Sessiz Pandemi: Veteriner Hekimlikte Antimikrobiyal Dirençin Mevcut Durumu, Gelecek Projeksiyonları ve Yeni Nesil Tanı Yöntemleri
Özet
Referanslar
Tang KWK, Millar BC, Moore JE. Antimicrobial resistance (AMR). British journal of biomedical science. 2023; 80: 11387. doi:10.3389/bjbs.2023.11387
Lautan O, Cheng YH, Pranata R, et al. Antimicrobial-resistant (AMR) bacteria in the food chain: Current challenges and global mitigation strategies. One Health. 2025; 101273. doi:10.1016/j.onehlt.2024.101273
Kurum S, Balcı Aİ, Çuhadar AH, et al. Overview Of Antimicrobial Resistance And Epidemiology Of Türkiye With A One Health Approach. Turkish Medical Journal. 2025; 10(2): 65-75.
WHO. Antimicrobial resistance. (15/02/2026 tarihinde https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance adresinden ulaşılmıştır).
Findik A. Tek Sağlık Yaklaşımında Antibiyotik Dirençliliği. Doğanın Sesi. 2022; 5(10); 53-64.
Caneschi A, Bardhi A, Barbarossa A, et al. The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: a narrative review. Antibiotics. 2023; 12(3); 487. doi:10.3390/antibiotics12030487
Founou RC, Blocker AJ, Noubom M, et al. The COVID-19 pandemic: A threat to antimicrobial resistance containment. Future Science OA. 2021; 7(8); FSO736. doi:10.2144/fsoa-2021-0012
Mothadaka MP, Vaiyapuri M, Rao Badireddy M, et al. Handbook on antimicrobial resistance. Singapore: Springer; 2023.
Puri B, Vaishya R, Vaish A. Antimicrobial resistance: Current challenges and future directions. Medical Journal Armed Forces India. 2025; 81(3): 247-258. doi:10.1016/j.mjafi.2024.08.006
Murray CJ, Ikuta KS, Sharara F, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 2022; 399(10325): 629-655. doi:10.1016/S0140-6736(21)02724-0
Thakare R, Kesharwani P, Dasgupta A, Srinivas N, Chopra S. Antibiotics: past, present, and future. In: Kesharwani P, Chopra S, Dasgupta A (eds) Drug discovery targeting drug-resistant bacteria. 1st ed. India: Academic Press; 2020. p. 1-8. doi:10.1016/B978-0-12-818480-6.00001-4
Guardabassi L, Jensen LB, Kruse H. Guide to antimicrobial use in animals. Oxford, UK: Blackwell Pub;2008.
Kirchhelle C. Pharming animals: a global history of antibiotics in food production (1935–2017). Palgrave communications. 2018; 4(1): 96. doi:10.1057/s41599-018-0152-2
Acharya KP, Wilson RT. Antimicrobial resistance in Nepal. Frontiers in medicine. 2019; 6: 105. doi:10.3389/fmed.2019.00105
Centers for Disease Control and Prevention. One Health Basics. (21/03/2023 tarihinde https://www.cdc.gov/onehealth/basics/index.html adresinden ulaşılmıştır).
Brissot H, Cervantes S, Guardabassi L, et al. GRAM: Guidance for the rational use of antimicrobials: Recommendations for dogs and cats. 2nd ed. France: Ceva Santé Animale; 2016.
Wall B, Marshall L, Mateus A, et al. Drivers, dynamics and epidemiology of antimicrobial resistance in animal production. Roma: FAO; 2016.
Alara JA, Alara OR. An overview of the global alarming increase of multiple drug resistant: a major challenge in clinical diagnosis. Infectious Disorders-Drug Targets. 2024; 24(3): 26-42. doi:10.2174/1568005324666230822104526
Arikan MS, Mat B, Alkan H, et al. Determination of Subclinical Mastitis Prevalence in Dairy Cows in Türkiye through Meta-Analysis and Production Loss Calculation. Pakistan Veterinary Journal. 2024; 44(2).
