Radikal Prostatektomi Sonrası İyileşme Dönemi

Özet

Radikal prostatektomi (RP), lokalize prostat kanserinin küratif tedavisinde temel cerrahi yöntemlerden biridir. Ancak operasyon sonrasında ortaya çıkabilen komplikasyonlar, hastaların fiziksel, cinsel ve psikososyal iyilik hâlini önemli ölçüde etkileyebilir. Bu bölümde RP sonrası iyileşme süreci, erken dönem yönetimi, idrar kaçırma ve erektil disfonksiyon gibi sık karşılaşılan fonksiyonel sorunlar ile psikososyal destek yaklaşımları bütüncül bir bakış açısıyla ele alınmaktadır. Cerrahi sonrası erken dönemde bulantı-kusma kontrolü, opioid dışı analjezi yöntemleri, erken mobilizasyon ve beslenme ile idrar sondası yönetimi önemli iyileşme adımlarıdır. İdrar kaçırma RP sonrası sık görülen bir komplikasyon olup pelvik taban egzersizleri, yaşam tarzı değişiklikleri ve gerekirse cerrahi girişimlerle yönetilmektedir. Benzer şekilde erektil disfonksiyon, sinir koruyucu cerrahiye rağmen gelişebilmektedir ve medikal tedavi, cihazlar ya da protez uygulamalarıyla rehabilitasyon hedeflenmektedir. RP sonrası psikolojik sorunlar sıklıkla kaygı, depresyon ve düşük özgüven ile kendini göstermektedir. Multidisipliner yaklaşım, psikolojik destek ve hasta-aile eğitimi iyileşme sürecinin temelini oluşturur. Dijital sağlık teknolojilerinin kullanımı, hasta takibini kişiselleştirmekte ve destekleyici hizmetleri daha erişilebilir hale getirmektedir. Tüm bu yaklaşımlar, RP sonrası iyileşmeyi sadece medikal değil, aynı zamanda insana dokunan bir sürece dönüştürmeyi amaçlamaktadır.

Referanslar

Gandaglia, G., et al., Epidemiology and prevention of prostate cancer. European urology oncology, 2021. 4(6): p. 877-892.

Trewartha, D. and K. Carter, Advances in prostate cancer treatment. Nature reviews. Drug discovery, 2013. 12(11): p. 823.

Mellman, I., G. Coukos, and G. Dranoff, Cancer immunotherapy comes of age. Nature, 2011. 480(7378): p. 480-489.

Mohan, R. and P.F. Schellhammer, Treatment options for localized prostate cancer. American Family Physician, 2011. 84(4): p. 413-420.

Burt, J., et al., Radical prostatectomy: men's experiences and postoperative needs. Journal of clinical nursing, 2005. 14(7): p. 883-890.

Shaikh, S.I., et al., Postoperative nausea and vomiting: A simple yet complex problem. Anesthesia Essays and Researches, 2016. 10(3): p. 388-396.

Weibel, S., et al., Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta‐analysis. Anaesthesia, 2021. 76(7): p. 962-973.

Joshi, G.P., et al., Optimal pain management for radical prostatectomy surgery: what is the evidence? BMC anesthesiology, 2015. 15: p. 1-10.

Deniz, M., et al., Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy. Journal of International Medical Research, 2012. 40(6): p. 2362-2369.

Rodrigues Pessoa, R., et al., Enhanced recovery after surgery review and urology applications in 2020. BJUI compass, 2020. 1(1): p. 5-14.

Lewis, S.J., H.K. Andersen, and S. Thomas, Early enteral nutrition within 24 h of intestinal surgery versus later commencement of feeding: a systematic review and meta-analysis. Journal of Gastrointestinal Surgery, 2009. 13(3): p. 569-575.

Wu, C., et al., A review of enhanced recovery after surgery concept in perioperative radical prostatectomy for prostate cancer. Journal of Robotic Surgery, 2024. 19(1): p. 9.

Sun, Y., et al., Decreased urethral mucosal damage and delayed bacterial colonization during short-term urethral catheterization using a novel trefoil urethral catheter profile in rabbits. The Journal of urology, 2011. 186(4): p. 1497-1501.

