Osteoartrite Algoritmik Yaklaşım

1. Xing D, Wang Q, Yang Z, Hou Y, Zhang W, Chen Y, Lin J. Evi-dence-based guidelines for intra-articular injection in knee osteoarthritis: Formulating and evaluating research questi¬ons. Int J Rheum Dis. 2018 Aug;21(8):1533-1542.

2. Miller A, Lutsky KF, Shearin J, Cantlon M, Wolfe S, Bered¬jiklian PK. Radiographic Patterns of Radiocarpal and Mid¬carpal Arthritis. J Am Acad Orthop Surg Glob Res Rev. 2017 Jun;1(3):e017.

3. Berenbaum F, Wallace IJ, Lieberman DE, Felson DT. Mo¬dern-day environmental factors in the pathogenesis of oste¬oarthritis. Nat Rev Rheumatol. 2018 Nov;14(11):674-681.

4. Kriz J, Seegenschmiedt HM, Bartels A, Micke O, Muecke R, Schaefer U, Haverkamp U, Eich HT. Updated strategies in the treatment of benign diseases-a patterns of care study of the german cooperative group on benign diseases. Adv Radiat Oncol. 2018 Jul-Sep;3(3):240-244.

5. Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biol. 2018 Oct;71-72:51-69.

6. O’Brien J, Hamilton K, Williams A, Fell J, Mulford J, Che¬ney M, Wu S, Bird ML. Improving physical activity, pain and function in patients waiting for hip and knee arthroplasty by combining targeted exercise training with behaviour change counselling: study protocol for a randomised controlled tri¬al. Trials. 2018 Aug 07;19(1):425.

7. Loef M, Schoones JW, Kloppenburg M, Ioan-Facsinay A. Fat¬ty acids and osteoarthritis: different types, different effects. Jo¬int Bone Spine. 2019 Jul;86(4):451-458.

8. Donahue SW. Krogh’s principle for musculoskeletal physio¬logy and pathology. J Musculoskelet Neuronal Interact. 2018 Sep 01;18(3):284-291.

9. Tashjian RZ, Chalmers PN. Future Frontiers in Shoulder Arthroplasty and the Management of Shoulder Osteoarthri¬tis. Clin Sports Med. 2018 Oct;37(4):609-630.

10. Ackerman IN, Cavka B, Lippa J, Bucknill A. The feasibility of implementing the ICHOM Standard Set for Hip and Knee Osteoarthritis: a mixed-methods evaluation in public and pri¬vate hospital settings. J Patient Rep Outcomes. 2017;2:32.

11. Donahue SW. Krogh’s principle for musculoskeletal physio¬logy and pathology. J Musculoskelet Neuronal Interact. 2018 Sep 01;18(3):284-291.

12. di Laura Frattura G, Filardo G, Giunchi D, Fusco A, Zaffagni¬ni S, Candrian C. Risk of falls in patients with knee osteoarth¬ritis undergoing total knee arthroplasty: A systematic review and best evidence synthesis. J Orthop. 2018 Sep;15(3):903- 908.

13. Bortoluzzi A, Furini F, Scirè CA. Osteoarthritis and its mana-gement - Epidemiology, nutritional aspects and environmen¬tal factors. Autoimmun Rev. 2018 Nov;17(11):1097-1104.

14. Loures FB, Correia W, Reis JH, Pires E Albuquerque RS, de Paula Mozela A, de Souza EB, Maia PV, Barretto JM. Outco¬mes after knee arthroplasty in extra-articular deformity. Int Orthop. 2019 Sep;43(9):2065-2070.

15. Stewart HL, Kawcak CE. The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis. Front Vet Sci. 2018;5:178.

16. Quinn RH, Murray J, Pezold R, Hall Q. Management of Os-teoarthritis of the Hip. J Am Acad Orthop Surg. 2018 Oct 15;26(20):e434-e436.

