Histolojik Analiz Yöntemleri: Hematoksilen - Eozin, İmmünohistokimya ve İmmünfloresan

Lambert K. Wild brains: The value of neuroethological approaches in preclinical behavioral neuroscience animal models. Neurosci. Biobehav. Rev; 2023; 146:105044. doi: 10.1016/j.neubiorev.2023.105044

Yanshree Y, Fung WS, Lee ML, et al. The monkey head mushroom and memory enhancement in Alzheimer’s disease. Cells; 2022; 11:2284. doi:10.3390/cells11152284

Agar A, Akcay G. Nörolojik hastaliklarin deneysel hayvan modelleri, Ankara: Akademisyen Kitabevi; 2018.

Ellenbroek B, Youn J. Rodent models in neuroscience research: is it a rat race? Disease Models Mechanism; 2016; 9(10):1079–1087. doi: /10.1242/dmm.026120

Arakawa H, Iguchi Y. Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models. Neuroscience Research;2018;135:1-12. doi: 10.1016/j.neures.2018.02.001.

Nakajima R, Hagihara H, Miyakawa T. Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila. Molecular Brain; 2012; 14: 135. doi:10.1186/s13041-021-00840-4

Brunson Sarah, Liu Shaolin. Immunohistochemistry and its Applications in Neuroscience. Anatomy Physiology; 2024; (1): 5. doi:10.33552/APOAJ.2024.01.000521

Zhang J, Xiong H. Protocol Brain Tissue Preparation, Sectioning, and Staining Protocol. Current Laboratory Methods in Neuroscience Research; 2013; 3–30. doi.org/10.1007/978-1-4614-8794-4_1

Garman RH, Li AA, Kaufmann W, et al. Recommended Methods for Brain Processing and Quantitative Analysis in Rodent Developmental Neurotoxicity Studies. Toxicologic Pathology; 2015; 44(1):14-42. doi: 10.1177/0192623315596858

Bancroft JD. Theory and practice of histological techniques. 3rd ed. London: Churchill Livingstone; 1990.

Carson FL. Histotechnology Asel Instructional text. 2nd ed. Chicago: ASCP 1997.

Doku takip işlemi (10.11.2025 tarihinde https://www.labtestsguide.com/tissue-processing adresinden ulaşılmıştır).

SÜMAE YUNUS Araştırma Bülteni; 2004; 4:1.

Doku takip işlemi (10.11.2025 tarihinde https://www.leicabiosystems.com/knowledge-pathway/an-introduction-to-specimen-processing/ adresinden ulaşılmıştır).

Feldman A, Wolfe D. Tissue Processing and Hematoxylin and Eosin Staining. Histopathology Methods and Protocols; 2014: 1180: 31-43. doi: 10.1007/978-1-4939-1050-2_3.

Richardson DS, Guan W, Matsumoto K, et al. Tissue Clearing. Nature Reviews Methods Primers. 2021;1(1):84. doi: 10.1038/s43586-021-00080-9.

Lim JI, Lim K-J, Choi J-Y, Lee Y-K. Modified paraffin wax for improvement of histological analysis efficiency. Microscopy Research and Technique. 2010; 73(8): 761-765. doi: 10.1002/jemt.20818.

Raza G, Iqbal S, Samad Farooq A. Paraffin Wax-Based Thermal Composites. Paraffin - Thermal Energy Storage Applications. Intech Open. 2021; 9. doi: 10.5772/intechopen.97195

Fischer AH, Jacobson KA, Rose J, et al. Hematoxylin and eosin staining of tissue and cell sections. Cold Spring Harbor Protocols. 2008. doi: 10.1101/pdb.prot4986.

Nissl boyama yöntemi (10.11.2025 tarihinde https://pathologycenter.jp/method-e/he.html adresinden ulaşılmıştır).

Knowles RB, Sabry JH, Martone ME, et al. Translocation of RNA granules in living neurons. The Journal of Neuroscience, 1996; 16: 7812–7820. doi: 10.1523/JNEUROSCI.16-24-07812.1996.

Kosik KS, Krichevsky AM. The message and the messenger: delivering RNA in neurons. Sci STKE. 2002:PE16. doi: 10.1126/stke.2002.126.pe16. 2002

Gonthier B, Signorini-Allibe N, Soubeyran A, et al. Ethanol can modify the effects of certain free radical-generating systems on astrocytes. Alcohol Clinical Experimental Research. 2004; 28: 526–34. doi: 10.1097/01.alc.0000122271.32522.a7.

