Sekonder Metabolit Üretimi

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Aguilar-Méndez, E. D., Monribot-Villanueva, J. L., Guerrero-Analco, J. A., & De-la-Peña, C., 2024. Chlorophyll deficiency in Agave angustifolia Haw.: unveiling the impact on secondary metabolite production. Planta, 260(4), 77.

Ahmad, N., Rab, A., Ahmad, N., 2016. Light-induced biochemical variations in secondary metabolite production and antioxidant activity in callus cultures of Stevia rebaudiana (Bert).. Journal of photochemistry and photobiology. B, Biology, 154, 51-6. https://doi.org/10.1016/j.jphotobiol.2015.11.015

Ahmadpoor, F., Zare, N., Asghari, R., Sheikhzadeh, P., 2022. Sterilization protocols and the effect of plant growth regulators on callus induction and secondary metabolites production in in vitro cultures Melia azedarach L. AMB Express, 12. https://doi.org/10.1186/s13568-022-01343-8

Ahsan, S. M., Injamum-Ul-Hoque, M., Shaffique, S., Ayoobi, A., Rahman, M. A., Rahman, M. M., & Choi, H. W., 2024. Illuminating Cannabis sativa L.: The power of light in enhancing C. sativa growth and secondary metabolite production. Plants, 13(19), 2774.

Alamgir, A. N. M., 2018. Secondary Metabolites: Secondary Metabolic Products Consisting of C and H; C, H, and O; N, S, and P Elements; and O/N Heterocycles. Therapeutic Use of Medicinal Plants and their Extracts: Volume 2 (C. 74, ss. 165-309). Springer International Publishing. https://doi.org/10.1007/978-3-319-92387-1_3

Alcalde, M., Perez-Matas, E., Escrich, A., Cusido, R., Palazón, J., Bonfill, M., 2022. Biotic Elicitors in Adventitious and Hairy Root Cultures: A Review from 2010 to 2022. Molecules, 27. https://doi.org/10.3390/molecules27165253.

Ali, A., Mashwani, Z., Raja, N., Mohammad, S., Luna-Arias, J., Ahmad, A., Kaushik, P., 2023. Phytomediated selenium nanoparticles and light regimes elicited in vitro callus cultures for biomass accumulation and secondary metabolite production in Caralluma tuberculata. Frontiers in Plant Science, 14. https://doi.org/10.3389/fpls.2023.1253193

Ali, A., Mohammad, S., Khan, M., Raja, N., Arif, M., Kamil, A., Mashwani, Z., 2019. Silver nanoparticles elicited in vitro callus cultures for accumulation of biomass and secondary metabolites in Caralluma tuberculata. Artificial Cells, Nanomedicine, and Biotechnology, 47, 715 - 724. https://doi.org/10.1080/21691401.2019.1577884

Anjitha, K., Sameena, P., Puthur, J., 2021. Functional aspects of plant secondary metabolites in metal stress tolerance and their importance in pharmacology. Plant Stress. https://doi.org/10.1016/j.stress.2021.100038.

Arora, L., Narula, A., 2017. Gene Editing and Crop Improvement Using CRISPR-Cas9 System. Frontiers in Plant Science, 8. https://doi.org/10.3389/fpls.2017.01932.

Badyal, S., Singh, H., Yadav, A. K., Sharma, S., Bhushan, I., 2020. Plant secondary metabolites and their uses. Plant Archives, 20(2), 3336-40.

Bakır, Ö., 2020. Sekonder metabolitler ve rolleri. Uluslararası Anadolu Ziraat Mühendisliği Bilimleri Dergisi, 2(4), 39-45. https://dergipark.org.tr/en/pub/uazimder/issue/57919/760126

Banaev, E. V., Erst, A. A., Khramova, E. P., Tomoshevich, M. A., Shaldaeva, T. M., 2024. In vitro culture of Atraphaxis frutescens (L.) K. Koch: effects of D-mannitol and pH on a propagation coefficient, secondary-metabolite levels, and antiradical activity. Plant Cell, Tissue and Organ Culture (PCTOC), 156(2), 46.

Baransel, G. Ş., Yücel, O., Yıldırım, E., Kalyon, G., Emik, S., Erol, A., Kara, N. T., 2025. Green synthesized silver nanoparticles enhance drought tolerance in cotton plants cultured in vitro. Physiology and Molecular Biology of Plants, 1-20.

Baydu, F. Y., Bektaş, E., 2025. Effects of Zinc Oxide Nanoparticles on Growth and Secondary Metabolite Accumulation in In Vitro Culture of Ocimum basilicum L. Journal of Apitherapy and Nature, 8(1), 37-60.

