Peroksit İçermeyen Diş Beyazlatma Sistemleri
Özet
Diş beyazlatma, estetik diş hekimliğinde en sık uygulanan tedavilerden biridir. Ancak geleneksel hidrojen peroksit ve karbamid peroksit bazlı beyazlatma yöntemleri, diş hassasiyeti, mine demineralizasyonu ve potansiyel biyolojik etkiler gibi istenmeyen sonuçlarla ilişkilendirilebilmektedir. Bu nedenle son yıllarda, daha güvenli ve biyouyumlu alternatifler sunmayı amaçlayan peroksit içermeyen diş beyazlatma sistemlerine yönelik ilgi giderek artmaktadır. Bu bölümde, peroksit içermeyen beyazlatma yaklaşımlarının etki mekanizmaları, klinik potansiyelleri ve biyouyumluluk özellikleri güncel literatür ışığında ele alınmaktadır. Ftalimidoperoksikaproik asit bazlı sistemlerin selektif oksidasyon mekanizması, papain ve bromelain gibi enzimatik ajanların biyokatalitik etkileri ve mavi kovarin ile titanyum dioksit gibi optik ajanların sağladığı görsel beyazlatma etkileri incelenmektedir. Ayrıca aktif kömür ve silika gibi aşındırıcı bileşenlerin yüzeysel lekelerin uzaklaştırılmasındaki rolleri ile bu sistemlerin diş dokuları ve restoratif materyallerle etkileşimleri değerlendirilmektedir. Bu bağlamda, estetik beklentiler ile biyolojik güvenlik arasında dengeli yaklaşım sunan peroksit içermeyen beyazlatma sistemleri, daha biyouyumlu ve koruyucu estetik tedavi seçenekleri olarak dikkat çekmektedir. Mevcut bilimsel veriler bu sistemlerin klinik kullanım açısından umut verici olduğunu göstermekte olup, gelecekte yapılacak kapsamlı klinik çalışmaların bu yaklaşımların etkinliğini ve uzun dönem güvenliğini ortaya koyması beklenmektedir.
Tooth whitening is one of the most commonly performed procedures in aesthetic dentistry. However, conventional hydrogen peroxide and carbamide peroxide–based whitening methods may be associated with adverse effects such as tooth sensitivity, enamel demineralization, and potential biological concerns. In response to these limitations, increasing attention has been directed toward peroxide-free tooth whitening systems designed to provide safer and more biocompatible alternatives. This chapter reviews the mechanisms of action, clinical potential, and biocompatibility of peroxide-free whitening approaches based on current scientific evidence. Particular emphasis is placed on the selective oxidation mechanism of phthalimidoperoxycaproic acid- based systems, the biocatalytic activity of enzymatic agents such as papain and bromelain, and the visual whitening effects produced by optical agents including blue covarine and titanium dioxide. The role of abrasive components such as activated charcoal and silica in removal of extrinsic stains is also discussed, together with the interactions of these systems with dental tissues and restorative materials. In this context, peroxide-free whitening systems represent promising aesthetic approaches that aim to balance aesthetic expectations with biological safety. Current scientific evidence suggests these systems show promising potential for clinical use; however, further well-designed clinical studies are needed to establish their effectiveness and long-term safety.
Referanslar
Montero Tomás DBM, Pecci-Lloret MP, Guerrero-Gironés J. Effectiveness and abrasiveness of activated charcoal as a whitening agent: A systematic review of in vitro studies. Annals of Anatomy-Anatomischer Anzeiger. 2023; 245:151998. doi: 10.1016/j.aanat.2022.151998.
Joiner A, Philpotts CJ, Ashcroft AT, et al. A novel optical approach to achieving tooth whitening. Journal of Dentistry. 2008; 36(Suppl 1): S8–S14. doi: 10.1016/j.jdent.2008.02.005.
Kaewpinta A, Khongkhunthian S, Chaijareenont P, et al. Tooth whitening efficacy of pigmented rice gels containing carbamide peroxide. Drug Discoveries & Therapeutics. 2018; 12(3): 126–132. doi: 10.5582/ddt.2018.01023
Lin PY, Chen LN, Tseng CF, et al. Tooth-whitening agents and polymer-based carriers: efficacy, safety, and clinical perspectives. Polymers. 2025; 17: 2545. doi: 10.3390/polym17182545.
