Metamfetamin İntoksikasyonuna Bağlı Kardiyopulmoner Arrest Vakasında Yoğun Bakım Yönetimi
Özet
Madde kullanımı, özellikle genç erişkinlerde ciddi sağlık sorunlarına yol açabilen önemli bir halk sağlığı sorunudur. Bu olgu sunumunda, 27 yaşında erkek bir hastanın bilinmeyen miktarda metamfetamin alımı sonrası kardiyopulmoner arrest geçirmesi ve ardından yoğun bakım sürecindeki yönetimi ele alınmaktadır. 112 acil sağlık ekibinin yaptığı 15 dakikalık kardiyopulmoner resüsitasyon sonrası spontan dolaşımı sağlanan hasta, yoğun bakım ünitesine entübe ve bilinci kapalı olarak kabul edilmiştir. Hastanın idrarında yüksek düzeyde metamfetamin saptanmış ve beyin manyetik rezonans görüntülemesinde hipoksik hasara bağlı yaygın beyin hasarı tespit edilmiştir. Hastanın 142 günlük yoğun bakım takibi boyunca bilinci açılmamış ve bu süreç sonunda ikinci bir kardiyopulmoner arrest geçirerek kaybedilmiştir. Bu vaka, metamfetamin kullanımının ölümcül sonuçları ve yoğun bakım süreçlerinin önemini vurgulamaktadır.
Substance use is a significant public health issue that can lead to serious health problems, especially among young adults. In this case report, the management of a 27-year-old male patient who experienced cardiopulmonary arrest after ingesting an unknown amount of methamphetamine and was subsequently admitted to the intensive care unit is presented. Following 15 minutes of cardiopulmonary resuscitation performed by the emergency medical team, spontaneous circulation was achieved, and the patient was admitted to the intensive care unit intubated and unconscious. A high level of methamphetamine was detected in the patient’s urine, and magnetic resonance imaging of the brain revealed diffuse brain injury due to hypoxic damage. During his 142-day follow-up in the intensive care unit, the patient remained unconscious and eventually suffered a second cardiopulmonary arrest, resulting in death. This case highlights the fatal consequences of methamphetamine use and emphasizes the importance of intensive care management.
Referanslar
Zaidi S, Khan U, Sagheer S, et al. Multiple biventricular thrombi associated with methamphetamine-associated cardiomyopathy. Ochsner Journal, 2022; 22(2), 192-195. doi:10.31486/toj.21.0097
Kevil C, Goeders N, Woolard M, et all. Methamphetamine use and cardiovascular disease. Arteriosclerosis Thrombosis and Vascular Biology, 2019; 39(9), 1739-1746. doi:10.1161/atvbaha.119.312461
Lappin J, Darke S, Farrell M. Stroke and methamphetamine use in young adults: a review. Journal of Neurology Neurosurgery & Psychiatry, 2017; 88(12), 1079-1091. doi:10.1136/jnnp-2017-316071
Bakhsh AA, Bakhsh, AR, Karamelahi Z, et al. Communicating resuscitation. Saudi Medical Journal, 2018; 39(3), 261-266. doi:10.15537/smj.2018.3.21885
Ohbe H. Tagami T, Uda K, et al. Incidence and outcomes of in-hospital cardiac arrest in japan 2011–2017: a nationwide inpatient database study. Journal of Intensive Care, 2022;10(1). doi:10.1186/s40560-022-00601-y
Hiramatsu T. Bullet fragments spontaneously migrating in opposite directions after a cardiac arrest treated with extracorporeal cardiopulmonary resuscitation following a gunshot wound to the head: a case report. Trauma Case Reports, 2020; 28, 100330. doi:10.1016/j.tcr.2020.100330
Örken C, Tavşanlı ME. Neurologic manifestations of ıllicit drug addiction. Okmeydanı Tıp Dergisi, 2014; 30 (Ek sayı 2):110-114. doi:10.5222/otd.supp2.2014.110
Sarımehmetoğlu AC, Helvacı A. Subtance addiction and cardiovascular system. Okmeydanı Tıp Dergisi 30 (Ek sayı 2):99-103, 2014 doi:10.5222/otd.supp2.2014.099
Koriem K, Soliman R. Chlorogenic and caftaric acids in liver toxicity and oxidative stress induced by methamphetamine. Journal of Toxicology, 2014; 1-10. doi:10.1155/2014/583494
Nader J, Rapino C, Gennequin B, et al. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of cb2 receptors. Neuropharmacology, 2014;87, 214-221. doi:10.1016/j.neuropharm.2014.03.014
Tschumi C, Daszkowski A, Sharpe A, et al. A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. Addiction Biology, 2019;25(4). doi:10.1111/adb.12763
Taheri P, Keshavarzi S, Ebadi M, et al. Neuroprotective Effects of Forced Exercise and Bupropion on Chronic Methamphetamine-induced Cognitive Impairment via Modulation of cAMP Response Element-binding Protein/Brain-derived Neurotrophic Factor Signaling Pathway, Oxidative Stress, and Inflammatory Biomarkers in Rats. Adv Biomed Res. 2018;7:151. doi:10.4103/abr.abr_11_18