Bhambhani, S., Kondhare, K. R., Giri, A. P., 2021. Diversity in Chemical Structures and Biological Properties of Plant Alkaloids. Molecules, 26(11), 3374. https://doi.org/10.3390/molecules26113374

Bhaskar, R., Xavier, L., Udayakumaran, G., Kumar, D., Venkatesh, R., Nagella, P., 2021. Biotic elicitors: a boon for the in-vitro production of plant secondary metabolites. Plant Cell, Tissue and Organ Culture (PCTOC), 149, 7 - 24. https://doi.org/10.1007/s11240-021-02131-1.

Bhavaniramya, S., Vishnupriya, S., Al-Aboody, M. S., Vijayakumar, R., Baskaran, D., 2019. Role of essential oils in food safety: Antimicrobial and antioxidant applications. Grain & Oil Science and Technology, 2(2), 49-55. https://doi.org/10.1016/j.gaost.2019.03.001

Bistgani, Z., Hashemi, M., Dacosta, M., Craker, L., Maggi, F., Morshedloo, M., 2019. Effect of salinity stress on the physiological characteristics, phenolic compounds and antioxidant activity of Thymus vulgaris L. and Thymus daenensis Celak. Industrial Crops and Products. https://doi.org/10.1016/J.INDCROP.2019.04.055.

Borah, A., Singh, S., Chattopadhyay, R., Kaur, J., Bari, V., 2024. Integration of CRISPR/Cas9 with multi-omics technologies to engineer secondary metabolite productions in medicinal plant: Challenges and Prospects. Functional & integrative genomics, 24 6, 207 . https://doi.org/10.1007/s10142-024-01486-w.

Bulut, M., 2025. Chemodiversity of sulfur-containing metabolites emphasizing the ecophysiology of Allium plants and the developmental innovations in bulb formation. Current Opinion in Plant Biology, 85, 102724.

Cabañas-García, E., Areche, C., Gómez-Aguirre, Y., Bórquez, J., Muñoz, R., Cruz-Sosa, F., Balch, E., 2021. Biomass production and secondary metabolite identification in callus cultures of Coryphantha macromeris (Engelm.) Britton & Rose (Cactaceae), a traditional medicinal plant. South African Journal of Botany, 137, 1-9. https://doi.org/10.1016/j.sajb.2020.10.002

Cambaz, E., Çördük, N., 2023. Secondary Metabolite Production in Callus Culture of Verbascum scamandri Murb.. Acta Societatis Botanicorum Poloniae. https://doi.org/10.5586/asbp/165894

Caser, M., Chitarra, W., D'Angiolillo, F., Perrone, I., Demasi, S., Lovisolo, C., ... Scariot, V., 2019. Drought stress adaptation modulates plant secondary metabolite production in Salvia dolomitica Codd. Industrial Crops and Products, 129, 85-96.

Chakraborty, A., Mukherjee, S., Biswas, D., Santra, I., Halder, T., Alam, M. M., ... Ghosh, B., 2024. Elite chemotype selection, antipathogenic activities, secondary metabolite fingerprinting of in vitro regenerated Tinospora cordifolia (Willd.) Hook. f. & Thomson–a plant with multipurpose therapeutic significance. Plant Cell, Tissue and Organ Culture (PCTOC), 157(2), 48.

Chamkhi, I., Benali, T., Aanniz, T., Menyiy, N., Guaouguaou, F., Omari, N., El‐Shazly, M., Zengin, G., Bouyahya, A., 2021. Plant-microbial interaction: The mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants. Plant physiology and biochemistry: PPB, 167, 269-295. https://doi.org/10.1016/j.plaphy.2021.08.001.

Chattopadhyay, S., Farkya, S., Srivastava, A., Bisaria, V., 2002. Bioprocess considerations for production of secondary metabolites by plant cell suspension cultures. Biotechnology and Bioprocess Engineering, 7, 138-149. https://doi.org/10.1007/BF02932911.

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Chrysargyris, A., Papakyriakou, E., Petropoulos, S. A., Tzortzakis, N., 2019. The combined and single effect of salinity and copper stress on growth and quality of Mentha spicata plants. Journal of hazardous materials, 368, 584-593.

Cuadra, P., Harborne, J. B., Waterman, P. G, 1997. Increases in surface flavonols and photosynthetic pigments in Gnaphalium luteo-album in response to UV-B radiation. Phytochemistry, 45(7), 1377-1383.

