology, 2001. 45(5-6): p. 695-706.
Foster, B., On the discovery of cementum. Journal of periodontal research, 2017. 52(4): p. 666-685.
Arzate, H., M. Zeichner‐David, and G. Mercado‐Celis, Cementum proteins: role in cementogenesis, biomineralization, periodontium formation and regeneration. Periodontology 2000, 2015. 67(1): p. 211-233.
Asundi, A. and A. Kishen, A strain gauge and photoelastic analysis of in vivo strain and in vitro stress distribution in human dental supporting structures. Archives of oral biology, 2000. 45(7): p. 543-550.
Wang, R. and S. Weiner, Strain–structure relations in human teeth using Moiré fringes. Journal of biomechanics, 1997. 31(2): p. 135-141.
Jandt, K.D. and B.W. Sigusch, Future perspectives of resin-based dental materials. Dental materials, 2009. 25(8): p. 1001-1006.
Singh, P., et al., Overview and recent advances in composite resin: A review. Int J Sci Stud, 2015. 3(9): p. 169-72.
Ilie, N. and R. Hickel, Resin composite restorative materials. Australian dental journal, 2011. 56: p. 59-66.
Zhou, X., et al., Development and status of resin composite as dental restorative materials. Journal of Applied Polymer Science, 2019. 136(44): p. 48180.
Bayne, S.C., H.O. Heymann, and E.J. Swift Jr, Update on dental composite restorations. Journal of the American Dental Association (1939), 1994. 125(6): p. 687-701.
Ilie, N. and R. Hickel, Investigations on mechanical behaviour of dental composites. Clinical oral investigations, 2009. 13: p. 427-438.
Hahnel, S., et al., Investigation of mechanical properties of modern dental composites after artificial aging for one year. Operative dentistry, 2010. 35(4): p. 412-419.
Breschi, L., et al., The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems. Dental Materials, 2024.
Hardan, L., et al., Effect of different application modalities on the bonding performance of adhesive systems to dentin: A systematic review and meta-analysis. Cells, 12 (1), 190. 2023.
Nakabayashi, N., K. Kojima, and E. Masuhara, The promotion of adhesion by the infiltration of monomers into tooth substrates. Journal of biomedical materials research, 1982. 16(3): p. 265-273.
Bourgi, R., et al., Reinforced universal adhesive by ribose crosslinker: A novel strategy in adhesive dentistry. Polymers, 2021. 13(5): p. 704.
Pashley, D.H., et al., State of the art etch-and-rinse adhesives. Dental materials, 2011. 27(1): p. 1-16.
Van Meerbeek, B., et al., State of the art of self-etch adhesives. Dental materials, 2011. 27(1): p. 17-28.
Van Landuyt, K., et al., Technique sensitivity of water-free one-step adhesives. Dental materials, 2008. 24(9): p. 1258-1267.
Unemori, M., et al., Self-etching adhesives and postoperative sensitivity. American Journal of Dentistry, 2004. 17(3): p. 191-195.
Ozer, F. and M.B. Blatz, Self-etch and etch-and-rinse adhesive systems in clinical dentistry. Compendium of Continuing Education in Dentistry (15488578), 2013. 34(1).
Hass, V., et al., Bonding performance of universal adhesive systems applied in etch-and-rinse and self-etch strategies on natural dentin caries. Operative dentistry, 2019. 44(5): p. 510-520.
Gunay, A., et al., Comparison of antibacterial activity, cytotoxicity, and fluoride release of glass ionomer restorative dental cements in dentistry. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 2023. 29: p. e939065-1.
Ghilotti, J., et al., Remineralizing ability of resin modified glass ionomers (RMGICs): A systematic review. Journal of Functional Biomaterials, 2023. 14(8): p. 421.
Kaya, D.T. and Y.D.D.R.E. Tirali, Cam iyonomer simanlardaki gelişmeler. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 2013. 23.
Nicholson, J.W., Polyacid-modified composite resins (“compomers”) and their use in clinical dentistry. Dental materials, 2007. 23(5): p. 615-622.
Guggenberger, R., R. May, and K. Stefan, New trends in glass-ionomer chemistry. Biomaterials, 1998. 19(6): p. 479-483.
