Maggot Terapisinin (Larva Tedavisi) Cerrahi Bakımda Kullanımı
Özet
Larva terapisi olarak da bilinen Maggot Debritman Terapisi, yarayı temizleme ve debride etme amacıyla kullanılan geleneksel ve tamamlayıcı tıp uygulamalarından biridir. Terapi sırasında, steril sinek larvaları nekrotik dokuyu parçalamakta ve yara debritmanını destekleyen enzimler salgılamaktadırlar. İnfeksiyonu kontrol etmeye yardımcı olan antimikrobiyal özelliklere de sahip olan larvalar, yara iyileşmesini desteklemede ve bakteri yükünü azaltmada etkili olup, anestezi riskini ve ameliyat süresini azaltmakta, akut ve kronik yaraların debritmanında başarıyla kullanılmaktadır. Maggot terapisinin uygulanmasında rol alan cerrahi hemşiresi ve diğer sağlık profesyonellerinin bilgi, beceri ve deneyimleri bu tedavinin güvenle kullanılmasında önemlidir.
Maggot debridement therapy, also known as larva therapy, is a traditional and complementary medicine practice used to clean and debride wounds. During therapy, sterile fly larvae break down necrotic tissue and release enzymes that support wound debridement. Possessing antimicrobial properties that help control infection, the larvae are effective in promoting wound healing and reducing bacterial load, thereby decreasing anesthesia risk and surgery time. They are successfully used in the debridement of acute and chronic wounds. The knowledge, skills, and experience of surgical nurses and other healthcare professionals involved in the application of maggot therapy are crucial for its safe use.
Referanslar
Davydov L. Maggot therapy in wound management in modern era and a review of published literature. Journal of Pharmacy Practice. 2010;24(1):89-93. doi:10.1177/0897190010366938
Morozov A, Sherman R. Survey of patients of the Tver region of Russia regarding maggots and maggot therapy. International Wound Journal. 2018;16(2):401-405. doi:10.1111/iwj.13046
Sherman R. Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair and Regeneration. 2002;10(4):208-214. doi:10.1046/j.1524-475x.2002.10403.x
Bazaliński D, Przybek-Mita J, Pytlak K, et al. Larval wound therapy: Possibilities and potential limitations-a literature review. J Clin Med. 2023;12(21):6862. doi:10.3390/jcm12216862
Polat N, Koç M, Ayhan H, et al. A systematic review of effective bioagent in chronic wounds: The maggot biotherapy pyramid. Ankara Medical Journal. 2022;22(2):282-304. doi:10.5505/amj.2022.43109
Mumcuoğlu KY, Özkan AT. Süpüratif kronik yaraların maggot debridman tedavisi. Türkiye Parazitoloji Dergisi. 2009;33(4):307-315.
Dauros‐Singorenko P, Rosario R, Windsor J, et al. The transcriptional responses of cultured wound cells to the excretions and secretions of medicinal Lucilia sericata larvae. Wound Repair and Regeneration. 2017;25(1):51-61. doi:10.1111/wrr.12499
Zubir M, Holloway S, Norhayati M. Maggot therapy in wound healing: A systematic review. International Journal of Environmental Research and Public Health. 2020;17(17):6103-6114. doi:10.3390/ijerph17176103
Taylan Özkan A, Mumcuoğlu KY. Kronik venöz ülserli bir olgunun maggot debridman tedavisi ile sağaltımı. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2007;64(1):31-34.
Nigam Y. The principles of maggot therapy and its role in contemporary wound care. Nursing Times. 2021;117(9):39-44.