Shekarriz, B., J. Upadhyay, and D.P. Wood, Intraoperative, perioperative, and long-term complications of radical prostatectomy. Urol Clin North Am, 2001. 28(3): p. 639-53.

Foote, J., S. Yun, and G.E. Leach, Postprostatectomy incontinence: pathophysiology, evaluation, and management. Urologic Clinics of North America, 1991. 18(2): p. 229-241.

Moore, K.N., et al., Urinary incontinence after radical prostatectomy: can men at risk be identified preoperatively? Journal of Wound Ostomy & Continence Nursing, 2007. 34(3): p. 270-279.

Gacci, M., et al., Latest Evidence on Post-Prostatectomy Urinary Incontinence. J Clin Med, 2023. 12(3).

Gacci, M., et al., Vardenafil can improve continence recovery after bilateral nerve sparing prostatectomy: results of a randomized, double blind, placebo-controlled pilot study. The journal of sexual medicine, 2010. 7(1_Part_1): p. 234-243.

Bianco Jr, F.J., P.T. Scardino, and J.A. Eastham, Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function (“trifecta”). Urology, 2005. 66(5): p. 83-94.

Imamura, M., et al., Lifestyle interventions for the treatment of urinary incontinence in adults. Cochrane Database of Systematic Reviews, 2015(12).

Sciarra, A., et al., A biofeedback‐guided programme or pelvic floor muscle electric stimulation can improve early recovery of urinary continence after radical prostatectomy: a meta‐analysis and systematic review. International Journal of Clinical Practice, 2021. 75(10): p. e14208.

Kotecha, P., A. Sahai, and S. Malde, Use of duloxetine for postprostatectomy stress urinary incontinence: a systematic review. European urology focus, 2021. 7(3): p. 618-628.

Sebastianelli, A., et al., Systematic review and meta‐analysis on the efficacy and tolerability of mirabegron for the treatment of storage lower urinary tract symptoms/overactive bladder: Comparison with placebo and tolterodine. International Journal of Urology, 2018. 25(3): p. 196-205.

Sandhu, J.S., et al., Incontinence after prostate treatment: AUA/SUFU guideline. The Journal of urology, 2019. 202(2): p. 369-378.

Bratu, O., et al., Erectile dysfunction post-radical prostatectomy–a challenge for both patient and physician. Journal of medicine and life, 2017. 10(1): p. 13.

Asker, H., et al., An update on the current status and future prospects of erectile dysfunction following radical prostatectomy. The Prostate, 2022. 82(12): p. 1135-1161.

Montorsi, F. and A. Burnett, Erectile dysfunction after radical prostatectomy. BJU international, 2004. 93(1): p. 1-2.

Saleh, A., et al., Management of erectile dysfunction post-radical prostatectomy. Research and reports in urology, 2015: p. 19-33.

Gruenwald, I., et al., Shockwave treatment of erectile dysfunction. Therapeutic advances in urology, 2013. 5(2): p. 95-99.

Marcu, D., et al., Penile prosthesis–a viable solution for erectile dysfunction refractory to conservative therapy.

Izidoro, L.C.d.R., et al., Health-related quality of life and psychosocial factors after radical prostatectomy. Acta Paulista de Enfermagem, 2019. 32: p. 169-177.

Emanu, J.C., I.K. Avildsen, and C.J. Nelson, Erectile dysfunction after radical prostatectomy: prevalence, medical treatments, and psychosocial interventions. Current opinion in supportive and palliative care, 2016. 10(1): p. 102-107.

Roth, A.J., M.I. Weinberger, and C.J. Nelson, Prostate cancer: psychosocial implications and management. Future oncology, 2008. 4(4): p. 561-568.

Hajjar, R.R., Psychosocial impact of urinary incontinence in the elderly population. Clinics in geriatric medicine, 2004. 20(3): p. 553-564.

Yuan, Y., et al., Psychological nursing approach on anxiety and depression of patients with severe urinary incontinence after radical prostatectomy–a pilot study. Journal of International Medical Research, 2019. 47(11): p. 5689-5701.

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21 Ocak 2026

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