Deliperi, S., et al., In vitro evaluation of giomers microleakage after exposure to 33% hydrogen peroxide: self-etch vs total-etch adhesives. Operative dentistry, 2006. 31(2): p. 227-232.
Koenraads, H., G. Van der Kroon, and J. Frencken, Compressive strength of two newly developed glass-ionomer materials for use with the Atraumatic Restorative Treatment (ART) approach in class II cavities. dental materials, 2009. 25(4): p. 551-556.
Patel, M.U., et al., An in vitro evaluation of microleakage of posterior teeth restored with amalgam, composite and zirconomer–A stereomicroscopic study. Journal of clinical and diagnostic research: JCDR, 2015. 9(7): p. ZC65.
Nigam, A.G., et al., Estimation of fluoride release from various dental materials in different media—an in vitro study. International journal of clinical pediatric dentistry, 2009. 2(1): p. 1.
Kadiyala, S.V. and J.D. Raj, Recent advances and modifications of dental restorative materials—A review. International Journal of Recent Advances in Multidisciplinary Research, 2016. 3(7): p. 1609-1616.
Sharma, A., M. Singh, and V. Pandey, Glass ionomer cement-a phoenix and its new flight. Int J Res Health Allied Sci, 2015. 1(1): p. 9-12.
AlOtaibi, G., Recent advancements in glass ionomer materials with introduction of nanotechnology: a review. International Journal of Oral Care and Research, 2019. 7(1): p. 21-23.
Karakaş, S.N., Güçlendirilmiş cam iyonomer siman çeşitleri. Current Research in Dental Sciences, 2022. 32(4): p. 297-304.
Ille, C.-E., et al., Exploring the Properties and Indications of Chairside CAD/CAM Materials in Restorative Dentistry. Journal of Functional Biomaterials, 2025. 16(2): p. 46.
UZUN, G., An Overvıew Of Dental Cad Cam Systems. Journal of Biotechnology & Biotechnological Equipment, 2008(1).
Doumit, M., et al., Wear behavior of 3D printed, minimally invasive restorations: Clinical data after 24 months in function. The Journal of Prosthetic Dentistry, 2025.
Melo, M., et al., Developing bioactive dental resins for restorative dentistry. Journal of Dental Research, 2023. 102(11): p. 1180-1190.
Singer, L. and C. Bourauel, Herbalism and glass-based materials in dentistry: review of the current state of the art. Journal of Materials Science: Materials in Medicine, 2023. 34(11): p. 60.
Eliaz, N. and N. Metoki, Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials, 2017. 10(4): p. 334.
Christie, B., et al., Advances and challenges in regenerative dentistry: a systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells. Materials Today Bio, 2023. 23: p. 100815.
Zhao, R., et al., Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments. Regenerative Biomaterials, 2025. 12: p. rbae129.
Friend, C., Smart materials: the emerging technology. Materials world, 1996. 4: p. 16-18.
Ibarretxe, G., Bioactive Materials for Next-Generation Dentistry. 2022, MDPI. p. 782.
Kothari, S.Y., V. Srikumar, and N. Singh, Comparative efficacy of platelet rich plasma injection, corticosteroid injection and ultrasonic therapy in the treatment of periarthritis shoulder. Journal of Clinical and Diagnostic Research: JCDR, 2017. 11(5): p. RC15.
Çolak, G. and M. Uğurlu, Restoratif Diş Hekimliğinde Güncel Tedavi Yaklaşımlarının Değerlendirilmesi. Aydın Dental Journal, 2024. 10(1): p. 47-56.
Atak, D. and M. Aksoy, Kanıta Dayalı Diş Hekimliği Uygulamaları: Geleneksel Derleme. Turkiye Klinikleri Journal of Dental Sciences, 2022. 28(1).
Dorri, M., et al., Atraumatic restorative treatment versus conventional restorative treatment for managing dental caries. Cochrane Database of Systematic Reviews, 2017(12).
Agrawal, A., et al., Immediate Dentin Sealing: Advancing Bonding Efficacy and Clinical Success. Cureus, 2025. 17(1).
ÜÇÜNCÜ, M.K., Immediate Dentin Sealing" Protokolü. Bütün Yayın Hakları Saklıdır Kaynak gösterilerek tanıtım için yapılacak kısa alıntılar dışında yayıncının ve editörün yazılı izni olmaksızın hiçbir yolla çoğaltılamaz.: p. 119.