Guner B, Ozturk B, Erkan AA, et al. Distribution of bacterial pathogens and antimicrobial resistance in cows with clinical mastitis in a dairy farm, Türkiye. Journal of the Hellenic Veterinary Medical Society. 2024; 75(3): 7675-7684. doi:10.12681/jhvms.32044
Kürekci C, Yüksel M, Celil Ozaslan BG, et al. Diversity and resistance profiles of ESBL-producing gram-negative bacteria from dairy farms in Southern Türkiye. Antibiotics. 2024; 13(12): 1134. doi:10.3390/antibiotics13121134
Ardıçlı Ö, Demirbilek SK, Carlı KT. Pathogens isolated from bovine clinical mastitis and their antimicrobial resistance. Medycyna Weterynaryjna. 2022; 78(1): 19-24. Doi: 10.21521/mw.6606.
Akar K, Holzer K, Hoelzle LE, et al. An evaluation of the lineage of Brucella isolates in Turkey by a whole-genome single-nucleotide polymorphism analysis. Veterinary Sciences. 2024; 11(7): 316. doi:10.3390/vetsci11070316
Celik E, Kayman T, Buyuk F, et al. The canonical Brucella species-host dependency is changing, however, the antibiotic susceptibility profiles remain unchanged. Microbial Pathogenesis. 2023; 182: 106261. doi:10.1016/j.micpath.2023.106261
Yumuk Z, O’Callaghan D. Brucellosis in Turkey—an overview. International Journal of Infectious Diseases. 2012; 16(4): e228-e235. doi:10.1016/j.ijid.2012.01.002
Alzuheir IM. Veterinarians’ perspectives on livestock diseases and antimicrobial use in Palestine. Veterinary world. 2025; 18(2): 519.
Khalifa HO, Oreiby A, Abd El-Hafeez AA, et al. High beta-lactam and quinolone resistance of Enterobacteriaceae from the respiratory tract of sheep and goat with respiratory disease. Animals. 2021; 11(8): 2258 doi:10.3390/ani11082258
Pehlivanoglu F, Ozturk D, Turutoglu H. Carriage of plasmidic AmpC beta-lactamase producing Escherichia coli in cattle and sheep and characterisation of the isolates in terms of antibiogram profiles, phylogeny and virulence. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2020; 26(4).
Eltai NO, Dogan N (eds). Antimicrobial Resistance in Veterinary Science. Basel, İsviçre: MDPI; 2025. doi:10.3390/books978-3-7258-3353-5
Tawor AB, Erganiş O, Kebabçıoğlu C, et al. Pasteurella multocida and Mannheimia haemolytica; virulence factors, diseases, and notably increasing antibiotic resistance rate among their isolates: a comprehensive review. Journal of Istanbul Veterinary Sciences. 2024; 8(2): 110-125.
Karadeniz Pütür ELİ, Büyük F, Ersoy Y. Phenotypic and molecular characterization and antimicrobial susceptibility pattern of Pasteurella and Mannheimia species obtained from cattle and sheep with pneumonia. Turkish Journal of Veterinary & Animal Sciences. 2024; 48(6): 227-242. doi:10.55730/1300-0128.4354
Hatipoglu F, Terzi F, Ates MB, et al. Determination of Mannheimia haemolytica and its macrolide antibiotic resistance genes in fibrinous pneumonia of cattle. Revista Cientifica de la Facultade de Veterinaria. 2024; 34(3).
Ozturk Y, Celik S, Sahin E, et al. Assessment of farmers’ knowledge, attitudes and practices on antibiotics and antimicrobial resistance. Animals. 2019; 9(9): 653. doi:10.3390/ani9090653
Çufaoğlu G, Ambarcıoğlu P, Derinöz AN, et al. Prevalence, serotype diversity and antibiotic resistance of Salmonella among poultry meat and eggs in Turkiye: A meta-analysis. Journal of Agricultural Sciences. 2023; 29(2): 519-533 doi:10.15832/ankutbd.1105151
Kandir H, Öztürk D. Antimicrobial resistance of E. coli and Salmonella isolated from wild birds in a Rehabilitation Center in Turkey. Archives of Razi Institute. 2022; 77(1): 257. doi:10.22092/ari.2021.354673.1616
Uslu A, Toslak EE, Denizli O, et al. Microbiological Analysis of Gut Flora and Determination of Antibiotic Resistance from White Storks (Ciconia Ciconia) Resting Area during Migration in Türkiye. Eurasian Journal of Veterinary Sciences. 2024; 40(3). doi:10.15312/EurasianJVetSci.2024.428
Yildiz M, Demirbilek SK. Investigation of prevalence and antimicrobial resistance of Salmonella in pet dogs and cats in Turkey. Veterinary medicine and science. 2024; 10(4): e1513. doi:10.1002/vms3.1513
Al S, Dışhan A, Barel M, et al. Assessment of carbapenem resistance and carbapenemase genes in wastewater from cattle slaughterhouses: Implications for environmental antibiotic resistance surveillance. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2025; 72(1): 91-97. doi:10.33988/auvfd.1408846
Sağlık Bakanlığı. Antimikrobiyal direnç ile mücadele ulusal eylem planı 2026-2030. (25/02/2026 tarihinde https://dosyamerkez.saglik.gov.tr/Eklenti/53757/0/antimikrobiyal-direnc-ile-mucadele-ulusal-eylem-plani-2026-2030pdf.pdf adresinden ulaşılmıştır).