Sherman RA. Mechanisms of maggot-induced wound healing: what do we know, and where do we go from here? Evidence-Based Complementary and Alternative Medicine. 2014;2014(1):1-13. doi:10.1155/2014/592419
Mumcuoğlu KY. Clinical applications for maggots in wound care. The American Journal of Clinical Dermatology. 2001;2(4):219-227. doi:1175-0561/01/0004-0219/22.00/0
Nigam Y, Wilson MR. Maggot Debridement. In: Stadler F (ed.) A complete guide to maggot therapy: Clinical practice, therapeutic principles, production, distribution, and ethics. Cambridge: Open Book Publishers; 2022. p.143–152. doi:10.11647/OBP.0300.01
Telford G, Brown AP, Seabra RAM, et al. Degradation of eschar from venous leg ulcers using a recombinant chymotrypsin from Lucilia sericata. The British Journal of Dermatology. 2010;163(3):523-531. doi:10.1111/j.1365-2133.2010.09854.x
Brown A, Horobin A, Blount DG, et al. Blow fly Lucilia sericata nuclease digests DNA associated with wound slough/eschar and with Pseudomonas aeruginosa biofilm. Medical and Veterinary Entomology.2012;26(4):432-439.doi:10.1111/j.13652915.2012.01029.x
Thomas S, Wynn K, Fowler T, et al. The effect of containment on the properties of sterile maggots. The British Journal of Nursing. 2002;11(12):21-26. doi:10.12968/bjon.2002.11.Sup2.10294
Čeřovský V, Žďárek J, Fučík V, et al. Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata. Cellular and Molecular Life Sciences. 2010;67(3):455-466. doi: 10.1007/s00018-009-0194-0
Kenawy M, Abdel-Hamid Y. Maggot therapy “use of fly larvae for treatment of wounds”- a review. Egyptian Academic Journal of Biological Sciences E Medical Entomology & Parasitology. 2020;12(2):1-10. doi:10.21608/eajbse.2020.104166
Shayya S, Stadler F. Maggot therapy could provide affordable and efficacious wound care in Lebanon and other low- and middle-income countries. Healthcare in Low-Resource Settings. 2023;11(1):11161-11165. doi:10.4081/hls.2023.11161
Stadler F, Arjona T, Beaumont G, et al. Maggot menageries: High school student contributions to medicinal maggot production in compromised healthcare settings. Citizen Science Theory and Practice. 2021;6(1): 36-52. doi:10.5334/cstp.401
Morris D, Flores M, Harris L, et al. Larval therapy and larval excretions/secretions: A potential treatment for biofilm in chronic wounds? a systematic review. Microorganisms. 2023;11(2):457-456. doi:10.3390/microorganisms11020457
Sherman RA, Stadler F. Wound aetiologies, patient characteristics, and healthcare settings amenable to maggot therapy. In: Stadler F (ed.) A Complete Guide to Maggot Therapy. Cambridge: Open Book Publishers; 2022. p.39–63. doi:10.11647/OBP.0300.01
Jordan A, Khiyani N, Bowers SR, et al. Maggot debridement therapy: A practical review. International Journal of Academic Medicine. 2018;4(1):21-34. doi:10.4103/IJAM.IJAM_6_18
Fonseca‐Muñoz A, Sarmiento‐Jiménez H, Pérez‐Pacheco R, et al. Clinical study of maggot therapy for Fournier's gangrene. International Wound Journal. 2020;17(6):1642-1649. doi:10.1111/iwj.13444
Przybek-Mita J, Bazaliński D, Sztembis R, et al. Perceived stress and readiness to undertake biodebridement in the group of nurses undertaking prevention and treatment of chronic wounds. Frontiers in Public Health. 2022;10(1):1-11. doi:10.3389/fpubh.2022.1090677
Hopkins R, Williams S, Brown A, et al. Evaluating nursing opinion and perception of maggot therapy for hard-to-heal wound management. Journal of Wound Care. 2022;31(10):846-863. doi:10.12968/jowc.2022.31.10.846
Asotibe J, Achebe I, Mbachi C, et al. Wound myiasis in severe venous stasis ulcer. Cureus. 2020;12(6):e8585. doi:10.7759/cureus.8585
Margolin L, Gialanella P. Assessment of the antimicrobial properties of maggots. International Wound Journal. 2010;7(3):202-204. doi:10.1111/j.1742-481x.2010.00234.x
Mumford Z, Nigam Y. Maggots in medicine: A narrative review discussing the barriers to maggot debridement therapy and its utilisation in the treatment of chronic wounds. Journal of Clinical Medicine. 2024;13(22):6746-6773. doi:10.3390/jcm13226746
Meimeti E, Marakomichelakis G, Provatopoulou X, et al. Maggot debridement therapy in diabetic foot ulcer patients in Greece. Research Square. 2023;Version 1. doi:10.21203/rs.3.rs-3584790/v1
Uçar N, Kuş FS, Fırat T. Diabetik ayak ülserli hastada maggot debridman tedavisine ağrısız yaklaşım: Olgu sunumu. International Anatolia Academic Online Journal Health Sciences. 2018;4(1):1-7.
