Üreme Tıbbında Ek Uygulamalar (Add-Ons)
Özet
Referanslar
Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet 1978;2:366.
The European IVF-Monitoring Consortium for the European Society of Human Reproduction and Embryology, Wyns C, De Geyter C, Calhaz-Jorge C, Kupka MS, Motrenko T, Smeenk J, Bergh C, Tandler-Schneider A, Rugescu IA et al. ART in Europe, 2018: results generated from European registries by ESHRE. Hum Reprod Open 2022;2022:hoac022.
Kamath MS, Bosteels J, D'Hooghe TM, Seshadri S, Weyers S, Mol BWJ, Broekmans FJ, Sunkara SK. Screening hysteroscopy in subfertile women and women undergoing assisted reproduction. Cochrane Database Syst Rev 2019;4:CD012856.
El-Toukhy T, El Tokhy O. Hysteroscopy or not before intracytoplasmic sperm injection: how significant is the difference? Gynecol Obstet Invest 2016;81:568.
Smit JG, Kasius JC, Eijkemans MJC, Koks CAM, van Golde R, Nap AW, Scheffer GJ, Manger PAP, Hoek A, Schoot BC et al. Hysteroscopy before in-vitro fertilisation (inSIGHT): a multicentre, randomised controlled trial. Lancet 2016;387:2622–2629
Cao H, You D, Yuan M, Xi M. Hysteroscopy after repeated implantation
failure of assisted reproductive technology: a meta-analysis. J Obstet Gynaecol Res 2018;44:365–373
Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, Coomarasamy A. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update 2019;25:202–223.
Sim on C, Gomez C, Ruiz M, Mol BW, Valbuena D. Response to: Comments on the methodology of an endometrial receptivity array trial. Reprod Biomed Online 2021;42:284.
Doyle N, Jahandideh S, Hill MJ, Widra EA, Levy M, Devine K. Effect of timing by endometrial receptivity testing vs standard timing of frozen embryo transfer on live birth in patients undergoing in vitro fertilization: a randomized clinical trial. JAMA 2022; 328:2117–2125.
Moffett A, Shreeve N. Local immune recognition of trophoblast in early human pregnancy: controversies and questions. Nat Rev Immunol 2023;23:222–235.
Woon EV, Greer O, Shah N, Nikolaou D, Johnson M, Male V. Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and metaanalysis. Hum Reprod Update 2022;36:548–582.
Moffett A, Chazara O, Colucci F, Johnson MH. Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention. Reprod Biomed Online 2016;33:763–769.
Melo P, Thornton T, Coomarasamy A, Granne I. Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction. Fertil Steril 2022; 117:1144–1159.
Sfakianoudis K, Rapani A, Grigoriadis S, Pantou A, Maziotis E, Kokkini G, Tsirligkani C, Bolaris S, Nikolettos K, Chronopoulou M et al. The role of uterine natural killer cells on recurrent miscarriage and recurrent implantation failure: from pathophysiology to treatment. Biomedicines 2021;9:1425.
Shan Y, Zhao H, Zhao D, Wang J, Cui Y, Bao H. Assisted oocyte activation with calcium ionophore improves pregnancy outcomes and offspring safety in infertile patients: a systematic review and meta-analysis. Front Physiol 2021;12:751905.
Nikiforaki D, Vanden Meerschaut F, de Roo C, Lu Y, Ferrer-Buitrago M, de Sutter P, Heindryckx B. Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern. Fertil Steril 2016; 105:798–806.e2.
Li B, Zhou Y, Yan Z, Li M, Xue S, Cai R, Fu Y, Hong Q, Long H, Yin M et al. Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen-thawed embryo transfer: a 6-year population-based retrospective study. Arch Gynecol Obstet 2019a;300:1083–1092.
Long R, Wang M, Yang QY, Hu SQ, Zhu LX, Jin L. Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis. Reprod Biol Endocrinol 2020;18:123.
ESHRE Guideline Group on Female Fertility Preservation, Anderson RA, Amant F, Braat D, D'Angelo A, Chuva de Sousa Lopes SM, Demeestere I, Dwek S, Frith L, Lambertini M, Maslin C et al. ESHRE guideline: female fertility preservation. Hum Reprod Open 2020;2020:hoaa052.