Caneschi, A., Bardhi, A., Barbarossa, A., & Zaghini, A. (2023). The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: a narrative review. Antibiotics, 12(3), 487.
Palma E, Tilocca B, Roncada P. Antimicrobial resistance in veterinary medicine: An overview. International journal of molecular sciences. 2020; 21(6): 1914. doi:10.3390/ijms21061914
Yılmaz N, Sert H, Cengiz M. Systemic Barriers to Antimicrobial Stewardship in Turkiye: Insights from Veterinary Practices. Journal of Research in Veterinary Medicine. 2025; 44(2): 146-151.
Miller L, Hurley K (eds). Infectious disease management in animal shelters. Ames, Iowa: Wiley-Blackwell; 2009.
Bilge N, Sezer C, Vatansever L, et al. Occurrence and molecular characterization of cephalosporin resistant Escherichia coli isolates from chicken meat. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2020; 26(4).
Aslantaş Ö. Antimicrobial resistance among commensal Escherichia coli from broilers in Turkey. Israel Journal of Veterinary Medicine. 2018; 73(3): 19-24.
Bhalodi AA, van Engelen TS, Virk HS, et al. Impact of antimicrobial therapy on the gut microbiome. Journal of Antimicrobial Chemotherapy. 2019; 74(1): i6-i15. doi:10.1093/jac/dkz139
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Alatawi AD, Hetta HF, Ali MAS, et al. Diagnostic innovations to combat antibiotic resistance in critical care: tools for targeted therapy and stewardship. Diagnostics. 2025; 15(17): 2244. doi:10.3390/diagnostics15172244
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Velazquez-Meza ME, Galarde-López M, Carrillo-Quiróz B, et al. Antimicrobial resistance: one health approach. Veterinary world. 2022; 15(3): 743. doi:10.14202/vetworld.2022.743-752
Pinto Ferreira J, Gochez D, Jeannin M, et al. From OIE standards to responsible and prudent use of antimicrobials: Supporting stewardship for the use of antimicrobial agents in animals. JAC-Antimicrobial Resistance. 2022; 4(2): dlac017. doi:10.1093/jacamr/dlac017
Nickell JS, White BJ. Metaphylactic antimicrobial therapy for bovine respiratory disease in stocker and feedlot cattle. Veterinary Clinics: Food Animal Practice. 2010; 26(2): 285-301. doi:10.1016/j.cvfa.2010.04.006
Pellissery AJ, Denagamage T, Pedersen M, et al Veterinarians’ Perspectives on the Antimicrobial Resistance (AMR) Dashboard: A Survey of Needs and Preferences to Inform Development. Veterinary Sciences. 2025; 12(10): 940.
Referanslar
Tang KWK, Millar BC, Moore JE. Antimicrobial resistance (AMR). British journal of biomedical science. 2023; 80: 11387. doi:10.3389/bjbs.2023.11387
Lautan O, Cheng YH, Pranata R, et al. Antimicrobial-resistant (AMR) bacteria in the food chain: Current challenges and global mitigation strategies. One Health. 2025; 101273. doi:10.1016/j.onehlt.2024.101273
Kurum S, Balcı Aİ, Çuhadar AH, et al. Overview Of Antimicrobial Resistance And Epidemiology Of Türkiye With A One Health Approach. Turkish Medical Journal. 2025; 10(2): 65-75.
WHO. Antimicrobial resistance. (15/02/2026 tarihinde https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance adresinden ulaşılmıştır).
Findik A. Tek Sağlık Yaklaşımında Antibiyotik Dirençliliği. Doğanın Sesi. 2022; 5(10); 53-64.
