Embriyolarda Gerçekleştirilen Cerrahi Müdahaleler (AHA, Biopsi Tekniği)

Wassarman PM. Zona pellucida glycoproteins. Journal of Biological Chemistry. 2008. https://doi.org/10.1074/jbc.R800027200.

Lefièvre L, Conner SJ, Salpekar A, Olufowobi O, Ashton P, Pavlovic B, et al. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction. 2004;19(7). https://doi.org/10.1093/humrep/deh301.

Gupta SK, Bhandari B, Shrestha A, Biswal BK, Palaniappan C, Malhotra SS, et al. Mammalian zona pellucida glycoproteins: Structure and function during fertilization. Cell and Tissue Research. 2012. https://doi.org/10.1007/s00441-011-1319-y.

Bedford JM, Cross NL. Normal penetration of rabbit spermatozoa through a trypsin- and acrosin-resistant zona pellucida. Journal of Reproduction and Fertility. 1978;54(2). https://doi.org/10.1530/jrf.0.0540385.

Wiley LM. Cavitation in the mouse preimplantation embryo: Na K-ATPase and the origin of nascent blastocoele fluid. Developmental Biology. 1984;105(2). https://doi.org/10.1016/0012-1606(84)90290-2.

Deotalu S, More A, Karadbhajne P, Chaudhari K. Unlocking the Potential of Assisted Hatching in Assisted Reproductive Technology: A Narrative Review. Cureus. 2024;16(5). https://doi.org/10.7759/CUREUS.60736.

Wang H, Zhou F, Guo Y, Ju LA. Micropipette-based biomechanical nanotools on living cells. European Biophysics Journal. 2022. https://doi.org/10.1007/s00249-021-01587-5.

Yano K, Yano C, Kubo T, Ôhashi I, Maeda N, Fukaya T. Chemical zona pellucida thinning with acidified Tyrode’s solution: Comparison between partial and circumferential techniques. Journal of Assisted Reproduction and Genetics. 2007;24(10). https://doi.org/10.1007/s10815-007-9131-z.

Alteri A, Viganò P, Maizar AA, Jovine L, Giacomini E, Rubino P. Revisiting embryo assisted hatching approaches: a systematic review of the current protocols. Journal of Assisted Reproduction and Genetics. 2018. https://doi.org/10.1007/s10815-018-1118-4.

Cohen J, Malter H, Fehilly C, Wright G, Elsner C, Kort H, et al. IMPLANTATION OF EMBRYOS AFTER PARTIAL OPENING OF OOCYTE ZONA PELLUCIDA TO FACILITATE SPERM PENETRATION. The Lancet. 1988. https://doi.org/10.1016/S0140-6736(88)90710-6.

Albertini DF, Crosignani PG, Dumoulin J, Evers JLH, Leridon H, Mastenbroek S, et al. IVF, from the past to the future: The inheritance of the Capri Workshop Group. Human Reproduction Open. 2020. https://doi.org/10.1093/HROPEN/HOAA040.

Hammadeh ME, Fischer-Hammadeh C, Ali KR. Assisted hatching in assisted reproduction: A state of the art. Journal of Assisted Reproduction and Genetics. 2011. https://doi.org/10.1007/s10815-010-9495-3.

Schöpper B, Ludwig M, Edenfeld J, Al-Hasani S, Diedrich K. Possible applications of lasers in assisted reproductive technologies. In: Human Reproduction. 1999. https://doi.org/10.1093/humrep/14.suppl_1.186.

Obruca A, Strohmer H, Sakkas D, Menezo Y, Kogosowski A, Barak Y, et al. Use of Lasers in Assisted Fertilization and Hatching. Human Reproduction. 1994;9(9).

Fankhauser F, Kwasniewska S. Clinical effects of the Nd:YAG laser operating in the photodisruptive and thermal modes: A review. Ophthalmologica. 2003. https://doi.org/10.1159/000068240.

Petersen CG, Mauri AL, Baruffi RLR, Pontes A, Franco JG. Zona thinning with a noncontact diode laser in ICSI embryos from women of advanced age. Journal of Assisted Reproduction and Genetics. 2002;19(11). https://doi.org/10.1023/A:1020907801849.

Cohen J, Alikani M, Trowbridge J, Rosenwaks Z. Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Human Reproduction. 1992;7(5). https://doi.org/10.1093/oxfordjournals.humrep.a137720.

