Veteriner Aşılarında Yeni Nesil Adjuvantlar

Marzouk E, Alajaji AI. Preventive immunology for livestock and zoonotic infectious diseases in the One Health era: from mechanistic insights to innovative interventions. Vet Sci. 2025;12(10):1014.

Brun A. An overview of veterinary viral diseases and vaccine technologies. In: Vaccine Technologies for Veterinary Viral Diseases: Methods and Protocols. 2022. p. 1–26.

Carpenter A, Waltenburg MA, Hall A, et al. Vaccine preventable zoonotic diseases: challenges and opportunities for public health progress. Vaccines. 2022;10(7):993.

Kar P, Rajesh JB, Das M. New developments in veterinary vaccines. J Adv Biol Biotechnol. 2025;28(5):597–608.

Huang Z, Gong H, Sun Q, et al. Research progress on emulsion vaccine adjuvants. Heliyon. 2024;10(3).

Ermolayev AV, Ershov AE, Sorokina TS, et al. Gaston Ramon and concise history of anatoxins (to the centenary of discovery). Probl Soc Hyg Public Health Hist Med. 2024;32(1).

Cox JC, Coulter AR. Advances in adjuvant technology and application. In: Animal parasite control utilizing biotechnology. Boca Raton: CRC Press; 2024. p. 49–112.

Antipov A, Petrovsky N. One Health adjuvant selection for vaccines against zoonotic infections. Explor Med. 2025;6:1001316.9.

Nooraei S, Sarkar Lotfabadi A, Akbarzadehmoallemkolaei M, et al. Immunogenicity of different types of adjuvants and nano-adjuvants in veterinary vaccines: a comprehensive review. Vaccines. 2023;11(2):453.

Lykins WR, Fox CB. Practical considerations for next-generation adjuvant development and translation. Pharmaceutics. 2023;15(7):1850.

Oboge H, Riitho V, Nyamai M, et al. Safety and efficacy of toll-like receptor agonists as therapeutic agents and vaccine adjuvants for infectious diseases in animals: a systematic review. Front Vet Sci. 2024;11:1428713.

Heegaard PM, Dedieu L, Johnson N, et al. Adjuvants and delivery systems in veterinary vaccinology: current state and future developments. Arch Virol. 2011;156(2):183–202.

Kumar V, Verma A, Singh R, et al. Recombinant vaccines: current updates and future prospects. Asian Pac J Trop Med. 2024;17(8):338–350.

Pinho Favaro MT, Atienza-Garriga J, Martínez-Torró C, et al. Recombinant vaccines in 2022: a perspective from the cell factory. Microb Cell Fact. 2022;21(1):203.

Verma SK, Mahajan P, Singh NK, Gupta A, Aggarwal R, Rappuoli R, et al. New-age vaccine adjuvants, their development, and future perspective. Front Immunol. 2023;14:1043109.

Zhao T, Cai Y, Jiang Y, et al. Vaccine adjuvants: mechanisms and platforms. Signal Transduct Target Ther. 2023;8(1):283.

Spickler AR, Roth JA. Adjuvants in veterinary vaccines: modes of action and adverse effects. J Vet Intern Med. 2003;17(3):273–281.

Tizard IR. Adjuvants and adjuvanticity. In: Vaccines for veterinarians. 2020. p. 75.

Reinke S, Thakur A, Gartlan C, et al. Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants. Vaccines. 2020;8(3):554.

Kaurav M, Madan J, Sudheesh MS, et al. Combined adjuvant-delivery system for new generation vaccine antigens: alliance has its own advantage. Artif Cells Nanomed Biotechnol. 2018;46(sup3):818–831.

Olive C. Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants. Expert Rev Vaccines. 2012;11(2):237–256.

Nazeri S, Zakeri S, Mehrizi AA, et al. Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice. Med Microbiol Immunol. 2018;207(5):271–286.

Zhang R, Wei Y, Liu X, et al. Development and efficacy evaluation of a novel water-in-oil-in-water adjuvant for an inactivated foot-and-mouth disease vaccine. Pharm Dev Technol. 2024;29(2):75–85.

Morgan PM. Immune response in mammals and chickens. In: IgY-Technology: Production and Application of Egg Yolk Antibodies: Basic Knowledge for a Successful Practice. Cham: Springer International Publishing; 2021. p. 31–47.

Guérin JL, Balloy D, Pinson M, et al. Vaccination technology in poultry: principles of vaccine administration. Avian Dis. 2024;67(4):489–494.

Deville S, Carneaux E, Bertrand F, et al. Adjuvant formulation for companion animals vaccines. Procedia Vaccinol. 2011;4:104–112.

