Peri-İmplantitis Tedavisinde İmplant Yüzeyi Dekontaminasyonu ve Elektrolitik Yaklaşım

Yazarlar

Özet

Peri-implantitis, biyofilmle ilişkili inflamasyon ve ilerleyici kemik kaybı ile karakterize olan ve implant başarısını tehdit eden önemli bir klinik tablodur. Tedavide temel hedef, biyofilm kaynaklı inflamatuvar yükün azaltılması ve hastalığın ilerlemesinin durdurulmasıdır. Ancak implant yüzeyinin makro ve mikro-topografisi, pürüzlülüğü, yüzey serbest enerjisi ve erişimi kısıtlayan defekt morfolojileri, etkili dekontaminasyonu güçleştirmektedir. Güncel klinik uygulamalarda mekanik/fiziksel yöntemler, hava-toz abraziv sistemler, kimyasal ajanlar ve enerji temelli teknikler farklı kombinasyonlarla kullanılıyor olmasına rağmen biyofilmi tamamen elimine eden ve yüzey bütünlüğünü güvenle koruyan üstün bir yöntem henüz tanımlanamamıştır. Son yıllarda elektrolitik/elektrokimyasal dekontaminasyon, implant yüzeyinde elektrokimyasal süreçler aracılığıyla biyofilm yükünü azaltmayı amaçlayan yenilikçi bir yaklaşım olarak öne çıkmıştır. İn vitro çalışmalar, bu yöntemin bakteri yükünü azaltabildiğini ve bazı koşullarda hücresel uyumluluk açısından avantaj sağlayabildiğini göstermektedir. Klinik çalışmalar ise elektrolitik yaklaşımın rekonstrüktif tedavi protokollerine entegre edilebildiğini ve klinik/radyografik iyileşmeye katkı sunabileceğini bildirmektedir. Bununla birlikte mevcut kanıtlar, yöntemin klinik üstünlüğünü kesin olarak ortaya koymak için yeterli değildir. Elektrolitik yaklaşım, güncel veriler ışığında, özellikle erişimi güç implant yüzeylerinde tamamlayıcı bir dekontaminasyon stratejisi olarak değerlendirilmektedir.

Peri-implantitis is a biofilm-associated pathological condition characterized by inflammation of the peri-implant mucosa and progressive bone loss, posing a major threat to implant survival. The primary treatment goal is to reduce the biofilm-related inflammatory burden and prevent further disease progression. However, effective decontamination remains challenging because of implant macro- and micro-topography, surface roughness, surface free energy, and defect morphologies that limit access to contaminated areas. Current treatment strategies include mechanical/physical methods, air-powder abrasive systems, chemical agents, and energy-based techniques, often applied in combination. Nevertheless, no single method has yet been shown to eliminate biofilm while preserving implant surface integrity and biocompatibility. In recent years, electrolytic/electrochemical decontamination has emerged as an innovative approach aimed at reducing biofilm burden through electrochemical processes on the implant surface. In vitro studies suggest that this approach can reduce bacterial load and may offer favorable cellular compatibility under certain conditions. Clinical studies also indicate that electrolytic decontamination can be integrated into reconstructive peri-implantitis treatment protocols and may contribute to clinical and radiographic improvement. However, current evidence is still insufficient to establish clinical superiority. Based on available data, the electrolytic approach should be considered a complementary decontamination strategy, particularly for implant micro-topographies that are difficult to access.

Referanslar

Berglundh T, Armitage G, Araujo MG, et al. Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of Clinical Periodontology. 2018;45(S20). doi:10.1111/jcpe.12957.

Derks J, Tomasi C. Peri‐implant health and disease. A systematic review of current epidemiology. Journal of Clinical Periodontology. 2015;42(S16). doi:10.1111/jcpe.12334.

Leung K, Bi J, Giannelis G, et al. Decontamination of multispecies oral biofilm from rough implant surface by airflow with glycine. Clinical and Experimental Dental Research. 2022;8(1): 322–328. doi:10.1002/cre2.507.

Herrera D, Berglundh T, Schwarz F, et al. Prevention and treatment of peri‐implant diseases—The EFP S3 level clinical practice guideline. Journal of Clinical Periodontology. 2023;50(S26): 4–76. doi:10.1111/jcpe.13823.

Cosgarea R, Roccuzzo A, Jepsen K, et al. Efficacy of mechanical/physical approaches for implant surface decontamination in non‐surgical submarginal instrumentation of peri‐implantitis. A systematic review. Journal of Clinical Periodontology. 2023;50(S26): 188–211. doi:10.1111/jcpe.13762.