Özdemir SB, Çelik N. Effect of toothpaste with blue covarine on color stability and demineralization after bleaching treatments. Current Research in Dental Sciences. 2025; 35(3): 207–213.
Ribeiro JS, de Oliveira da Rosa WL, da Silva AF, et al. Efficacy of natural, peroxide-free tooth-bleaching agents: A systematic review, meta-analysis, and technological prospecting. Phytotherapy Research. 2020; 34(5): 1060–1070. doi: 10.1002/ptr.6590.
Kwon SR, Wertz PW. Review of the mechanism of tooth whitening. Journal of Esthetic and Restorative Dentistry. 2015; 27(5): 240–257. doi: 10.1111/jerd.12152.
Joiner A. The bleaching of teeth: a review of the literature. Journal of Dentistry. 2006; 34(7): 412–419. doi: 10.1016/j.jdent.2006.02.002.
Müller-Heupt LK, Wiesmann-Imilowski N, Kaya S, et al. Effectiveness and safety of over-the-counter tooth-whitening agents compared to hydrogen peroxide in vitro. International Journal of Molecular Sciences. 2023; 24: 1956. doi: 10.3390/ijms24031956.
Pascolutti M, de Oliveira D. A radical-free approach to teeth whitening. Dentistry Journal. 2021; 9: 148. doi: 10.3390/dj9120148.
Fayed AMH, Sedky Y. Shear bond strength of orthodontic brackets bonded to bleached enamel using a novel PAP-based bleaching agent- an ın vitro study. Egyptian Dental Journal. 2024; 70: 9–17. doi: 10.21608/edj.2023.234903.2711
Rifane TO, Nascimento IS, Santos SCAV, et al. Peroxide-free titanium dioxide nanoparticle-based photocatalytic bleaching: In vitro study on bovine teeth. BioMed Research International. 2025; 2025: 9311501. doi: 10.1155/2025/9311501.
Bersezio C, Estay J, Sáez M, et al. Six-month follow-up of the effect of nonvital bleaching on IL-1β and RANK-L: A randomized clinical trial. Operative Dentistry. 2019; 44(5): E212–E222. doi: 10.2341/18-023-C.
Khan AA, Alkhureif AA, Bautista LSJ, et al. Peroxide-free bleaching gel: effect on the surface and mechanical properties of restorative composite materials. Applied Sciences. 2023; 13: 5935. doi: 10.3390/app13105935.
Melo M, Fioresta R, Sanz JL, et al. Effect of highly concentrated bleaching gels on enamel microhardness and superficial morphology, and the recovery action of four remineralizing agents. BMC Oral Health. 2022; 22: 645. doi: 10.1186/s12903-022-02693-2.
Hale A, Eldeniz AÜ, Erdemir A. Farklı sodyum perborat tiplerinin kompozitin bağlanma dayanımı üzerine etkisinin mikrotensile test tekniği ile belirlenmesi. Journal of Istanbul University Faculty of Dentistry. 2005; 39(3-4): 51–56.
Qin J, Zhang X, Li Y, et al. A bio-safety tooth-whitening composite gels with novel phthalimide peroxy caproic acid. Composites Communications. 2019; 13: 107–111. doi: 10.1016/j.coco.2019.04.002.
Cuc S, Sarosi C, Petean I, et al. Whitening efficiency of papain and bromelain gels in removing dental stains. Gels. 2025; 11(2): 100. doi: 10.3390/gels11020100.
Ribeiro JS, Barboza AS, Cuevas-Suárez CE, et al. Novel in-office peroxide-free tooth-whitening gels: bleaching effectiveness, enamel surface alterations, and cell viability. Scientific Reports. 2020; 10: 10016. doi: 10.1038/s41598-020-66733-z
Solanki MN, Attur KM, Vachhani KA, et al. Phytochemicals in vital tooth bleaching: evaluation of efficacy with papaya, pineapple, or kiwi extracts and 30% hydrogen peroxide. Journal of Conservative Dentistry and Endodontics. 2024; 27: 760–764. doi: 10.4103/jcde.jcde_201_24.
Moldovan A, Cuc S, Gasparik C, et al. Effect of experimental bleaching gels with enzymes on composite and enamel. International Dental Journal. 2025; 75(2): 1234–1245.
