İntratorasik Organ Prezervasyonu

Lepoittevin M, Giraud S, Kerforne T, et al. Preservation of Organs to Be Transplanted: An Essential Step in the Transplant Process. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute; 2022;23(9): 4989. doi:10.3390/ijms23094989

Maathuis M-HJ, Leuvenink HGD, Ploeg RJ. Perspectives in Organ Preservation. Transplantation. 2007;83(10): 1289. doi:10.1097/01.tp.0000265586.66475.cc

Pradegan N, Gallo M, Fabozzo A, et al. Nonischemic Donor Heart Preservation: New Milestone in Heart Transplantation History. ASAIO Journal. 2023;69(8): 725. doi:10.1097/MAT.0000000000002001

Ughetto A, Roubille F, Molina A, et al. Heart graft preservation technics and limits: an update and perspectives. Frontiers in Cardiovascular Medicine. 2023;10: 1248606. doi:10.3389/fcvm.2023.1248606

Hess NR, Ziegler LA, Kaczorowski DJ. Heart Donation and Preservation: Historical Perspectives, Current Technologies, and Future Directions. Journal of Clinical Medicine. Multidisciplinary Digital Publishing Institute; 2022;11(19): 5762. doi:10.3390/jcm11195762

Gasmi A, Peana M, Arshad M, et al. Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis. Archives of Toxicology. 2021;95(4): 1161–1178. doi:10.1007/s00204-021-02974-9

Zheng Y, Sun J, Luo Z, et al. Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications. Cell Death & Disease. Nature Publishing Group; 2024;15(11): 1–19. doi:10.1038/s41419-024-07244-x

Turer AT, Hill JA. Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy. The American Journal of Cardiology. 2010;106(3): 360–368. doi:10.1016/j.amjcard.2010.03.032

Murphy GS, Hessel EA, Groom RC. Optimal perfusion during cardiopulmonary bypass: an evidence-based approach. Anesthesia and Analgesia. 2009;108(5): 1394–1417. doi:10.1213/ane.0b013e3181875e2e

Vrints CJM. Pathophysiology of the no-reflow phenomenon. Acute Cardiac Care. Taylor & Francis; 2009;11(2): 69–76. doi:10.1080/17482940902978061

Heusch G. The Coronary Circulation as a Target of Cardioprotection. Circulation Research. Lippincott Williams & WilkinsHagerstown, MD; 2016; doi:10.1161/CIRCRESAHA.116.308640

Badoe N, Shah P. History of Heart Transplant. In: Bogar L, Stempien-Otero A (eds.) Contemporary Heart Transplantation. Cham: Springer International Publishing; 2020. p. 3–12. doi:10.1007/978-3-319-58054-8_1

Crawford TC, Magruder JT, Grimm JC, et al. The Paradoxical Relationship Between Donor Distance and Survival After Heart Transplantation. The Annals of Thoracic Surgery. 2017;103(5): 1384–1391. doi:10.1016/j.athoracsur.2017.01.055

Gaffey AC, Chen CW, Chung JJ, et al. Extended distance cardiac allograft can successfully be utilized without impacting long-term survival. The Journal of Heart and Lung Transplantation. 2017;36(9): 968–972. doi:10.1016/j.healun.2017.04.002

Chew HC, Macdonald PS, Dhital KK. The donor heart and organ perfusion technology. Journal of Thoracic Disease. 2019;11(Suppl 6): S938–S945. doi:10.21037/jtd.2019.02.59

Que W, Hu X, Fujino M, et al. Prolonged Cold Ischemia Time in Mouse Heart Transplantation Using Supercooling Preservation. Transplantation. 2020;104(9): 1879. doi:10.1097/TP.0000000000003089

Lechiancole A, Sponga S, Benedetti G, et al. Graft preservation in heart transplantation: current approaches. Frontiers in Cardiovascular Medicine. 2023;10: 1253579. doi:10.3389/fcvm.2023.1253579

Das SN, Chauhan S, Saxena N. Myocardial preservation during cardiac surgery. Annals of Cardiac Anaesthesia. 2002;5(1): 25–32.

Barth AS, Tomaselli GF. Cardiac Metabolism and Arrhythmias. Circulation: Arrhythmia and Electrophysiology. 2009;2(3): 327–335. doi:10.1161/CIRCEP.108.817320

Watts RP, Thom O, Fraser JF. Inflammatory Signalling Associated with Brain Dead Organ Donation: From Brain Injury to Brain Stem Death and Posttransplant Ischaemia Reperfusion Injury. Journal of Transplantation. 2013;2013: 521369. doi:10.1155/2013/521369

McKeown DW, Bonser RS, Kellum JA. Management of the heartbeating brain-dead organ donor. BJA: British Journal of Anaesthesia. 2012;108(suppl_1): i96–i107. doi:10.1093/bja/aer351