Ramanauskaite A, Schwarz F, Cafferata EA, et al. Photo/mechanical and physical implant surface decontamination approaches in conjunction with surgical peri‐implantitis treatment: A systematic review. Journal of Clinical Periodontology. 2023;50(S26): 317–335. doi:10.1111/jcpe.13783.

Baima G, Citterio F, Romandini M, et al. Surface decontamination protocols for surgical treatment of peri‐implantitis: A systematic review with meta‐analysis. Clinical Oral Implants Research. 2022;33(11): 1069–1086. doi:10.1111/clr.13992.

Mohn D, Zehnder M, Stark WJ, et al. Electrochemical Disinfection of Dental Implants – a Proof of Concept. Neyrolles O (ed.) PLoS ONE. 2011;6(1): e16157. doi:10.1371/journal.pone.0016157.

Schlee M, Rathe F, Brodbeck U, et al. Treatment of Peri-Implantitis—Electrolytic Cleaning Versus Mechanical and Electrolytic Cleaning—A Randomized Controlled Clinical Trial—Six-Month Results. Journal of Clinical Medicine. 2019;8(11): 1909. doi: 10.3390/jcm8111909.

Odeh V, Virto L, Garcia‐Quismondo E, et al. Antibacterial Effect of Combined Electrolytic and Chemical Decontamination Methods on Dental Implant Surfaces: In Vitro Study. Clinical Oral Implants Research. 2025;36(11): 1434–1444. doi:10.1111/clr.70012.

Alonso‐Español A, Bravo E, Carrillo De Albornoz A, et al. Antimicrobial Effect and Cytocompatibility After Using Different Decontamination Methods on Titanium Implant Surfaces: An In Vitro Study. Clinical Oral Implants Research. 2025;36(5): 626–639. doi:10.1111/clr.14410.

Schlee M, Wang HL, Stumpf T, et al. Treatment of Periimplantitis with Electrolytic Cleaning versus Mechanical and Electrolytic Cleaning: 18-Month Results from a Randomized Controlled Clinical Trial. Journal of Clinical Medicine. 2021;10(16): 3475. doi:10.3390/jcm10163475.

Monje A, Navarro‐Mesa S, Soldini C, et al. Surface Decontamination on the Reconstructive Therapy of Peri‐Implantitis: A Multicenter Randomized Clinical Trial. Clinical Implant Dentistry and Related Research. 2025;27(4): e70075. doi:10.1111/cid.70075.

Monje A, Pons R, Peña P. Electrolytic Surface Decontamination in the Reconstructive Therapy of Peri-Implantitis: Single-Center Outcomes of a Randomized Controlled Trial. International Journal of Periodontics & Restorative Dentistry. 2024; 1–23. doi:10.11607/prd.7151.

Hakkers J, Meijer HJA, De Waal YCM, et al. Electrolytic Cleaning as Part of Surgical Reconstructive Peri-Implantitis Treatment: A Case Series. Dentistry Journal. 2025;13(6): 237. doi:10.3390/dj13060237.

De Campos Kajimoto N, De Paiva Buischi Y, Mohamadzadeh M, et al. The Oral Microbiome of Peri-Implant Health and Disease: A Narrative Review. Dentistry Journal. 2024;12(10): 299. doi:10.3390/dj12100299.

Flemming HC, Wingender J. The biofilm matrix. Nature Reviews Microbiology.2010;8(9):623–633. doi:10.1038/nrmicro2415.

Chun Giok K, Menon RK. The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies. Antibiotics.2023;12(11):1610.doi:10.3390/antibiotics12111610.

Carvalho ÉBS, Romandini M, Sadilina S, et al. Microbiota associated with peri‐implantitis—A systematic review with meta‐analyses. Clinical Oral Implants Research. 2023;34(11): 1176–1187. doi:10.1111/clr.14153.

Polymeri A, Van Der Horst J, Buijs MJ, et al. Submucosal microbiome of peri‐implant sites: A cross‐sectional study. Journal of Clinical Periodontology. 2021;48(9): 1228–1239. doi: 10.1111/jcpe.13502.

Serroni M, Borgnakke WS, Romano L, et al. History of periodontitis as a risk factor for implant failure and incidence of peri‐implantitis: A systematic review, meta‐analysis, and trial sequential analysis of prospective cohort studies. Clinical Implant Dentistry and Related Research. 2024;26(3): 482–508. doi:10.1111/cid.13330.