Carnet F, Perrin-Cocon L, Paillot R, et al. An inventory of adjuvants used for vaccination in horses: the past, the present and the future. Vet Res. 2023;54(1):18.

Adams A. Progress, challenges and opportunities in fish vaccine development. Fish Shellfish Immunol. 2019;90:210–214.

Tafalla C, Bøgwald J, Dalmo RA. Adjuvants and immunostimulants in fish vaccines: current knowledge and future perspectives. Fish Shellfish Immunol. 2013;35(6):1740–1750.

Burakova Y, Madera R, McVey S, et al. Adjuvants for animal vaccines. Viral Immunol. 2018;31(1):11–22.

Facciolà A, Visalli G, Laganà A, et al. An overview of vaccine adjuvants: current evidence and future perspectives. Vaccines. 2022;10(5):819.

European Medicines Agency. Data requirements for adjuvants in vaccines for veterinary use (EMEA/CVMP/IWP/273974/2009-Rev.1). Amsterdam: EMA; 2022. Available from: https://www.who.int/publications/m.

Koff WC, Burton DR, Johnson PR, et al. Accelerating next-generation vaccine development for global disease prevention. Science. 2013;340(6136):1232910.

Petrovsky N. Comparative safety of vaccine adjuvants: a summary of current evidence and future needs. Drug Saf. 2015;38(11):1059–1074.

World Health Organization. Adjuvants and vaccines: safety, regulatory and pharmacovigilance considerations. Geneva: WHO Press; 2013. Available from: https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics

Nel A, Xia T, Madler L, et al. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–627.

Ren H, Jia W, Xie Y, et al. Adjuvant physiochemistry and advanced nanotechnology for vaccine development. Chem Soc Rev. 2023;52(15):5172–5254.

Barbosa RDM, Silva AM, Silva CFD, et al. Production technologies, regulatory parameters, and quality control of vaccine vectors for veterinary use. Technologies. 2022;10(5):109.

Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta Mol Cell Res. 2002;1589(1):1–13.

Akira S, Kaisho T, Kaisho T. "Toll-like receptors: critical proteins linking innate and acquired immunity." Nat immunol. 2001: 2(8) 675-680.

Zhang M, Wang C, Pan J, et al. Advancing novel veterinary vaccines: from comprehensive antigen and adjuvant design to preparation process optimization. Int Immunopharmacol. 2025;145:113784.

Marzouk E, Alajaji AI. Preventive immunology for livestock and zoonotic infectious diseases in the One Health era: from mechanistic insights to innovative interventions. Vet Sci. 2025;12(10):1014.

Brun A. An overview of veterinary viral diseases and vaccine technologies. In: Vaccine Technologies for Veterinary Viral Diseases: Methods and Protocols. 2022. p. 1–26.

Carpenter A, Waltenburg MA, Hall A, et al. Vaccine preventable zoonotic diseases: challenges and opportunities for public health progress. Vaccines. 2022;10(7):993.

Kar P, Rajesh JB, Das M. New developments in veterinary vaccines. J Adv Biol Biotechnol. 2025;28(5):597–608.

Huang Z, Gong H, Sun Q, et al. Research progress on emulsion vaccine adjuvants. Heliyon. 2024;10(3).

Ermolayev AV, Ershov AE, Sorokina TS, et al. Gaston Ramon and concise history of anatoxins (to the centenary of discovery). Probl Soc Hyg Public Health Hist Med. 2024;32(1).

Cox JC, Coulter AR. Advances in adjuvant technology and application. In: Animal parasite control utilizing biotechnology. Boca Raton: CRC Press; 2024. p. 49–112.

Antipov A, Petrovsky N. One Health adjuvant selection for vaccines against zoonotic infections. Explor Med. 2025;6:1001316.9.

Nooraei S, Sarkar Lotfabadi A, Akbarzadehmoallemkolaei M, et al. Immunogenicity of different types of adjuvants and nano-adjuvants in veterinary vaccines: a comprehensive review. Vaccines. 2023;11(2):453.

Lykins WR, Fox CB. Practical considerations for next-generation adjuvant development and translation. Pharmaceutics. 2023;15(7):1850.

Oboge H, Riitho V, Nyamai M, et al. Safety and efficacy of toll-like receptor agonists as therapeutic agents and vaccine adjuvants for infectious diseases in animals: a systematic review. Front Vet Sci. 2024;11:1428713.

Heegaard PM, Dedieu L, Johnson N, et al. Adjuvants and delivery systems in veterinary vaccinology: current state and future developments. Arch Virol. 2011;156(2):183–202.

Kumar V, Verma A, Singh R, et al. Recombinant vaccines: current updates and future prospects. Asian Pac J Trop Med. 2024;17(8):338–350.