Gopinath S, James V, Vidhya S, et al. Effect of bleaching with hydrogen peroxide containing sweet potato extract on human enamel: An in vitro spectrophotometric and scanning electron microscopy analysis. Journal of Conservative Dentistry. 2013; 16(1): 45–49. doi: 10.4103/0972-0707.105298
Joiner A, Luo W. Tooth colour and whiteness: a review. Journal of Dentistry. 2017; 67(Suppl 1): S3–S10. doi: 10.1016/j.jdent.2017.09.006.
Zhang L, Joiner A, Gupta AK, et al. Effect of blue covarine toothpastes on tooth colour: A randomised crossover study. International Dental Journal. 2025; 75(5): 100938. doi: 10.1016/j.identj.2025.100938.
Ashcroft AT, Joiner A, Philpotts CJ, et al. Evaluation of a new silica whitening toothpaste containing blue covarine on the colour of anterior restoration materials in vitro. Journal of Dentistry. 2008; 36(Suppl 1): S26–S31. doi: 10.1016/j.jdent.2008.02.007
Radwan Ali, Alwan AH. Titanium dioxide nanoparticles in dentistry: multifaceted applications and innovations. Future Dental Research. 2023; 1(1): 12–25. doi: 10.57238/fdr.2023.144821.1001
Racovita AD. Titanium dioxide: structure, impact, and toxicity. International Journal of Environmental Research and Public Health. 2022; 19(9): 5681. doi: 10.3390/ijerph19095681.
Matos ICRT, Vieira JGF, Silva LMA, et al. Effects of experimental bleaching gels containing co-doped titanium dioxide and niobium pentoxide combined with violet light. Clinical Oral Investigations. 2023; 27(8): 4827–4841. doi: 10.21203/rs.3.rs-2782811/v1.
Altıparmak ET, Oktay EA, Karaoğlanoğlu S. Charcoal-containing toothpastes. Gulhane Medical Journal. 2022; 64: 295–300. doi: 10.4274/gulhane.galenos.2021.43153
Aydın N, Süloğlu AK, İdil N, et al. Examination of cytotoxic and antimicrobial effect of whitening toothpastes: an in vitro study. Acta Odontologica Scandinavica. 2024; 83: 327–333. doi: 10.2340/aos. v83.40774.
Huaman-Sarmiento AC, et al. Uses and applications of activated charcoal in the manufacture of toothpastes and oral rinses: A narrative review. Journal of International Oral Health. 2023; 15(3), 237-241.
Chhabile S, Vishwakarma P, Agrawal A, et al. Effectiveness of papain-based organic dentifrices versus commercial whitening dentifrice on tea-induced tooth stains: An in vitro study. Cureus. 2024; 16(9): e69225. doi: 10.7759/cureus.69225.
Li Y. Stain removal and whitening by baking soda dentifrice: A review of literature. Journal of the American Dental Association. 2017; 148(Suppl 11): S20–S26. doi: 10.1016/j.adaj.2017.09.009.
European Commission. Scientific Committee on Consumer Safety (SCCS): Opinion on Hydrogen peroxide. 2011.
Cheng YL, Zhong BJ, Su C, et al. Enhanced tooth bleaching with a hydrogen peroxide/titanium dioxide gel. BMC Oral Health. 2024; 24: 923. doi: 10.1186/s12903-024-04691-y.
Elnawawy MSA, Gharote H, Pullishery F, et al. Effect of various vital bleaching systems on clinical outcomes and patient satisfaction. Cureus. 2024; 16(7): e65648. doi: 10.7759/cureus.65648.
Carneiro BT, Kury M, Lopes JC, et al. Effect of whitening toothpastes and activated charcoal powder on enamel wear and surface roughness. Brazilian Oral Research. 2023; 37: e092. doi: 10.1590/1807-3107bor-2023.vol37.0092.
Koc Vural UK, Bagdatli Z, Yilmaz AE, et al. Effects of charcoal-based whitening toothpastes on human enamel in terms of color, surface roughness, and microhardness: an in vitro study. Clinical oral investigations, 2021;25(10), 5977-5985. doi: 10.1007/s00784-021-03903-x.
Sato C, Rodrigues FA, Garcia DM, et al. Tooth bleaching increases dentinal protease activity. Journal of Dental Research. 2013; 92(2): 187–192. doi: 10.1177/0022034512470831.