Amer M, Metawae B, Hosny H, Raef A. Beneficial effect of adding pentoxifylline to processed semen samples on ICSI outcome in infertile males with mild and moderate asthenozoospermia: a randomized controlled prospective crossover study. Iran J Reprod Med 2013;11:939–944.
Ebner T, Tews G, Mayer RB, Ziehr S, Arzt W, Costamoling W, Shebl O. Pharmacological stimulation of sperm motility in frozen and thawed testicular sperm using the dimethylxanthine theophylline. Fertil Steril 2011;96:1331–1336.
Sandi-Monroy NL, Musanovic S, Zhu D, Szab o Z, Vogl A, Reeka N, Eibner K, Bundschu K, Gagsteiger F. Use of dimethylxanthine theophylline (SpermMobil(VR )) does not affect clinical, obstetric or perinatal outcomes. Arch Gynecol Obstet 2019;300:1435–1443.
Navas P, Paffoni A, Intra G, Gonz alez-Utor A, Clavero A, Gonzalvo MC, Dıaz R, Pena R, Restelli L, Somigliana E et al. Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa. Reprod Biomed Online 2017;34:414–421.
Lepine S, McDowell S, Searle LM, Kroon B, Glujovsky D, Yazdani A. Advanced sperm selection techniques for assisted reproduction. Cochrane Database Syst Rev 2019;7:CD010461.
Aydın Ş, Bulgan Kılıçdağ E, Çağlar Aytaç P, Çok T, Şimşek E, Haydardedeoğlu B. Prospective randomized controlled study of a microfluidic chip technology for sperm selection in male infertility patients. Andrologia 2022;54:e14415.
Yetkinel S, Kilicdag EB, Aytac PC, Haydardedeoglu B, Simsek E, Cok T. Effects of the microfluidic chip technique in sperm selection for intracytoplasmic sperm injection for unexplained infertility: a prospective, randomized controlled trial. J Assist Reprod Genet. 2019 Mar;36(3):403-409. doi: 10.1007/s10815-018-1375-2. Epub 2018 Dec 12. PMID: 30542782; PMCID: PMC6439003.
Teixeira DM, Hadyme Miyague A, Barbosa MA, Navarro PA, Raine-Fenning N, Nastri CO, Martins WP. Regular (ICSI) versus ultrahigh magnification (IMSI) sperm selection for assisted reproduction. Cochrane Database Syst Rev 2020;2:CD010167.
Hardy K, Spanos S. Growth factor expression and function in the human and mouse preimplantation embryo. J Endocrinol 2002; 172:221–236.
Armstrong S, MacKenzie J, Woodward B, Pacey A, Farquhar C. GMCSF (granulocyte macrophage colony-stimulating factor) supplementation in culture media for women undergoing assisted reproduction. Cochrane Database Syst Rev 2020;7:CD013497.
Lacey L, Hassan S, Franik S, Seif MW, Akhtar MA. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)). Cochrane Database Syst Rev 2021;3:CD001894.
Hviid KVR, Malchau SS, Pinborg A, Nielsen HS. Determinants of monozygotic twinning in ART: a systematic review and a metaanalysis. Hum Reprod Update 2018;24:468–483.
Fragouli E, Munne S, Wells D. The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies. Hum Reprod Update 2019;25:15–33.
van Montfoort A, Carvalho F, Coonen E, Kokkali G, Moutou C, Rubio C, Goossens V, De Rycke M. ESHRE PGT Consortium data collection XIX-XX: PGT analyses from 2016 to 2017. Hum Reprod Open 2021;2021:hoab024.
Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S. Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation.Cochrane Database Syst Rev 2020;9:CD005291.
Rubio C, Bellver J, Rodrigo L, Castill on G, Guill en A, Vidal C, Giles J, Ferrando M, Cabanillas S, Remoh ı J et al. In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril 2017;107:1122–1129.
Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, Sun X, Ling X, Li H, Hao C et al. Live birth with or without preimplantation genetic testing for aneuploidy. N Engl J Med 2021;385:2047–2058.
