Hemodiyaliz Tedavisi Alan Hastalarda Beslenme Sorunları ve Kanıta Dayalı Tedavi Bakım Uygulamaları

Yazarlar

Özet

Hemodiyaliz tedavisi alan hastalarda en önemli mortalite nedenleri arasında malnutrisyon, sıvı volüm fazlalığı ve elektrolit dengesizlikleri yer almaktadır. Hemodiyalizde pek çok faktör malnütrisyona zemin hazırlayabilmekte, diyet ve sıvı kısıtlamasına uyumsuzluk hastanın prognozunu kötüleştirebilmektedir. Bu bağlamda kılavuzların önerilerine dayanarak beslenme durumunun değerlendirilmesi, devamlı izlem ve elektrolit dengesinin sürdürülmesi önemlidir. Tedavide kısıtlama odaklı değil seçenek sunma yaklaşımı izlenmeli, hasta ihtiyaçlarına ve kliniğine göre bireyselleştirilme yapılmalıdır. Burada en büyük rol hasta değerlendirme ve eğitim becerileri sayesinde hasta sonuçlarını etkilemede kritik bir role sahip olan hemşirelere düşmektedir. Bu bölümde hemodiyaliz tedavisi alan hastalarda beslenme sorunları ve tedavi bakım uygulamaları, kılavuzların önerileri eşliğinde ele alınmıştır.

Referanslar

Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease – A systematic review and meta-analysis. PLoS ONE. 2016; 11: 1-18. doi:10.1371/journal.pone.0158765

Süleymanlar G, Utaş C, Arınsoy T, et al. A population based survey of chronic renal disease in Turkey - The CREDIT study. Nephrol Dial Transplant. 2011; 26: 1862-71. doi: 10.1093/ndt/gfq656

Türkiye’de Nefroloji, Diyaliz ve Transplantasyon Registry Raporu 2022. (10.04.2024 tarihinde chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://nefroloji.org.tr/uploads/pdf/REGISTRY2022_web.pdf adresinden ulaşılmıştır).

Msaad R, Essadik R, Mohtadi K. Predictors of mortality in hemodialysis patients. The Pan African Medical Journal. 2019; 33(1): 2-14. doi: 10.11604/pamj.2019.33.61.18083

Ghorbani A, Hayati F, Karandish M, Sabzali S. The prevalence of malnutrition in hemodialysis patients. J Renal Inj Prev. 2020; 9(2): 1-6. doi: 10.34172/jrip.2020.15.

Becker PJ, Nieman Carney L, Corkins MR. Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: indicators recommended for the identification and documentation of pediatric malnutrition (undernutrition). J Acad Nutr Diet. 2014; 114: 1988-2000. doi: 10.1177/0884533614557642

National Institute of Health and Care Excellence. Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition. 2006. (28.04.2024 tarihinde chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.nice.org.uk/guidance/cg32/resources/nutrition-support-for-adults-oral-nutrition-support-enteral-tube-feeding-and-parenteral-nutrition-pdf-975383198917 adresinden ulaşılmıştır).

National Institute of Health and Care Excellence. Nutrition support in adults. 2012. (28.04.2024 tarihinde chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.nice.org.uk/guidance/qs24/resources/nutrition-support-in-adults-pdf-2098545777349 adresinden ılaşılmıştır).

Pupim, LB, Cuppari L, Ikizler TA. Nutrition and metabolism in kidney disease. Seminars in Nephrology. 2006; 26: 134-157. doi: 10.1016/j.semnephrol.2005.09.010.

Drechsler C., Grootendorst DC, Pilz S. Wasting and sudden cardiac death in hemodialysis patients: a post hoc analysis of 4D (Die Deutsche Diabetes Dialyse Studie). Am J Kidney Dis. 2011; 58: 599-607. doi: 10.1053/j.ajkd.2011.05.026.

