Radiomics In Oral And Maxillofacial Radiology: Current Uses And Future Perspectives For Quantitative Dental Imaging

Yazarlar

Mediha Ertürk

Özet

This chapter provides a comprehensive overview of radiomics in oral and maxillofacial radiology, emphasizing its role in converting routine imaging data into quantitative, clinically meaningful information. Radiomics enables the extraction of numerical features related to intensity, texture, shape, and spatial patterns from radiological images. The chapter explains the main stages of the radiomics workflow, including image acquisition, preprocessing, segmentation, feature extraction, feature selection, reproducibility assessment, and artificial intelligence-based statistical modelling. It also discusses dental applications, including oral cancer evaluation, jaw lesion differentiation, lymph node metastasis prediction, endodontic and periodontal disease assessment, temporomandibular joint analysis, medication-related osteonecrosis of the jaw, implant-related bone evaluation, osteoporosis screening, and forensic identification. The chapter highlights limitations restricting clinical translation, such as imaging protocol differences, segmentation variability, small retrospective datasets, and insufficient external validation. Overall, radiomics is presented as a promising decision-support approach that may complement conventional radiological interpretation and contribute to more objective, personalized, and data-driven diagnosis, prognosis, and treatment planning in dentistry.

Referanslar

Gillies RJ, Kinahan PE, Hricak HJR. Radiomics: images are more than pictures,they are data.2016;278(2):563-77.doi:10.1148/radiol.2015151169

McCague C, Ramlee S, Reinius M, Selby I, Hulse D, Piyatissa P, et al. Introduction to radiomics for a clinical audience.2023;78(2):83-98. doi:10.1016/j.crad.2022.08.149

Lodwick GS, Keats TE, Dorst JPJR. The coding of roentgen images for computer analysis as applied to lung cancer. 1963;81(2):185-200. doi:10.1148/81.2.185

Haralick RM., Shanmugam K., Dinstein IH. (1973). Textural features for image classification. IEEE Transactions on systems, man, and cybernetics, (6), 610-621.

Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, Van Stiphout RG, Granton P, et al. Radiomics: extracting more information from medical images using advanced feature analysis.2012;48(4):441-6. doi:10.1016/j.ejca.2011.11.036

Aerts HJ, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Carvalho S, et al. Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach.2014;5(1):4006. doi:10.1038/ncomms5006

Lubner MG, Smith AD, Sandrasegaran K, Sahani DV, Pickhardt PJJR. CT texture analysis: definitions, applications, biologic correlates, and challenges. 2017;37(5):1483-503. doi:10.1148/rg.2017170056

Koçak B, Durmaz EŞ, Ateş E, Kılıçkesmez ÖJD, radiology i. Radiomics with artificial intelligence: a practical guide for beginners. 2019;25(6):485. doi:10.5152/dir.2019.19321

Van Timmeren JE, Cester D, Tanadini-Lang S, Alkadhi H, Baessler BJIii. Radiomics in medical imaging—“how-to” guide and critical reflection. 2020;11(1):91. doi:10.1186/s13244-020-00887-2

Scapicchio C, Gabelloni M, Barucci A, Cioni D, Saba L, Neri EJLrm. A deep look into radiomics. 2021;126(10):1296-311. doi:10.1007/s11547-021-01389-x

Schneider CA, Rasband WS, Eliceiri KWJNm. NIH Image to ImageJ: 25 years of image analysis. 2012;9(7):671-5. doi:10.1038/nmeth.2089

McAuliffe MJ, Lalonde FM, McGarry D, Gandler W, Csaky K, Trus BL, editors. Medical image processing, analysis and visualization in clinical research. Proceedings 14th IEEE symposium on computer-based medical systems CBMS 2001; 2001: IEEE.

Nioche C, Orlhac F, Boughdad S, Reuzé S, Goya-Outi J, Robert C, et al. LIFEx: a freeware for radiomic feature calculation in multimodality imaging to accelerate advances in the characterization of tumor heterogeneity. 2018;78(16):4786-9.doi:10.1158/0008-5472.CAN-18-0125

Rizzo S, Botta F, Raimondi S, Origgi D, Fanciullo C, Morganti AG, et al. Radiomics: the facts and the challenges of image analysis. 2018;2(1):36. doi:10.1186/s41747-018-0068-z

Chawla NV, Bowyer KW, Hall LO, Kegelmeyer WPJJoair. SMOTE: synthetic minority over-sampling technique. 2002;16:321-57.doi: 10.1613/jair.953

Tibshirani R."Regression shrinkage and selection via the lasso." Journal of the Royal Statistical Society Series B: Statistical Methodology 58.1 (1996): 267-288.