Josic, U., et al., Does immediate dentin sealing influence postoperative sensitivity in teeth restored with indirect restorations? A systematic review and meta‐analysis. Journal of Esthetic and Restorative Dentistry, 2022. 34(1): p. 55-64.
Magne, P., Immediate dentin sealing: a fundamental procedure for indirect bonded restorations. Journal of Esthetic and Restorative Dentistry, 2005. 17(3): p. 144-154.
Taylor, A. and L. Burns, Deep margin elevation in restorative dentistry: a scoping review. Journal of Dentistry, 2024: p. 105066.
Geo, T., et al., Is Deep margin elevation a reliable tool for cervical margin relocation?–A comparative review. Journal of Oral Biology and Craniofacial Research, 2024. 14(1): p. 33-38.
Alovisi, M., et al., Combined endo-restorative treatment of a traumatized central incisor: a five-year follow-up. Journal of Adhesive Dentistry, 2020. 22(3): p. 249-254.
Fontana, M., Limited evidence for main reason for failure of partially excavated and restored teeth. Evidence-Based Dentistry, 2014. 15(1): p. 16-17.
Miotti, L.L., et al., Does the liner material influence pulpal vitality in deep carious cavities submitted to selective caries removal? A network meta-analysis review. Clinical Oral Investigations, 2023. 27(12): p. 7143-7156.
Warreth, A. and Y. Elkareimi, All-ceramic restorations: A review of the literature. The Saudi dental journal, 2020. 32(8): p. 365-372.
Saratti, C.M., et al., Fractography of clinical failures of indirect resin composite endocrown and overlay restorations. Dental Materials, 2021. 37(6): p. e341-e359.
Carvalho, M.A.d., et al., Current options concerning the endodontically-treated teeth restoration with the adhesive approach. Brazilian oral research, 2018. 32: p. e74.
Karadağ, G. and B. Erdal, The Effect of Polyethylene Fiber and Flowable Resin Composite on Fracture Resistance in the Restoration of Large MOD Cavities. Journal of Esthetic and Restorative Dentistry, 2025.
Metwaly, A.A., A.F. Elzoghby, and R.H. Abd ElAziz, Clinical performance of polyethylenefiber reinforced resin composite restorations in endodontically treated teeth:(a randomized controlled clinical trial). BMC Oral Health, 2024. 24(1): p. 1285.
Umapathy, V.R., P.M. Natarajan, and B. Swamikannu, Regenerative Strategies in Dentistry: Harnessing Stem Cells, Biomaterials and Bioactive Materials for Tissue Repair. Biomolecules, 2025. 15(4): p. 546.
Tyagi, G., et al., Comparative study of dentin remineralization with Nano-amorphous calcium phosphate-modified bioactive restoratives. Journal of Oral Biology and Craniofacial Research, 2025. 15(4): p. 684-690.
Abou Neel, E.A., et al., Demineralization–remineralization dynamics in teeth and bone. International journal of nanomedicine, 2016: p. 4743-4763.
Ionescu, A.C., et al., Dental tissue remineralization by bioactive calcium phosphate nanoparticles formulations. Scientific Reports, 2022. 12(1): p. 5994.
Schestakow, A., et al., The role of collagen cross-linker in dentin mineralization: a scoping review. Journal of Dentistry, 2025: p. 105799.
Cai, J., J. Palamara, and M.F. Burrow, Effects of collagen crosslinkers on dentine: A literature review. Calcified Tissue International, 2018. 102(3): p. 265-279.
Mai, S., et al., Extrafibrillar collagen demineralization-based chelate-and-rinse technique bridges the gap between wet and dry dentin bonding. Acta biomaterialia, 2017. 57: p. 435-448.
ÇELİK, Z.C., Biyomimetik Bakış Açısıyla Dentin-Pulpa Kompleksi. Turkiye Klinikleri Restorative Dentistry-Special Topics, 2023. 9(2): p. 9-13.
Colloc, T.N. and P.L. Tomson, Vital pulp therapies in permanent teeth: what, when, where, who, why and how? British Dental Journal, 2025. 238(7): p. 458-468.