Çalışkan, T., Hatipoğlu, R., Kırıcı, S., 2019. Sekonder bitki metabolitlerinin in vitro koşullarda üretimi. Turkish Journal of Agriculture-Food Science and Technology, 7(7), 971-980. https://agrifoodscience.com/index.php/TURJAF/article/view/2447

Darigh, F., Iranbakhsh, A., Ardebili, Z. O., Ebadi, M., Hassanpour, H., 2022. Simulated microgravity contributed to modification of callogenesis performance and secondary metabolite production in Cannabis Indica. Plant Physiology and Biochemistry, 186, 157-168.

Del-Saz, N., Iglesias-Sanchez, A., Alonso-Forn, D., López-Gómez, M., Palma, F., Clemente‐Moreno, M., Fernie, A., Ribas-Carbó, M., Florez-Sarasa, I., 2022. The Lack of Alternative Oxidase 1a Restricts in vivo Respiratory Activity and Stress-Related Metabolism for Leaf Osmoprotection and Redox Balancing Under Sudden Acute Water and Salt Stress in Arabidopsis thaliana. Frontiers in Plant Science, 13. https://doi.org/10.3389/fpls.2022.833113.

Derbassi, N. B., Pedrosa, M. C., Heleno, S., Carocho, M., Ferreira, I. C., Barros, L., 2022. Plant volatiles: Using Scented molecules as food additives. Trends in Food Science & Technology, 122, 97-103.

Desta, B., Amare, G., 2021. Paclobutrazol as a plant growth regulator. Chemical and Biological Technologies in Agriculture, 8, 1-15. https://doi.org/10.1186/s40538-020-00199-z.

Devi, A., Devi, K., Devi, P., Devi, M., Das, S., 2023. Metabolic engineering of plant secondary metabolites: prospects and its technological challenges. Frontiers in Plant Science, 14. https://doi.org/10.3389/fpls.2023.1171154.

Devrnja, N., Milutinović, M., Savić, J., 2022. When scent becomes a weapon—Plant essential oils as potent bioinsecticides. Sustainability, 14(11), 6847. https://www.mdpi.com/2071-1050/14/11/6847

Dubey, S., Shri, M., Gupta, A., Rani, V., Chakrabarty, D., 2018. Toxicity and detoxification of heavy metals during plant growth and metabolism. Environmental Chemistry Letters, 16, 1169-1192. https://doi.org/10.1007/s10311-018-0741-8.

Ejsmont, W., Kiss, A. K., Grzegorczyk-Karolak, I., 2025. Optimization of In Vitro Shoot Culture Parameters for Enhanced Biomass and Rosmarinic Acid Production in Salvia atropatana. Molecules, 30(12), 2654.

El Sherif, F., AlDayel, M., Ismail, M. B., Alrajeh, H. S., Younis, N. S., Khattab, S., 2023. Bio-stimulant for improving Simmondsia chinensis secondary metabolite production, as well as antimicrobial activity and wound healing abilities. Plants, 12(18), 3311.

Elshafie, H. S., Camele, I., Mohamed, A. A., 2023. A comprehensive review on the biological, agricultural and pharmaceutical properties of secondary metabolites based-plant origin. International journal of molecular sciences, 24(4), 3266. https://www.mdpi.com/1422-0067/24/4/3266

Fàbregas, N., Fernie, A., 2019. The metabolic response to drought. Journal of Experimental Botany, 70, 1077–1085. https://doi.org/10.1093/jxb/ery437.

Faehnrich, B., Franz, C., Nemaz, P., Kaul, H.-P., 2021. Medicinal plants and their secondary metabolites − State of the art and trends in breeding, analytics and use in feed supplementation− with special focus on German chamomile. Journal of Applied Botany and Food Quality, 61-74 Pages. https://doi.org/10.5073/JABFQ.2021.094.008

Falsini, S., Ballantini, S., Pittella, A., Fico, G., Giuliani, C., Palchetti, E., ... Innocenti, M., 2025. Secondary Metabolites Composition and Their Histochemical Localization in the Fruit of Piper malgassicum Papini, Palchetti, Gori and Rota Nodari (Piperaceae). Chemistry & Biodiversity, e03289.

Fazili, M., Bashir, I., Ahmad, M., Yaqoob, U., Geelani, S., 2022. In vitro strategies for the enhancement of secondary metabolite production in plants: a review. Bulletin of the National Research Centre, 46. https://doi.org/10.1186/s42269-022-00717-z.