Lodebo BT, Shah A, Kopple JD. Is it important to prevent and treat protein energy wasting in chronic kidney disease and chronic dialysis patients? J Ren Nutr. 2018; 28: 369–79. https://doi.org/10.1053/j.jrn.2018.04.002

Wright M, Southcott E, MacLaughlin H, Wineberg S. Clinical practice guideline on undernutrition in chronic kidney disease. BMC Nephrology. 2019; 20: 370. https://doi.org/10.1186/s12882-019-1530-8

Katalinic L, Premuzic V, Basic Jukic N. Hypoproteinemia as a factor in assessing malnutrition and predicting survival on hemodialysis. Journal of Artificial Organs. 2019; 22: 230–236. doi: 10.1007/s10047-019-01098-3

Sahathevan S, Khor BH, Ng HM. Understanding development of malnutrition in hemodialysis patients: A narrative review. Nutrients. 2020. 12(10): 3147. https://doi.org/10.3390/nu12103147.

Cano N, Fiaccadori E, Tesinsky P, T. ESPEN guidelines on enteral nutrition: adult renal failure. Clin Nutr. 2006; 25: 295–310. doi: 10.1016/j.clnu.2006.01.023

Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013; 3(1):1–150

Türker PF. Böbrek hastalıklarında beslenme durumunun saptanması. Beslenme ve Diyet Dergisi. 2018; 46: 30-35. doi: https://doi.org/10.33076/2018.BDD.1168

İkizler TA, Cano N, Franch HF. Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney Int. 2013; 84: 1096–107. doi: 10.1038/ki.2013.147

Yıldıran H, Gençer F. Böbrek Hastalıkları ve Protein Metabolizması. Beslenme ve Diyet Dergisi. 2018; 46: 7-12. https://doi.org/10.33076/2018.BDD.1165

National Guideline Centre (UK). Modalities of RRT: Renal replacement therapy and conservative management: Evidence review. London: National Institute for Health and Care Excellence (NICE); 2018. (31.05.2024 tarihinde nice.org.uk/guidance/ng107.adresinden ulaşılmıştır).

Ikizler TA, Burrowes JD, Byham-Gray LD. KDOQI Clinical Practıce Guideline For Nutrition in CKD: 2020 Update. Am J Kidney Dis. 2020; 76(3): 24-93. doi: 10.1053/j.ajkd.2020.05.006.

Naylor HL, Jackson H, Walker GH, Macafee S, Magee K, Hooper L, Stewart L, MacLaughlin HL. British dietetic association evidence-based guidelines for the protein requirements of adults undergoing maintenance haemodialysis or peritoneal dialysis. J Hum Nutr Diet. 2013; 26: 315–28. doi:10.1111/jhn.12052

Lopes AA, Bragg-Gresham JL, Elder SJ. Independent and joint associations of nutritional status indicators with mortality risk among chronic hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). J Ren Nutr. 2010; 20(4): 224-34. doi: 10.1053/j.jrn.2009.10.002.

Toigo G, Aparicio M, Oattman P. Expert working group report on nutrition in adult patients with renal insufficiency (Part 2 of 2). Clinical Nutrition. 2000; 19(4): 281-291. doi:10.1054/clnu.2000.0129

Mah_JY, Choy_SW, Roberts_MA. Oral protein-based supplements versus placebo or no treatment for people with chronic kidney disease requiring dialysis. Cochrane Database of Systematic Reviews 2020; 5: 1-78. doi: 10.1002/14651858.CD012616.pub2.

Schweda F. Salt feedback on the renin-angiotensin aldosterone system. Pflugers Arch. 2015; 467(3): 565-576.

Kotchen TA, Cowley Jr AW, Frohlich ED. Salt in health and disease–a delicate balance. N Engl J Med. 2013; 368(13): 1229-1237.

Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S. Reduced dietary salt for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014; 12: CD009217.

Borrelli S, Provenzano M, Gagliardi I, Michael A, Liberti ME, De Nicola L, Conte G, Garofalo C, Andreucci M. Sodium Intake and Chronic Kidney Disease. International Journal of Molecular Sciences. 2020; 21(13):4744. https://doi.org/10.3390/ijms21134744

Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int. 2014; 2014: 406960.

Aaron KJ, Sanders PW. Role of Dietary Salt and Potassium Intake in Cardiovascular Health and Disease: A Review of the Evidence. Mayo Clinic Proceedings. 2013; 88(9): 987-995, https://doi.org/10.1016/j.mayocp.2013.06.005.

He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure. Cochrane Database Syst Rev. 2013;4: CD004937.