Mao, J.J., et al., Regenerative endodontics: barriers and strategies for clinical translation. Dental Clinics of North America, 2012. 56(3): p. 639-649.
Baktır, S., H. Balkaya, and S. Demirbuğa, Biyomimetik Dİş Hekimliği. Selcuk Dental Journal, 2025. 12(1): p. 149-156.
Qiao, L., et al., Bioactive Materials in Vital Pulp Therapy: Promoting Dental Pulp Repair Through Inflammation Modulation. Biomolecules, 2025. 15(2): p. 258.
Komora, P., et al., Comparison of bioactive material failure rates in vital pulp treatment of permanent matured teeth–a systematic review and network meta-analysis. Scientific Reports, 2024. 14(1): p. 18421.
Pinto, K.P., et al., Success rate of direct pulp capping on permanent teeth using bioactive materials: a systematic review and meta-analysis of randomized clinical trials. Restorative Dentistry & Endodontics, 2024. 49(4): p. e34.
Albernaz Neves, J., et al., Systematic review and meta analysis of first and second generation bioceramic materials in primary dentition pulpotomies. Scientific Reports, 2025. 15(1): p. 1-13.
Karunakaran, S., et al., Effectiveness of mineral trioxide aggregate and its modifications in inducing dentin bridge formation during pulp capping: a systematic review. Journal of Conservative Dentistry and Endodontics, 2025. 28(3): p. 222-230.
De Deus, G., et al., Introduction to mineral trioxide aggregate, in Mineral Trioxide Aggregate in Dentistry: From Preparation to Application. 2014, Springer. p. 1-17.
Camilleri, J., Mineral trioxide aggregate: present and future developments. Endodontic Topics, 2015. 32(1): p. 31-46.
Bastos, M.C., et al., Clinical and radiographic success of pulpotomy and pulpectomy in primary and permanent teeth: a Systematic Review and Meta-Analysis. Journal of Clinical and Experimental Dentistry, 2024. 16(9): p. e1120.
Awawdeh, L., et al., Outcomes of vital pulp therapy using mineral trioxide aggregate or biodentine: a prospective randomized clinical trial. Journal of endodontics, 2018. 44(11): p. 1603-1609.
Najeeb, S., et al., Efficacy of enamel matrix derivative in vital pulp therapy: A review of literature. Iranian Endodontic Journal, 2017. 12(3): p. 269.
Sculean, A., et al., Clinical and Histologic Evaluation of Human lntrabony Defects Treated with an Enamel Matrix Protein Derivative (Emdogain). International Journal of Periodontics & Restorative Dentistry, 2000. 20(4).
Zafar, M.S., et al., Biomimetic aspects of restorative dentistry biomaterials. Biomimetics, 2020. 5(3): p. 34.
Referanslar
Singer, L., A. Fouda, and C. Bourauel, Biomimetic approaches and materials in restorative and regenerative dentistry. BMC oral health, 2023. 23(1): p. 105.
Paryani, M., et al., Evolution of Biomimetic Approaches for Regenerative and Restorative Dentistry. Cureus, 2023. 15(1).
Reis, A., et al., Biomimetic Restorative Dentistry: an evidence-based discussion of common myths. Journal of Applied Oral Science, 2024. 32: p. e20240271.
Attik, N., R. Richert, and S. Garoushi, Biomechanics, Bioactive and Biomimetic philosophy in restorative dentistry ̶ Quo vadis? Journal of Dentistry, 2024. 148: p. 105036.
Jadhav, G.R., et al., Biomimetic approach to strengthen the incisal fracture composite build-up: an in vitro study. BMC Oral Health, 2024. 24(1): p. 42.
Goswami, S., Biomimetic dentistry. Journal of Oral Research and Review, 2018. 10(1): p. 28-32.
Kimble, P., et al., Decision making in the restoration of endodontically treated teeth: effect of biomimetic dentistry training. Dentistry Journal, 2023. 11(7): p. 159.
Luo, X., et al., Research progress of biomimetic materials in oral medicine. Journal of biological engineering, 2023. 17(1): p. 72.
Yu, W., X. Wang, and H. Yang, Clinically oriented automatic three-dimensional enamel segmentation via deep learning. BMC Oral Health, 2025. 25(1): p. 133.
