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Referanslar

Roth GA, Huffman MD, Moran AE, et al. Global and regional patterns in cardiovascular mortality from 1990 to 2013. Circulation; 2015;132:1667–1678. doi:10.1161/CIRCULATIONAHA. 114.008720.

Nubong T, Kim CW, Khetpal V, Hulten E , Ramirez V. Update in Cardiovascular Prevention: From Risk Scores to Imaging. R I Med J (2013); 2025;108:9-15.

Le A, Peng H, Golinsky D, et al. What causes prematüre coronary artery Disease? Curr Atheroscler Rep 2024; 26:189-203. doi.org/10.1007/s11883-024-01200-y.

Ferket BS, Genders TS, Colkesen EB, et al. Systematic review of guidelines on imaging of asymptomatic coronary artery disease. J Am Coll Cardiol; 2011;57:1591- 1600. doi: 10.1016/j.jacc.2010.10.055.

Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol; 2010;56:50-103. doi: 10.1016/j.jacc.2010.09.001.

Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, et al. AHA/ACC/ASE/CHEST /SAEM/SCCT/SCMR Guideline for the evaluation and diagnosis of chest pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol; 2021;78:e187–285. doi: 10.1016/j.jacc.2021.07.053.

Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A R Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol; 2011;57:215-367. doi: 10.1016/j.jacc.2011.02.011.

Litmanovich D, Koweek LMH, Ghoshhajra BB, et al. ACR Appropriateness Criteria® Chronic Chest Pain-High Probability of Coronary Artery Disease: 2021 Update. J Am Coll Radiol; 2022;19 (5S):S1-S18. doi: 10.1016/j.jacr.2022.02.021.

Lam DH, Tiwana J, Li S, Kirkpatrick JN, Cheng RK. Appropriate use of multimodality stress testing for chest pain in new patient referrals to cardiologists. Coron Artery Dis; 2021; 32:184-190. doi: 10.1097/MCA.0000000000000928.

Flotats A, Knuuti J, Gutberlet M, et al. Hybrid cardiac imaging: SPECT/CT and PET/CT. A joint position state- ment by the European Association of Nuclear Medicine (EANM), the European Society of Cardiac Radiology (ESCR) and the European Council of Nuclear Cardiology (ECNC). Eur J Nucl Med Mol Imaging; 2011;38:201-212. doi: 10.1007/s00259-010-1586-y.

Biering-Sorensen T, Mogelvang R, Pedersen S, et al. Usefulness of the myocardial performance index determined by tissue Doppler imaging m-mode for predicting mortality in the general population. Am J Cardiol, 2011;107:478-483. doi: 10.1016/j.amjcard.2010.09.044.

Chopra HK. Echocardiography in acute coronary syndromes. Indian Heart J; 2010;62:282-285.

Kajander S, Joutsiniemi E, Saraste M, et al. Cardiac Positron Emission Tomography/Computed Tomography Imaging Accurately Detects Anatomically and Functionally Significant Coronary Artery Disease.Circulation; 2010;122:603-613. doi: 10.1161/CIRCULATIONAHA.109.915009.

Liga R, Neglia D, Kusch A, Favilli B, Giorgetti A, Gimelli A. Prognostic Role of Dynamic CZT Imaging in CAD Patients: Interaction Between Absolute Flow and CAD Burden.

JACC: Cardiovascular Imaging; 2022; 15:540-542. doi: 10.1016/j.jcmg.2021.09.030.

Pontone G, Andreini D, Bartorelli AL, et al. Comparison between low-dose multidetector computed coronary angiography and myocardial perfusion imaging test in patients with intermediate pre-test likelihood of coronary artery disease. Int J Cardiol; 2011;147:454-457. doi: 10.1016/j.ijcard.2010.12.107.

Garcia EV, Faber TL, Esteves FP. Cardiac dedicated ultrafast SPECT cameras: New designs and clinical implications. J Nucl Med; 2011;52:210-7. doi: 10.2967/jnumed.110.081323.

Sredojeviç M, Liga R, Gimelli A. CZT SPECT study and the imaging of coronary disease: state of art. Clin Transl Imaging; 2023; 11: 339-349. Doi: 10.1007/s40336-023-00562-8.

Schwitter J, Arai AE. Assessment of cardiac ischaemia and viability: role of cardiovascular magnetic resonance. European Heart Journal; 2011; 32, 799–809. doi:10.1093/eurheartj/ehq481.