Barklin A. Systemic inflammation in the brain‐dead organ donor. Acta Anaesthesiologica Scandinavica. 2009;53(4): 425–435. doi:10.1111/j.1399-6576.2008.01879.x

Anwar ASMT, Lee J. Medical Management of Brain-Dead Organ Donors. Acute and Critical Care. 2019;34(1): 14–29. doi:10.4266/acc.2019.00430

Kutsogiannis DJ, Pagliarello G, Doig C, et al. Medical management to optimize donor organ potential: review of the literature. Canadian Journal of Anaesthesia = Journal Canadien D’anesthesie. 2006;53(8): 820–830. doi:10.1007/BF03022800

Braithwaite SA, Kaaij NP van der. New Techniques for Optimization of Donor Lungs/Hearts. Anesthesiology Clinics. Elsevier; 2019;37(4): 639–660. doi:10.1016/j.anclin.2019.08.010

Güvenç Doğan OK. Donör Bakımı. [Online] Turkish Journal of Intensive Care; doi:10.4274/tybd.galenos.2023.50570

Blitzer D, Baran DA, Lirette S, et al. Does donor treatment with inotropes and/or vasopressors impact post-transplant outcomes? Clinical Transplantation. 2023;37(4): e14912. doi:10.1111/ctr.14912

Carter KT, Lirette ST, Baran DA, et al. The Effect of Cardiac Preservation Solutions on Heart Transplant Survival. Journal of Surgical Research. Elsevier; 2019;242: 157–165. doi:10.1016/j.jss.2019.04.041

Buckberg GD, Athanasuleas CL. Cardioplegia: solutions or strategies? European Journal of Cardio-Thoracic Surgery. 2016;50(5): 787–791. doi:10.1093/ejcts/ezw228

Cullen PP, Tsui SS, Caplice NM, et al. A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation. Interactive Cardiovascular and Thoracic Surgery. 2021;32(5): 683–694. doi:10.1093/icvts/ivaa333

Minasian SM, Galagudza MM, Dmitriev YV, et al. Preservation of the donor heart: from basic science to clinical studies. Interactive CardioVascular and Thoracic Surgery. 2015;20(4): 510–519. doi:10.1093/icvts/ivu432

Salvemini D, Cuzzocrea S. Superoxide, superoxide dismutase and ischemic injury. Current Opinion in Investigational Drugs (London, England: 2000). 2002;3(6): 886–895.

Zhou K, Zhang X, Li D, et al. Myocardial Protection With Different Cardioplegia in Adult Cardiac Surgery: A Network Meta-Analysis. Heart, Lung and Circulation. 2022;31(3): 420–429. doi:10.1016/j.hlc.2021.09.004

Carvajal C, Goyal A, Tadi P. Cardioplegia. StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. http://www.ncbi.nlm.nih.gov/books/NBK554463/

Whittaker A, Aboughdir M, Mahbub S, et al. Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review. Perfusion. 2021;36(4): 338–351. doi:10.1177/0267659120942656

Bradić J, Andjić M, Novaković J, et al. Cardioplegia in Open Heart Surgery: Age Matters. Journal of Clinical Medicine. Multidisciplinary Digital Publishing Institute; 2023;12(4): 1698. doi:10.3390/jcm12041698

Li Y, Guo S, Liu G, et al. Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis. Artificial Organs. 2016;40(5): 489–496. doi:10.1111/aor.12585

Kaliyev R, Lesbekov T, Bekbossynov S, et al. Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system. Journal of Cardiac Surgery. 2019;34(10): 969–975. doi:10.1111/jocs.14162

Lema Zuluaga GL, Serna Agudelo RE, Zuleta Tobón JJ. Preservation solutions for liver transplantation in adults: celsior versus custodiol: a systematic review and meta-analysis with an indirect comparison of randomized trials. Transplantation Proceedings. 2013;45(1): 25–32. doi:10.1016/j.transproceed.2012.02.031

Qin G, Jernryd V, Sjöberg T, et al. Machine Perfusion for Human Heart Preservation: A Systematic Review. Transplant International: Official Journal of the European Society for Organ Transplantation. 2022;35: 10258. doi:10.3389/ti.2022.10258

Bryner BS, Schroder JN, Milano CA. Heart transplant advances: Ex vivo organ-preservation systems. JTCVS Open. Elsevier; 2021;8: 123–127. doi:10.1016/j.xjon.2021.04.020

Mauerhofer C, Grumet L, Schemmer P, et al. Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings. International Journal of Molecular Sciences. 2021;22(19): 10675. doi:10.3390/ijms221910675

Safaei N, Sheikhalizadeh MA, Badalzadeh R. Effect of ischemic postconditioning on myocardial protection in patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass. Journal of Cardiovascular and Thoracic Research. 2016;8(2): 65–71. doi:10.15171/jcvtr.2016.13

