Vaka 18

Özet

Glioblastoma multiforme, erişkinlerde en sık görülen ve en agresif primer beyin tümörüdür. MRG’de halkasal kontrastlanan, santral nekroz ve geniş vazojenik ödem ile karakterizedir. Difüzyon ve perfüzyon bulguları yüksek hücresellik ve artmış vaskülariteyi destekler. Tedavi cerrahi, radyoterapi ve kemoterapi kombinasyonunu içerir.

Referanslar

Louis DN, Perry A, Wesseling P et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncology. 2021 Aug 1;23(8):1231–1251. doi:10.1093/neuonc/noab106.

Küker W, Nägele T, Korfel A et al. Primary central nervous system lymphoma: MRI features at presentation and during follow-up. European Journal of Radiology. 2005 Dec;52(3):229–239. doi:10.1016/j.ejrad.2004.12.003.

Pope WB, Qiao XJ, Kim HJ et al. MRI in brain metastases: diagnosis and monitoring. Neuro Oncology. 2016 Jan;18(1):104–115. doi:10.1093/neuonc/nov269.

Desprechins B, Stadnik T, Koerts G et al. Use of diffusion-weighted MR imaging in differential diagnosis between brain abscess and necrotic tumor. AJNR American Journal of Neuroradiology. 1999 Aug;20(7):1252–1257.

Hygino da Cruz LC Jr, Rodriguez I, Domingues RC et al. Differentiating radiation necrosis from tumor recurrence in patients with gliomas: perfusion MR imaging findings. Radiology. 2011 Sep;260(3):873–881. doi:10.1148/radiol.11110121.

Ostrom QT, Cioffi G, Waite KA et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States, 2015–2019. Neuro Oncology. 2023;25(Suppl 2):ii1–ii95. doi:10.1093/neuonc/noad112.

Hygino da Cruz LC Jr, Rodriguez I, Domingues RC et al. Diffusion and perfusion MR imaging in assessing treatment response in glioblastomas. AJNR American Journal of Neuroradiology. 2011 Jan;32(1):75–84. doi:10.3174/ajnr.A2232.

Law M, Young RJ, Babb JS et al. Glioma grading using perfusion MR imaging and proton MR spectroscopy. AJNR American Journal of Neuroradiology. 2003 Nov–Dec;24(10):1989–1998.

Hegi ME, Diserens AC, Gorlia T et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. New England Journal of Medicine. 2005 Mar 10;352(10):997–1003. doi:10.1056/NEJMoa043331.

Kickingereder P, Gotz M, Muschelli J et al. Radiogenomics of glioblastoma: machine learning–based classification of molecular characteristics by MR imaging features. Radiology. 2016 Dec;281(3):907–918. doi:10.1148/radiol.2016161382.

Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New England Journal of Medicine. 2005 Mar 10;352(10):987–996. doi:10.1056/NEJMoa043330.

Weller M, van den Bent M, Hopkins K et al. EANO guidelines on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncology. 2021 Sep;22(9):e391–e403. doi:10.1016/S1470-2045(21)00203-6.

Sayfalar

101-110

Yayınlanan

24 Aralık 2025

Lisans

Lisans