Collart-Dutilleul, P.-Y., et al., Raman confocal microscopy atlas of human tooth. Archives of Oral Biology, 2025. 173: p. 106189.
Beniash, E., et al., The hidden structure of human enamel. Nature communications, 2019. 10(1): p. 4383.
West, N.X. and A. Joiner, Enamel mineral loss. Journal of dentistry, 2014. 42: p. S2-S11.
Robinson, C., J. Weatherell, and A. Hallsworth, Variation in composition of dental enamel within thin ground tooth sections. Caries research, 1971. 5(1): p. 44-57.
Monteiro, N. and P.C. Yelick, Advances and perspectives in tooth tissue engineering. Journal of tissue engineering and regenerative medicine, 2017. 11(9): p. 2443-2461.
Marshall, S.J., et al., The dentin–enamel junction—a natural, multilevel interface. Journal of the European Ceramic Society, 2003. 23(15): p. 2897-2904.
Dong, X. and N. Ruse, Fatigue crack propagation path across the dentinoenamel junction complex in human teeth. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 2003. 66(1): p. 103-109.
Xu, C., et al., Chemical/molecular structure of the dentin–enamel junction is dependent on the intratooth location. Calcified tissue international, 2009. 84: p. 221-228.
Demarco, F.F., et al., Dental pulp tissue engineering. Brazilian dental journal, 2011. 22: p. 3-13.
Mjör, I.A., Pulp-dentin biology in restorative dentistry. (No Title), 2002.
Diekwisch, T., The developmental biology of cementum. The International journal of developmental biology, 2001. 45(5-6): p. 695-706.
Foster, B., On the discovery of cementum. Journal of periodontal research, 2017. 52(4): p. 666-685.
Arzate, H., M. Zeichner‐David, and G. Mercado‐Celis, Cementum proteins: role in cementogenesis, biomineralization, periodontium formation and regeneration. Periodontology 2000, 2015. 67(1): p. 211-233.
Asundi, A. and A. Kishen, A strain gauge and photoelastic analysis of in vivo strain and in vitro stress distribution in human dental supporting structures. Archives of oral biology, 2000. 45(7): p. 543-550.
Wang, R. and S. Weiner, Strain–structure relations in human teeth using Moiré fringes. Journal of biomechanics, 1997. 31(2): p. 135-141.
Jandt, K.D. and B.W. Sigusch, Future perspectives of resin-based dental materials. Dental materials, 2009. 25(8): p. 1001-1006.
Singh, P., et al., Overview and recent advances in composite resin: A review. Int J Sci Stud, 2015. 3(9): p. 169-72.
Ilie, N. and R. Hickel, Resin composite restorative materials. Australian dental journal, 2011. 56: p. 59-66.
Zhou, X., et al., Development and status of resin composite as dental restorative materials. Journal of Applied Polymer Science, 2019. 136(44): p. 48180.
Bayne, S.C., H.O. Heymann, and E.J. Swift Jr, Update on dental composite restorations. Journal of the American Dental Association (1939), 1994. 125(6): p. 687-701.
Ilie, N. and R. Hickel, Investigations on mechanical behaviour of dental composites. Clinical oral investigations, 2009. 13: p. 427-438.
Hahnel, S., et al., Investigation of mechanical properties of modern dental composites after artificial aging for one year. Operative dentistry, 2010. 35(4): p. 412-419.
Breschi, L., et al., The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems. Dental Materials, 2024.
Hardan, L., et al., Effect of different application modalities on the bonding performance of adhesive systems to dentin: A systematic review and meta-analysis. Cells, 12 (1), 190. 2023.
Nakabayashi, N., K. Kojima, and E. Masuhara, The promotion of adhesion by the infiltration of monomers into tooth substrates. Journal of biomedical materials research, 1982. 16(3): p. 265-273.
Bourgi, R., et al., Reinforced universal adhesive by ribose crosslinker: A novel strategy in adhesive dentistry. Polymers, 2021. 13(5): p. 704.
Pashley, D.H., et al., State of the art etch-and-rinse adhesives. Dental materials, 2011. 27(1): p. 1-16.
Van Meerbeek, B., et al., State of the art of self-etch adhesives. Dental materials, 2011. 27(1): p. 17-28.