Romanos GE, Mistretta L, Newman A, et al. Implant Surface Decontamination Methods That Can Impact Implant Wettability. Materials. 2024;17(24): 6249. doi:10.3390/ma17246249.

Mellado-Valero A, Buitrago-Vera P, Solá-Ruiz MF, et al. Decontamination of dental implant surface in peri-implantitis treatment: a literature review. Medicina Oral, Patologia Oral Y Cirugia Bucal. 2013;18(6): e869-876. doi:10.4317/medoral.19420.

Bollenl CML, Lambrechts P, Quirynen M. Comparison of surface roughness of oral hard materials to the threshold surface roughness for bacterial plaque retention: A review of the literature. Dental Materials. 1997;13(4): 258–269. doi:10.1016/S0109-5641(97)80038-3.

Quirynen M, Van Der Mei HC, Bollen CML, et al. An in vivo Study of the Influence of the Surface Roughness of Implants on the Microbiology of Supra- and Subgingival Plaque. Journal of Dental Research. 1993;72(9): 1304–1309. doi:10.1177/ 00220345930720090801.

Louropoulou A, Slot DE, Van Der Weijden FA. Titanium surface alterations following the use of different mechanical instruments: a systematic review. Clinical Oral Implants Research. 2012;23(6): 643–658. doi:10.1111/j.1600-0501.2011.02208.x.

Moharrami M, Perrotti V, Iaculli F, et al. Effects of air abrasive decontamination on titanium surfaces: A systematic review of in vitro studies. Clinical Implant Dentistry and Related Research. 2019;21(2): 398–421. doi:10.1111/cid.12747.

Delgado-Ruiz R, Romanos G. Potential Causes of Titanium Particle and Ion Release in Implant Dentistry: A Systematic Review. International Journal of Molecular Sciences. 2018;19(11): 3585. doi:10.3390/ijms19113585.

Ossowska A, Zieliński A. The Mechanisms of Degradation of Titanium Dental Implants. Coatings. 2020;10(9): 836. doi:10.3390/coatings10090836.

Virto L, Odeh V, Garcia‐Quismondo E, et al. Electrochemical decontamination of titanium dental implants. An in vitro biofilm model study. Clinical Oral Implants Research. 2023;34(5): 486–497. doi:10.1111/clr.14055.

Assunção MA, Botelho J, Machado V, et al. Dental Implant Surface Decontamination and Surface Change of an Electrolytic Method versus Mechanical Approaches: A Pilot In Vitro Study. Journal of Clinical Medicine. 2023;12(4): 1703. doi:10.3390/jcm12041703.

Koch M, Göltz M, Xiangjun M, et al. Electrochemical Disinfection of Dental Implants Experimentally Contaminated with Microorganisms as a Model for Periimplantitis. Journal of Clinical Medicine. 2020;9(2): 475. doi:10.3390/jcm9020475.

Schneider S, Rudolph M, Bause V, et al. Electrochemical removal of biofilms from titanium dental implant surfaces. Bioelectrochemistry. 2018;121: 84–94. doi:10.1016/j.bioelechem.2018.01.008.

Ratka C, Weigl P, Henrich D, et al. The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces. Journal of Clinical Medicine. 2019;8(9): 1397. doi:10.3390/jcm8091397.

Klein A, Rasperini G, Gruber R, et al. Electrolytic Cleaning of Dental Implants: A Scoping Review of Clinical Studies. Dentistry Journal. 2025;13(4): 172. doi:10.3390/dj13040172.

Schlee M, Naili L, Rathe F, et al. Is Complete Re-Osseointegration of an Infected Dental Implant Possible? Histologic Results of a Dog Study: A Short Communication. Journal of Clinical Medicine. 2020;9(1): 235. doi:10.3390/jcm9010235.

Bosshardt DD, Brodbeck UR, Rathe F, et al. Evidence of re-osseointegration after electrolytic cleaning and regenerative therapy of peri-implantitis in humans: a case report with four implants. Clinical Oral Investigations. 2022;26(4): 3735–3746. doi:10.1007/s00784-021-04345-1.

Referanslar

Berglundh T, Armitage G, Araujo MG, et al. Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of Clinical Periodontology. 2018;45(S20). doi:10.1111/jcpe.12957.

Derks J, Tomasi C. Peri‐implant health and disease. A systematic review of current epidemiology. Journal of Clinical Periodontology. 2015;42(S16). doi:10.1111/jcpe.12334.

Leung K, Bi J, Giannelis G, et al. Decontamination of multispecies oral biofilm from rough implant surface by airflow with glycine. Clinical and Experimental Dental Research. 2022;8(1): 322–328. doi:10.1002/cre2.507.