Phang Z, Khoo S, Gunasagaran J, et al. Clinical outcome of maggot debridement therapy followed by negative pressure wound therapy for chronic hand wound with multi-drug resistant organism infection. Journal of Orthopaedic Surgery. 2021;29(3):1-7. doi:10.1177/23094990211067302
Peterson J, Jung J, Hoffman L, et al. Nursing management of maggot debridement therapy (MDT) for wound debridement in patients with chronic graft versus host disease wounds. Biology of Blood and Marrow Transplantation. 2016;22(3):456-466. doi:10.1016/j.bbmt.2015.11.1041
Lepage O, Doumbia A, Perron‐Lepage M, et al. The use of maggot debridement therapy in 41 equids. Equine Veterinary Journal. 2012;44(43):120-125. doi:10.1111/j.2042-3306.2012.00609.x
Stadler F, Shaban R, Tatham P. Maggot debridement therapy in disaster medicine. Prehospital and Disaster Medicine. 2015;31(1):79-84. doi:10.1017/s1049023x15005427
Referanslar
Davydov L. Maggot therapy in wound management in modern era and a review of published literature. Journal of Pharmacy Practice. 2010;24(1):89-93. doi:10.1177/0897190010366938
Morozov A, Sherman R. Survey of patients of the Tver region of Russia regarding maggots and maggot therapy. International Wound Journal. 2018;16(2):401-405. doi:10.1111/iwj.13046
Sherman R. Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair and Regeneration. 2002;10(4):208-214. doi:10.1046/j.1524-475x.2002.10403.x
Bazaliński D, Przybek-Mita J, Pytlak K, et al. Larval wound therapy: Possibilities and potential limitations-a literature review. J Clin Med. 2023;12(21):6862. doi:10.3390/jcm12216862
Polat N, Koç M, Ayhan H, et al. A systematic review of effective bioagent in chronic wounds: The maggot biotherapy pyramid. Ankara Medical Journal. 2022;22(2):282-304. doi:10.5505/amj.2022.43109
Mumcuoğlu KY, Özkan AT. Süpüratif kronik yaraların maggot debridman tedavisi. Türkiye Parazitoloji Dergisi. 2009;33(4):307-315.
Dauros‐Singorenko P, Rosario R, Windsor J, et al. The transcriptional responses of cultured wound cells to the excretions and secretions of medicinal Lucilia sericata larvae. Wound Repair and Regeneration. 2017;25(1):51-61. doi:10.1111/wrr.12499
Zubir M, Holloway S, Norhayati M. Maggot therapy in wound healing: A systematic review. International Journal of Environmental Research and Public Health. 2020;17(17):6103-6114. doi:10.3390/ijerph17176103
Taylan Özkan A, Mumcuoğlu KY. Kronik venöz ülserli bir olgunun maggot debridman tedavisi ile sağaltımı. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2007;64(1):31-34.
Nigam Y. The principles of maggot therapy and its role in contemporary wound care. Nursing Times. 2021;117(9):39-44.
Sherman RA. Mechanisms of maggot-induced wound healing: what do we know, and where do we go from here? Evidence-Based Complementary and Alternative Medicine. 2014;2014(1):1-13. doi:10.1155/2014/592419
Mumcuoğlu KY. Clinical applications for maggots in wound care. The American Journal of Clinical Dermatology. 2001;2(4):219-227. doi:1175-0561/01/0004-0219/22.00/0
Nigam Y, Wilson MR. Maggot Debridement. In: Stadler F (ed.) A complete guide to maggot therapy: Clinical practice, therapeutic principles, production, distribution, and ethics. Cambridge: Open Book Publishers; 2022. p.143–152. doi:10.11647/OBP.0300.01
Telford G, Brown AP, Seabra RAM, et al. Degradation of eschar from venous leg ulcers using a recombinant chymotrypsin from Lucilia sericata. The British Journal of Dermatology. 2010;163(3):523-531. doi:10.1111/j.1365-2133.2010.09854.x
Brown A, Horobin A, Blount DG, et al. Blow fly Lucilia sericata nuclease digests DNA associated with wound slough/eschar and with Pseudomonas aeruginosa biofilm. Medical and Veterinary Entomology.2012;26(4):432-439.doi:10.1111/j.13652915.2012.01029.x
Thomas S, Wynn K, Fowler T, et al. The effect of containment on the properties of sterile maggots. The British Journal of Nursing. 2002;11(12):21-26. doi:10.12968/bjon.2002.11.Sup2.10294