Van Landuyt, K., et al., Technique sensitivity of water-free one-step adhesives. Dental materials, 2008. 24(9): p. 1258-1267.
Unemori, M., et al., Self-etching adhesives and postoperative sensitivity. American Journal of Dentistry, 2004. 17(3): p. 191-195.
Ozer, F. and M.B. Blatz, Self-etch and etch-and-rinse adhesive systems in clinical dentistry. Compendium of Continuing Education in Dentistry (15488578), 2013. 34(1).
Hass, V., et al., Bonding performance of universal adhesive systems applied in etch-and-rinse and self-etch strategies on natural dentin caries. Operative dentistry, 2019. 44(5): p. 510-520.
Gunay, A., et al., Comparison of antibacterial activity, cytotoxicity, and fluoride release of glass ionomer restorative dental cements in dentistry. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 2023. 29: p. e939065-1.
Ghilotti, J., et al., Remineralizing ability of resin modified glass ionomers (RMGICs): A systematic review. Journal of Functional Biomaterials, 2023. 14(8): p. 421.
Kaya, D.T. and Y.D.D.R.E. Tirali, Cam iyonomer simanlardaki gelişmeler. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 2013. 23.
Nicholson, J.W., Polyacid-modified composite resins (“compomers”) and their use in clinical dentistry. Dental materials, 2007. 23(5): p. 615-622.
Guggenberger, R., R. May, and K. Stefan, New trends in glass-ionomer chemistry. Biomaterials, 1998. 19(6): p. 479-483.
Deliperi, S., et al., In vitro evaluation of giomers microleakage after exposure to 33% hydrogen peroxide: self-etch vs total-etch adhesives. Operative dentistry, 2006. 31(2): p. 227-232.
Koenraads, H., G. Van der Kroon, and J. Frencken, Compressive strength of two newly developed glass-ionomer materials for use with the Atraumatic Restorative Treatment (ART) approach in class II cavities. dental materials, 2009. 25(4): p. 551-556.
Patel, M.U., et al., An in vitro evaluation of microleakage of posterior teeth restored with amalgam, composite and zirconomer–A stereomicroscopic study. Journal of clinical and diagnostic research: JCDR, 2015. 9(7): p. ZC65.
Nigam, A.G., et al., Estimation of fluoride release from various dental materials in different media—an in vitro study. International journal of clinical pediatric dentistry, 2009. 2(1): p. 1.
Kadiyala, S.V. and J.D. Raj, Recent advances and modifications of dental restorative materials—A review. International Journal of Recent Advances in Multidisciplinary Research, 2016. 3(7): p. 1609-1616.
Sharma, A., M. Singh, and V. Pandey, Glass ionomer cement-a phoenix and its new flight. Int J Res Health Allied Sci, 2015. 1(1): p. 9-12.
AlOtaibi, G., Recent advancements in glass ionomer materials with introduction of nanotechnology: a review. International Journal of Oral Care and Research, 2019. 7(1): p. 21-23.
Karakaş, S.N., Güçlendirilmiş cam iyonomer siman çeşitleri. Current Research in Dental Sciences, 2022. 32(4): p. 297-304.
Ille, C.-E., et al., Exploring the Properties and Indications of Chairside CAD/CAM Materials in Restorative Dentistry. Journal of Functional Biomaterials, 2025. 16(2): p. 46.
UZUN, G., An Overvıew Of Dental Cad Cam Systems. Journal of Biotechnology & Biotechnological Equipment, 2008(1).
Doumit, M., et al., Wear behavior of 3D printed, minimally invasive restorations: Clinical data after 24 months in function. The Journal of Prosthetic Dentistry, 2025.
Melo, M., et al., Developing bioactive dental resins for restorative dentistry. Journal of Dental Research, 2023. 102(11): p. 1180-1190.
Singer, L. and C. Bourauel, Herbalism and glass-based materials in dentistry: review of the current state of the art. Journal of Materials Science: Materials in Medicine, 2023. 34(11): p. 60.
Eliaz, N. and N. Metoki, Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials, 2017. 10(4): p. 334.
Christie, B., et al., Advances and challenges in regenerative dentistry: a systematic review of calcium phosphate and silicate-based materials on human dental pulp stem cells. Materials Today Bio, 2023. 23: p. 100815.