Verpoest W, Staessen C, Bossuyt PM, Goossens V, Altarescu G, Bonduelle M, Devesa M, Eldar-Geva T, Gianaroli L, Griesinger G et al. Preimplantation genetic testing for aneuploidy by microarray analysis of polar bodies in advanced maternal age: a randomized clinical trial. Hum Reprod 2018;33:1767–1776.
Rubio C, Bellver J, Rodrigo L, Castill on G, Guill en A, Vidal C, Giles J, Ferrando M, Cabanillas S, Remoh ı J et al. In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril 2017;107:1122–1129.
Natsuaki MN, Dimler LM. Pregnancy and child developmental outcomes after preimplantation genetic screening: a meta-analytic and systematic review. World J Pediatr 2018;14:555–569.
Hou W, Shi G, Ma Y, Liu Y, Lu M, Fan X, Sun Y. Impact of preimplantation genetic testing on obstetric and neonatal outcomes: a systematic review and meta-analysis. Fertil Steril 2021a; 116:990–1000.
Zheng W, Yang C, Yang S, Sun S, Mu M, Rao M, Zu R, Yan J, Ren B, Yang R et al. Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis. Hum Reprod Update 2021;27:989–1012.
Armstrong S, Bhide P, Jordan V, Pacey A, Marjoribanks J, Farquhar C. Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database Syst Rev 2019;5:CD011320.
Kirkegaard K, Hindkjaer JJ, Grøndahl ML, Kesmodel US, Ingerslev HJ. A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator. J Assist Reprod Genet 2012;29:565–572.
Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Azargashb E. Effects of autologous platelet-rich plasma on endometrial Good practice on add-ons | 2099 expansion in patients undergoing frozen-thawed embryo transfer: a double-blind RCT. Int J Reprod Biomed 2019;17:443–448.
Nazari L, Salehpour S, Hosseini MS, Hashemi Moghanjoughi P. The effects of autologous platelet-rich plasma in repeated implantation: a randomized controlled trial. Hum Fertil 2020;23:209–213.
Nazari L, Salehpour S, Hosseini S, Hashemi T, Borumandnia N, Azizi E. Effect of autologous platelet-rich plasma for treatment of recurrent pregnancy loss: a randomized controlled trial. Obstet Gynecol Sci 2022a;65:266–272.
Nazari L, Salehpour S, Hosseini S, Sheibani S, Hosseinirad H. The effects of autologous platelet-rich plasma on pregnancy outcomes in repeated implantation failure patients undergoing frozen embryo transfer: a randomized controlled trial. Reprod Sci 2022b;29:993–1000.
Panda SR, Sachan S, Hota S. A systematic review evaluating the efficacy of intra-ovarian infusion of autologous platelet-rich plasma in patients with poor ovarian reserve or ovarian insufficiency. Cureus 2020;12:e12037.
Navali N, Sadeghi L, Farzadi L, Ghasemzadeh A, Hamdi K, Hakimi P, Niknafs B. Intraovarian injection of autologous platelet-rich plasma improves therapeutic approaches in the patients with poor ovarian response: a before-after study. Int J Fertil Steril 2022;16:90–94.
The ESHRE Guideline Group on Ovarian Stimulation, Bosch E, Broer S, Griesinger G, Grynberg M, Humaidan P, Kolibianakis E, Kunicki M, La Marca A, Lainas G et al. ESHRE guideline: ovarian stimulation for IVF/ICSI. Hum Reprod Open 2020;2020:hoaa009. Full version available via www.eshre.eu/guidelines.
Lensen SF, Armstrong S, Gibreel A, Nastri CO, Raine-Fenning N, Martins WP. Endometrial injury in women undergoing in vitro fertilisation (IVF). Cochrane Database Syst Rev 2021c;6:CD009517.
Hou W, Shi G, Cai B, Ding C, Song J, Zhang X, Xu Y. Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis. Arch Gynecol Obstet 2018;298:1061–1069.
Hosseinisadat R, Saeed L, Ashourzadeh S, Heidari SS, Habibzadeh V. Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: an RCT. Int J Reprod Biomed 2021;19:773–780.