Li D, Yang DL, An J, Jiao J, Zhou YM, Wu QJ, et al. Effect of assisted hatching on pregnancy outcomes: A systematic review and meta-analysis of randomized controlled trials. Scientific Reports. 2016;6. https://doi.org/10.1038/srep31228.

Das S, Blake D, Farquhar C, Seif MMW. Assisted hatching on assisted conception (IVF and ICSI). Cochrane Database of Systematic Reviews. 2009. https://doi.org/10.1002/14651858.CD001894.pub4.

Carney SK, Das S, Blake D, Farquhar C, Seif MMW, Nelson L. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). Cochrane Database of Systematic Reviews. 2012. https://doi.org/10.1002/14651858.CD001894.pub5.

Valojerdi MR, Eftekhari-Yazdi P, Karimian L, Ashtiani SK. Effect of laser zona pellucida opening on clinical outcome of assisted reproduction technology in patients with advanced female age, recurrent implantation failure, or frozen-thawed embryos. Fertility and Sterility. 2008;90(1). https://doi.org/10.1016/j.fertnstert.2007.06.005.

Alteri A, Reschini M, Guarneri C, Bandini V, Bertapelle G, Pinna M, et al. The effect of laser-assisted hatching on vitrified/warmed blastocysts: the ALADDIN randomized controlled trial. Fertility and Sterility. 2024;122(1). https://doi.org/10.1016/j.fertnstert.2024.02.010.

Kanter JR, Boulet SL, Kawwass JF, Jamieson DJ, Kissin DM. Trends and correlates of monozygotic twinning after single embryo transfer. Obstetrics and Gynecology. 2015;125(1). https://doi.org/10.1097/AOG.0000000000000579.

Luke B, Brown MB, Wantman E, Stern JE. Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles. In: Fertility and Sterility. 2014. https://doi.org/10.1016/j.fertnstert.2013.11.034.

Kissin DM, Kawwass JF, Monsour M, Boulet SL, Session DR, Jamieson DJ. Assisted hatching: Trends and pregnancy outcomes, United States, 2000-2010. Fertility and Sterility. 2014;102(3). https://doi.org/10.1016/j.fertnstert.2014.06.013.

Schieve LA, Meikle SF, Peterson HB, Jeng G, Burnett NM, Wilcox LS. Does assisted hatching pose a risk for monozygotic twinning in pregnancies conceived through in vitro fertilization? Fertility and Sterility. 2000;74(2). https://doi.org/10.1016/S0015-0282(00)00602-6.

Gardner DK, Weissman A, Howles CM, Shoham Z. Textbook of Assisted Reproductive Techniques: Volume 1: Laboratory Perspectives, Sixth Edition. Textbook of Assisted Reproductive Techniques: Volume 1: Laboratory Perspectives, Sixth Edition. 2023. https://doi.org/10.1201/9781003268598.

Hassold T, Hall H, Hunt P. The origin of human aneuploidy: Where we have been, where we are going. Human Molecular Genetics. 2007. https://doi.org/10.1093/hmg/ddm243.

Montag M, Köster M, Strowitzki T, Toth B. Polar body biopsy. Fertility and Sterility. 2013. https://doi.org/10.1016/j.fertnstert.2013.05.053.

Principles of IVF Laboratory Practice. Principles of IVF Laboratory Practice. 2023. https://doi.org/10.1017/9781009030601.

Xu K, Montag M. New perspectives on embryo biopsy: Not how, but when and why?. Seminars in Reproductive Medicine. 2012. https://doi.org/10.1055/s-0032-1313905.

Kalma Y, Bar-El L, Asaf-Tisser S, Malcov M, Reches A, Hasson J, et al. Optimal timing for blastomere biopsy of 8-cell embryos for preimplantation genetic diagnosis. Human Reproduction. 2018;33(1). https://doi.org/10.1093/humrep/dex343.

Kirkegaard K, Juhl Hindkjaer J, Ingerslev HJ. Human embryonic development after blastomere removal: A time-lapse analysis. Human Reproduction. 2012;27(1). https://doi.org/10.1093/humrep/der382.

Aoyama N, Kato K. Trophectoderm biopsy for preimplantation genetic test and technical tips: A review. Reproductive Medicine and Biology. 2020. https://doi.org/10.1002/rmb2.12318.

De Boer KA, Catt JW, Jansen RPS, Leigh D, McArthur S. Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF. Fertility and Sterility. 2004;82(2). https://doi.org/10.1016/j.fertnstert.2003.11.064.