Herrera D, Berglundh T, Schwarz F, et al. Prevention and treatment of peri‐implant diseases—The EFP S3 level clinical practice guideline. Journal of Clinical Periodontology. 2023;50(S26): 4–76. doi:10.1111/jcpe.13823.

Cosgarea R, Roccuzzo A, Jepsen K, et al. Efficacy of mechanical/physical approaches for implant surface decontamination in non‐surgical submarginal instrumentation of peri‐implantitis. A systematic review. Journal of Clinical Periodontology. 2023;50(S26): 188–211. doi:10.1111/jcpe.13762.

Ramanauskaite A, Schwarz F, Cafferata EA, et al. Photo/mechanical and physical implant surface decontamination approaches in conjunction with surgical peri‐implantitis treatment: A systematic review. Journal of Clinical Periodontology. 2023;50(S26): 317–335. doi:10.1111/jcpe.13783.

Baima G, Citterio F, Romandini M, et al. Surface decontamination protocols for surgical treatment of peri‐implantitis: A systematic review with meta‐analysis. Clinical Oral Implants Research. 2022;33(11): 1069–1086. doi:10.1111/clr.13992.

Mohn D, Zehnder M, Stark WJ, et al. Electrochemical Disinfection of Dental Implants – a Proof of Concept. Neyrolles O (ed.) PLoS ONE. 2011;6(1): e16157. doi:10.1371/journal.pone.0016157.

Schlee M, Rathe F, Brodbeck U, et al. Treatment of Peri-Implantitis—Electrolytic Cleaning Versus Mechanical and Electrolytic Cleaning—A Randomized Controlled Clinical Trial—Six-Month Results. Journal of Clinical Medicine. 2019;8(11): 1909. doi: 10.3390/jcm8111909.

Odeh V, Virto L, Garcia‐Quismondo E, et al. Antibacterial Effect of Combined Electrolytic and Chemical Decontamination Methods on Dental Implant Surfaces: In Vitro Study. Clinical Oral Implants Research. 2025;36(11): 1434–1444. doi:10.1111/clr.70012.

Alonso‐Español A, Bravo E, Carrillo De Albornoz A, et al. Antimicrobial Effect and Cytocompatibility After Using Different Decontamination Methods on Titanium Implant Surfaces: An In Vitro Study. Clinical Oral Implants Research. 2025;36(5): 626–639. doi:10.1111/clr.14410.

Schlee M, Wang HL, Stumpf T, et al. Treatment of Periimplantitis with Electrolytic Cleaning versus Mechanical and Electrolytic Cleaning: 18-Month Results from a Randomized Controlled Clinical Trial. Journal of Clinical Medicine. 2021;10(16): 3475. doi:10.3390/jcm10163475.

Monje A, Navarro‐Mesa S, Soldini C, et al. Surface Decontamination on the Reconstructive Therapy of Peri‐Implantitis: A Multicenter Randomized Clinical Trial. Clinical Implant Dentistry and Related Research. 2025;27(4): e70075. doi:10.1111/cid.70075.

Monje A, Pons R, Peña P. Electrolytic Surface Decontamination in the Reconstructive Therapy of Peri-Implantitis: Single-Center Outcomes of a Randomized Controlled Trial. International Journal of Periodontics & Restorative Dentistry. 2024; 1–23. doi:10.11607/prd.7151.

Hakkers J, Meijer HJA, De Waal YCM, et al. Electrolytic Cleaning as Part of Surgical Reconstructive Peri-Implantitis Treatment: A Case Series. Dentistry Journal. 2025;13(6): 237. doi:10.3390/dj13060237.

De Campos Kajimoto N, De Paiva Buischi Y, Mohamadzadeh M, et al. The Oral Microbiome of Peri-Implant Health and Disease: A Narrative Review. Dentistry Journal. 2024;12(10): 299. doi:10.3390/dj12100299.

Flemming HC, Wingender J. The biofilm matrix. Nature Reviews Microbiology.2010;8(9):623–633. doi:10.1038/nrmicro2415.

Chun Giok K, Menon RK. The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies. Antibiotics.2023;12(11):1610.doi:10.3390/antibiotics12111610.

Carvalho ÉBS, Romandini M, Sadilina S, et al. Microbiota associated with peri‐implantitis—A systematic review with meta‐analyses. Clinical Oral Implants Research. 2023;34(11): 1176–1187. doi:10.1111/clr.14153.