Caneschi A, Bardhi A, Barbarossa A, et al. The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: a narrative review. Antibiotics. 2023; 12(3); 487. doi:10.3390/antibiotics12030487
Founou RC, Blocker AJ, Noubom M, et al. The COVID-19 pandemic: A threat to antimicrobial resistance containment. Future Science OA. 2021; 7(8); FSO736. doi:10.2144/fsoa-2021-0012
Mothadaka MP, Vaiyapuri M, Rao Badireddy M, et al. Handbook on antimicrobial resistance. Singapore: Springer; 2023.
Puri B, Vaishya R, Vaish A. Antimicrobial resistance: Current challenges and future directions. Medical Journal Armed Forces India. 2025; 81(3): 247-258. doi:10.1016/j.mjafi.2024.08.006
Murray CJ, Ikuta KS, Sharara F, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 2022; 399(10325): 629-655. doi:10.1016/S0140-6736(21)02724-0
Thakare R, Kesharwani P, Dasgupta A, Srinivas N, Chopra S. Antibiotics: past, present, and future. In: Kesharwani P, Chopra S, Dasgupta A (eds) Drug discovery targeting drug-resistant bacteria. 1st ed. India: Academic Press; 2020. p. 1-8. doi:10.1016/B978-0-12-818480-6.00001-4
Guardabassi L, Jensen LB, Kruse H. Guide to antimicrobial use in animals. Oxford, UK: Blackwell Pub;2008.
Kirchhelle C. Pharming animals: a global history of antibiotics in food production (1935–2017). Palgrave communications. 2018; 4(1): 96. doi:10.1057/s41599-018-0152-2
Acharya KP, Wilson RT. Antimicrobial resistance in Nepal. Frontiers in medicine. 2019; 6: 105. doi:10.3389/fmed.2019.00105
Centers for Disease Control and Prevention. One Health Basics. (21/03/2023 tarihinde https://www.cdc.gov/onehealth/basics/index.html adresinden ulaşılmıştır).
Brissot H, Cervantes S, Guardabassi L, et al. GRAM: Guidance for the rational use of antimicrobials: Recommendations for dogs and cats. 2nd ed. France: Ceva Santé Animale; 2016.
Wall B, Marshall L, Mateus A, et al. Drivers, dynamics and epidemiology of antimicrobial resistance in animal production. Roma: FAO; 2016.
Alara JA, Alara OR. An overview of the global alarming increase of multiple drug resistant: a major challenge in clinical diagnosis. Infectious Disorders-Drug Targets. 2024; 24(3): 26-42. doi:10.2174/1568005324666230822104526
Arikan MS, Mat B, Alkan H, et al. Determination of Subclinical Mastitis Prevalence in Dairy Cows in Türkiye through Meta-Analysis and Production Loss Calculation. Pakistan Veterinary Journal. 2024; 44(2).
Guner B, Ozturk B, Erkan AA, et al. Distribution of bacterial pathogens and antimicrobial resistance in cows with clinical mastitis in a dairy farm, Türkiye. Journal of the Hellenic Veterinary Medical Society. 2024; 75(3): 7675-7684. doi:10.12681/jhvms.32044
Kürekci C, Yüksel M, Celil Ozaslan BG, et al. Diversity and resistance profiles of ESBL-producing gram-negative bacteria from dairy farms in Southern Türkiye. Antibiotics. 2024; 13(12): 1134. doi:10.3390/antibiotics13121134
Ardıçlı Ö, Demirbilek SK, Carlı KT. Pathogens isolated from bovine clinical mastitis and their antimicrobial resistance. Medycyna Weterynaryjna. 2022; 78(1): 19-24. Doi: 10.21521/mw.6606.
Akar K, Holzer K, Hoelzle LE, et al. An evaluation of the lineage of Brucella isolates in Turkey by a whole-genome single-nucleotide polymorphism analysis. Veterinary Sciences. 2024; 11(7): 316. doi:10.3390/vetsci11070316
Celik E, Kayman T, Buyuk F, et al. The canonical Brucella species-host dependency is changing, however, the antibiotic susceptibility profiles remain unchanged. Microbial Pathogenesis. 2023; 182: 106261. doi:10.1016/j.micpath.2023.106261
Yumuk Z, O’Callaghan D. Brucellosis in Turkey—an overview. International Journal of Infectious Diseases. 2012; 16(4): e228-e235. doi:10.1016/j.ijid.2012.01.002
Alzuheir IM. Veterinarians’ perspectives on livestock diseases and antimicrobial use in Palestine. Veterinary world. 2025; 18(2): 519.
