Multipl Sklerozda İmmünsupresif Tedaviler

Yazarlar

Özet

Multipl skleroz (MS), inflamasyon, demiyelinizasyon ve nörodejenerasyon ile seyreden kronik otoimmün bir santral sinir sistemi hastalığıdır. Hastalık modifiye edici tedavilere rağmen bazı hastalarda yüksek hastalık aktivitesi ve progresyon devam edebilmektedir. Bu durumlarda immünsupresif tedaviler, bağışıklık aracılı patolojik süreçleri baskılayarak hastalık kontrolünde önemli bir seçenek sunar. Bu bölümde MS’nin patofizyolojisi, klinik alt tipleri ve hastalık progresyon mekanizmaları özetlenmiş; siklofosfamid, metotreksat, azatiopürin, mitoksantron ve seçici immünsupresif ajanlar başta olmak üzere immünsupresif tedavilerin etki mekanizmaları, klinik etkinlikleri ve güvenlilik profilleri güncel literatür ışığında ele alınmıştır. İmmünsupresif tedavilerin uygun hasta seçimiyle, özellikle agresif ve progresif MS formlarında anlamlı klinik fayda sağlayabileceği vurgulanmıştır.

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21 Ocak 2026

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