Torky H, El-Desouky ES, El-Baz A, Aly R, El-Taher O, Shata A, Hussein A, Marie H, Deif O, Eldemery A et al. Effect of intra uterine granulocyte colony stimulating factor vs. human chorionic gonadotropin at ovum pick up day on pregnancy rate in IVF/ICSI cases with recurrent implantation failure. JBRA Assist Reprod 2022;26:274–279.
Craciunas L, Tsampras N, Raine-Fenning N, Coomarasamy A. Intrauterine administration of human chorionic gonadotropin 2094 | ESHRE Add-ons working group et al. (hCG) for subfertile women undergoing assisted reproduction.Cochrane Database Syst Rev 2018;10:CD011537.
Melo P, Thornton T, Coomarasamy A, Granne I. Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction. Fertil Steril 2022; 117:1144–1159.
Hou Z, Jiang F, Yang J, Liu Y, Zha H, Yang X, Bie J, Meng Y. What is the impact of granulocyte colony-stimulating factor (G-CSF) in subcutaneous injection or intrauterine infusion and during both the fresh and frozen embryo transfer cycles on recurrent implantation failure: a systematic review and meta-analysis? Reprod Biol Endocrinol 2021b;19:125.
Siristatidis CS, Sertedaki E, Karageorgiou V, Vaidakis D. Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction. Cochrane Database Syst Rev 2020;8:CD013063.
Szczykutowicz J, Kału_za A, Ka zmierowska-Niemczuk M, Ferens- Sieczkowska M. The potential role of seminal plasma in the fertilization outcomes. Biomed Res Int 2019;2019:5397804.
Ata B, Abou-Setta AM, Seyhan A, Buckett W. Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology cycles (IVF, ICSI and frozen embryo transfer). Cochrane Database Syst Rev 2018;2:CD011809.
Achilli C, Duran-Retamal M, Saab W, Serhal P, Seshadri S. The role of immunotherapy in in vitro fertilization and recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril 2018;110:1089–1100.
Kim YJ. Glucocorticoid therapy in assisted reproduction. Clin Exp Reprod Med 2021;48:295–302.
Wang J, Wang T, Ding W, Wu J, Wu G, Wang Y, Zhou Z, Xu L, Cui Y. Efficacy of antioxidant therapy on sperm quality measurements after varicocelectomy: a systematic review and meta-analysis. Andrologia 2019;51:e13396.
Scaruffi P, Licata E, Maccarini E, Massarotti C, Bovis F, Sozzi F, Stigliani S, Dal Lago A, Casciano I, Rago R et al. Oral antioxidant treatment of men significantly improves the reproductive outcome of IVF cycles. J Clin Med 2021;10:3254.
Agarwal A, Hamada A, Esteves SC. Insight into oxidative stress in varicocele-associated male infertility: part 1. Nat Rev Urol 2012;9:678–690.
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ. Antioxidants for female subfertility. Cochrane Database Syst Rev 2020;8:CD007807.
de Ligny W, Smits RM, Mackenzie-Proctor R, Jordan V, Fleischer K, de Bruin JP, Showell MG. Antioxidants for male subfertility. Cochrane Database Syst Rev 2022;5:CD007411.
Stein J, Harper JC. Analysis of fertility clinic marketing of complementary therapy add-ons. Reprod Biomed Soc Online 2021;13:24–36.
HFEA. Our National Patient Survey Results. 2018. https://www.hfea.gov.uk/about-us/news-and-press-releases/2018-news-and-pressreleases/our-national-patient-survey-results/ (18 April 2022, date last accessed).
Lensen S, Hammarberg K, Polyakov A, Wilkinson J, Whyte S, Peate M, Hickey M. How common is add-on use and how do patients decide whether to use them? A national survey of IVF patients. Hum Reprod 2021a;36:1854–1861.
Stener-Victorin E, Fujisawa S, Kurosawa M. Ovarian blood flow responses to electroacupuncture stimulation depend on estrous cycle and on site and frequency of stimulation in anesthetized rats. J Appl Physiol (1985) 2006;101:84–91.