Kwiecinski J, Wolny R, Chwala A, Slomka P. Advances in the assessment of coronary artery disease activity with PET/CT and CTA. Tomography; 2023;9:328–341. doi: 10. 3390/tomography 90100 26.

Lee DS, Verocai F, Husain M et al. Cardiovascular outcomes are predicted by exercise-stress myocardial perfusion imaging: Impact on death, myocardial infarction, and coronary revascularization procedures. Am Heart J; 2011;161:900-907.

Tamaki N, Manabe O. Current status and perspectives of nuclear cardiology. Ann Nucl Med; 2024;38:20-30. doi: 10.1007/s12149-023-01878-1.

Verberne HJ, Acampa W, Anagnostopoulos C, et al. EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging; 2015;42:1929–1940. 10. 1007/ s00259- 015- 3139-x.

Dheer P, Gupta P, Taywade SK , Passah A, Pandey AK, Patel C. Optimization of Ordered Subset Expectation Maximization Parameters for Image Reconstruction in Tc-99m Methoxyisobutylisonitrile Myocardial Perfusion SPECT and Comparison with Corresponding Filtered Back Projection-Reconstructed Images. Indian J Nucl Med 2021;36:14-20. doi: 10.4103/ijnm. IJNM_140_20.

Abbott BG, Case JA, Dorbala S, et al. Contemporary Cardiac SPECT Imaging—Innovations and Best Practices: An Information Statement from the American Society of Nuclear Cardiology. J Nucl Cardiol; 2018;25:1847–1860. doi:10.1007/s12350-018-1348-y.

Hirata K, Matsui Y, Yamada A, et al. Generative AI and large language models in nuclear medicine: current status and future prospects. Ann Nucl Med; 2024; 38, 853–864. doi.org/10.1007/s12149-024-01981-x.

Wang H, Guo R, Li B. Applications of Artificial Intelligence in Nuclear Medicine. In: Liu, S. (ed) Artificial Intelligence in Medical Imaging in China. Singapore: Springer: 2024. doi.org/10.1007/978-981-99-8441-1_17.

Badesha AS, Frood R, Bailey MA, Coughlin PM, Scarsbrook AF. A Scoping Review of Machine-Learning Derived Radiomic Analysis of CT and PET Imaging to Investigate Atherosclerotic Cardiovascular Disease. Tomography; 2024; 10, 1455–1487. doi.org/10.3390/tomography10090108.

Cho SG, Lee JE, Cho KH, et al. ·Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis. European Journal of Nuclear Medicine and Molecular Imaging; 2025; 52:1050–1059. doi.org/10.1007/s00259-024-06948-8.

Slart RHJA, WilliamsMC, Juarez-Orozco LE, et al. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT. European Journal of Nuclear Medicine and Molecular Imaging; 2021; 48:1399–1413. doi.org/10.1007/s00259-021-05341-z.

Tang J, Lee TS, He X, Segars WP, Tsui BM. Comparison of 3D OS-EM and 4D MAP-RBI-EM reconstruction algorithms for cardiac motion abnormality classification using a motion observer. IEEE Trans Nucl Sci ; 2010; 57:2571. doi: 10.1109/TNS.2010.2050604.

Zhang H, Caobelli F, Che W, et al. The prognostic value of CZT SPECT myocardial blood flow (MBF) quantification in patients with ischemia and no obstructive coronary artery disease (INOCA): a pilot study. Eur J Nucl Med Mol Imaging; 2023;50:1940-1953. doi: 10.1007/ s00259-023-06125-3.

Cerqueira MD, Allman KC, Ficaro EP et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol; 2010;17:709-718. doi: 10.1007/s12350-010-9244-0.

Gunalp B. Role of cardiac ultrafast cameras with CZT solid-state detectors and software developments on radiation absorbed dose reduction to the patients. Radiat Prot Dosimetry; 2015;165:461-463. doi: 10.1093/rpd/ncv096.

Lindner O, Pascual TNB, Mercuri M, et al. Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries. Eur J Nucl Med Mol Imaging; 2016; 43:718–728. doi: 10.1007/s00259-015-3270-8.