Polymeri A, Van Der Horst J, Buijs MJ, et al. Submucosal microbiome of peri‐implant sites: A cross‐sectional study. Journal of Clinical Periodontology. 2021;48(9): 1228–1239. doi: 10.1111/jcpe.13502.

Serroni M, Borgnakke WS, Romano L, et al. History of periodontitis as a risk factor for implant failure and incidence of peri‐implantitis: A systematic review, meta‐analysis, and trial sequential analysis of prospective cohort studies. Clinical Implant Dentistry and Related Research. 2024;26(3): 482–508. doi:10.1111/cid.13330.

Romanos GE, Mistretta L, Newman A, et al. Implant Surface Decontamination Methods That Can Impact Implant Wettability. Materials. 2024;17(24): 6249. doi:10.3390/ma17246249.

Mellado-Valero A, Buitrago-Vera P, Solá-Ruiz MF, et al. Decontamination of dental implant surface in peri-implantitis treatment: a literature review. Medicina Oral, Patologia Oral Y Cirugia Bucal. 2013;18(6): e869-876. doi:10.4317/medoral.19420.

Bollenl CML, Lambrechts P, Quirynen M. Comparison of surface roughness of oral hard materials to the threshold surface roughness for bacterial plaque retention: A review of the literature. Dental Materials. 1997;13(4): 258–269. doi:10.1016/S0109-5641(97)80038-3.

Quirynen M, Van Der Mei HC, Bollen CML, et al. An in vivo Study of the Influence of the Surface Roughness of Implants on the Microbiology of Supra- and Subgingival Plaque. Journal of Dental Research. 1993;72(9): 1304–1309. doi:10.1177/ 00220345930720090801.

Louropoulou A, Slot DE, Van Der Weijden FA. Titanium surface alterations following the use of different mechanical instruments: a systematic review. Clinical Oral Implants Research. 2012;23(6): 643–658. doi:10.1111/j.1600-0501.2011.02208.x.

Moharrami M, Perrotti V, Iaculli F, et al. Effects of air abrasive decontamination on titanium surfaces: A systematic review of in vitro studies. Clinical Implant Dentistry and Related Research. 2019;21(2): 398–421. doi:10.1111/cid.12747.

Delgado-Ruiz R, Romanos G. Potential Causes of Titanium Particle and Ion Release in Implant Dentistry: A Systematic Review. International Journal of Molecular Sciences. 2018;19(11): 3585. doi:10.3390/ijms19113585.

Ossowska A, Zieliński A. The Mechanisms of Degradation of Titanium Dental Implants. Coatings. 2020;10(9): 836. doi:10.3390/coatings10090836.

Virto L, Odeh V, Garcia‐Quismondo E, et al. Electrochemical decontamination of titanium dental implants. An in vitro biofilm model study. Clinical Oral Implants Research. 2023;34(5): 486–497. doi:10.1111/clr.14055.

Assunção MA, Botelho J, Machado V, et al. Dental Implant Surface Decontamination and Surface Change of an Electrolytic Method versus Mechanical Approaches: A Pilot In Vitro Study. Journal of Clinical Medicine. 2023;12(4): 1703. doi:10.3390/jcm12041703.

Koch M, Göltz M, Xiangjun M, et al. Electrochemical Disinfection of Dental Implants Experimentally Contaminated with Microorganisms as a Model for Periimplantitis. Journal of Clinical Medicine. 2020;9(2): 475. doi:10.3390/jcm9020475.

Schneider S, Rudolph M, Bause V, et al. Electrochemical removal of biofilms from titanium dental implant surfaces. Bioelectrochemistry. 2018;121: 84–94. doi:10.1016/j.bioelechem.2018.01.008.

Ratka C, Weigl P, Henrich D, et al. The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces. Journal of Clinical Medicine. 2019;8(9): 1397. doi:10.3390/jcm8091397.

Klein A, Rasperini G, Gruber R, et al. Electrolytic Cleaning of Dental Implants: A Scoping Review of Clinical Studies. Dentistry Journal. 2025;13(4): 172. doi:10.3390/dj13040172.

Schlee M, Naili L, Rathe F, et al. Is Complete Re-Osseointegration of an Infected Dental Implant Possible? Histologic Results of a Dog Study: A Short Communication. Journal of Clinical Medicine. 2020;9(1): 235. doi:10.3390/jcm9010235.

Bosshardt DD, Brodbeck UR, Rathe F, et al. Evidence of re-osseointegration after electrolytic cleaning and regenerative therapy of peri-implantitis in humans: a case report with four implants. Clinical Oral Investigations. 2022;26(4): 3735–3746. doi:10.1007/s00784-021-04345-1.

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