Kokkali G, Vrettou C, Traeger-Synodinos J, Jones GM, Cram DS, Stavrou D, et al. Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of β-thalassaemia major: Case report. Human Reproduction. 2005;20(7). https://doi.org/10.1093/humrep/deh893.

Carvalho F, Coonen E, Goossens V, Kokkali G, Rubio C, Meijer-Hoogeveen M, et al. ESHRE PGT Consortium good practice recommendations for the organisation of PGT. Human Reproduction Open. 2020;2020(3). https://doi.org/10.1093/hropen/hoaa021.

Gleicher N, Metzger J, Croft G, Kushnir VA, Albertini DF, Barad DH. A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use. Reproductive Biology and Endocrinology. 2017;15(1). https://doi.org/10.1186/s12958-017-0251-8.

Gleicher N, Patrizio P, Mochizuki L, Barad DH. Previously reported and here added cases demonstrate euploid pregnancies followed by PGT-A as “mosaic” as well as “aneuploid” designated embryos. Reproductive Biology and Endocrinology. 2023;21(1). https://doi.org/10.1186/s12958-023-01077-7.

McArthur SJ, Leigh D, Marshall JT, De Boer KA, Jansen RPS. Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts. Fertility and Sterility. 2005;84(6). https://doi.org/10.1016/j.fertnstert.2005.05.063.

Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, et al. Correlation between standard blastocyst morphology, euploidy and implantation: An observational study in two centers involving 956 screened blastocysts. Human Reproduction. 2014;29(6). https://doi.org/10.1093/humrep/deu033.

Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, et al. Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management. Journal of Assisted Reproduction and Genetics. 2016. https://doi.org/10.1007/s10815-016-0768-3.

Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, et al. Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. Human Reproduction Update. 2023. https://doi.org/10.1093/humupd/dmad010.

Cimadomo D, Rienzi L, Capalbo A, Rubio C, Innocenti F, García-Pascual CM, et al. The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. Human Reproduction Update. 2020. https://doi.org/10.1093/humupd/dmaa019.

Yang D, Feng D, Gao Y, Sagnelli M, Wang X, Li D. An effective method for trophectoderm biopsy using mechanical blunt dissection: a step-by-step demonstration. Fertility and Sterility. 2020;114(2). https://doi.org/10.1016/j.fertnstert.2020.05.035.

Xue S, Gao Y, Wang R, Yang D, Peng Q, Li D. An innovative design for trophectoderm biopsy without laser pulses: a step-by-step demonstration. Fertility and Sterility. 2023;120(5). https://doi.org/10.1016/j.fertnstert.2023.07.010.

Coll L, Parriego M, Carrasco B, Rodríguez I, Boada M, Coroleu B, et al. The effect of trophectoderm biopsy technique and sample handling on artefactual mosaicism. Journal of Assisted Reproduction and Genetics. 2022;39(6). https://doi.org/10.1007/s10815-022-02453-9.

De Vos A, De Munck N. Trophectoderm Biopsy: Present State of the Art. Genes. 2025;16(2). https://doi.org/10.3390/GENES16020134.

Kokkali G, Coticchio G, Bronet F, Celebi C, Cimadomo D, Goossens V, et al. ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT. Human Reproduction Open. 2020;2020(3). https://doi.org/10.1093/hropen/hoaa020.

Zhang S, Luo K, Cheng D, Tan Y, Lu C, He H, et al. Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality. Fertility and Sterility. 2016;105(5). https://doi.org/10.1016/j.fertnstert.2016.01.011.

Guzman L, Nuñez D, López R, Inoue N, Portella J, Vizcarra F, et al. The number of biopsied trophectoderm cells may affect pregnancy outcomes. Journal of Assisted Reproduction and Genetics. 2019;36(1). https://doi.org/10.1007/s10815-018-1331-1.

Lu M man, Wen Y xing, Liu Y liang, Ding C hui, Zhou C quan, Xu Y wen. Trophectoderm biopsy reduces the level of serum β-human chorionic gonadotropin in early pregnancy. Fertility and Sterility. 2020;114(4). https://doi.org/10.1016/j.fertnstert.2020.05.015.

Makhijani R, Bartels CB, Godiwala P, Bartolucci A, Diluigi A, Nulsen J, et al. Impact of trophectoderm biopsy on obstetric and perinatal outcomes following frozen-thawed embryo transfer cycles. Human Reproduction. 2021;36(2). https://doi.org/10.1093/humrep/deaa316.

