Masif Hemoptizi ile Yoğun Bakıma Kabul Edilen Hastada Primer Testis Tümörü Tanısı
Özet
Masif hemoptizi, hava yolu obstrüksiyonu, oksijenizasyon bozulması ve hemodinamik instabiliteye yol açabilen, acil değerlendirme ve hızlı müdahale gerektiren yaşamı tehdit eden bir klinik durumdur. Çoğunlukla bronşiyal arter kaynaklı kanamalar sorumludur. Etiyolojide enfeksiyonlar, bronşektazi, maligniteler, vasküler anomaliler ve immünolojik hastalıklar ön planda yer alırken nadiren ekstratorasik maligniteler de ilk bulgu olarak hemoptizi ile ortaya çıkabilir. Masif hemoptizi yönetiminde öncelik hava yolu güvenliğinin sağlanması ve hemodinamik stabilizasyonun korunmasıdır. Tanısal yaklaşımda kontrastlı toraks BT ve bronkoskopi kanama odağının lokalizasyonu ve etiyolojinin belirlenmesinde kritik rol oynar. Tedavi; medikal stabilizasyon, antifibrinolitik ajanlar, bronkoskopik girişimler ve bronşiyal arter embolizasyonunu içerir; seçilmiş olgularda cerrahi tedavi gerekebilir. Sunulan olgu, genç bir hastada masif hemoptizinin metastatik testis tümörünün ilk bulgusu olarak ortaya çıkabileceğini göstermekte ve kapsamlı fizik muayene ile geniş diferansiyel tanı yaklaşımının önemini vurgulamaktadır.
Massive hemoptysis is a life-threatening clinical condition that may lead to airway obstruction, impaired oxygenation, and hemodynamic instability, requiring urgent evaluation and prompt intervention. Most cases originate from the bronchial arterial circulation. While infections, bronchiectasis, malignancies, vascular abnormalities, and immune-mediated diseases constitute the major etiologies, extrathoracic malignancies may rarely present with hemoptysis as the initial manifestation. Management priorities include securing the airway and maintaining hemodynamic stability. Contrast-enhanced chest CT and bronchoscopy play critical roles in localizing the bleeding source and identifying the underlying cause. Treatment strategies include medical stabilization, antifibrinolytic therapy, bronchoscopic interventions, and bronchial artery embolization, with surgical resection reserved for selected cases. The presented case illustrates that massive hemoptysis may be the first manifestation of metastatic testicular cancer in a young patient and emphasizes the importance of thorough physical examination and a broad differential diagnostic approach.
Referanslar
Ibrahim WH. Massive haemoptysis: the definition should be revised. Eur Respir J 2008; 32:1131.
Sakr L, Dutau H. Massive hemoptysis: an update on the role of bronchoscopy in diagnosis and management. Respiration 2010; 80:38.
Khalil A, Parrot A, Nedelcu C, et al. Severe hemoptysis of pulmonary arterial origin: signs and role of multidetector row CT angiography. Chest 2008; 133:212.
Knott-Craig CJ, Oostuizen JG, Rossouw G, et al. Management and prognosis of massive hemoptysis. Recent experience with 120 patients. J Thorac Cardiovasc Surg 1993; 105:394.
Cahill BC, Ingbar DH. Massive hemoptysis. Assessment and management. Clin Chest Med 1994; 15:147.
Rasmussen, V. On haemoptysis, especially when fatal, in its anatomical and clinical aspects. Edinburgh Med J 1968; 14:385.
Cahill BC, Ingbar DH. Massive hemoptysis. Assessment and management. Clin Chest Med 1994; 15:147.
Muniappan A, Tapias LF, Butala P, et al. Surgical therapy of pulmonary aspergillomas: a 30-year North American experience. Ann Thorac Surg 2014; 97:432.
Farid S, Mohamed S, Devbhandari M, et al. Results of surgery for chronic pulmonary Aspergillosis, optimal antifungal therapy and proposed high risk factors for recurrence--a National Centre's experience. J Cardiothorac Surg 2013; 8:180.
Pea L, Roda L, Boussaud V, Lonjon B. Desmopressin therapy for massive hemoptysis associated with severe leptospirosis. Am J Respir Crit Care Med 2003; 167: 726-8
Porter DK, Van Every MJ, Anthracite RF, Mack JW Jr. Massive hemoptysis in cystic fibrosis. Arch Intern Med 1983; 143: 287-90.
Kucukay F, Topcuoglu OM, Alpar A, et al. Bronchial Artery Embolization with Large Sized (700-900 µm) Tris-acryl Microspheres (Embosphere) for Massive Hemoptysis: Long-Term Results (Clinical Research). Cardiovasc Intervent Radiol 2018; 41:225.
Shigemura N, Wan IY, Yu SC, et al. Multidisciplinary management of life-threatening massive hemoptysis: a 10-year experience. Ann Thorac Surg 2009; 87:849.
Razazi K, Parrot A, Khalil A, et al. Severe haemoptysis in patients with nonsmall cell lung carcinoma. Eur Respir J 2015; 45:756.
Scapa JV, Fishbein GA, Wallace WD, Fishbein MC. Diffuse Alveolar Hemorrhage and Pulmonary Vasculitides: Histopathologic Findings. Semin Respir Crit Care Med 2018; 39:425.