Baumgarten R, Cerci RJ, de Nadai Costa A, Radiation exposure after myocardial perfusion imaging with Cadmium-Zinc-Telluride camera versus conventional camera J Nucl Cardiol; 2021;28:992-999. doi: 10.1007/s12350-020-02146-9.

Nappi C, Acampa W, Nicolai E, et al. Long-term prognostic value of low-dose normal stress-only myocardial perfusion imaging by wide beam reconstruction: A competing risk analysis. J Nucl Cardiol; 2020;27:547-557. doi: 10.1007/s12350-018-1373-x.

Romero-Farina G, Candell-Riera J, Aguadé-Bruix S, Castell-Conesa J, García-Dorado D. Impact of myocardial perfusion gated-SPECT on the decision to perform coronary angiography in patients with left ventricular dysfunction of ischemic origin. Rev Esp Med Nucl; 2011;30:141-146. doi: 10.1016/ j.remn.2010.12.006.

AlBadri A, Piccinelli M, Cho SG, et al. Rationale and design of the quantification of myocardial blood flow using dynamic PET/CTA-fused imagery (DEMYSTIFY) to determine physiological significance of specific coronary lesions. J Nucl Cardiol; 2020;27:1030–1039. doi. org/ 10. 1007/ s12350- 020- 02052-0.

Bom MJ, Schumacher SP, Driessen RS, et al. Impact of individualized segmentation on diagnostic performance of quantitative positron emission tomography for haemodynamically significant coronary artery disease. Eur Heart J Cardiovasc Imaging; 2019;20:525–532. doi. org/ 10. 1093/ ehjci/ jey201.

Zhang K, Yujie SunY, Wu Shuang, et al. Systematic imaging in medicine: a comprehensive review. European Journal of Nuclear Medicine and Molecular Imaging; 2021;48:1736–1758. doi.org/10.1007/s00259-020-05107-z.

Karaçavuş S. PET/BT ve PET/MR görüntüleme ve görüntü işleme. In: Kibar M (Ed). Nükleer Tıp ve Moleküler Görüntüleme: Metodoloji ve Klinik Uygulamalar. Ankara: Akademisyen Kitabevi; 2023. pp.355-361.doi: 10.37609/akya.2897.

Baskaran L, Yan L, Tan CS, et al. Evaluating the American Heart Association/American College of Cardiology Guideline—Recommended and Contemporary Pretest Probability Models in a Mixed Asian Cohort: The Contribution of Coronary Artery Calcium. J Am Heart Assoc; 2024;13:e033879. doi: 10.1161/JAHA.123.033879.

Cho SG, Lee JE, Cho KH, et al. Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis. European Journal of Nuclear Medicine and Molecular Imaging; 2025;52:1050–1059. doi.org/10.1007/s00259-024-06948-8.

Kontos MC, Dilsizian V, Weiland F, et al. Iodofiltic acid I 123 (BMIPP) fatty acid imaging improves initial diagnosis in emergency department patients with suspected acute coronary syndromes: A multicenter trial. J Am Coll Cardiol; 2010;56:290-299. doi: 10.1016/j.jacc.2010.03.045.

Takanami K, Arai A, Umezawa R, et al. Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT. Radiother Oncol; 2016; 119 (1):77-83. doi: 10.1016/j.radonc. 2016.01.024.

Koenders SS, van Dalen JA, Jager PL, Mouden M, Slump CH, van Dijk JD. Patient-tailored risk assessment of obstructive coronary artery disease using Rubidium-82 PET-based myocardial flow quantification with visual interpretation. J Nucl Cardiol; 2023;30:1890-1896. doi: 10.1007/s12350-023-03237-z.

Abadie BQ, Chan N, Sharalaya Z, et al. Negative Predictive Value and Prognostic Associations of Rb-82 PET/CT with Myocardial Blood Flow in CAV. JACC Heart Fail; 2023;11(5):555-565. doi: 10.1016/j.jchf.2022.11.012.

Kıraç FS. Kardiyak PET Perfüzyon ve Viyabilite Çalışmaları. Turkiye Klinikleri J Nucl Med-Special Topics; 2015;1:31-40.