17. Dobson GP, Letson HL, Grant A, McEwen P, Hazratwa¬la K, Wilkinson M, Morris JL. Defining the osteoarthritis patient: back to the future. Osteoarthritis Cartilage. 2018 Aug;26(8):1003-1007.

18. Healey EL, Afolabi EK, Lewis M, Edwards JJ, Jordan KP, Fin-ney A, Jinks C, Hay EM, Dziedzic KS. Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain. BMC Musculoskelet Disord. 2018 Aug 17;19(1):295

19. De Laroche R, Simon E, Suignard N, Williams T, Henry MP, Robin P, Abgral R, Bourhis D, Salaun PY, Dubrana F, Que¬rellou S. Clinical interest of quantitative bone SPECT-CT in the preoperative assessment of knee osteoarthritis. Medicine (Baltimore). 2018 Aug;97(35):e11943.

20. Ma X, Zhao W, Yang F, Chin KY. Efficacy and mechanisms of curcumin in the treatment of osteoarthritis: A scoping review. Biomol Biomed. 2025 Mar 7;25(4):761-785. doi: 10.17305/ bb.2024.11045. PMID: 39720988; PMCID: PMC11959387.

21. Bensa A, Previtali D, Sangiorgio A, Boffa A, Salerno M, Filar¬do G. PRP Injections for the Treatment of Knee Osteoarthri¬tis: The Improvement Is Clinically Significant and Influenced by Platelet Concentration: A Meta-analysis of Randomized Controlled Trials. Am J Sports Med. 2025 Mar;53(3):745-754. doi: 10.1177/03635465241246524. Epub 2025 Jan 3. PMID: 39751394; PMCID: PMC11874499.

22. Michel BA, Stucki G, Frey D, De Vathaire F, Vignon E, Bru-ehlmann P, Uebelhart D. Chondroitins 4 and 6 sulfate in os-teoarthritis of the knee: a randomized, controlled trial. Arth¬ritis Rheum. 2005 Mar;52(3):779-86. doi: 10.1002/art.20867. PMID: 15751094.

23. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005 Apr 18;2005(2):CD002946. doi: 10.1002/14651858.CD002946. pub2. PMID: 15846645; PMCID: PMC8459392.

24. Bruyere O, Pavelka K, Rovati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause. 2004 Mar-Apr;11(2):138-43. doi: 10.1097/01. gme.0000087983.28957.5d. PMID: 15021442.

25. Clegg DO, Reda DJ, Harris CL, Klein MA, O’Dell JR, Hoo¬per MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jack¬son CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808. doi: 10.1056/NEJMoa052771. PMID: 16495392.

26. Loyola-Sánchez A, Richardson J, MacIntyre NJ. Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis. Osteoarthritis Carti¬lage. 2010 Sep;18(9):1117-26. doi: 10.1016/j.joca.2010.06.010. Epub 2010 Jul 14. PMID: 20637297.

27. Zhang Y, Han Y, Sun Y, Hao L, Gao Y, Ye J, Wang H, Zhang T, Liu Y, Yang Y. Osteoarthritis: molecular pathogenesis and potential therapeutic options. Signal Transduct Target Ther. 2026 Mar 4;11(1):81. doi: 10.1038/s41392-025-02556-6. PMID: 41781374; PMCID: PMC12960730.

28. Johnston SS, Ammann E, Scamuffa R, Samuels J, Stokes A, Fegelman E, Hsiao CW. Association of body mass index and osteoarthritis with healthcare expenditures and utilizati¬on. Obes Sci Pract. 2020 Jan 13;6(2):139-151. doi: 10.1002/ osp4.398. PMID: 32313672; PMCID: PMC7156818.

29. Xiao ZF, Su GY, Hou Y, Chen SD, Lin DK. Cartilage degra-dation in osteoarthritis: A process of osteochondral remode¬ling resembles the endochondral ossification in growth pla¬te? Med Hypotheses. 2018 Dec;121:183-187. doi: 10.1016/j. mehy.2018.08.023. Epub 2018 Aug 27. PMID: 30396477.

