Definition of Geriatry/Vulnerability/Frailty (Ageing, Frailty and Metabolic Changes)

Özet

Referanslar

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019). From discoveries in ageing research to therapeutics for healthy ageing. Nature, 571(7764), 183-192.

Blackburn, E. H., Epel, E. S., & Lin, J. (2006). Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science, 311(5769), 1087-1091.4. Jones, M. J., Goodman, S. J., & Kobor, M. S. (2015). DNA methylation and healthy human aging. Aging Cell, 14(6), 924-932.

Ferrucci, L., Baroni, M., Ranchelli, A., Lauretani, F., Maggio, M., Mecocci, P., ... & Bandinelli, S. (2016). Interaction between bone and muscle in older persons with mobility limitations. Current Pharmaceutical Design, 22(23), 3437-3444.

Zamboni, M., Mazzali, G., Fantin, F., Rossi, A., & Di Francesco, V. (2008). Sarcopenic obesity: a new category of obesity in the elderly. Nutrition, Metabolism and Cardiovascular Diseases, 18(5), 388-395.

Bartzokis, G., Lu, P. H., & Mintz, J. (2012). Human brain myelination and iron: a proposed developmental model. Frontiers in Neuroanatomy, 6, 27.

Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14(10), 3156.

Piwek, L., Ellis, D. A., Andrews, S., & Joinson, A. (2016). The rise of consumer health wearables: promises and barriers. PLoS Medicine, 13(2), e1001953.

Topol, E. J. (2019). High-performance medicine: the convergence of human and artificial intelligence. Nature Medicine, 25(1), 44-56.

Izquierdo, M., Rodriguez-Mañas, L., Sinclair, A. J., & Vivifrail Investigators. (2021). What is new in exercise regimes for frail older people-how does the Erasmus Vivifrail Project take us forward? Journal of Nutrition, Health and Aging, 25(3), 267-268.

Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., ... & McBurnie, M. A. (2001). Frailty in older adults: evidence for a phenotype. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(3), M146-M157.

Morley, J. E., Vellas, B., van Kan, G. A., Anker, S. D., Bauer, J. M., Bernabei, R., ... & Fried, L. P. (2013). Frailty consensus: a call to action. Journal of the American Medical Directors Association, 14(6), 392-397.

Rockwood, K., Andrew, M., & Mitnitski, A. (2005). A comparison of two approaches to measuring frailty in elderly people. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 60(7), 738-743.

Ferri, E., Scaglione, D., & Valenti, P. (2012). The impact of frailty and delirium on mortality in elderly patients in an internal medicine setting. Archives of Gerontology and Geriatrics, 54(2), 175-179.

Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001). Accumulation of deficits as a proxy measure of aging. The Scientific World Journal, 1, 323-336.

Campbell, A. J., & Buchner, D. M. (1997). Unstable disability and the fluctuations of frailty. Age and Ageing, 26(4), 315-318.

Kane, R. L., & Ouslander, J. G. (2002). Geriatrics in the United States: manpower projections and training considerations. The Gerontologist, 42(1), 1-6.

Walston, J., McBurnie, M. A., Newman, A., Tracy, R. P., Kop, W. J., Hirsch, C. H., ... & Fried, L. P. (2002). Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities. Archives of Internal Medicine, 162(20), 2333-2341.

Ferrucci, L., & Studenski, S. (2019). Clinical problems of aging: frailty, sarcopenia, and falls. Aging Clinical and Experimental Research, 31(6), 689-691.

Rattray, N. J., & Martins, S. R. (2017). Metabolomics and aging: a review. Advances in Geriatric Medicine and Research, 1(1), e170004.

Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004). Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59(3), M255-M263.

Lipsitz, L. A. (2002). Dynamics of stability: the physiologic basis of functional health and frailty. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57(3), B115-B125.

Morley, J. E. (2004). Hormones and the aging process. Journal of the American Geriatrics Society, 52(3), S315-S318.

