Periodontolojide Platelet Rich Fibrin (PRF) Kullanımı
Özet
Platelet-rich fibrin (PRF), son yıllarda diş hekimliğinde yara iyileşmesini biyolojik olarak destekleyen otojen bir biyomateryal olarak giderek artan ilgi görmektedir. Antikoagülan veya dış aktivatör gerektirmeden hastanın kendi kanından elde edilmesi ve üç boyutlu fibrin matriksi içerisinde trombositler, lökositler ve çeşitli büyüme faktörlerini barındırması PRF’i klinik açıdan değerli bir biyolojik ajan haline getirmiştir. Bu bölümde PRF’in tarihsel gelişimi, biyolojik temeli, etki mekanizmaları ve hazırlanma protokolleri ayrıntılı biçimde ele alınmıştır. Ayrıca PRF türevleri, fibrin membranlarının özellikleri ve farklı biyomateryaller ile etkileşimleri tartışılmıştır. Bölümün klinik kısmında PRF’in periodontoloji, implantoloji ve oral cerrahi alanlarındaki kullanım endikasyonları güncel literatür ışığında değerlendirilmiştir. Mevcut kanıtlar, PRF’in özellikle yumuşak doku iyileşmesi, postoperatif konfor ve erken yara stabilitesi üzerinde olumlu etkiler sağlayabildiğini göstermektedir. Bununla birlikte PRF’in sert doku rejenerasyonunda tek başına belirleyici bir materyal olmadığı ve daha çok biyolojik destekleyici bir ajan olarak değerlendirilmesi gerektiği vurgulanmaktadır. Sonuç olarak PRF, doğru endikasyon ve uygun cerrahi tekniklerle birlikte kullanıldığında periodontoloji ve oral cerrahi pratiğinde önemli bir biyolojik destekleyici materyal olarak değerlendirilebilir.
Platelet-rich fibrin (PRF) has gained increasing attention in dentistry as an autologous biomaterial that biologically supports wound healing. PRF is obtained from the patient’s own blood without the use of anticoagulants or external activators and contains platelets, leukocytes, and multiple growth factors within a three-dimensional fibrin matrix. These characteristics make PRF a biologically active and clinically valuable material in regenerative dentistry. This chapter discusses the historical development of PRF, its biological basis, mechanisms of action, and preparation protocols. In addition, PRF derivatives, characteristics of PRF membranes, and their interactions with other biomaterials are addressed. The clinical applications of PRF in periodontology, implant dentistry, and oral surgery are evaluated based on current scientific evidence. Available data indicate that PRF may positively influence soft tissue healing, postoperative comfort, and early wound stabilization. However, PRF should not be considered a standalone regenerative material for hard tissue regeneration and is better regarded as a biological adjunct that supports surgical outcomes. When used with appropriate indications and surgical techniques, PRF can serve as an important biological adjunct in periodontal and oral surgical procedures.
Referanslar
Sağsöz A, Acun Kaya F. Use of platelet-rich fibrin (PRF) in the periodontology: A review. Journal of Medical and Dental Investigations. 2023;4: e230317. doi:10.5577/jomdi.e230317
Chandran P, Sivadas A. Platelet-rich fibrin: its role in periodontal regeneration. The Saudi Journal for Dental Research. 2014;5(2):117-122. doi:10.1016/j.ksujds.2013.09.001
Yu H-Y, Chang Y-C. A bibliometric analysis of platelet-rich fibrin in dentistry. International Journal of Environmental Research and Public Health. 2022;19:12545. doi:10.3390/ijerph191912545
Feigin K, Shope B. Use of platelet-rich plasma and platelet rich fibrin in dentistry and oral surgery: introduction and review of the literature. Journal of Veterinary Dentistry. 2019;36(2):109-123. doi:10.1177/0898756419876057
Song P, He D, Ren S, et al. Platelet-rich fibrin in dentistry. Journal of Applied Biomaterials & Functional Materials. 2024:1-25. doi:10.1177/22808000241299588
Naik B, Karunakar P, Jayadev M, et al. Role of platelet rich fibrin in wound healing: a critical review. Journal of Conservative Dentistry. 2013;16(4):284-293. doi:10.4103/0972-0707.114344
Deeb M. Role of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in oro-facial tissue regeneration: a narrative review. Journal of Advanced Oral Research. 2020;11:232020681989583. doi:10.1177/2320206819895836
Del Corso M, Vervelle A, Simonpieri A, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: periodontal and dentoalveolar surgery. Current Pharmaceutical Biotechnology. 2012;13(7):1207-1230. doi:10.2174/138920112800624391
Borie E, Oliví D, Orsi I, et al. Platelet-rich fibrin application in dentistry: a literature review. International Journal of Clinical and Experimental Medicine. 2015;8:7922-7929.