Salihoğlu YS, Özdemir S. Pozitron emisyon tomografi miyokart perfüzyon görüntüleme. In: Kibar M (Ed). Nükleer Tıp ve Moleküler Görüntüleme: Metodoloji ve Klinik Uygulamalar. Ankara: Akademisyen Kitabevi; 2023. pp 677-686. doi: 10.37609/akya.2897

Özgenç E, Gündoğdu E, Ocak M. Radyofarmasötikler. In: Kibar M (Ed). Nükleer Tıp ve Moleküler Görüntüleme: Metodoloji ve Klinik Uygulamalar. Ankara: Akademisyen Kitabevi; 2023. pp 99-123. doi: 10.37609/akya.2897.

Naya M, Di Carli MF. Myocardial perfusion PET/CT to evaluate known and suspected coronary artery disease. Q J Nucl Med Mol Imaging; 2010;54:145-156.

Jia Y, Hu Y, Yang L, et al. Prognostic value of transient ischemic dilatation by 13N-ammonia PET MPI for short-term outcomes in patients with non-obstructive CAD. Ann Nucl Med; 2025;39:47-57. doi: 10.1007/s12149-024-01976-8.

Gajic M, Galafton A, Heiniger PS, et al. Effect of acute intravenous beta-blocker administration on myocardial blood flow during same-day hybrid CCTA/PET imaging. Int J Cardiovasc Imaging; 2024; 40: 2203-2212. doi: 10.1007/s10554-024-03212-w.

Lehtonen E, Kujala I, Tamminen J, et al. Incremental prognostic value of downstream positron emission tomography perfusion imaging after coronary computed tomography angiography: a study using machine learning. European Heart Journal - Cardiovascular Imaging; 2024; 25: 285–292. doi: 10.1093/ehjci/jead246

Jones DA, Beirne AM, Kelham M, et al. Computed tomography cardiac angiography before invasive coronary angiography in patients with previous bypass surgery: the BYPASS-CTCA trial. Circulation; 2023;148:1371–1380. Doi: 10. 1161/ CIRCU LATIONAHA. 123. 064465.

Mikail N, Rossi A, Bengs S, et al. Imaging of heart disease in women: review and case presentation. European Journal of Nuclear Medicine and Molecular Imaging; 2022; 50:130–159. doi: 10.1007/s00259-022-05914-6.

Kupusovic J, Kessler L, Kazek S, et al. Delayed 68Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction. IJC Heart & Vasculature; 2024; 50: 101340. doi: 10.1016/j.ijcha.2024.101340.

Kessler L, Kupusovic J, Ferdinandus J, et al. Visualization of Fibroblast Activation After Myocardial Infarction Using Ga-68 FAPI PET. Clin Nucl Med; 2021; 46 :807-813. doi: 10.1097/RLU.0000000000003745.

Bucerius J, Dijkgraaf I, Mottaghy FM, Schurgers LJ. Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon. European Journal of Nuclear Medicine and Molecular Imaging; 2019; 46:251–265. doi:10.1007/s00259-018-4176-z.

Lieverse TGF, van Praagh, Mulder DJ, Lambers Heerspink HJ, Wolterink JM, Slart RHJA. Quantitative aortic Na[18F]F positron emission tomography computed tomography as a tool to associate vascular calcification with major adverse cardiovascular events. European Journal of Nuclear Medicine and Molecular Imaging; 2025;52:501–509. doi:10.1007/s00259-024-06901-9.

Mushtaq S , Fabio Fazzari , Mancini ME, Pontone G. The era of interventional imaging has arrived: what role for computed tomography and magnetic resonance? Eur Heart J Suppl; 2025 19;27(Suppl 1):i22-i26. doi: 10.1093/eurheartjsupp/suae112.

Catania R, Quinn S, Rahsepar AA, et al. Quantitative Stress First-Pass Perfusion Cardiac MRI: State of the Art. Radiographics; 2025;45:e240115. doi: 10.1148/rg.240115.

Ko SM. Current Status of Cardiac CT for Nuclear Medicine Professionals: Coronary Artery Disease Evaluation. Nuclear Medicine and Molecular Imaging; 2024;58:418–430. doi: 10.1007/s13139-024-00859-0.

Moon JH, Park EA, Lee W, et al. The Diagnostic Accuracy, Image Quality and Radiation Dose of 64-Slice Dual-Source CT in Daily Practice: A Single Institution’s Experience. Korean J Radiol; 2011;12:308-318. doi: 10.3348/kjr.2011.12.3.308.