Githens T, DeBaun M, Campbell S, et al. Rates of perioperative complications among patients undergoing orthopedic trauma surgery despite having positive results for methamphetamine. Orthopedics, 2019;42(4):192-196. doi:10.3928/01477447-20190523-01
Tserensodnom B, Baatar K, Jambaldorj A, et al. Extrapyramidal dysfunction as a consequence of hypoxic brain injury. Central Asian Journal of Medical Sciences, 2017;3(2), 190-194. doi:10.24079/cajms.2017.06.013
Tu L, Wang Y, Chen D, et al. Protective effects of notoginsenoside r1 via regulation of the pi3k-akt-mtor/jnk pathway in neonatal cerebral hypoxic–ischemic brain injury. Neurochemical Research, 2018;43(6):1210-1226. doi:10.1007/s11064-018-2538-3
Cadet J, Krasnova I, Walther D, et al. Increased expression of proenkephalin and prodynorphin mrnas in the nucleus accumbens of compulsive methamphetamine taking rats. Scientific Reports, 2016;6:37002. doi:10.1038/srep37002
Lee N, Zheng G, Leggas M, et al. Gz-11608, a vesicular monoamine transporter-2 inhibitor, decreases the neurochemical and behavioral effects of methamphetamine. Journal of Pharmacology and Experimental Therapeutics, 2019;371(2):526-543. doi:10.1124/jpet.119.258699
Mulkey S, Yap V, Swearingen C, et al. Riggins, M., Kaiser, J., & Schaefer, G. (2012). Quantitative cranial magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy. Pediatric Neurology, 2012;47(2):101-108. doi:10.1016/j.pediatrneurol.2012.05.009
Okubo M, Komukai S, Andersen L, et al. Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study. BMJ, 2024;384:e076019. doi:10.1136/bmj-2023-076019
Wong I, Choi Y, Lam R, et al. Impact of post-dispatch advice on bystander cardiopulmonary resuscitation in out-of-hospital cardiac arrest in hong kong. Hong Kong Journal of Emergency Medicine, 2023;30(6):413-421. doi:10.1177/10249079231183428
Ko R, Huh K, Kim D, et al. Nosocomial infections in in-hospital cardiac arrest patients who undergo extracorporeal cardiopulmonary resuscitation. Plos One, 2020;15(12):e0243838. doi:10.1371/journal.pone.0243838
Yogaratnam J, Jacob R, Naik S, et al. Prolonged delirium secondary to hypoxic-ischemic encephalopathy following cardiac arrest. Clinical Psychopharmacology and Neuroscience, 2023;11(1):39-42. doi:10.9758/cpn.2013.11.1.39
Chang C, Lian H, Sung Y. Cystic encephalomalacia in a young woman after cardiac arrest due to diabetic ketoacidosis and thyroid storm. Cureus, 2022;4(3):e23707. doi:/10.7759/cureus.23707
Urbanoski K, Joordens C, Kolla G, et al. Community networks of services for pregnant and parenting women with problematic substance use. Plos One, 2018;13(11):e0206671. doi:10.1371/journal.pone.0206671
Onyenwe C, Onwumere C, Odilibe I. (2024). Public health strategies for preventing youth substance use: a review of prevention programs and conceptual approaches. International Journal of Biology and Pharmacy Research Updates, 2024;3(1):012-019. doi:10.53430/ijbpru.2024.3.1.0022
Nedungadi P, Menon R, Gutjahr G, et al. Adolescents as ambassadors in substance abuse awareness programs: interpersonal and intrapersonal effects. Sustainability, 2023;15(4):3491. doi:10.3390/su15043491
Dague A, Chavva H, Brazeau D, et al. Maternal use of methamphetamine induces sex‐dependent changes in myocardial gene expression in adult offspring. Physiological Reports, 2022;10(22):e15509. doi:10.14814/phy2.15509
Alniak I, Ulusoy S, Cebeci BA. The use of methamphetamine in the probation population. Dusunen Adam Journal of Psychiatry and Neurological Sciences 2022 ;35(1):2-12. doi: 10.14744/DAJPNS.2022.00166
Liu Z, Zhou T, Ziegler A, et al. Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications. Oxidative Medicine and Cellular Longevity, 2017: 2525967. doi:10.1155/2017/2525967
Akanji M, Rotimi D, Elebiyo T, et al. Redox homeostasis and prospects for therapeutic targeting in neurodegenerative disorders. Oxidative Medicine and Cellular Longevity, 2021: 9971885. doi:10.1155/2021/9971885
Prangnell A, Daly-Grafstein B, Dong H, et al. Factors associated with inability to access addiction treatment among people who inject drugs in vancouver, canada. Substance Abuse Treatment Prevention and Policy, 2016;11(9). doi:10.1186/s13011-016-0053-6
Stein B, Pacula R, Gordon A, et al. Where is buprenorphine dispensed to treat opioid use disorders? the role of private offices, opioid treatment programs, and substance abuse treatment facilities in urban and rural counties. Milbank Quarterly, 2015;93(3):561-583. doi:10.1111/1468-0009.12137