Tekrarlayan Gebelik Kayıpları: Etyopatogenez, Tanı Algoritmaları ve Kanıta Dayalı Yönetimin Kapsamlı İncelemesi

Özet

Referanslar

Regan L, Rai R. Epidemiology and the medical causes of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14(5):839-54.

The ESHRE Guideline Group on RPL. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open. 2017;2017(2):ho004.

Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2020;113(5):973-982.

Garrido-Gimenez C, Alijotas-Reig J. Recurrent miscarriage: causes, evaluation and management. Postgrad Med J. 2015;91(1073):151-162.

Sugiura-Ogasawara M, et al. Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage. Hum Reprod. 2012;27(8):2297-302.

De Braekeleer M, Dao TN. Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod. 1990;5:519–28.

Stephenson MD, Sierra S. Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of a structural chromosome rearrangement. Hum Reprod. 2006;21:1076–82.

Chan YY, et al. Prevalence of congenital uterine anomalies in unselected and high risk populations: a systematic review. Hum Reprod Update. 2011;17(6):761-71.

Grimbizis GF, et al. Hysteroscopic septum resection in women with recurrent abortions or infertility. Hum Reprod. 1998;13(5):1188-93.

Alexander EK, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-389.

Palomba S, et al. Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review. Fertil Steril. 2009;92(5):1646-58.

Miyakis S, Lockshin MD, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306.

Quenby S, et al. (ALIFE2 Investigators). ALIFE2 study: Low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia. Lancet. 2023.

Robinson L, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod. 2012;27(10):2908-17.

McQueen DB, et al. Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil Steril. 2015;104(4):927-31.

Empson M, et al. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev. 2005;(2):CD002859.

Coomarasamy A, et al. PROMISE: Progesterone in Recurrent Miscarriage. N Engl J Med. 2015;373:2141-8.

Coomarasamy A, et al. Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence (PRISM Trial). N Engl J Med. 2019;380:1815-1824.

Musters AM, et al. Supportive care for women with unexplained recurrent pregnancy loss: systematic review. BMJ. 2011;342:d3689.

Referanslar

Regan L, Rai R. Epidemiology and the medical causes of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14(5):839-54.

The ESHRE Guideline Group on RPL. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open. 2017;2017(2):ho004.

Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2020;113(5):973-982.

Garrido-Gimenez C, Alijotas-Reig J. Recurrent miscarriage: causes, evaluation and management. Postgrad Med J. 2015;91(1073):151-162.

Sugiura-Ogasawara M, et al. Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage. Hum Reprod. 2012;27(8):2297-302.

De Braekeleer M, Dao TN. Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod. 1990;5:519–28.

Stephenson MD, Sierra S. Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of a structural chromosome rearrangement. Hum Reprod. 2006;21:1076–82.

Chan YY, et al. Prevalence of congenital uterine anomalies in unselected and high risk populations: a systematic review. Hum Reprod Update. 2011;17(6):761-71.

Grimbizis GF, et al. Hysteroscopic septum resection in women with recurrent abortions or infertility. Hum Reprod. 1998;13(5):1188-93.

Alexander EK, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-389.

Palomba S, et al. Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review. Fertil Steril. 2009;92(5):1646-58.

Miyakis S, Lockshin MD, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306.

Quenby S, et al. (ALIFE2 Investigators). ALIFE2 study: Low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia. Lancet. 2023.

Robinson L, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod. 2012;27(10):2908-17.

McQueen DB, et al. Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil Steril. 2015;104(4):927-31.

Empson M, et al. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev. 2005;(2):CD002859.

Coomarasamy A, et al. PROMISE: Progesterone in Recurrent Miscarriage. N Engl J Med. 2015;373:2141-8.

Coomarasamy A, et al. Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence (PRISM Trial). N Engl J Med. 2019;380:1815-1824.

Musters AM, et al. Supportive care for women with unexplained recurrent pregnancy loss: systematic review. BMJ. 2011;342:d3689.

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1 Haziran 2026

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