Maroules CD, Rybicki FJ, Ghoshhajra BB, et al. Use of coronary computed tomographic angiography for patients presenting with acute chest pain to the emergency department: An expert consensus document of the Society of cardiovascular computed tomography (SCCT): Endorsed by the American College of Radiology (ACR) and North American Society for cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr; 2023;17:146-163. doi: 10.1016/ j.jcct.2022.09.003.

Schulz A, Otton J, Hussain T, Miah T, Schuster A. Clinical Advances in Cardiovascular Computed Tomography: From Present Applications to Promising Developments. Curr Cardiol Rep; 2024;26:1063-1076. doi: 10.1007/s11886-024-02110-w.

Ho KT, Chua KC, Klotz E, Panknin C. Stress and Rest Dynamic Myocardial Perfusion Imaging by Evaluation of Complete Time-Attenuation Curves With Dual- Source CT. J Am Coll Cardiol Img; 2010;3:811-820.

Caobelli F, Dweck MR, Albano D, et al. Hybrid cardiovascular imaging. A clinical consensus statement of the european association of nuclear medicine (EANM) and the european association of cardiovascular imaging (EACVI) of the ESC. European Journal of Nuclear Medicine and Molecular Imaging; 2025; 52:1095–1118. Doi:10.1007/s00259-024-06946-w.

Joseph J, Velasco A, Hage FG, Reyes E. Guidelines in review: Comparison of ESC and ACC/AHA guidelines for the diagnosis and management of patients with stable coronary artery disease. Nucl Cardiol; 2018;25:509–515. doi:10.1007/s12350-017-1055-0.

Hecth HS. Electron beam tomography: current parctice and implications for nuclear cardiology. J Nucl Cardiol; 2000;7:714-721. doi: 10.1067/mnc.2000.108907.

Daniell AL, Wong ND, Friedman JD et al. Concordance of coronary artery calcium estimates between MDCT and electron beam tomography. Am J Roentgenol; 2005;185:1542-1545. doi: 10.2214/ AJR.04.0333.

Chung SY, Lee KY, Chun EJ, et al. Comparison of stress perfusion MRI and SPECT for detection of myocardial ischemia in patients with angiographically proven three-vessel coronary artery disease. Am J Roentgenol; 2010;195:356-362. doi: 10.2214/AJR.08.1839.

Mintz GS, Nissen SE, Anderson WD, et al. American College of Cardiology Clinical Expert Consensus Document on Standarts for Acquisition, Measurement, and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Expert consensus documents. J Am Coll Cardiol; 2001;37:1478-1492. doi: 10.1016/s0735-1097(01)01175-5.

Galo J, Chaturvedi A , Al-Qaraghuli A,et al. Machine Learning in Intravascular Ultrasound: Validating Automated Lesion Assessment for Complex Coronary Interventions. Catheter Cardiovasc Interv; 2025 Feb 21. doi: 10.1002/ccd.31458. Online ahead of print.

Saito Y, Kobayashi Y , Fujii K , et al. CVIT 2025 clinical expert consensus document on intravascular ultrasound. Cardiovasc Interv Ther; 2025 Jan 27. doi: 10.1007/s12928-025-01090-0. Online ahead of print.

Nicholls SJ, Hsu A, Wolski K, et al. Intravascular ultrasound-derived measures of coronary atherosclerotic plaque burden and clinical outcome. J Am Coll Cardiol; 2010;55:2399-2407. doi: 10.1016/ j.jacc.2010.02.026.

Zheng M, Choi SY, Tahk SJ, et al. The relationship between volumetric plaque components and classical cardiovascular risk factors and the metabolic syndrome a 3-vessel coronary artery virtual histology-intravascular ultrasound analysis. JACC Cardiovasc Interv; 2011;4:503-510. doi: 10.1016/j.jcin.2010.12.015.

Patel MR, Calhoon JH, Dehmer GJ, et al. ACC/AATS/AHA/ASE/ ASNC/SCAI/ SCCT/STS 2017 Appropriate Use Criteria for Coronary Revascularization in Patients With Stable Ischemic Heart Disease. JNC; 2017;24:1759-1792. doi.org/10.1007/ s12350-017-0917-9.

Muscogiuri G, Weir-McCall JR, Tregubova M, et al. ESR Essentials: imaging in stable chest pain – practice recommendations by ESCR. Eur Radiol; 2024;34: 6559-6567. doi: 10.1007/s00330-024-10739-y.

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