Garofalo C, Borrelli S, Provenzano M, De Stefano T, Vita C, Chiodini P, Minutolo R, Nicola LD, Conte G. Dietary Salt Restriction in Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials. Nutrients. 2018; 10(6):732. https://doi.org/10.3390/nu10060732

Meuleman Y, Hoekstra T, Dekker FW, et al. Sodium restriction in patients with CKD: a randomized controlled trial of self-management support. Am J Kidney Dis. 2017; 69(5): 576-586.

Meuleman Y, Hoekstra T, Dekker FW, van der Boog PJM, van Dijk S. Perceived sodium reduction barriers among patients with chronic kidney disease: which barriers are important and which patients experience barriers? Int J Behav Med. 2018;25(1): 93-102.

Fouque D, Vennegoor M, Wee PT. EBPG Guideline on Nutrition. Nephrol Dial Transplant. 2007; 22 (2): 45–87. doi:10.1093/ndt/gfm020

KDIGO, Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD). Kidney International Supplements. 2017; 7(1): 15-48.

Cupisti A, Kovesdy CP, D’Alessandro C. Dietary Approach to Recurrent or Chronic Hyperkalaemia in Patients with Decreased Kidney Function. Nutrients. 2018; 10(261): 2-15. doi: 10.3390/nu10030261

Ketteler M, Block GA, Evenepoel P, et al. Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone disorder (CKD-MBD) guideline update: what’s changed and why it matters. Kidney Int. 2017; 92(1): 26-36. doi: 10.1016/j.kint.2017.04.006.

Sherman RA, Mehta O. Phosphorus and potassium content of enhanced meat and poultry products: implications for patients who receive dialysis. Clin J Am Soc Nephrol. 2009; 4(8):1370-1373. doi: 10.2215/CJN.02830409

St-Jules DE, Woolf K, Pompeii ML. Reexamining the phosphorus-protein dilemma: does phosphorus restriction compromise protein status? J Ren Nutr. 2016; 26(3):136-140. doi: 10.1053/j.jrn.2015.12.004

Yan B, Su X, Xu B. Effect of diet protein restriction on progression of chronic kidney disease: A systematic review and meta-analysis. PLoS ONE. 2018; 13(11): 1-19. doi: 10.1371/journal.pone.0206134

Benini O, D’Alessandro C, Gianfaldoni D. Extraphosphate load from food additives in commonly eaten foods: a real and insidious danger for renal patients. J Ren Nutr. 2011;21(4):303- 308. doi: 10.1053/j.jrn.2010.06.021

Parpia AS, L’Abbe M, Goldstein M. The impact of additives on the phosphorus, potassium, and sodium content of commonly consumed meat, poultry, and fish products among patients with chronic kidney disease. J Ren Nutr. 2018;28(2):83-90. doi: 10.1053/j.jrn.2017.08.01

Kalantar-Zadeh K, Gutekunst L, Mehrotra R. Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney disease. Clin J Am Soc Nephrol. 2010; 5(3): 519-530. doi: 10.2215/CJN.06080809

Gutierrez OM. Sodium- and phosphorus-based food additives: persistent but surmountable hurdles in the management of nutrition in chronic kidney disease. Adv Chronic Kidney Dis. 2013; 20(2):150-156. doi: 10.1053/j.ackd.2012.10.008

Cupisti A, Kalantar-Zadeh K. Management of natural and added dietary phosphorus burden in kidney disease. Semin Nephrol. 2013; 33(2):180-190. doi: 10.1016/j.semnephrol.2012.12.018

Barril-Cuadrado G, Puchulu MB, Sanchez-Tomero JA. Table showing dietary phosphorus/protein ratio for the Spanish population. Usefulness in chronic kidney disease. Nefrologia. 2013; 33(3):362-371. doi: 10.3265/Nefrologia.pre2013.Feb.1191

Caldeira D, Amaral T, David C. Educational strategies to reduce serum phosphorus in hyperphosphatemic patients with chronic kidney disease: systematic review with metaanalysis. J Ren Nutr. 2011; 21(4): 285-294. doi: 10.1053/j.jrn.2010.11.006

Beto J.A., Schury K.A., Bansal V.K. Strategies to promote adherence to nutritional advice in patients with chronic kidney disease: a narrative review and commentary. International Journal of Nephrology and Renovascular Disease. 2016; 9: 21-33. doi: 10.2147/IJNRD.S76831.