Rodríguez-Barragué J, Vola-Gelmini J, Skuras-Siedemburg M, et al. Natural antioxidants to restore immediate bond strength to bleached enamel: Systematic review and meta-analysis of in vitro studies. Journal of Esthetic and Restorative Dentistry. 2021; 33(5): 702–712. doi: 10.1111/jerd.12743.
Bhasker N, Sailaja PM, Sandeep S, et al. Comparative evaluation of various antioxidants on the shear bond strength of composite resin to bleached enamel – an in vitro study. Indian Journal of Dental Research. 2024; 35(2): 227–231. doi: 10.4103/ijdr.ijdr_893_23.
Qi F, Huang H, Wang M, et al. Applications of Antioxidants in Dental Procedures. Antioxidants. 2022; 11(12): 2492. doi: 10.3390/antiox11122492.
Arabshahi-Delouee S, Urooj A. Antioxidant properties of various solvent extracts of mulberry (Morus indica L.) leaves. Food Chemistry. 2007; 102: 1233–1240. doi: 10.1016/j.foodchem.2006.07.013.
Küçükyıldırım T. Beyaz dut ekstraktlarının antioksidan aktivitelerinin belirlenmesi. Yüksek Lisans Tezi. Edirne: Trakya Üniversitesi; 2017.
Gallinari MO, Fagundes TC, da Silva LMAV, et al. A new approach for dental bleaching using violet light with or without the use of whitening gel: study of bleaching effectiveness. Operative Dentistry. 2019; 44(5): 521–529. doi: 10.2341/18-092-C.
Referanslar
Montero Tomás DBM, Pecci-Lloret MP, Guerrero-Gironés J. Effectiveness and abrasiveness of activated charcoal as a whitening agent: A systematic review of in vitro studies. Annals of Anatomy-Anatomischer Anzeiger. 2023; 245:151998. doi: 10.1016/j.aanat.2022.151998.
Joiner A, Philpotts CJ, Ashcroft AT, et al. A novel optical approach to achieving tooth whitening. Journal of Dentistry. 2008; 36(Suppl 1): S8–S14. doi: 10.1016/j.jdent.2008.02.005.
Kaewpinta A, Khongkhunthian S, Chaijareenont P, et al. Tooth whitening efficacy of pigmented rice gels containing carbamide peroxide. Drug Discoveries & Therapeutics. 2018; 12(3): 126–132. doi: 10.5582/ddt.2018.01023
Lin PY, Chen LN, Tseng CF, et al. Tooth-whitening agents and polymer-based carriers: efficacy, safety, and clinical perspectives. Polymers. 2025; 17: 2545. doi: 10.3390/polym17182545.
Özdemir SB, Çelik N. Effect of toothpaste with blue covarine on color stability and demineralization after bleaching treatments. Current Research in Dental Sciences. 2025; 35(3): 207–213.
Ribeiro JS, de Oliveira da Rosa WL, da Silva AF, et al. Efficacy of natural, peroxide-free tooth-bleaching agents: A systematic review, meta-analysis, and technological prospecting. Phytotherapy Research. 2020; 34(5): 1060–1070. doi: 10.1002/ptr.6590.
Kwon SR, Wertz PW. Review of the mechanism of tooth whitening. Journal of Esthetic and Restorative Dentistry. 2015; 27(5): 240–257. doi: 10.1111/jerd.12152.
Joiner A. The bleaching of teeth: a review of the literature. Journal of Dentistry. 2006; 34(7): 412–419. doi: 10.1016/j.jdent.2006.02.002.
Müller-Heupt LK, Wiesmann-Imilowski N, Kaya S, et al. Effectiveness and safety of over-the-counter tooth-whitening agents compared to hydrogen peroxide in vitro. International Journal of Molecular Sciences. 2023; 24: 1956. doi: 10.3390/ijms24031956.
Pascolutti M, de Oliveira D. A radical-free approach to teeth whitening. Dentistry Journal. 2021; 9: 148. doi: 10.3390/dj9120148.