1. Xing D, Wang Q, Yang Z, Hou Y, Zhang W, Chen Y, Lin J. Evi-dence-based guidelines for intra-articular injection in knee osteoarthritis: Formulating and evaluating research questi¬ons. Int J Rheum Dis. 2018 Aug;21(8):1533-1542.

2. Miller A, Lutsky KF, Shearin J, Cantlon M, Wolfe S, Bered¬jiklian PK. Radiographic Patterns of Radiocarpal and Mid¬carpal Arthritis. J Am Acad Orthop Surg Glob Res Rev. 2017 Jun;1(3):e017.

3. Berenbaum F, Wallace IJ, Lieberman DE, Felson DT. Mo¬dern-day environmental factors in the pathogenesis of oste¬oarthritis. Nat Rev Rheumatol. 2018 Nov;14(11):674-681.

4. Kriz J, Seegenschmiedt HM, Bartels A, Micke O, Muecke R, Schaefer U, Haverkamp U, Eich HT. Updated strategies in the treatment of benign diseases-a patterns of care study of the german cooperative group on benign diseases. Adv Radiat Oncol. 2018 Jul-Sep;3(3):240-244.

5. Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biol. 2018 Oct;71-72:51-69.

6. O’Brien J, Hamilton K, Williams A, Fell J, Mulford J, Che¬ney M, Wu S, Bird ML. Improving physical activity, pain and function in patients waiting for hip and knee arthroplasty by combining targeted exercise training with behaviour change counselling: study protocol for a randomised controlled tri¬al. Trials. 2018 Aug 07;19(1):425.

7. Loef M, Schoones JW, Kloppenburg M, Ioan-Facsinay A. Fat¬ty acids and osteoarthritis: different types, different effects. Jo¬int Bone Spine. 2019 Jul;86(4):451-458.

8. Donahue SW. Krogh’s principle for musculoskeletal physio¬logy and pathology. J Musculoskelet Neuronal Interact. 2018 Sep 01;18(3):284-291.

9. Tashjian RZ, Chalmers PN. Future Frontiers in Shoulder Arthroplasty and the Management of Shoulder Osteoarthri¬tis. Clin Sports Med. 2018 Oct;37(4):609-630.

10. Ackerman IN, Cavka B, Lippa J, Bucknill A. The feasibility of implementing the ICHOM Standard Set for Hip and Knee Osteoarthritis: a mixed-methods evaluation in public and pri¬vate hospital settings. J Patient Rep Outcomes. 2017;2:32.

11. Donahue SW. Krogh’s principle for musculoskeletal physio¬logy and pathology. J Musculoskelet Neuronal Interact. 2018 Sep 01;18(3):284-291.

12. di Laura Frattura G, Filardo G, Giunchi D, Fusco A, Zaffagni¬ni S, Candrian C. Risk of falls in patients with knee osteoarth¬ritis undergoing total knee arthroplasty: A systematic review and best evidence synthesis. J Orthop. 2018 Sep;15(3):903- 908.

13. Bortoluzzi A, Furini F, Scirè CA. Osteoarthritis and its mana-gement - Epidemiology, nutritional aspects and environmen¬tal factors. Autoimmun Rev. 2018 Nov;17(11):1097-1104.

14. Loures FB, Correia W, Reis JH, Pires E Albuquerque RS, de Paula Mozela A, de Souza EB, Maia PV, Barretto JM. Outco¬mes after knee arthroplasty in extra-articular deformity. Int Orthop. 2019 Sep;43(9):2065-2070.

15. Stewart HL, Kawcak CE. The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis. Front Vet Sci. 2018;5:178.

16. Quinn RH, Murray J, Pezold R, Hall Q. Management of Os-teoarthritis of the Hip. J Am Acad Orthop Surg. 2018 Oct 15;26(20):e434-e436.