Čeřovský V, Žďárek J, Fučík V, et al. Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata. Cellular and Molecular Life Sciences. 2010;67(3):455-466. doi: 10.1007/s00018-009-0194-0
Kenawy M, Abdel-Hamid Y. Maggot therapy “use of fly larvae for treatment of wounds”- a review. Egyptian Academic Journal of Biological Sciences E Medical Entomology & Parasitology. 2020;12(2):1-10. doi:10.21608/eajbse.2020.104166
Shayya S, Stadler F. Maggot therapy could provide affordable and efficacious wound care in Lebanon and other low- and middle-income countries. Healthcare in Low-Resource Settings. 2023;11(1):11161-11165. doi:10.4081/hls.2023.11161
Stadler F, Arjona T, Beaumont G, et al. Maggot menageries: High school student contributions to medicinal maggot production in compromised healthcare settings. Citizen Science Theory and Practice. 2021;6(1): 36-52. doi:10.5334/cstp.401
Morris D, Flores M, Harris L, et al. Larval therapy and larval excretions/secretions: A potential treatment for biofilm in chronic wounds? a systematic review. Microorganisms. 2023;11(2):457-456. doi:10.3390/microorganisms11020457
Sherman RA, Stadler F. Wound aetiologies, patient characteristics, and healthcare settings amenable to maggot therapy. In: Stadler F (ed.) A Complete Guide to Maggot Therapy. Cambridge: Open Book Publishers; 2022. p.39–63. doi:10.11647/OBP.0300.01
Jordan A, Khiyani N, Bowers SR, et al. Maggot debridement therapy: A practical review. International Journal of Academic Medicine. 2018;4(1):21-34. doi:10.4103/IJAM.IJAM_6_18
Fonseca‐Muñoz A, Sarmiento‐Jiménez H, Pérez‐Pacheco R, et al. Clinical study of maggot therapy for Fournier's gangrene. International Wound Journal. 2020;17(6):1642-1649. doi:10.1111/iwj.13444
Przybek-Mita J, Bazaliński D, Sztembis R, et al. Perceived stress and readiness to undertake biodebridement in the group of nurses undertaking prevention and treatment of chronic wounds. Frontiers in Public Health. 2022;10(1):1-11. doi:10.3389/fpubh.2022.1090677
Hopkins R, Williams S, Brown A, et al. Evaluating nursing opinion and perception of maggot therapy for hard-to-heal wound management. Journal of Wound Care. 2022;31(10):846-863. doi:10.12968/jowc.2022.31.10.846
Asotibe J, Achebe I, Mbachi C, et al. Wound myiasis in severe venous stasis ulcer. Cureus. 2020;12(6):e8585. doi:10.7759/cureus.8585
Margolin L, Gialanella P. Assessment of the antimicrobial properties of maggots. International Wound Journal. 2010;7(3):202-204. doi:10.1111/j.1742-481x.2010.00234.x
Mumford Z, Nigam Y. Maggots in medicine: A narrative review discussing the barriers to maggot debridement therapy and its utilisation in the treatment of chronic wounds. Journal of Clinical Medicine. 2024;13(22):6746-6773. doi:10.3390/jcm13226746
Meimeti E, Marakomichelakis G, Provatopoulou X, et al. Maggot debridement therapy in diabetic foot ulcer patients in Greece. Research Square. 2023;Version 1. doi:10.21203/rs.3.rs-3584790/v1
Uçar N, Kuş FS, Fırat T. Diabetik ayak ülserli hastada maggot debridman tedavisine ağrısız yaklaşım: Olgu sunumu. International Anatolia Academic Online Journal Health Sciences. 2018;4(1):1-7.
Phang Z, Khoo S, Gunasagaran J, et al. Clinical outcome of maggot debridement therapy followed by negative pressure wound therapy for chronic hand wound with multi-drug resistant organism infection. Journal of Orthopaedic Surgery. 2021;29(3):1-7. doi:10.1177/23094990211067302
Peterson J, Jung J, Hoffman L, et al. Nursing management of maggot debridement therapy (MDT) for wound debridement in patients with chronic graft versus host disease wounds. Biology of Blood and Marrow Transplantation. 2016;22(3):456-466. doi:10.1016/j.bbmt.2015.11.1041
Lepage O, Doumbia A, Perron‐Lepage M, et al. The use of maggot debridement therapy in 41 equids. Equine Veterinary Journal. 2012;44(43):120-125. doi:10.1111/j.2042-3306.2012.00609.x
Stadler F, Shaban R, Tatham P. Maggot debridement therapy in disaster medicine. Prehospital and Disaster Medicine. 2015;31(1):79-84. doi:10.1017/s1049023x15005427