Zhao, R., et al., Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments. Regenerative Biomaterials, 2025. 12: p. rbae129.
Friend, C., Smart materials: the emerging technology. Materials world, 1996. 4: p. 16-18.
Ibarretxe, G., Bioactive Materials for Next-Generation Dentistry. 2022, MDPI. p. 782.
Kothari, S.Y., V. Srikumar, and N. Singh, Comparative efficacy of platelet rich plasma injection, corticosteroid injection and ultrasonic therapy in the treatment of periarthritis shoulder. Journal of Clinical and Diagnostic Research: JCDR, 2017. 11(5): p. RC15.
Çolak, G. and M. Uğurlu, Restoratif Diş Hekimliğinde Güncel Tedavi Yaklaşımlarının Değerlendirilmesi. Aydın Dental Journal, 2024. 10(1): p. 47-56.
Atak, D. and M. Aksoy, Kanıta Dayalı Diş Hekimliği Uygulamaları: Geleneksel Derleme. Turkiye Klinikleri Journal of Dental Sciences, 2022. 28(1).
Dorri, M., et al., Atraumatic restorative treatment versus conventional restorative treatment for managing dental caries. Cochrane Database of Systematic Reviews, 2017(12).
Agrawal, A., et al., Immediate Dentin Sealing: Advancing Bonding Efficacy and Clinical Success. Cureus, 2025. 17(1).
ÜÇÜNCÜ, M.K., Immediate Dentin Sealing" Protokolü. Bütün Yayın Hakları Saklıdır Kaynak gösterilerek tanıtım için yapılacak kısa alıntılar dışında yayıncının ve editörün yazılı izni olmaksızın hiçbir yolla çoğaltılamaz.: p. 119.
Josic, U., et al., Does immediate dentin sealing influence postoperative sensitivity in teeth restored with indirect restorations? A systematic review and meta‐analysis. Journal of Esthetic and Restorative Dentistry, 2022. 34(1): p. 55-64.
Magne, P., Immediate dentin sealing: a fundamental procedure for indirect bonded restorations. Journal of Esthetic and Restorative Dentistry, 2005. 17(3): p. 144-154.
Taylor, A. and L. Burns, Deep margin elevation in restorative dentistry: a scoping review. Journal of Dentistry, 2024: p. 105066.
Geo, T., et al., Is Deep margin elevation a reliable tool for cervical margin relocation?–A comparative review. Journal of Oral Biology and Craniofacial Research, 2024. 14(1): p. 33-38.
Alovisi, M., et al., Combined endo-restorative treatment of a traumatized central incisor: a five-year follow-up. Journal of Adhesive Dentistry, 2020. 22(3): p. 249-254.
Fontana, M., Limited evidence for main reason for failure of partially excavated and restored teeth. Evidence-Based Dentistry, 2014. 15(1): p. 16-17.
Miotti, L.L., et al., Does the liner material influence pulpal vitality in deep carious cavities submitted to selective caries removal? A network meta-analysis review. Clinical Oral Investigations, 2023. 27(12): p. 7143-7156.
Warreth, A. and Y. Elkareimi, All-ceramic restorations: A review of the literature. The Saudi dental journal, 2020. 32(8): p. 365-372.
Saratti, C.M., et al., Fractography of clinical failures of indirect resin composite endocrown and overlay restorations. Dental Materials, 2021. 37(6): p. e341-e359.
Carvalho, M.A.d., et al., Current options concerning the endodontically-treated teeth restoration with the adhesive approach. Brazilian oral research, 2018. 32: p. e74.
Karadağ, G. and B. Erdal, The Effect of Polyethylene Fiber and Flowable Resin Composite on Fracture Resistance in the Restoration of Large MOD Cavities. Journal of Esthetic and Restorative Dentistry, 2025.
Metwaly, A.A., A.F. Elzoghby, and R.H. Abd ElAziz, Clinical performance of polyethylenefiber reinforced resin composite restorations in endodontically treated teeth:(a randomized controlled clinical trial). BMC Oral Health, 2024. 24(1): p. 1285.
Umapathy, V.R., P.M. Natarajan, and B. Swamikannu, Regenerative Strategies in Dentistry: Harnessing Stem Cells, Biomaterials and Bioactive Materials for Tissue Repair. Biomolecules, 2025. 15(4): p. 546.