Ganie, I. B., Ahmad, Z., Shahzad, A., Zaushintsena, A., Neverova, O., Ivanova, S., ... Tahseen, S., 2022. Biotechnological intervention and secondary metabolite production in Centella asiatica L. Plants, 11(21), 2928.

Ge, W., Xin, J., Tian, R., 2023. Phenylpropanoid pathway in plants and its role in response to heavy metal stress: a review. Sheng wu Gong Cheng xue bao= Chinese Journal of Biotechnology, 39(2), 425-445. https://doi.org/10.13345/j.cjb.220338.

Ghasemi, S., Kumleh, H., Kordrostami, M., 2018. Changes in the expression of some genes involved in the biosynthesis of secondary metabolites in Cuminum cyminum L. under UV stress. Protoplasma, 256, 279 - 290. https://doi.org/10.1007/s00709-018-1297-y.

Ghosh, S., Adhikari, S., Adhikari, A., Hossain, Z., 2021. Contribution of plant miRNAome studies towards understanding heavy metal stress responses: Current Status and Future Perspectives. Environmental and Experimental Botany. https://doi.org/10.1016/j.envexpbot.2021.104705.

Golkar, P., Taghizadeh, M., 2018. In vitro evaluation of phenolic and osmolite compounds, ionic content, and antioxidant activity in safflower (Carthamus tinctorius L.) under salinity stress. Plant Cell, Tissue and Organ Culture (PCTOC), 134, 357-368. https://doi.org/10.1007/s11240-018-1427-4.

Goncharuk, E., Zagoskina, N., 2023. Heavy Metals, Their Phytotoxicity, and the Role of Phenolic Antioxidants in Plant Stress Responses with Focus on Cadmium: Review. Molecules, 28. https://doi.org/10.3390/molecules28093921.

Hachlafi, N. E., Aanniz, T., Menyiy, N. E., Baaboua, A. E., Omari, N. E., Balahbib, A., Shariati, M. A., Zengin, G., Fikri-Benbrahim, K., Bouyahya, A., 2023. In Vitro and In Vivo Biological Investigations of Camphene and Its Mechanism Insights: A Review. Food Reviews International, 39(4), 1799-1826. https://doi.org/10.1080/87559129.2021.1936007

Halder, M., Sarkar, S., Jha, S., 2019. Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures. Engineering in Life Sciences, 19, 880 - 895. https://doi.org/10.1002/elsc.201900058.

Han, T., Miao, G., 2024. Strategies, Achievements, and Potential Challenges of Plant and Microbial Chassis in the Biosynthesis of Plant Secondary Metabolites. Molecules, 29. https://doi.org/10.3390/molecules29092106.

Hasanuzzaman, M., Zhou, M., Shabala, S., 2023. How Does Stomatal Density and Residual Transpiration Contribute to Osmotic Stress Tolerance?. Plants, 12. https://doi.org/10.3390/plants12030494.

He, J., Yao, L., Pecoraro, L., Liu, C., Wang, J., Huang, L., Gao, W., 2022. Cold stress regulates accumulation of flavonoids and terpenoids in plants by phytohormone, transcription process, functional enzyme, and epigenetics. Critical Reviews in Biotechnology, 43, 680 - 697. https://doi.org/10.1080/07388551.2022.2053056.

Hill, C. R., Shafaei, A., Balmer, L., Lewis, J. R., Hodgson, J. M., Millar, A. H., Blekkenhorst, L. C., 2023. Sulfur compounds: From plants to humans and their role in chronic disease prevention. Critical Reviews in Food Science and Nutrition, 63(27), 8616-8638. https://doi.org/10.1080/10408398.2022.2057915

Humbal, A., Pathak, B., 2023. Harnessing nanoparticle-mediated elicitation in plant tissue culture: a promising approach for secondary metabolite production. Plant Cell, Tissue and Organ Culture (PCTOC), 155, 385 - 402. https://doi.org/10.1007/s11240-023-02612-5.

Hussein, R. A., El-Anssary, A. A., 2019. Plants secondary metabolites: The key drivers of the pharmacological actions of medicinal plants. Herbal medicine, 1(3), 11-30.

Ibrahim, M. H., Chee Kong, Y., Mohd Zain, N. A., 2017. Effect of cadmium and copper exposure on growth, secondary metabolites and antioxidant activity in the medicinal plant Sambung Nyawa (Gynura procumbens (Lour.) Merr). Molecules, 22(10), 1623.