Gianaroli L, Magli MC, Pomante A, Crivello AM, Cafueri G, Valerio M, et al. Blastocentesis: A source of DNA for preimplantation genetic testing. Results from a pilot study. Fertility and Sterility. 2014;102(6). https://doi.org/10.1016/j.fertnstert.2014.08.021.

Capalbo A, Romanelli V, Patassini C, Poli M, Girardi L, Giancani A, et al. Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions. Fertility and Sterility. 2018;110(5). https://doi.org/10.1016/j.fertnstert.2018.05.031.

Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, et al. Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications. Fertility and Sterility. 2019;112(3). https://doi.org/10.1016/j.fertnstert.2019.04.038.

Feichtinger M, Vaccari E, Carli L, Wallner E, Mädel U, Figl K, et al. Non-invasive preimplantation genetic screening using array comparative genomic hybridization on spent culture media: a proof-of-concept pilot study. Reproductive BioMedicine Online. 2017;34(6). https://doi.org/10.1016/j.rbmo.2017.03.015.

Cimadomo D, Capalbo A, Ubaldi FM, Scarica C, Palagiano A, Canipari R, et al. The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis. BioMed Research International. 2016. https://doi.org/10.1155/2016/7193075.

Wassarman PM. Zona pellucida glycoproteins. Journal of Biological Chemistry. 2008. https://doi.org/10.1074/jbc.R800027200.

Lefièvre L, Conner SJ, Salpekar A, Olufowobi O, Ashton P, Pavlovic B, et al. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction. 2004;19(7). https://doi.org/10.1093/humrep/deh301.

Gupta SK, Bhandari B, Shrestha A, Biswal BK, Palaniappan C, Malhotra SS, et al. Mammalian zona pellucida glycoproteins: Structure and function during fertilization. Cell and Tissue Research. 2012. https://doi.org/10.1007/s00441-011-1319-y.

Bedford JM, Cross NL. Normal penetration of rabbit spermatozoa through a trypsin- and acrosin-resistant zona pellucida. Journal of Reproduction and Fertility. 1978;54(2). https://doi.org/10.1530/jrf.0.0540385.

Wiley LM. Cavitation in the mouse preimplantation embryo: Na K-ATPase and the origin of nascent blastocoele fluid. Developmental Biology. 1984;105(2). https://doi.org/10.1016/0012-1606(84)90290-2.

Deotalu S, More A, Karadbhajne P, Chaudhari K. Unlocking the Potential of Assisted Hatching in Assisted Reproductive Technology: A Narrative Review. Cureus. 2024;16(5). https://doi.org/10.7759/CUREUS.60736.

Wang H, Zhou F, Guo Y, Ju LA. Micropipette-based biomechanical nanotools on living cells. European Biophysics Journal. 2022. https://doi.org/10.1007/s00249-021-01587-5.

Yano K, Yano C, Kubo T, Ôhashi I, Maeda N, Fukaya T. Chemical zona pellucida thinning with acidified Tyrode’s solution: Comparison between partial and circumferential techniques. Journal of Assisted Reproduction and Genetics. 2007;24(10). https://doi.org/10.1007/s10815-007-9131-z.

Alteri A, Viganò P, Maizar AA, Jovine L, Giacomini E, Rubino P. Revisiting embryo assisted hatching approaches: a systematic review of the current protocols. Journal of Assisted Reproduction and Genetics. 2018. https://doi.org/10.1007/s10815-018-1118-4.

Cohen J, Malter H, Fehilly C, Wright G, Elsner C, Kort H, et al. IMPLANTATION OF EMBRYOS AFTER PARTIAL OPENING OF OOCYTE ZONA PELLUCIDA TO FACILITATE SPERM PENETRATION. The Lancet. 1988. https://doi.org/10.1016/S0140-6736(88)90710-6.

Albertini DF, Crosignani PG, Dumoulin J, Evers JLH, Leridon H, Mastenbroek S, et al. IVF, from the past to the future: The inheritance of the Capri Workshop Group. Human Reproduction Open. 2020. https://doi.org/10.1093/HROPEN/HOAA040.

Hammadeh ME, Fischer-Hammadeh C, Ali KR. Assisted hatching in assisted reproduction: A state of the art. Journal of Assisted Reproduction and Genetics. 2011. https://doi.org/10.1007/s10815-010-9495-3.