Sabe SA, Harris DD, Broadwin M, et al. Cardioprotection in cardiovascular surgery. Basic Research in Cardiology. 2024;119(4): 545–568. doi:10.1007/s00395-024-01062-0

Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biology. 2015;6: 524–551. doi:10.1016/j.redox.2015.08.020

Slodzinski MK, Aon AM, O’Rourke B. Glutathione Oxidation as a Trigger of Mitochondrial Depolarization and Oscillation in Intact Hearts. Journal of molecular and cellular cardiology. 2008;45(5): 650–660. doi:10.1016/j.yjmcc.2008.07.017

Zhang N, Aiyasiding X, Li W, et al. Neutrophil degranulation and myocardial infarction. Cell Communication and Signaling. 2022;20(1): 50. doi:10.1186/s12964-022-00824-4

Jiang K, Hwa J, Xiang Y. Novel strategies for targeting neutrophil against myocardial infarction. Pharmacological Research. 2024;205: 107256. doi:10.1016/j.phrs.2024.107256

Naruka V, Salmasi MY, Arjomandi Rad A, et al. Use of Cytokine Filters During Cardiopulmonary Bypass: Systematic Review and Meta-Analysis. Heart, Lung & Circulation. 2022;31(11): 1493–1503. doi:10.1016/j.hlc.2022.07.015

Ozgur OS, Namsrai B-E, Pruett TL, et al. Current practice and novel approaches in organ preservation. Frontiers in Transplantation. Frontiers; 2023;2. doi:10.3389/frtra.2023.1156845

Kounatidis D, Brozou V, Anagnostopoulos D, et al. Donor Heart Preservation: Current Knowledge and the New Era of Machine Perfusion. International Journal of Molecular Sciences. 2023;24(23): 16693. doi:10.3390/ijms242316693

Lerman JB, Agarwal R, Patel CB, et al. Donor Heart Recovery and Preservation Modalities in 2024. JACC. Heart failure. 2024;12(3): 427–437. doi:10.1016/j.jchf.2023.10.012

Rega F, Lebreton G, Para M, et al. Hypothermic oxygenated perfusion of the donor heart in heart transplantation: the short-term outcome from a randomised, controlled, open-label, multicentre clinical trial. The Lancet. Elsevier; 2024;404(10453): 670–682. doi:10.1016/S0140-6736(24)01078-X

Nilsson J, Jernryd V, Qin G, et al. A nonrandomized open-label phase 2 trial of nonischemic heart preservation for human heart transplantation. Nature Communications. Nature Publishing Group; 2020;11(1): 2976. doi:10.1038/s41467-020-16782-9

Pinnelas R, Kobashigawa JA. Ex vivo normothermic perfusion in heart transplantation: a review of the TransMedics® Organ Care System. Future Cardiology. 2022;18(1): 5–15. doi:10.2217/fca-2021-0030

Egle M, Longnus S, Yildiz M, et al. Surgical techniques for cardiac procurement, preparation and perfusion using the Organ Care System. Multimedia manual of cardiothoracic surgery: MMCTS. 2024;2024. doi:10.1510/mmcts.2024.057

Wan L, Powell-Palm MJ, Lee C, et al. Preservation of rat hearts in subfreezing temperature isochoric conditions to – 8 °C and 78 MPa. Biochemical and Biophysical Research Communications. 2018;496(3): 852–857. doi:10.1016/j.bbrc.2018.01.140

Faria I, Canizares S, Devos L, et al. Machine perfusion organ preservation: Highlights from the American Transplant Congress 2023. Artificial Organs. 2024;48(7): 794–799. doi:10.1111/aor.14765

Plumblee L, Atkinson C, Jaishankar D, et al. Nanotherapeutics in transplantation: How do we get to clinical implementation? American Journal of Transplantation. 2022;22(5): 1293–1298. doi:10.1111/ajt.17012

Chen F, Date H. Update on ischemia-reperfusion injury in lung transplantation. Current Opinion in Organ Transplantation. 2015;20(5): 515. doi:10.1097/MOT.0000000000000234

Jungraithmayr W. Novel Strategies for Endothelial Preservation in Lung Transplant Ischemia-Reperfusion Injury. Frontiers in Physiology. Frontiers; 2020;11. doi:10.3389/fphys.2020.581420

Hidalgo MA, Shah KA, Fuller BJ, et al. Cold ischemia–induced damage to vascular endothelium results in permeability alterations in transplanted lungs. The Journal of Thoracic and Cardiovascular Surgery. 1996;112(4): 1027–1035. doi:10.1016/S0022-5223(96)70104-6