Pinho Favaro MT, Atienza-Garriga J, Martínez-Torró C, et al. Recombinant vaccines in 2022: a perspective from the cell factory. Microb Cell Fact. 2022;21(1):203.

Verma SK, Mahajan P, Singh NK, Gupta A, Aggarwal R, Rappuoli R, et al. New-age vaccine adjuvants, their development, and future perspective. Front Immunol. 2023;14:1043109.

Zhao T, Cai Y, Jiang Y, et al. Vaccine adjuvants: mechanisms and platforms. Signal Transduct Target Ther. 2023;8(1):283.

Spickler AR, Roth JA. Adjuvants in veterinary vaccines: modes of action and adverse effects. J Vet Intern Med. 2003;17(3):273–281.

Tizard IR. Adjuvants and adjuvanticity. In: Vaccines for veterinarians. 2020. p. 75.

Reinke S, Thakur A, Gartlan C, et al. Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants. Vaccines. 2020;8(3):554.

Kaurav M, Madan J, Sudheesh MS, et al. Combined adjuvant-delivery system for new generation vaccine antigens: alliance has its own advantage. Artif Cells Nanomed Biotechnol. 2018;46(sup3):818–831.

Olive C. Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants. Expert Rev Vaccines. 2012;11(2):237–256.

Nazeri S, Zakeri S, Mehrizi AA, et al. Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice. Med Microbiol Immunol. 2018;207(5):271–286.

Zhang R, Wei Y, Liu X, et al. Development and efficacy evaluation of a novel water-in-oil-in-water adjuvant for an inactivated foot-and-mouth disease vaccine. Pharm Dev Technol. 2024;29(2):75–85.

Morgan PM. Immune response in mammals and chickens. In: IgY-Technology: Production and Application of Egg Yolk Antibodies: Basic Knowledge for a Successful Practice. Cham: Springer International Publishing; 2021. p. 31–47.

Guérin JL, Balloy D, Pinson M, et al. Vaccination technology in poultry: principles of vaccine administration. Avian Dis. 2024;67(4):489–494.

Deville S, Carneaux E, Bertrand F, et al. Adjuvant formulation for companion animals vaccines. Procedia Vaccinol. 2011;4:104–112.

Carnet F, Perrin-Cocon L, Paillot R, et al. An inventory of adjuvants used for vaccination in horses: the past, the present and the future. Vet Res. 2023;54(1):18.

Adams A. Progress, challenges and opportunities in fish vaccine development. Fish Shellfish Immunol. 2019;90:210–214.

Tafalla C, Bøgwald J, Dalmo RA. Adjuvants and immunostimulants in fish vaccines: current knowledge and future perspectives. Fish Shellfish Immunol. 2013;35(6):1740–1750.

Burakova Y, Madera R, McVey S, et al. Adjuvants for animal vaccines. Viral Immunol. 2018;31(1):11–22.

Facciolà A, Visalli G, Laganà A, et al. An overview of vaccine adjuvants: current evidence and future perspectives. Vaccines. 2022;10(5):819.

European Medicines Agency. Data requirements for adjuvants in vaccines for veterinary use (EMEA/CVMP/IWP/273974/2009-Rev.1). Amsterdam: EMA; 2022. Available from: https://www.who.int/publications/m.

Koff WC, Burton DR, Johnson PR, et al. Accelerating next-generation vaccine development for global disease prevention. Science. 2013;340(6136):1232910.

Petrovsky N. Comparative safety of vaccine adjuvants: a summary of current evidence and future needs. Drug Saf. 2015;38(11):1059–1074.

World Health Organization. Adjuvants and vaccines: safety, regulatory and pharmacovigilance considerations. Geneva: WHO Press; 2013. Available from: https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics

Nel A, Xia T, Madler L, et al. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–627.

Ren H, Jia W, Xie Y, et al. Adjuvant physiochemistry and advanced nanotechnology for vaccine development. Chem Soc Rev. 2023;52(15):5172–5254.

Barbosa RDM, Silva AM, Silva CFD, et al. Production technologies, regulatory parameters, and quality control of vaccine vectors for veterinary use. Technologies. 2022;10(5):109.

Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta Mol Cell Res. 2002;1589(1):1–13.

Akira S, Kaisho T, Kaisho T. "Toll-like receptors: critical proteins linking innate and acquired immunity." Nat immunol. 2001: 2(8) 675-680.

Zhang M, Wang C, Pan J, et al. Advancing novel veterinary vaccines: from comprehensive antigen and adjuvant design to preparation process optimization. Int Immunopharmacol. 2025;145:113784.