Fayed AMH, Sedky Y. Shear bond strength of orthodontic brackets bonded to bleached enamel using a novel PAP-based bleaching agent- an ın vitro study. Egyptian Dental Journal. 2024; 70: 9–17. doi: 10.21608/edj.2023.234903.2711
Rifane TO, Nascimento IS, Santos SCAV, et al. Peroxide-free titanium dioxide nanoparticle-based photocatalytic bleaching: In vitro study on bovine teeth. BioMed Research International. 2025; 2025: 9311501. doi: 10.1155/2025/9311501.
Bersezio C, Estay J, Sáez M, et al. Six-month follow-up of the effect of nonvital bleaching on IL-1β and RANK-L: A randomized clinical trial. Operative Dentistry. 2019; 44(5): E212–E222. doi: 10.2341/18-023-C.
Khan AA, Alkhureif AA, Bautista LSJ, et al. Peroxide-free bleaching gel: effect on the surface and mechanical properties of restorative composite materials. Applied Sciences. 2023; 13: 5935. doi: 10.3390/app13105935.
Melo M, Fioresta R, Sanz JL, et al. Effect of highly concentrated bleaching gels on enamel microhardness and superficial morphology, and the recovery action of four remineralizing agents. BMC Oral Health. 2022; 22: 645. doi: 10.1186/s12903-022-02693-2.
Hale A, Eldeniz AÜ, Erdemir A. Farklı sodyum perborat tiplerinin kompozitin bağlanma dayanımı üzerine etkisinin mikrotensile test tekniği ile belirlenmesi. Journal of Istanbul University Faculty of Dentistry. 2005; 39(3-4): 51–56.
Qin J, Zhang X, Li Y, et al. A bio-safety tooth-whitening composite gels with novel phthalimide peroxy caproic acid. Composites Communications. 2019; 13: 107–111. doi: 10.1016/j.coco.2019.04.002.
Cuc S, Sarosi C, Petean I, et al. Whitening efficiency of papain and bromelain gels in removing dental stains. Gels. 2025; 11(2): 100. doi: 10.3390/gels11020100.
Ribeiro JS, Barboza AS, Cuevas-Suárez CE, et al. Novel in-office peroxide-free tooth-whitening gels: bleaching effectiveness, enamel surface alterations, and cell viability. Scientific Reports. 2020; 10: 10016. doi: 10.1038/s41598-020-66733-z
Solanki MN, Attur KM, Vachhani KA, et al. Phytochemicals in vital tooth bleaching: evaluation of efficacy with papaya, pineapple, or kiwi extracts and 30% hydrogen peroxide. Journal of Conservative Dentistry and Endodontics. 2024; 27: 760–764. doi: 10.4103/jcde.jcde_201_24.
Moldovan A, Cuc S, Gasparik C, et al. Effect of experimental bleaching gels with enzymes on composite and enamel. International Dental Journal. 2025; 75(2): 1234–1245.
Gopinath S, James V, Vidhya S, et al. Effect of bleaching with hydrogen peroxide containing sweet potato extract on human enamel: An in vitro spectrophotometric and scanning electron microscopy analysis. Journal of Conservative Dentistry. 2013; 16(1): 45–49. doi: 10.4103/0972-0707.105298
Joiner A, Luo W. Tooth colour and whiteness: a review. Journal of Dentistry. 2017; 67(Suppl 1): S3–S10. doi: 10.1016/j.jdent.2017.09.006.
Zhang L, Joiner A, Gupta AK, et al. Effect of blue covarine toothpastes on tooth colour: A randomised crossover study. International Dental Journal. 2025; 75(5): 100938. doi: 10.1016/j.identj.2025.100938.
Ashcroft AT, Joiner A, Philpotts CJ, et al. Evaluation of a new silica whitening toothpaste containing blue covarine on the colour of anterior restoration materials in vitro. Journal of Dentistry. 2008; 36(Suppl 1): S26–S31. doi: 10.1016/j.jdent.2008.02.007
Radwan Ali, Alwan AH. Titanium dioxide nanoparticles in dentistry: multifaceted applications and innovations. Future Dental Research. 2023; 1(1): 12–25. doi: 10.57238/fdr.2023.144821.1001
Racovita AD. Titanium dioxide: structure, impact, and toxicity. International Journal of Environmental Research and Public Health. 2022; 19(9): 5681. doi: 10.3390/ijerph19095681.