Cormick G, Belizán JM. Calcium Intake and Health. Nutrients. 2019; 11: 1-16.

Kim SM, Jung JY. Nutritional management in patients with chronic kidney disease. Korean J Intern Med. 2020; 35: 1279-1290. doi: 10.1056/NEJMra1700312

Brunelli SM, Sibbel S, Do TP. Facility dialysate calcium practices and clinical outcomes among patients receiving hemodialysis: a retrospective observational study. Am J Kidney Dis. 2015; 66(4): 655-665. doi: 10.1053/j.ajkd.2015.03.038

Hill Gallant KM, Spiegel DM. Calcium Balance in Chronic Kidney Disease. Curr Osteoporos Rep. 2017; 15: 214–221. doi: 10.1007/s11914-017-0368-x

Dhondup T, Qian Q. Electrolyte and Acid–Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure. Blood Purif. 2017; 43:179–188. doi: 10.1159/000452725

Gallieni M, Caputo F, Filippini A. Prevalence and progression of cardiovascular calcifications in peritoneal dialysis patients: a prospective study. Bone. 2012; 51(3): 332-337. doi: 10.1016/j.bone.2012.06.002

Schlieper G, Schurgers L, Brandenburg V. Vascular calcification in chronic kidney disease: an update. Nephrol Dial Transplant. 2016; 31: 31–39. doi: 10.1093/ndt/gfv111

Markaki A, Kyriazis J, Stylianou K. The role of serum magnesium and calcium on the association between adiponectin levels and all-cause mortality in end-stage renal disease patients. PLoS One. 2012; 7(12): 1-7 doi: 10.1371/journal.pone.0052350

Palmer BF, Colbert G, Cleg DJ. Potassium Homeostasis, Chronic Kidney Disease, and the Plant-Enriched Diets. KIDNEY 360. 2020; 1: 65-71. doi: https://doi.org/10.34067/KID.0000222019

de Rooij ENM, Dekker FW, Le Cessie S. Serum Potassium and Mortality Risk in Hemodialysis Patients: A Cohort Study. Kidney Medicine. 2022; 4(1): 1-9. doi: 10.1016/ j.xkme.2021.08.013

Shibata S, Uchida S. Hyperkalemia in patients undergoing hemodialysis: Itspathophysiology and management. Ther Apher Dial. 2022; 26: 3–14. doi: 10.1111/1744-9987.13721

Yusuf AA, Hu Y, Singh B. Serum Potassium Levels and Mortality in Hemodialysis Patients: A Retrospective Cohort Study. American Journal of Nephrology. 2016; 44: 179–186. doi: 10.1159/000448341

Karaboyas A, Zee J, Brunelli SM. Dialysate Potassium, Serum Potassium, Mortality, and Arrhythmia Events in Hemodialysis: Results From the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2017;69(2): 266-277.

Ferrey A, You AS, Kovesdy CP. Dialysate Potassium and Mortality in a Prospective Hemodialysis Cohort. Am J Nephrol. 2018; 47: 415–423. doi: 10.1159/000489961

Vrdoljak I, Vukomanović A, Bituh M, Rumora Samarin I, Panjkota Krbavčić I. The Impact Of Educatıon About Specıfıc Cookıng Methods On Serum Potassıum Levels In Patıents On Hemodıalysıs. Hrana u zdravlju i bolesti. 2018;7(1):12-17.

AlSahow A. Moderate stepwise restriction of potassium intake to reduce risk of hyperkalemia in chronic kidney disease: A literature review. World J Nephrol. 2023; 12(4): 73-81. doi: 10.5527/wjn.v12.i4.73.

Martínez-Pineda M, Vercet A, Yagüe-Ruiz C. Are Food Additives a Really Problematic Hidden Source of Potassium for Chronic Kidney Disease Patients? Nutrients. 2021; 13(10):3569. doi: 10.3390/nu13103569

Picard K. Potassium Additives and Bioavailability: Are We Missing Something in Hyperkalemia Management? Journal of Renal Nutrition. 2019; 29(4): 350-353. doi: https://doi.org/10.1053/j.jrn.2018.10.003.