Gao W, Jiang T, Liu Y, et al. Endothelial progenitor cells attenuate the lung ischemia/reperfusion injury following lung transplantation via the endothelial nitric oxide synthase pathway. The Journal of Thoracic and Cardiovascular Surgery. 2019;157(2): 803–814. doi:10.1016/j.jtcvs.2018.08.092

Ferrari RS, Andrade CF. Oxidative Stress and Lung Ischemia-Reperfusion Injury. Oxidative Medicine and Cellular Longevity. 2015;2015(1): 590987. doi:10.1155/2015/590987

Mathis S, Putzer G, Schneeberger S, et al. The Endothelial Glycocalyx and Organ Preservation—From Physiology to Possible Clinical Implications for Solid Organ Transplantation. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute; 2021;22(8): 4019. doi:10.3390/ijms22084019

Sack F-U, Dollner R, Reidenbach B, et al. Intravital Microscopy of Pulmonary Microcirculation After Single Lung Transplantation in Pigs. Transplantation Proceedings. 2006;38(3): 737–740. doi:10.1016/j.transproceed.2006.01.060

Niroomand A, Hirdman G, Pierre L, et al. Proteomic changes to immune and inflammatory processes underlie lung preservation using ex vivo cytokine adsorption. Frontiers in Cardiovascular Medicine. Frontiers; 2023;10. doi:10.3389/fcvm.2023.1274444

Lindstedt S, Silverborn M, Lannemyr L, et al. Design and Rationale of Cytokine Filtration in Lung Transplantation (GLUSorb): Protocol for a Multicenter Clinical Randomized Controlled Trial. JMIR Research Protocols. 2023;12(1): e52553. doi:10.2196/52553

Götzfried J, Smirnova NF, Morrone C, et al. Preservation with α1-antitrypsin improves primary graft function of murine lung transplants. The Journal of Heart and Lung Transplantation. 2018;37(8): 1021–1028. doi:10.1016/j.healun.2018.03.015

Cypel M, Rubacha M, Yeung J, et al. Normothermic Ex Vivo Perfusion Prevents Lung Injury Compared to Extended Cold Preservation for Transplantation. American Journal of Transplantation. 2009;9(10): 2262–2269. doi:10.1111/j.1600-6143.2009.02775.x

Halpern SE, Kesseli SJ, Au S, et al. Lung transplantation after ex vivo lung perfusion versus static cold storage: An institutional cost analysis. American Journal of Transplantation. 2022;22(2): 552–564. doi:10.1111/ajt.16794

Burlage LC, Karimian N, Westerkamp AC, et al. Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers. HPB. 2017;19(6): 538–546. doi:10.1016/j.hpb.2017.02.439

Hoetzenecker K, Benazzo A, Schwarz S, et al. The Advent of Semi-Elective Lung Transplantation—Prolonged Static Cold Storage at 10°C. Transplant International. Frontiers Publishing Partnerships; 2024;37: 12310. doi:10.3389/ti.2024.12310

Wu M, Yang Q, Yim APC, et al. Cellular electrophysiologic and mechanical evidence of superior vascular protection in pulmonary microcirculation by Perfadex compared with Celsior. The Journal of Thoracic and Cardiovascular Surgery. 2009;137(2): 492–498. doi:10.1016/j.jtcvs.2008.08.047

Medeiros IL, Pêgo-Fernandes PM, Mariani AW, et al. Comparison of lung preservation solutions in human lungs using an ex vivo lung perfusion experimental model. Clinics. 2012;67(9): 1101–1106. doi:10.6061/clinics/2012(09)19

Wittwer T, Albes JM, Fehrenbach A, et al. Experimental lung preservation with perfadex: effect of the no-donor nitroglycerin on postischemic outcome. The Journal of Thoracic and Cardiovascular Surgery. 2003;125(6): 1208–1216. doi:10.1016/S0022-5223(02)73244-3

L L, X W, Z Y. Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies. Biochemistry & pharmacology : open access. 2016;5(4): 213. doi:10.4172/2167-0501.1000213

Salameh A, Dhein S. Strategies for Pharmacological Organoprotection during Extracorporeal Circulation Targeting Ischemia-Reperfusion Injury. Frontiers in Pharmacology. Frontiers; 2015;6. doi:10.3389/fphar.2015.00296

Rodrigo R, Prieto JC, Castillo R. Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n−3 fatty acids: molecular mechanisms and potential clinical applications. Clinical Science. 2012;124(1): 1–15. doi:10.1042/CS20110663

Yemaneberhan KH, Kang M, Jang JH, et al. Beyond the icebox: modern strategies in organ preservation for transplantation. Clinical Transplantation and Research. 2024;38(4): 377–403. doi:10.4285/ctr.24.0039

Maganti HB, Bailey AJM, Kirkham AM, et al. Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta‐analysis of preclinical studies. Stem Cells Translational Medicine. 2021;10(7): 996–1007. doi:10.1002/sctm.20-0520