Nari̇ngenin

Aherne SA, O’Brien NM. Dietary flavonols: Chemistry, food content, and metabolism. Nutrition Journal. 2002; 18(1): 75–81. doi: 10.1016/s0899-9007(01)00695-5.

Alam MA, Subhan N, Rahman MM, et al., Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition. 2014; 5(4): 404–417. doi: 10.3945/an.113.005603

Zhang L, Song L, Zhang P, Liu T, Zhou L, Yang G, Lin R, Zhang J. Solubilities of naringin and naringenin in different solvents and dissociation constants of naringenin. Journal of Chemical & Engineering Data. 2015; 60(3): 932–940. doi: 10.1021/je501004g

Aron PM, Kennedy JA. Flavan-3-ols: Nature, occurrence and biological activity. Molecular Nutrition & Food Research. 2008; 52(1): 79–104. doi: 10.1002/mnfr.200700137

Wang S, Yang C, Tu H, et al., Characterization and metabolic diversity of flavonoids in Citrusspecies. ScientificReports. 2017; 7(1): 10549. doi: 10.1038/s41598-017-10970-2

Gaitan A, Ravetti S, Garro AG, et al., Preformulation studies and in vitro cytotoxicity of naringin. Drug Development and Industrial Pharmacy. 2025; 51 (4): 344–353. doi: 10.1080/03639045.2025.2471912.

Memariani Z, Abbas SQ, Ul H.S. et al., Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review. Pharmacological Research. 2021; 171: 105264. doi: 10.1016/j.phrs.2020.105264

Stabrauskiene J, Dalia M, Kopustinskiene M, et al. Naringin and naringenin: Their mechanisms of action and potential anticancer activities. Biomedicines. 2022; 10(7): 1686 doi: 10.3390/biomedicines10071686

Rebello, C. J., Robbie AB, Juan JLL, et al. Safety an dpharmacokinetics of naringenin: A randomized, controlled, single-ascending-dose clinical trial. Diabetes Obesity and Metabolism, 2019; 22(1): 91–98. doi: 10.1111/dom.13868.

Kawaguchi K, Maruyama H, Hasunuma et al., Suppression of inflammatory responses after on set of collagen induced arthritis in mice by oral administration of the Citrus flavanone naringin. Immunopharmacology and Immunotoxicology. 2011; 33(4): 723–729. doi: 10.3109/08923973.2011.564186.

Bailey, D.G.; Dresser, G.K. Interactions between grape fruit juice and cardiovascula rdrugs. American Journal of Cardiology. 2004; 4(5): 281–297. doi: 1175-3277/04/0005-0281/$31.00/0

Hsiu SL, Huang TY Hou, YC, et al., Comparison of metabolic pharmacokinetics of naringin and naringenin in rabbits. Life Sciences. 2002; 70(13): 1481–1489. doi: 10.1016/s0024-3205(01)01491-6

Tsai YJ, Tsai T.H. Mesenteric lymphatic absorption and the pharmacokinetics of naringin and naringenin in therat. Journal of Agricultural and Food Chemistry. 2012; 60(51): 12435–12442. doi:10.1021/jf301962g.

Tesseromatis C, Alevizou A. The role of the protein-binding on themode of drugaction as well the interactions with other drugs. European Journal of Drug Metabolism and Pharmacokinetics. 2008; 33(4): 225–230. doi: 10.1007/BF03190876

Najmanová I, Vopršalová M, Saso L, et al., The pharmacokinetics of flavanones. Critical Reviews in Food Science and Nutrition. 2020; 60(18): 3155–3171. doi: 10.1080/10408398.2019.1679085.

Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: Chemistry, metabolism and structure activity relationships, Journal of Nutritional Biochemistry, 2002; 13: 572-584. PMID: 12550068 doi: 10.1016/ S0955-2863(02)00208-5.

Hernández-Aquino E, Muriel P. Beneficial effects of naringenin in liver diseases: Molecular Mechanisms, World Journal of Gastroenterology. 2018; 24(16): 1679-1707. doi: 10.3748/wjg.v24.i16.1679.

Joshi R, Kulkarni YA, Wairkar S. Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update, Lfs Life Sciences. 2018; 215: 43-56. doi:10.1016/j.lfs.2018.10.066.

Rahman J, Tareq AM, Hossain M, et al. Biological evaluation, DFT calculations and molecular docking studies on the antidepressant and cytotoxicity activities of Cycaspectinata Buch. - Ham. Compounds. Pharmaceuticals. 2020; 13(9): 232. doi: 10.3390/ph13090232.

Arafah A, Rehman MU, Mir TM, Wal, AF, et al. Multi-Therapeutic Potential of Naringenin (40,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms. Plants. 2020; 9(12): 1784. doi: 10.3390/plants9121784

Ginwala R, Bhavsar R, Chigbu DI, et al. Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin. Antioxidants. 2019; 8: 35. doi: 10.3390/antiox8020035

Su W, Wang Y, Li P, et al., The potential application of the traditional Chinese herb Exocarpium Citrigrandis in the prevention andt reatment of COVID-19. Traditional Chinese Medicine. 2020; 5(3): 160–166. doi: 10.12032/TMR20200406172

Yan Y, Zhou H, Wu, C, et al., Ultrasound-assistedaqueous two-phase extraction of synephrine, naringin, and neohesperidin from Citrus aurantium L. Fruit lets. Preparative Biochemistry & Biotechnology. 2021; 51(8): 780–791. doi:10.1080/10826068.2020.1858427

Yuan X, Wu H, Xu H, et al., Notchsignaling: An emerging therapeutic target for cancer treatment. Cancer Letters. 2015; 369(1): 20–27. doi:10.1016/j.canlet.2015.07.048

Sun R, Liu C, Liu J, et al. Integrated network pharmacology and experimental verification reveal protective effect of naringenin in chronic wounds. Scientific Reports. 2023; 13(1): 132. doi:10.1038/s41598-022-26043-y

Ahmed S, Khan H, Aschner M, et al., Therapeutic potential of naringin in neurological disorders. Food and Chemical Toxicology. 2019; 132: 110646. doi: 10.1016/j.fct.2019.110646

Mahmoud AM, Hussein OE. Anti-diabeticeffect of naringin: Insights into the molecular mechanism. Diabetes & Obesity International Journal. 2016; 1(5): 1-3. doi:10.23880/DOİJ-16000128

Pandey VK, Shams R, Singh R, et al., Comprehensive review on clove (Caryophyllus aromaticus L.) essential oil and its significance in the formulation of edible coatings for potential food applications. Frontiers in Nutrition. 2022; 9: 987674. doi:10.3389/fnut.2022.987674