Jin WH, Lee, Joo Y, Hwan O. Association of food intake with serum levels of phosphorus and potassium in hemodialysis patients. Journal of Nutrition and Health. 2014; 47 (1): 33 – 44. doi: 10.4163/jnh.2014.47.1.33

Xie Z, McLean R, Marshall M. Dietary Sodium and Other Nutrient Intakes among Patients Undergoing Hemodialysis in New Zealand. Nutrients. 2018; 10(4):502. doı: 10.3390/nu10040502

Saglimbene VM, Su G, Wong G. Dietary intake in adults on hemodialysis compared with guideline recommendations. J Nephrol. 2021; 34: 1999–2007. doi: 10.1007/s40620-020-00962-3

Vrdoljak I, Krbavčić IP, Bituh M. Analysis of Different Thermal Processing Methods of Foodstuffs to Optimize Protein, Calcium, and Phosphorus Content for Dialysis Patients. Journal of Renal Nutrition. 2015; 25(3): 308-315. doi: https://doi.org/10.1053/j.jrn.2014.11.002

Akduman G, Gunes FE. Recipe Development for the Kidney Patient. Saudi Journal of Kidney Diseases and Transplantation. 2021; 32(3): 786-793. doı: 10.4103/1319-2442.336774

Alfonzo A, Harrison A, Baines R. Clinical Practice Guidelines Treatment of Acute Hyperkalaemia in Adults. UK Kidney Association. 2023. (27.04.2024 tarihinde chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://ukkidney.org/sites/renal.org/files/FINAL%20VERSION%20-%20UKKA%20CLINICAL%20PRACTICE%20GUIDELINE%20-%20MANAGEMENT%20OF%20HYPERKALAEMIA%20IN%20ADULTS%20-%20191223_0.pdf adresinden ulaşılmıştır).

Arslan S, Bekar Tuncalp F. The effects of diet and fluid education administered to patients of hemodialysis on some parameters. Journal of Human Sciences. 2017; 14(1): 346–354.

Barbecho NM, Campo VR, Yanez AO, Suazo SV. Nursing intervention in health promotion for people on hemodialysis, disciplinary perspective: Integrative review. Enfermería: Cuidados Humanizados. 2020; 9(1): 54 – 64.

Özkan I, Taylan S. Diet and fluid restriction experiences of patients on hemodialysis: a meta-synthesis study. Rev Nefrol Dial Traspl. 2022; 42(1): 22-40.

Mersal FA, Sedawy DAD, Mersal NA. Effect of Nursing Guideline on Dietary and Fluid Compliance among Patients Undergoing Hemodialysis. Journal of Health, Medicine and Nursing. 2016; 26: 35-45.

Başer E, Mollaoğlu M. The effect of a hemodialysis patient education program on fluid control and dietary compliance. Hemodial International. 2019. 23(3): 392-401. doi: 10.1111/hdi.12744.

Hashemi S, Tayebi A, Rahimi A, Einollahi B. Examining the effect of continuous care model on adherence to dietary regimen among patients receiving hemodialysis. Iran J Crit Care Nurs. 2015; 7(4): 215-220.

Hamşioğlu N, Uçar İ. Diyalizde Beslenme. Sezen A. Diyaliz Hemşireliği içinde. Nobel Tıp Kitabevleri: İstanbul; 2014. p. 317-332.

Alemdar H, Pakyüz S. Hemodiyaliz Hastalarında Öz Bakım Gücünün Yaşam Kalitesine Etkisinin Değerlendirilmesi. Nefroloji Hemşireliği Dergisi. 2015; 10(2):19-30.

Varol E, Karaca Sivrikaya S. Kronik Böbrek yetmezliğinde yaşam kalitesi ve hemşirelik. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2018; 8(2): 89-96.

Kosar Sahin, C., Ceylan, H., & Demir Barutcu, C. A scale development study: Primary Caregiver Burden Scale Individuals Receiving Hemodialysis Treatment. Therapeutic Apheresis and Dialysis, 2024; 28(4), 620-631.

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