β-laktam Antibiyotikler
Özet
β-laktam grubu antibiyotikler, β-laktam halkası varlığı nedeni ile isimlendirilmiş bakterisidal etkili antibiyotik grubudur. Hem gram negatif hem de gram pozitif hücre duvarı sentezinden sorumlu penisilin bağlayan proteinlerin (PBP) transpeptidaz aktivitesini inhibe ederek peptidoglikan sentezini bozarlar. Bu antibiyotikler, β-laktam halkası birimine farklı aktif grupların girmesi ile antibiyotik spektrumlarındaki çeşitliliklerine göre sınıflandırılırlar. Bu sınıflandırmaya göre: Penisilinler, sefalosporinler, karbapenemler ve monobaktamlar grupları bulunmaktadır. Ek olarak β-laktam/β-laktamaz kombinasyonları etkinliklerini arttırmak amacı ile kullanıma alınmıştır.
β-lactam group antibiotics are a group of bactericidal antibiotics named for the presence of a β-lactam ring. They generally act by inhibiting the transpeptidase activity of penicillin-binding proteins (PBPs) which are responsible for both gram negative and gram positive cell wall synthesis therefore disrupting peptidoglycan synthesis. They are sub-classified according to the diversity of their antibacterial spectrums by the integration of different active groups into the β-lactam ring unit. This group includes penicillins, cephalosporins, carbapenems and monobactams. In addition, β-lactam/β-lactamase combinations have been developed to increase their effectiveness.
Referanslar
Pandey N, Cascella M. Beta-Lactam Antibiotics. 2023 Jun 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
Moehring R, Sarubbi C. Prolonged infusions of β-lactam antibiotics. Uptodate Feb 2025. https://www.uptodate.com/contents/prolonged-infusions-of-beta-lactam-antibiotics/print (Erişim tarihi: 3.11.2025)
Craig WA. Pharmacokinetic/pharmocodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998;26:1-10.
Letourneau AR. β-lactam antibiotics: Mechanisms of action and resistance and adverse effects Bölüm Ed: David C Hooper Uptodate Feb 2025. http://112.2.34.14:9095/contents/beta-lactam-antibiotics-mechanisms-of-action-and-resistance-and-adverse-effects/print (Erişim tarihi: 3.11.2025)
Lima LM, Silva BNMD, Barbosa G, Barreiro EJ. β-lactam antibiotics: An overview from a medicinal chemistry perspective. Eur J Med Chem. 2020;208:112829. doi: 10.1016/j.ejmech.2020.112829.
The Sanford Guide to Antimicrobial Therapy 2025 (55th edition) Editörler: D.N.Gilbert, H.F.Chambers M.S. Saag AT, Pavia D, Black DH, Boucher DO, Freedman Kim.
Jacobson KL, Cohen SH, Inciardi JF et al. Clin. Infect Dis. 1995;21(5):1107-1113.
Siedner MJ, Galar A, Guzman-Suares BB et al. Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia. Clin. Infect Dis. 2014; 58(11) : 1554. doi: 10.1093/cid/ciu182.
Referanslar
Pandey N, Cascella M. Beta-Lactam Antibiotics. 2023 Jun 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
Moehring R, Sarubbi C. Prolonged infusions of β-lactam antibiotics. Uptodate Feb 2025. https://www.uptodate.com/contents/prolonged-infusions-of-beta-lactam-antibiotics/print (Erişim tarihi: 3.11.2025)
Craig WA. Pharmacokinetic/pharmocodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998;26:1-10.
Letourneau AR. β-lactam antibiotics: Mechanisms of action and resistance and adverse effects Bölüm Ed: David C Hooper Uptodate Feb 2025. http://112.2.34.14:9095/contents/beta-lactam-antibiotics-mechanisms-of-action-and-resistance-and-adverse-effects/print (Erişim tarihi: 3.11.2025)
Lima LM, Silva BNMD, Barbosa G, Barreiro EJ. β-lactam antibiotics: An overview from a medicinal chemistry perspective. Eur J Med Chem. 2020;208:112829. doi: 10.1016/j.ejmech.2020.112829.
The Sanford Guide to Antimicrobial Therapy 2025 (55th edition) Editörler: D.N.Gilbert, H.F.Chambers M.S. Saag AT, Pavia D, Black DH, Boucher DO, Freedman Kim.
Jacobson KL, Cohen SH, Inciardi JF et al. Clin. Infect Dis. 1995;21(5):1107-1113.
Siedner MJ, Galar A, Guzman-Suares BB et al. Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia. Clin. Infect Dis. 2014; 58(11) : 1554. doi: 10.1093/cid/ciu182.