Matos ICRT, Vieira JGF, Silva LMA, et al. Effects of experimental bleaching gels containing co-doped titanium dioxide and niobium pentoxide combined with violet light. Clinical Oral Investigations. 2023; 27(8): 4827–4841. doi: 10.21203/rs.3.rs-2782811/v1.
Altıparmak ET, Oktay EA, Karaoğlanoğlu S. Charcoal-containing toothpastes. Gulhane Medical Journal. 2022; 64: 295–300. doi: 10.4274/gulhane.galenos.2021.43153
Aydın N, Süloğlu AK, İdil N, et al. Examination of cytotoxic and antimicrobial effect of whitening toothpastes: an in vitro study. Acta Odontologica Scandinavica. 2024; 83: 327–333. doi: 10.2340/aos. v83.40774.
Huaman-Sarmiento AC, et al. Uses and applications of activated charcoal in the manufacture of toothpastes and oral rinses: A narrative review. Journal of International Oral Health. 2023; 15(3), 237-241.
Chhabile S, Vishwakarma P, Agrawal A, et al. Effectiveness of papain-based organic dentifrices versus commercial whitening dentifrice on tea-induced tooth stains: An in vitro study. Cureus. 2024; 16(9): e69225. doi: 10.7759/cureus.69225.
Li Y. Stain removal and whitening by baking soda dentifrice: A review of literature. Journal of the American Dental Association. 2017; 148(Suppl 11): S20–S26. doi: 10.1016/j.adaj.2017.09.009.
European Commission. Scientific Committee on Consumer Safety (SCCS): Opinion on Hydrogen peroxide. 2011.
Cheng YL, Zhong BJ, Su C, et al. Enhanced tooth bleaching with a hydrogen peroxide/titanium dioxide gel. BMC Oral Health. 2024; 24: 923. doi: 10.1186/s12903-024-04691-y.
Elnawawy MSA, Gharote H, Pullishery F, et al. Effect of various vital bleaching systems on clinical outcomes and patient satisfaction. Cureus. 2024; 16(7): e65648. doi: 10.7759/cureus.65648.
Carneiro BT, Kury M, Lopes JC, et al. Effect of whitening toothpastes and activated charcoal powder on enamel wear and surface roughness. Brazilian Oral Research. 2023; 37: e092. doi: 10.1590/1807-3107bor-2023.vol37.0092.
Koc Vural UK, Bagdatli Z, Yilmaz AE, et al. Effects of charcoal-based whitening toothpastes on human enamel in terms of color, surface roughness, and microhardness: an in vitro study. Clinical oral investigations, 2021;25(10), 5977-5985. doi: 10.1007/s00784-021-03903-x.
Sato C, Rodrigues FA, Garcia DM, et al. Tooth bleaching increases dentinal protease activity. Journal of Dental Research. 2013; 92(2): 187–192. doi: 10.1177/0022034512470831.
Rodríguez-Barragué J, Vola-Gelmini J, Skuras-Siedemburg M, et al. Natural antioxidants to restore immediate bond strength to bleached enamel: Systematic review and meta-analysis of in vitro studies. Journal of Esthetic and Restorative Dentistry. 2021; 33(5): 702–712. doi: 10.1111/jerd.12743.
Bhasker N, Sailaja PM, Sandeep S, et al. Comparative evaluation of various antioxidants on the shear bond strength of composite resin to bleached enamel – an in vitro study. Indian Journal of Dental Research. 2024; 35(2): 227–231. doi: 10.4103/ijdr.ijdr_893_23.
Qi F, Huang H, Wang M, et al. Applications of Antioxidants in Dental Procedures. Antioxidants. 2022; 11(12): 2492. doi: 10.3390/antiox11122492.
Arabshahi-Delouee S, Urooj A. Antioxidant properties of various solvent extracts of mulberry (Morus indica L.) leaves. Food Chemistry. 2007; 102: 1233–1240. doi: 10.1016/j.foodchem.2006.07.013.
Küçükyıldırım T. Beyaz dut ekstraktlarının antioksidan aktivitelerinin belirlenmesi. Yüksek Lisans Tezi. Edirne: Trakya Üniversitesi; 2017.
Gallinari MO, Fagundes TC, da Silva LMAV, et al. A new approach for dental bleaching using violet light with or without the use of whitening gel: study of bleaching effectiveness. Operative Dentistry. 2019; 44(5): 521–529. doi: 10.2341/18-092-C.