Panoskaltsis-Mortari A, Griese M, Madtes DK, et al. An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med 2011; 183:1262.
Du Rand IA, Blaikley J, Booton R, et al. British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE. Thorax 2013; 68 Suppl 1:i1.
Hetzel J, Maldonado F, Ravaglia C, et al. Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases: Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure. Respiration 2018; 95:188.
Dixit MD, Gan M, Narendra NG, et al. Aortopulmonary fistula: a rare complication of an aortic aneurysm. Tex Heart Inst J 2009; 36:483.
Sakr L, Dutau H. Massive hemoptysis: an update on the role of bronchoscopy in diagnosis and management. Respiration. 2010;80(1):38-58
Wand O, Guber E, Guber A, et al. Inhaled Tranexamic Acid for Hemoptysis Treatment: A Randomized Controlled Trial. Chest 2018; 154:1379.
Revel MP, Fournier LS, Hennebicque AS, et al. Can CT replace bronchoscopy in the detection of the site and cause of bleeding in patients with large or massive hemoptysis?AJR Am J Roentgenol. 2002;179(5):1217-24.
Khalil A, Soussan M, Mangiapan G, et al. Utility of high-resolution chest CT scan in the emergency management of hemoptysis in the intensive care unit: severity, localization and aetiology. BJR 2007; 80:21-25.
Conlan AA, Hurwitz SS. Management of massive haemoptysis with the rigid bronchoscope and cold saline lavage. Thorax 1980; 35:901-904.
Gong HJ, Salvatierra C. Clinical efficacy of early and delayed fiberoptic bronchoscopy in patients with hemoptysis. Am Rev Respir Dis 1981;124:221-225.
Cahill BC, Ingbar DH. Massive hemoptysis. Assessment and management. Clin Chest Med 1994; 15:147.
Zamani A. Bronchoscopic intratumoral injection of tranexamic acid: a new technique for control of biopsy-induced bleeding. Blood Coagul Fibrinolysis 2011; 22:440.
de Gracia J, de la Rosa D, Catalán E, et al. Use of endoscopic fibrinogen-thrombin in the treatment of severe hemoptysis. Respir Med 2003; 97:790.
Peralta AR, Chawla M, Lee RP. Novel Bronchoscopic Management of Airway Bleeding With Absorbable Gelatin and Thrombin Slurry. J Bronchology Interv Pulmonol 2018; 25:204.
Anantham D, Jagadesan R, Tiew PE. Clinical review: Independent lung ventilation in critical care. Crit Care 2005; 9:594.
Jolliet P, Soccal P, Chevrolet JC. Control of massive hemoptysis by endobronchial tamponade with a pulmonary artery balloon catheter. Crit Care Med 1992; 20:1730
Jeon K, Kim H, Yu CM, et al. Rigid bronchoscopic intervention in patients with respiratory failure caused by malignant central airway obstruction. J Thorac Oncol 2006; 1:319.
Lordan JL, Gascoigne A, Corris PA. The pulmonary physician in critical care * Illustrative case 7: Assessment and management of massive haemoptysis. Thorax 2003; 58:814.
Valipour A, Kreuzer A, Koller H, et al. Bronchoscopy-guided topical hemostatic tamponade therapy for the management of life-threatening hemoptysis. Chest 2005; 127:2113.
Sakr L, Dutau H. Massive hemoptysis: an update on the role of bronchoscopy in diagnosis and management. Respiration 2010; 80:38.
Khalil A, Parrot A, Nedelcu C, et al. Severe hemoptysis of pulmonary arterial origin: signs and role of multidetector row CT angiography. Chest 2008; 133:212.
Swanson KL, Johnson CM, Prakash UB, et al. Bronchial artery embolization : experience with 54 patients. Chest 2002; 121:789.
emy-Jardin M, Bouaziz N, Dumont P, et al. Bronchial and nonbronchial systemic arteries at multi-detector row CT angiography: comparison with conventional angiography. Radiology 2004; 233:741.
Sellars N, Belli AM. Non-bronchial collateral supply from the left gastric artery in massive haemoptysis. Eur Radiol 2001; 11:76.
Panda A, Bhalla AS, Goyal A. Bronchial artery embolization in hemoptysis: a systematic review. Diagn Interv Radiol 2017; 23:307.
Tom LM, Palevsky HI, Holsclaw DS, et al. Recurrent Bleeding, Survival, and Longitudinal Pulmonary Function following Bronchial Artery Embolization for Hemoptysis in a U.S. Adult Population. J Vasc Interv Radiol 2015; 26:1806.
Uflacker R, Kaemmerer A, Neves C, Picon PD. Management of massive hemoptysis by bronchial artery embolization. Radiology 1983; 146:627.
Ishikawa H, Ohbe H, Omachi N, et al. Spinal Cord Infarction after Bronchial Artery Embolization for Hemoptysis: A Nationwide Observational Study in Japan. Radiology 2021; 298:673.
Pekçolaklar A, Çitak N, Aksoy Y, et al. Surgery for life-threatening massive hemoptysis: Does the time of performed surgery and the timing of surgery affect the rates of complication and mortality? Indian J Surg 2022; 84:149.