Inam, M., Attique, I., Zahra, M., Khan, A., Hahim, M., Hano, C., Anjum, S., 2023. Metal oxide nanoparticles and plant secondary metabolism: unraveling the game-changer nano-elicitors. Plant Cell, Tissue and Organ Culture (PCTOC), 155, 327 - 344. https://doi.org/10.1007/s11240-023-02587-3.

In-On, A., Thananusak, R., Ruengjitchatchawalya, M., Vongsangnak, W., Laomettachit, T., 2022. Construction of light-responsive gene regulatory network for growth, development and secondary metabolite production in Cordyceps militaris. Biology, 11(1), 71.

Iqbal, S., Begum, F., Rabaan, A. A., Aljeldah, M., Al Shammari, B. R., Alawfi, A., Alshengeti, A., Sulaiman, T., Khan, A., 2023. Classification and multifaceted potential of secondary metabolites produced by Bacillus subtilis group: A comprehensive review. Molecules, 28(3), 927. https://www.mdpi.com/1420-3049/28/3/927

Isah, T., Umar, S., Mujib, A., Sharma, M. P., Rajasekharan, P. E., Zafar, N., Frukh, A., 2018. Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield. Plant Cell, Tissue and Organ Culture (PCTOC), 132(2), 239-265.

Jain, D., Bisht, S., Parvez, A., Singh, K., Bhaskar, P., Koubouris, G., 2024. Effective Biotic Elicitors for Augmentation of Secondary Metabolite Production in Medicinal Plants. Agriculture. https://doi.org/10.3390/agriculture14060796.

Jaiswal, D., Pandey-Rai, S., Agrawal, S., 2021. Untangling the UV-B radiation-induced transcriptional network regulating plant morphogenesis and secondary metabolite production. Environmental and Experimental Botany. https://doi.org/10.1016/j.envexpbot.2021.104655.

Jakovljević, D., Stanković, M., Warchoł, M., Skrzypek, E., 2022. Basil (Ocimum L.) cell and organ culture for the secondary metabolites production: a review. Plant Cell, Tissue and Organ Culture (PCTOC), 149, 61 - 79. https://doi.org/10.1007/s11240-022-02286-5.

Jamwal, K., Bhattacharya, S., Puri, S., 2018. Plant growth regulator mediated consequences of secondary metabolites in medicinal plants. Journal of applied research on medicinal and aromatic plants, 9, 26-38.

Javed, R., Gürel, E., 2019. Salt stress by NaCl alters the physiology and biochemistry of tissue culture-grownStevia rebaudiana Bertoni. Turkish Journal of Agriculture and Forestry, 43(1), 11-20.

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Khalafalla, M., 2025. Plant Cell Suspension Culture for Plant Secondary Metabolite Production: Current Status, Constraints, and Future Solutions. Polish Journal of Environmental Studies. https://doi.org/10.15244/pjoes/195703.

Khalifa, A. M., Abd-ElShafy, E., Abu-Khudir, R., Gaafar, R. M., 2022. Influence of gamma radiation and phenylalanine on secondary metabolites in callus cultures of milk thistle (Silybum marianum L.). Journal of Genetic Engineering and Biotechnology, 20(1), 166.

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Khayri, J., Banadka, A., Rashmi, R., Nagella, P., Alessa, F., Almaghasla, M., 2023. Cadmium toxicity in medicinal plants: An overview of the tolerance strategies, biotechnological and omics approaches to alleviate metal stress. Frontiers in Plant Science, 13. https://doi.org/10.3389/fpls.2022.1047410.

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Kruszka, D., Selvakesavan, R., Kachlicki, P., Franklin, G., 2022. Untargeted metabolomics analysis reveals the elicitation of important secondary metabolites upon treatment with various metal and metal oxide nanoparticles in Hypericum perforatum L. cell suspension cultures. Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2022.114561.

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Martínez-Chávez, L., Hernández-Ramírez, M., Feregrino-Pérez, A., Escalante, K., 2024. Cutting-Edge Strategies to Enhance Bioactive Compound Production in Plants: Potential Value of Integration of Elicitation, Metabolic Engineering, and Green Nanotechnology. Agronomy. https://doi.org/10.3390/agronomy14122822.

Mazhar, M. W., Ishtiaq, M., Maqbool, M., Jafri, F. I., Siddiqui, M. H., Alamri, S., Akhtar, M. S., 2024. Synergistic effects of selenium nanoparticles and LED light on enhancement of secondary metabolites in sandalwood (Santalum album) plants through in-vitro callus culturing technique. PeerJ, 12, e18106.

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