17.Koo TK, Li MYJJocm. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. 2016;15(2):155-63. doi: 10.1111/j.2517-6161.1996.tb02080.x

Hall EL, Kruger RP, Dwyer SJ, Hall DL, Mclaren RW, Lodwick GS. A survey of preprocessing and feature extraction techniques for radiographic images. 1971;100(9):1032-44. doi:1971;100(9):1032-44.

Sutton RN, Hall EL. Texture measures for automatic classification of pulmonary disease. IEEE Transactions on Computers, 100(7), 667-676.

Di Giannatale A, Di Paolo PL, Curione D, Lenkowicz J, Napolitano A, Secinaro A, et al. Radiogenomics prediction for MYCN amplification in neuroblastoma: a hypothesis generating study. 2021;68(9):e29110. doi:10.1002/pbc.29110

Lasocki A, Buckland ME, Drummond KJ, Wei H, Xie J, Christie M, et al. Conventional MRI features can predict the molecular subtype of adult grade 2–3 intracranial diffuse gliomas. 2022;64(12):2295-305. doi:10.1007/s00234-022-02975-0

Prencipe B, Delprete C, Garolla E, Corallo F, Gravina M, Natalicchio MI, et al. An explainable radiogenomic framework to predict mutational status of KRAS and EGFR in lung adenocarcinoma patients. 2023;10(7):747. doi:10.3390/bioengineering10070747

Abdolali F, Zoroofi RA, Otake Y, Sato YJCm, biomedicine pi. Automated classification of maxillofacial cysts in cone beam CT images using contourlet transformation and Spherical Harmonics. 2017;139:197-207. doi:10.1016/j.cmpb.2016.10.024

Jiang ZY, Lan TJ, Cai WX, Tao Q. Primary clinical study of radiomics for diagnosing simple bone cyst of the jaw. 2021;50(7):20200384. doi:10.1259/dmfr.20200384

Vidiri A, Dolcetti V, Mazzola F, Lucchese S, Laganaro F, Piludu F, et al. MRI in Oral Tongue Squamous Cell Carcinoma: A Radiomic Approach in the Local Recurrence Evaluation. Current oncology (Toronto, Ont). 2025;32(2). doi:10.3390/curroncol32020116

Lan T, Kuang S, Liang P, Ning C, Li Q, Wang L, et al. MRI-based deep learning and radiomics for prediction of occult cervical lymph node metastasis and prognosis in early-stage oral and oropharyngeal squamous cell carcinoma: a diagnostic study. International journal of surgery. (London,England).2024;110(8):4648-4659. doi:10.1097/JS9.0000000000001578.

Jin N, Qiao B, Zhao M, Li L, Zhu L, Zang X, et al. Predicting cervical lymph node metastasis in OSCC based on computed tomography imaging genomics.Cancermedicine.2023;12(18):19260-71.doi:10.1002/cam4.6474

Shao S, Mao N, Liu W, Cui J, Xue X, Cheng J, et al. Epithelial salivary gland tumors: Utility of radiomics analysis based on diffusion-weighted imaging for differentiation of benign from malignant tumors. Journal of X-ray science and technology. 2020;28(4):799-808. doi:10.3233/XST-190632

Hung KF, Ai QYH, Wong LM, Yeung AWK, Li DTS, Leung YY. Current Applications of Deep Learning and Radiomics on CT and CBCT for Maxillofacial Diseases. 2023;13(1):110. doi:10.3390/diagnostics13010110

Okada K, Rysavy S, Flores A, Linguraru MGJMp. Noninvasive differential diagnosis of dental periapical lesions in cone‐beam CT scans. 2015;42(4):1653-65. doi:10.1118/1.4914418

De Rosa CS, Bergamini ML, Palmieri M, de Santana Sarmento DJ, de Carvalho MO, Ricardo ALF, et al. Differentiation of periapical granuloma from radicular cyst using cone beam computed tomography images texture analysis. 2020;6(10). doi:10.1016/j.heliyon.2020.e05194

Yilmaz E, Kayikcioglu T, Kayipmaz SJCm, biomedicine pi. Computer-aided diagnosis of periapical cyst and keratocystic odontogenic tumor on cone beam computed tomography. 2017;146:91-100. doi:10.1016/j.cmpb.2017.05.012