Hubbard, R. E., O'Mahony, M. S., & Woodhouse, K. W. (2009). Frailty in older men and women. CMAJ, 181(12), 883-886.

Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., ... & Franceschi, C. (2018). Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes? Frontiers in Immunology, 8, 1960.

Guralnik, J. M., & Simonsick, E. M. (1993). Physical disability in older Americans. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 48(Special Issue), 3-10.

Gielen, E., O'Neill, T. W., Pye,S. R., Adams, J. E., Wu, F. C., Laurent, M. R., ... & Vanderschueren, D. (2015). Endocrine determinants of incident sarcopenia in middle-aged and elderly European men. The Journal of Clinical Endocrinology & Metabolism, 100(8), 3131-3138.

Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., ... & Lindeman, R. D. (1998). Epidemiology of sarcopenia among the elderly in New Mexico. American Journal of Epidemiology, 147(8), 755-763.

Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014). Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases. The Lancet Diabetes & Endocrinology, 2(10), 819-829.

Landi, F., Liperoti, R., Russo, A., Giovannini, S., Tosato, M., Barillaro, C., ... & Bernabei, R. (2012). Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clinical Nutrition, 31(5), 652-658.

Fiatarone, M. A., Marks, E. C., Ryan, N. D., Meredith, C. N., Lipsitz, L. A., & Evans, W. J. (1994). High-intensity strength training in nonagenarians: effects on skeletal muscle. JAMA, 272(24), 1909-1914.

Pedersen, B. K., & Saltin, B. (2015). Exercise as medicine-evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian Journal of Medicine & Science in Sports, 25, 1-72.

Snyder, P. J., Peachey, H., Berlin, J. A., Hannoush, P., Haddad, G., Dlewati, A., ... & Santanna, J. (1999). Effects of testosterone replacement in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 84(10), 3555-3563.

Flanagan, J. L., Simmons, P. A., Vehige, J., Willcox, M. D., & Garrett, Q. (2010). Role of carnitine in disease. Nutrition & Metabolism, 7(1), 30.

Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E., ... & Storer, T. W. (2010). Nutritional recommendations for the management of sarcopenia. Journal of the American Medical Directors Association, 11(6), 391-396.

Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., ... & Ravussin, E. (2007). Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Medicine, 4(3), e76.

Fontana, L., Partridge, L., & Longo, V. D. (2010). Extending healthy life span-from yeast to humans. Science, 328(5976), 321-326.

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., ... & Kirkland, J. L. (2015). The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell, 14(4), 644-658.

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nature Reviews Endocrinology, 14(10), 576-590.

Giansanti, D. (2020). The COVID-19 pandemic: new horizons for digital health. Digital Health, 6, 2055207620963939.

Landi, F., Calvani, R., Cesari, M., Tosato, M., Martone, A. M., Bernabei, R., ... & Marzetti, E. (2018). Sarcopenia: an overview on current definitions, diagnosis and treatment. Current Protein & Peptide Science, 19(7), 633-638.

Bratic, A., & Larsson, N. G. (2013). The role of mitochondria in aging. The Journal of Clinical Investigation, 123(3), 951-957.

Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology, 11(3), 298-300.

Finkel, T., Serrano, M., & Blasco, M. A. (2007). The common biology of cancer and ageing. Nature, 448(7155), 767-774.

Frayn, K. N. (2010). Metabolic regulation: a human perspective. Wiley-Blackwell.

Longo, V. D., & Mattson, M. P. (2014). Fasting: molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-192.

Veldhuis, J. D., Roemmich, J. N., & Richmond, E. J. (2005). Endocrine control of body composition in infancy, childhood, and puberty. Endocrine Reviews, 26(1), 114-146.

Ford, E. S., Giles, W. H., & Dietz, W. H. (2002). Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA, 287(3), 356-359.

Gelecek

17 Şubat 2026

Lisans

Lisans