Tyagi, G., et al., Comparative study of dentin remineralization with Nano-amorphous calcium phosphate-modified bioactive restoratives. Journal of Oral Biology and Craniofacial Research, 2025. 15(4): p. 684-690.
Abou Neel, E.A., et al., Demineralization–remineralization dynamics in teeth and bone. International journal of nanomedicine, 2016: p. 4743-4763.
Ionescu, A.C., et al., Dental tissue remineralization by bioactive calcium phosphate nanoparticles formulations. Scientific Reports, 2022. 12(1): p. 5994.
Schestakow, A., et al., The role of collagen cross-linker in dentin mineralization: a scoping review. Journal of Dentistry, 2025: p. 105799.
Cai, J., J. Palamara, and M.F. Burrow, Effects of collagen crosslinkers on dentine: A literature review. Calcified Tissue International, 2018. 102(3): p. 265-279.
Mai, S., et al., Extrafibrillar collagen demineralization-based chelate-and-rinse technique bridges the gap between wet and dry dentin bonding. Acta biomaterialia, 2017. 57: p. 435-448.
ÇELİK, Z.C., Biyomimetik Bakış Açısıyla Dentin-Pulpa Kompleksi. Turkiye Klinikleri Restorative Dentistry-Special Topics, 2023. 9(2): p. 9-13.
Colloc, T.N. and P.L. Tomson, Vital pulp therapies in permanent teeth: what, when, where, who, why and how? British Dental Journal, 2025. 238(7): p. 458-468.
Mao, J.J., et al., Regenerative endodontics: barriers and strategies for clinical translation. Dental Clinics of North America, 2012. 56(3): p. 639-649.
Baktır, S., H. Balkaya, and S. Demirbuğa, Biyomimetik Dİş Hekimliği. Selcuk Dental Journal, 2025. 12(1): p. 149-156.
Qiao, L., et al., Bioactive Materials in Vital Pulp Therapy: Promoting Dental Pulp Repair Through Inflammation Modulation. Biomolecules, 2025. 15(2): p. 258.
Komora, P., et al., Comparison of bioactive material failure rates in vital pulp treatment of permanent matured teeth–a systematic review and network meta-analysis. Scientific Reports, 2024. 14(1): p. 18421.
Pinto, K.P., et al., Success rate of direct pulp capping on permanent teeth using bioactive materials: a systematic review and meta-analysis of randomized clinical trials. Restorative Dentistry & Endodontics, 2024. 49(4): p. e34.
Albernaz Neves, J., et al., Systematic review and meta analysis of first and second generation bioceramic materials in primary dentition pulpotomies. Scientific Reports, 2025. 15(1): p. 1-13.
Karunakaran, S., et al., Effectiveness of mineral trioxide aggregate and its modifications in inducing dentin bridge formation during pulp capping: a systematic review. Journal of Conservative Dentistry and Endodontics, 2025. 28(3): p. 222-230.
De Deus, G., et al., Introduction to mineral trioxide aggregate, in Mineral Trioxide Aggregate in Dentistry: From Preparation to Application. 2014, Springer. p. 1-17.
Camilleri, J., Mineral trioxide aggregate: present and future developments. Endodontic Topics, 2015. 32(1): p. 31-46.
Bastos, M.C., et al., Clinical and radiographic success of pulpotomy and pulpectomy in primary and permanent teeth: a Systematic Review and Meta-Analysis. Journal of Clinical and Experimental Dentistry, 2024. 16(9): p. e1120.
Awawdeh, L., et al., Outcomes of vital pulp therapy using mineral trioxide aggregate or biodentine: a prospective randomized clinical trial. Journal of endodontics, 2018. 44(11): p. 1603-1609.
Najeeb, S., et al., Efficacy of enamel matrix derivative in vital pulp therapy: A review of literature. Iranian Endodontic Journal, 2017. 12(3): p. 269.
Sculean, A., et al., Clinical and Histologic Evaluation of Human lntrabony Defects Treated with an Enamel Matrix Protein Derivative (Emdogain). International Journal of Periodontics & Restorative Dentistry, 2000. 20(4).
Zafar, M.S., et al., Biomimetic aspects of restorative dentistry biomaterials. Biomimetics, 2020. 5(3): p. 34.