Scott JE, Willett IH. Binding of cationic dyes to nucleic acids and ther biological polyanions. Nature. 1966; 209:985–987. doi: 10.1038/209985a0.

Mills SE. Histology for Pathologists. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2007.

Sajadi E, Raoofi A, Abdi S, Azimi H, Abdollahifar MA. et al. The Modified Method of Luxol Fast Blue for Paraffin-Embedded Myelin Sheath Staining. International Journal of Morphology. 2020; 38(5): 1197-1200.

Lin F, Chen Z. Standardization of diagnostic immunohistochemistry: literature review and Geisinger experience. Archives of Pathology Laboratory Medicine; 2014; 138: 1564–1577. doi:10.5858/arpa.2014-0074-RA.

Taylor CR, Shi S-R, Barr NJ. Techniques of immunohistochemistry: principles, pitfalls, and standardization In: Dabbs DJ (ed) Diagnostic immunohistochemistry: theranostic and genomic applications, 3rd ed. Philadelphia: Saunders; 2010.

Shi SR, Key ME, Kalra KL (1991) Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. The journal of histochemistry and cytochemistry; 1991; 39: 741–748. doi:10.1177/39.6.1709656

Prichard J, Hicks D, Hammond E. Automated immunohistochemistry overview In: Fan L, Jeffrey P (eds) Handbook of practical immunohistochemistry: frequently asked questions, 2nd edn. New York: Springer; 2015.

Matt C, Rachel E, Nitsan G, et al. Intracellular Signaling and Biochemical Assays Guide to Research Techniques in Neuroscience, 2nd ed. Academic Press; 2015.

Charles W, Matthew K, George P. Techniques for studying the brain. The Brain, 2010;153-165.

Charles LW. Immunohistochemistry Applications in Pathology. Theory and Practice of Histological Techniques, 6. ed. Churchill Livingstone; 2008.

Calderon-Garcidueñas AL, Duyckaerts C. Alzheimer disease Neuropathology Handbook of Clinical Neurology; 2017; 145: 325-337. doi: 10.1016/B978-0-12-802395-2.00023-7.

Mehta RI, Schneider JA. Neuropathology of the Common Forms of Dementia. Clinics in Geriatric Medicine; 2023; 39(1): 91-107. doi: 10.1016/j.cger.2022.07.005.

Magaki SD, Williams CK, Vinters HV. Glial function (and dysfunction) in the normal & ischemic brain. Neuropharmacology; 2018; 5: 134(Pt B):218-225. doi: 10.1016/j.neuropharm.2017.11.009.

Philips BH, Browne KD, Cullen DK, Jaber SM. Rat models of central nervous system injury The Laboratory Rat , 3rd. Academic Press; 2020.

Magaki S, Hojat SA, Wei B, et al. An Introduction to the Performance of Immunohistochemistry. Methods in molecular biology; 2019; 1897:289-298. doi: 10.1007/978-1-4939-8935-5_25.

Hussaini HM, Seo B, Rich AM. Immunohistochemistry and Immunofluorescence. Methods Methods in Molecular Biology; 2023; 2588: 439-450. doi: 10.1007/978-1-0716-2780-8_26.

Becheva ZR, Gabrovska KI, Godjevargova TI. Comparison between direct and indirect immunofluorescence method for determination of somatic cell count. Chemical Papers. 2018; 72; 1861–1867. doi: 10.1007/s11696-018-0445-3

Niedenberger BA, Geyer CB. Advanced immunostaining approaches to study early male germ cell development. Stem Cell Research. 2018; 27; 162–168. doi: 10.1016/j.scr.2018.01.031

Mahmoudian J, Hadavi R, Jeddi-Tehrani M, et al. Comparison of the Photobleaching and Photostability Traits of Alexa Fluor 568- and Fluorescein Isothiocyanate- conjugated Antibody. Cell Journal; 2011; 13(3): 169-72.

Bataille Frauke, Troppmann S, Klebl F, et al. Multiparameter Immunofluorescence on Paraffin-Embedded Tissue Sections. Applied Immunohistochemistry Molecular Morphology; 2006; 14(2):225-228, doi: 10.1097/01.pai.0000162009.31931.10

İmmunfloresans boyama yöntemi (10.11.2025 tarihinde https://www.novusbio.com/support-by-application/Fluorescent-IHC-Staining-of-FFPE-Tissue adresinden ulaşılmıştır).