Lopes DLG, Lopes SLPdC, Ungaro DMdT, Gomes APM, Moura NBd, Gonçalves BC, et al. Radiomics-Driven CBCT Texture Analysis as a Novel Biosensor for Quantifying Periapical Bone Healing: A Comparative Study of Intracanal Medications. 2025;15(2):98. doi:10.3390/bios15020098

Hu Z, Wang X, Lan H. Multimodal Radiomics and Deep Learning Integration for Bone Health Assessment in Postmenopausal Women via Dental Radiographs: Development of an Interpretable Nomogram. 2025;35(6):e70239. doi: 10.1002/ima.70239

Nussi AD, de Castro Lopes SLP, De Rosa CS, Gomes JPP, Ogawa CM, Braz-Silva PH, et al. In vivo study of cone beam computed tomography texture analysis of mandibular condyle and its correlation with gender and age. 2023;39(1):191-7. doi:10.1007/s11282-022-00620-3

Li J, Jin F, Wang R, Shang X, Yang P, Zhu Y, et al. Guided Bone Regeneration in a Periodontally Compromised Individual with Autogenous Tooth Bone Graft: A Radiomics Analysis. Journal of functional biomaterials. 2023;14(4). doi:10.3390/jfb14040220

Karacaoglu F, Kolsuz ME, Bagis N, Evli C, Orhan KJPotIoME, Part H: Journal of Engineering in Medicine. Development and validation of intraoral periapical radiography-based machine learning model for periodontal defect diagnosis. 2023;237(5):607-18. doi:10.1177/09544119231162682

Jeon KJ, Kim YH, Choi H, Ha EG, Jeong H, Han SS. Radiomics approach to the condylar head for legal age classification using cone-beam computed tomography: A pilot study. PloS one. 2023;18(1):e0280523. doi:10.1371/journal.pone.0280523

Bianchi J, de Oliveira Ruellas AC, Goncalves JR, Paniagua B, Prieto JC, Styner M, et al. Osteoarthritis of the temporomandibular joint can be diagnosed earlier using biomarkers and machine learning. 2020;10(1):8012. doi:10.1038/s41598-020-64942-0

Bianchi J, Gonçalves JR, de Oliveira Ruellas AC, Ashman LM, Vimort J-B, Yatabe M, et al. Quantitative bone imaging biomarkers to diagnose temporomandibular joint osteoarthritis. 2021;50(2):227-35. doi:10.1016/j.ijom.2020.04.018

Konishi M, Nishi H, Kawaguchi H, Kakimoto NJOR. Radiomics-based classification of medication-related osteonecrosis of the jaw using panoramic radiographs. 2025;41(4):507-16. doi:10.1007/s11282-025-00826-1

Zhan D, Wang F, Zeng D, Hao L, Ye L, Qi Y, et al. Development of a Radiomic Model to Detect the Retromolar Canal on Panoramic Radiographs. 2025;37(193):383-93. doi:10.24976/Discov.Med.202537193.31

Costa A, de Souza Carreira B, Fardim K, Nussi A, da Silva Lima V, Miguel M, et al. Texture analysis of cone beam computed tomography images reveals dental implant stability. 2021;50(12):1609-16. doi:10.1016/j.ijom.2021.04.009

Ocak M, Çatak C, Aksoy S, Orhan K. A comparative analysis of YOLOv8 and nnU-Net v2 based pipelines for sex and age estimation from maxillary sinus morphometry on panoramic radiographs. International journal of legal medicine. 2026. doi:10.1007/s00414-026-03825-x

Nussi AD, de Castro Lopes SLP, De Rosa CS, Gomes JPP, Ogawa CM, Braz-Silva PH, et al. In vivo study of cone beam computed tomography texture analysis of mandibular condyle and its correlation with gender and age. Oral radiology. 2023;39(1):191-7. doi:10.1007/s11282-022-00620-3

Peng M, Yu B, Hu J, Xie X, He J. Radiomics-based classification of pediatric dental trauma in periapical radiographs: a preliminary study. BMC Medical Imaging.2025;25(1):336.doi:10.1186/s12880-025-01877-w

Ito K, Kondo T, Andreu-Arasa VC, Li B, Hirahara N, Muraoka H, et al. Quantitative assessment of the maxillary sinusitis using computed tomography texture analysis: odontogenic vs non-odontogenic etiology. Oral radiology. 2022;38(3):315-24. doi:10.1007/s11282-021-00558-y

Traverso A, Wee L, Dekker A, Gillies R, et al. Repeatability and reproducibility of radiomic features: a systematic review. International Journal of Radiation Oncology Biology Physics. 2018;102(4), 1143-1158.

Yayınlanan

12 Ağustos 2026

Lisans

Lisans