Schöpper B, Ludwig M, Edenfeld J, Al-Hasani S, Diedrich K. Possible applications of lasers in assisted reproductive technologies. In: Human Reproduction. 1999. https://doi.org/10.1093/humrep/14.suppl_1.186.

Obruca A, Strohmer H, Sakkas D, Menezo Y, Kogosowski A, Barak Y, et al. Use of Lasers in Assisted Fertilization and Hatching. Human Reproduction. 1994;9(9).

Fankhauser F, Kwasniewska S. Clinical effects of the Nd:YAG laser operating in the photodisruptive and thermal modes: A review. Ophthalmologica. 2003. https://doi.org/10.1159/000068240.

Petersen CG, Mauri AL, Baruffi RLR, Pontes A, Franco JG. Zona thinning with a noncontact diode laser in ICSI embryos from women of advanced age. Journal of Assisted Reproduction and Genetics. 2002;19(11). https://doi.org/10.1023/A:1020907801849.

Cohen J, Alikani M, Trowbridge J, Rosenwaks Z. Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Human Reproduction. 1992;7(5). https://doi.org/10.1093/oxfordjournals.humrep.a137720.

Li D, Yang DL, An J, Jiao J, Zhou YM, Wu QJ, et al. Effect of assisted hatching on pregnancy outcomes: A systematic review and meta-analysis of randomized controlled trials. Scientific Reports. 2016;6. https://doi.org/10.1038/srep31228.

Das S, Blake D, Farquhar C, Seif MMW. Assisted hatching on assisted conception (IVF and ICSI). Cochrane Database of Systematic Reviews. 2009. https://doi.org/10.1002/14651858.CD001894.pub4.

Carney SK, Das S, Blake D, Farquhar C, Seif MMW, Nelson L. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). Cochrane Database of Systematic Reviews. 2012. https://doi.org/10.1002/14651858.CD001894.pub5.

Valojerdi MR, Eftekhari-Yazdi P, Karimian L, Ashtiani SK. Effect of laser zona pellucida opening on clinical outcome of assisted reproduction technology in patients with advanced female age, recurrent implantation failure, or frozen-thawed embryos. Fertility and Sterility. 2008;90(1). https://doi.org/10.1016/j.fertnstert.2007.06.005.

Alteri A, Reschini M, Guarneri C, Bandini V, Bertapelle G, Pinna M, et al. The effect of laser-assisted hatching on vitrified/warmed blastocysts: the ALADDIN randomized controlled trial. Fertility and Sterility. 2024;122(1). https://doi.org/10.1016/j.fertnstert.2024.02.010.

Kanter JR, Boulet SL, Kawwass JF, Jamieson DJ, Kissin DM. Trends and correlates of monozygotic twinning after single embryo transfer. Obstetrics and Gynecology. 2015;125(1). https://doi.org/10.1097/AOG.0000000000000579.

Luke B, Brown MB, Wantman E, Stern JE. Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles. In: Fertility and Sterility. 2014. https://doi.org/10.1016/j.fertnstert.2013.11.034.

Kissin DM, Kawwass JF, Monsour M, Boulet SL, Session DR, Jamieson DJ. Assisted hatching: Trends and pregnancy outcomes, United States, 2000-2010. Fertility and Sterility. 2014;102(3). https://doi.org/10.1016/j.fertnstert.2014.06.013.

Schieve LA, Meikle SF, Peterson HB, Jeng G, Burnett NM, Wilcox LS. Does assisted hatching pose a risk for monozygotic twinning in pregnancies conceived through in vitro fertilization? Fertility and Sterility. 2000;74(2). https://doi.org/10.1016/S0015-0282(00)00602-6.

Gardner DK, Weissman A, Howles CM, Shoham Z. Textbook of Assisted Reproductive Techniques: Volume 1: Laboratory Perspectives, Sixth Edition. Textbook of Assisted Reproductive Techniques: Volume 1: Laboratory Perspectives, Sixth Edition. 2023. https://doi.org/10.1201/9781003268598.

Hassold T, Hall H, Hunt P. The origin of human aneuploidy: Where we have been, where we are going. Human Molecular Genetics. 2007. https://doi.org/10.1093/hmg/ddm243.

Montag M, Köster M, Strowitzki T, Toth B. Polar body biopsy. Fertility and Sterility. 2013. https://doi.org/10.1016/j.fertnstert.2013.05.053.