Miron RJ, Zucchelli G, Pikos MA, et al. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clinical Oral Investigations. 2017;21:1913-1927. doi:10.1007/s00784-017-2133-z
Strauss FJ, Stähli A, Gruber R. The use of platelet-rich fibrin to enhance the outcomes of implant therapy: a systematic review. Clinical Oral Implants Research. 2018;29(Suppl 18):6-19. doi:10.1111/clr.13275
Estrin NE, Tran TB, Ahmad P, et al. Analgesic effects of platelet-rich fibrin (PRF): a systematic review. Periodontology 2000. 2025. doi:10.1111/prd.70014
Ravi Kumar V, Gangadharan G. Platelet rich fibrin in dentistry: a review of literature. International Journal of Medicine. 2015;3(2):72-76. doi:10.14419/ijm.v3i2.5079
Laforgia A, Inchingolo AD, Riccaldo L, et al. The use of platelet-rich fibrin (PRF) in the management of dry socket: a systematic review. International Journal of Molecular Sciences. 2024;25(18):10069. doi:10.3390/ijms251810069
Gupta V, Bains V, Singh GP, et al. Regenerative potential of platelet rich fibrin in dentistry: literature review. Asian Journal of Oral Health and Allied Sciences. 2011;1.
Referanslar
Sağsöz A, Acun Kaya F. Use of platelet-rich fibrin (PRF) in the periodontology: A review. Journal of Medical and Dental Investigations. 2023;4: e230317. doi:10.5577/jomdi.e230317
Chandran P, Sivadas A. Platelet-rich fibrin: its role in periodontal regeneration. The Saudi Journal for Dental Research. 2014;5(2):117-122. doi:10.1016/j.ksujds.2013.09.001
Yu H-Y, Chang Y-C. A bibliometric analysis of platelet-rich fibrin in dentistry. International Journal of Environmental Research and Public Health. 2022;19:12545. doi:10.3390/ijerph191912545
Feigin K, Shope B. Use of platelet-rich plasma and platelet rich fibrin in dentistry and oral surgery: introduction and review of the literature. Journal of Veterinary Dentistry. 2019;36(2):109-123. doi:10.1177/0898756419876057
Song P, He D, Ren S, et al. Platelet-rich fibrin in dentistry. Journal of Applied Biomaterials & Functional Materials. 2024:1-25. doi:10.1177/22808000241299588
Naik B, Karunakar P, Jayadev M, et al. Role of platelet rich fibrin in wound healing: a critical review. Journal of Conservative Dentistry. 2013;16(4):284-293. doi:10.4103/0972-0707.114344
Deeb M. Role of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in oro-facial tissue regeneration: a narrative review. Journal of Advanced Oral Research. 2020;11:232020681989583. doi:10.1177/2320206819895836
Del Corso M, Vervelle A, Simonpieri A, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: periodontal and dentoalveolar surgery. Current Pharmaceutical Biotechnology. 2012;13(7):1207-1230. doi:10.2174/138920112800624391
Borie E, Oliví D, Orsi I, et al. Platelet-rich fibrin application in dentistry: a literature review. International Journal of Clinical and Experimental Medicine. 2015;8:7922-7929.
Miron RJ, Zucchelli G, Pikos MA, et al. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clinical Oral Investigations. 2017;21:1913-1927. doi:10.1007/s00784-017-2133-z
Strauss FJ, Stähli A, Gruber R. The use of platelet-rich fibrin to enhance the outcomes of implant therapy: a systematic review. Clinical Oral Implants Research. 2018;29(Suppl 18):6-19. doi:10.1111/clr.13275
Estrin NE, Tran TB, Ahmad P, et al. Analgesic effects of platelet-rich fibrin (PRF): a systematic review. Periodontology 2000. 2025. doi:10.1111/prd.70014
Ravi Kumar V, Gangadharan G. Platelet rich fibrin in dentistry: a review of literature. International Journal of Medicine. 2015;3(2):72-76. doi:10.14419/ijm.v3i2.5079
Laforgia A, Inchingolo AD, Riccaldo L, et al. The use of platelet-rich fibrin (PRF) in the management of dry socket: a systematic review. International Journal of Molecular Sciences. 2024;25(18):10069. doi:10.3390/ijms251810069
Gupta V, Bains V, Singh GP, et al. Regenerative potential of platelet rich fibrin in dentistry: literature review. Asian Journal of Oral Health and Allied Sciences. 2011;1.