17. Dobson GP, Letson HL, Grant A, McEwen P, Hazratwa¬la K, Wilkinson M, Morris JL. Defining the osteoarthritis patient: back to the future. Osteoarthritis Cartilage. 2018 Aug;26(8):1003-1007.

18. Healey EL, Afolabi EK, Lewis M, Edwards JJ, Jordan KP, Fin-ney A, Jinks C, Hay EM, Dziedzic KS. Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain. BMC Musculoskelet Disord. 2018 Aug 17;19(1):295

19. De Laroche R, Simon E, Suignard N, Williams T, Henry MP, Robin P, Abgral R, Bourhis D, Salaun PY, Dubrana F, Que¬rellou S. Clinical interest of quantitative bone SPECT-CT in the preoperative assessment of knee osteoarthritis. Medicine (Baltimore). 2018 Aug;97(35):e11943.

20. Ma X, Zhao W, Yang F, Chin KY. Efficacy and mechanisms of curcumin in the treatment of osteoarthritis: A scoping review. Biomol Biomed. 2025 Mar 7;25(4):761-785. doi: 10.17305/ bb.2024.11045. PMID: 39720988; PMCID: PMC11959387.

21. Bensa A, Previtali D, Sangiorgio A, Boffa A, Salerno M, Filar¬do G. PRP Injections for the Treatment of Knee Osteoarthri¬tis: The Improvement Is Clinically Significant and Influenced by Platelet Concentration: A Meta-analysis of Randomized Controlled Trials. Am J Sports Med. 2025 Mar;53(3):745-754. doi: 10.1177/03635465241246524. Epub 2025 Jan 3. PMID: 39751394; PMCID: PMC11874499.

22. Michel BA, Stucki G, Frey D, De Vathaire F, Vignon E, Bru-ehlmann P, Uebelhart D. Chondroitins 4 and 6 sulfate in os-teoarthritis of the knee: a randomized, controlled trial. Arth¬ritis Rheum. 2005 Mar;52(3):779-86. doi: 10.1002/art.20867. PMID: 15751094.

23. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005 Apr 18;2005(2):CD002946. doi: 10.1002/14651858.CD002946. pub2. PMID: 15846645; PMCID: PMC8459392.

24. Bruyere O, Pavelka K, Rovati LC, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster JY. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause. 2004 Mar-Apr;11(2):138-43. doi: 10.1097/01. gme.0000087983.28957.5d. PMID: 15021442.

25. Clegg DO, Reda DJ, Harris CL, Klein MA, O’Dell JR, Hoo¬per MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jack¬son CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808. doi: 10.1056/NEJMoa052771. PMID: 16495392.

26. Loyola-Sánchez A, Richardson J, MacIntyre NJ. Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis. Osteoarthritis Carti¬lage. 2010 Sep;18(9):1117-26. doi: 10.1016/j.joca.2010.06.010. Epub 2010 Jul 14. PMID: 20637297.

27. Zhang Y, Han Y, Sun Y, Hao L, Gao Y, Ye J, Wang H, Zhang T, Liu Y, Yang Y. Osteoarthritis: molecular pathogenesis and potential therapeutic options. Signal Transduct Target Ther. 2026 Mar 4;11(1):81. doi: 10.1038/s41392-025-02556-6. PMID: 41781374; PMCID: PMC12960730.

28. Johnston SS, Ammann E, Scamuffa R, Samuels J, Stokes A, Fegelman E, Hsiao CW. Association of body mass index and osteoarthritis with healthcare expenditures and utilizati¬on. Obes Sci Pract. 2020 Jan 13;6(2):139-151. doi: 10.1002/ osp4.398. PMID: 32313672; PMCID: PMC7156818.

29. Xiao ZF, Su GY, Hou Y, Chen SD, Lin DK. Cartilage degra-dation in osteoarthritis: A process of osteochondral remode¬ling resembles the endochondral ossification in growth pla¬te? Med Hypotheses. 2018 Dec;121:183-187. doi: 10.1016/j. mehy.2018.08.023. Epub 2018 Aug 27. PMID: 30396477.