Principles of IVF Laboratory Practice. Principles of IVF Laboratory Practice. 2023. https://doi.org/10.1017/9781009030601.

Xu K, Montag M. New perspectives on embryo biopsy: Not how, but when and why?. Seminars in Reproductive Medicine. 2012. https://doi.org/10.1055/s-0032-1313905.

Kalma Y, Bar-El L, Asaf-Tisser S, Malcov M, Reches A, Hasson J, et al. Optimal timing for blastomere biopsy of 8-cell embryos for preimplantation genetic diagnosis. Human Reproduction. 2018;33(1). https://doi.org/10.1093/humrep/dex343.

Kirkegaard K, Juhl Hindkjaer J, Ingerslev HJ. Human embryonic development after blastomere removal: A time-lapse analysis. Human Reproduction. 2012;27(1). https://doi.org/10.1093/humrep/der382.

Aoyama N, Kato K. Trophectoderm biopsy for preimplantation genetic test and technical tips: A review. Reproductive Medicine and Biology. 2020. https://doi.org/10.1002/rmb2.12318.

De Boer KA, Catt JW, Jansen RPS, Leigh D, McArthur S. Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF. Fertility and Sterility. 2004;82(2). https://doi.org/10.1016/j.fertnstert.2003.11.064.

Kokkali G, Vrettou C, Traeger-Synodinos J, Jones GM, Cram DS, Stavrou D, et al. Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of β-thalassaemia major: Case report. Human Reproduction. 2005;20(7). https://doi.org/10.1093/humrep/deh893.

Carvalho F, Coonen E, Goossens V, Kokkali G, Rubio C, Meijer-Hoogeveen M, et al. ESHRE PGT Consortium good practice recommendations for the organisation of PGT. Human Reproduction Open. 2020;2020(3). https://doi.org/10.1093/hropen/hoaa021.

Gleicher N, Metzger J, Croft G, Kushnir VA, Albertini DF, Barad DH. A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use. Reproductive Biology and Endocrinology. 2017;15(1). https://doi.org/10.1186/s12958-017-0251-8.

Gleicher N, Patrizio P, Mochizuki L, Barad DH. Previously reported and here added cases demonstrate euploid pregnancies followed by PGT-A as “mosaic” as well as “aneuploid” designated embryos. Reproductive Biology and Endocrinology. 2023;21(1). https://doi.org/10.1186/s12958-023-01077-7.

McArthur SJ, Leigh D, Marshall JT, De Boer KA, Jansen RPS. Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts. Fertility and Sterility. 2005;84(6). https://doi.org/10.1016/j.fertnstert.2005.05.063.

Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, et al. Correlation between standard blastocyst morphology, euploidy and implantation: An observational study in two centers involving 956 screened blastocysts. Human Reproduction. 2014;29(6). https://doi.org/10.1093/humrep/deu033.

Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, et al. Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management. Journal of Assisted Reproduction and Genetics. 2016. https://doi.org/10.1007/s10815-016-0768-3.

Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, et al. Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. Human Reproduction Update. 2023. https://doi.org/10.1093/humupd/dmad010.

Cimadomo D, Rienzi L, Capalbo A, Rubio C, Innocenti F, García-Pascual CM, et al. The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. Human Reproduction Update. 2020. https://doi.org/10.1093/humupd/dmaa019.

Yang D, Feng D, Gao Y, Sagnelli M, Wang X, Li D. An effective method for trophectoderm biopsy using mechanical blunt dissection: a step-by-step demonstration. Fertility and Sterility. 2020;114(2). https://doi.org/10.1016/j.fertnstert.2020.05.035.

Xue S, Gao Y, Wang R, Yang D, Peng Q, Li D. An innovative design for trophectoderm biopsy without laser pulses: a step-by-step demonstration. Fertility and Sterility. 2023;120(5). https://doi.org/10.1016/j.fertnstert.2023.07.010.

Coll L, Parriego M, Carrasco B, Rodríguez I, Boada M, Coroleu B, et al. The effect of trophectoderm biopsy technique and sample handling on artefactual mosaicism. Journal of Assisted Reproduction and Genetics. 2022;39(6). https://doi.org/10.1007/s10815-022-02453-9.

De Vos A, De Munck N. Trophectoderm Biopsy: Present State of the Art. Genes. 2025;16(2). https://doi.org/10.3390/GENES16020134.

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