Khalifa HO, Oreiby A, Abd El-Hafeez AA, et al. High beta-lactam and quinolone resistance of Enterobacteriaceae from the respiratory tract of sheep and goat with respiratory disease. Animals. 2021; 11(8): 2258 doi:10.3390/ani11082258
Pehlivanoglu F, Ozturk D, Turutoglu H. Carriage of plasmidic AmpC beta-lactamase producing Escherichia coli in cattle and sheep and characterisation of the isolates in terms of antibiogram profiles, phylogeny and virulence. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2020; 26(4).
Eltai NO, Dogan N (eds). Antimicrobial Resistance in Veterinary Science. Basel, İsviçre: MDPI; 2025. doi:10.3390/books978-3-7258-3353-5
Tawor AB, Erganiş O, Kebabçıoğlu C, et al. Pasteurella multocida and Mannheimia haemolytica; virulence factors, diseases, and notably increasing antibiotic resistance rate among their isolates: a comprehensive review. Journal of Istanbul Veterinary Sciences. 2024; 8(2): 110-125.
Karadeniz Pütür ELİ, Büyük F, Ersoy Y. Phenotypic and molecular characterization and antimicrobial susceptibility pattern of Pasteurella and Mannheimia species obtained from cattle and sheep with pneumonia. Turkish Journal of Veterinary & Animal Sciences. 2024; 48(6): 227-242. doi:10.55730/1300-0128.4354
Hatipoglu F, Terzi F, Ates MB, et al. Determination of Mannheimia haemolytica and its macrolide antibiotic resistance genes in fibrinous pneumonia of cattle. Revista Cientifica de la Facultade de Veterinaria. 2024; 34(3).
Ozturk Y, Celik S, Sahin E, et al. Assessment of farmers’ knowledge, attitudes and practices on antibiotics and antimicrobial resistance. Animals. 2019; 9(9): 653. doi:10.3390/ani9090653
Çufaoğlu G, Ambarcıoğlu P, Derinöz AN, et al. Prevalence, serotype diversity and antibiotic resistance of Salmonella among poultry meat and eggs in Turkiye: A meta-analysis. Journal of Agricultural Sciences. 2023; 29(2): 519-533 doi:10.15832/ankutbd.1105151
Kandir H, Öztürk D. Antimicrobial resistance of E. coli and Salmonella isolated from wild birds in a Rehabilitation Center in Turkey. Archives of Razi Institute. 2022; 77(1): 257. doi:10.22092/ari.2021.354673.1616
Uslu A, Toslak EE, Denizli O, et al. Microbiological Analysis of Gut Flora and Determination of Antibiotic Resistance from White Storks (Ciconia Ciconia) Resting Area during Migration in Türkiye. Eurasian Journal of Veterinary Sciences. 2024; 40(3). doi:10.15312/EurasianJVetSci.2024.428
Yildiz M, Demirbilek SK. Investigation of prevalence and antimicrobial resistance of Salmonella in pet dogs and cats in Turkey. Veterinary medicine and science. 2024; 10(4): e1513. doi:10.1002/vms3.1513
Al S, Dışhan A, Barel M, et al. Assessment of carbapenem resistance and carbapenemase genes in wastewater from cattle slaughterhouses: Implications for environmental antibiotic resistance surveillance. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2025; 72(1): 91-97. doi:10.33988/auvfd.1408846
Sağlık Bakanlığı. Antimikrobiyal direnç ile mücadele ulusal eylem planı 2026-2030. (25/02/2026 tarihinde https://dosyamerkez.saglik.gov.tr/Eklenti/53757/0/antimikrobiyal-direnc-ile-mucadele-ulusal-eylem-plani-2026-2030pdf.pdf adresinden ulaşılmıştır).
Caneschi, A., Bardhi, A., Barbarossa, A., & Zaghini, A. (2023). The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: a narrative review. Antibiotics, 12(3), 487.
Palma E, Tilocca B, Roncada P. Antimicrobial resistance in veterinary medicine: An overview. International journal of molecular sciences. 2020; 21(6): 1914. doi:10.3390/ijms21061914
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