Stener-Victorin E, Wu X. Effects and mechanisms of acupuncture in the reproductive system. Auton Neurosci 2010;157:46–51.
Lim CED, Ng RWC, Cheng NCL, Zhang GS, Chen H. Acupuncture for polycystic ovarian syndrome. Cochrane Database Syst Rev 2019;7:CD007689.
Jang S, Kim KH, Jun JH, You S. Acupuncture for in vitro fertilization in women with poor ovarian response: a systematic review. Integr Med Res 2020;9:100395.
Coyle ME, Stupans I, Abdel-Nour K, Ali H, Kotlyarsky M, Lie P, Tekin S, Thrimawithana T. Acupuncture versus placebo acupuncture for in vitro fertilisation: a systematic review and meta-analysis. Acupunct Med 2021;39:20–29.
Li M, Liu Y, Wang H, Zheng S, Deng Y, Li Y. The effects of acupuncture on pregnancy outcomes of recurrent implantation failure: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2021c;2021:6661235.
Wang X, Wang Y, Wei S, He B, Cao Y, Zhang N, Li M. An overview of systematic reviews of acupuncture for infertile women undergoing in vitro fertilization and embryo transfer. Front Public Health 2021b;9:651811.
Referanslar
Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet 1978;2:366.
The European IVF-Monitoring Consortium for the European Society of Human Reproduction and Embryology, Wyns C, De Geyter C, Calhaz-Jorge C, Kupka MS, Motrenko T, Smeenk J, Bergh C, Tandler-Schneider A, Rugescu IA et al. ART in Europe, 2018: results generated from European registries by ESHRE. Hum Reprod Open 2022;2022:hoac022.
Kamath MS, Bosteels J, D'Hooghe TM, Seshadri S, Weyers S, Mol BWJ, Broekmans FJ, Sunkara SK. Screening hysteroscopy in subfertile women and women undergoing assisted reproduction. Cochrane Database Syst Rev 2019;4:CD012856.
El-Toukhy T, El Tokhy O. Hysteroscopy or not before intracytoplasmic sperm injection: how significant is the difference? Gynecol Obstet Invest 2016;81:568.
Smit JG, Kasius JC, Eijkemans MJC, Koks CAM, van Golde R, Nap AW, Scheffer GJ, Manger PAP, Hoek A, Schoot BC et al. Hysteroscopy before in-vitro fertilisation (inSIGHT): a multicentre, randomised controlled trial. Lancet 2016;387:2622–2629
Cao H, You D, Yuan M, Xi M. Hysteroscopy after repeated implantation
failure of assisted reproductive technology: a meta-analysis. J Obstet Gynaecol Res 2018;44:365–373
Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, Coomarasamy A. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update 2019;25:202–223.
Sim on C, Gomez C, Ruiz M, Mol BW, Valbuena D. Response to: Comments on the methodology of an endometrial receptivity array trial. Reprod Biomed Online 2021;42:284.
Doyle N, Jahandideh S, Hill MJ, Widra EA, Levy M, Devine K. Effect of timing by endometrial receptivity testing vs standard timing of frozen embryo transfer on live birth in patients undergoing in vitro fertilization: a randomized clinical trial. JAMA 2022; 328:2117–2125.
Moffett A, Shreeve N. Local immune recognition of trophoblast in early human pregnancy: controversies and questions. Nat Rev Immunol 2023;23:222–235.
Woon EV, Greer O, Shah N, Nikolaou D, Johnson M, Male V. Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and metaanalysis. Hum Reprod Update 2022;36:548–582.
Moffett A, Chazara O, Colucci F, Johnson MH. Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention. Reprod Biomed Online 2016;33:763–769.
Melo P, Thornton T, Coomarasamy A, Granne I. Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction. Fertil Steril 2022; 117:1144–1159.
Sfakianoudis K, Rapani A, Grigoriadis S, Pantou A, Maziotis E, Kokkini G, Tsirligkani C, Bolaris S, Nikolettos K, Chronopoulou M et al. The role of uterine natural killer cells on recurrent miscarriage and recurrent implantation failure: from pathophysiology to treatment. Biomedicines 2021;9:1425.
Shan Y, Zhao H, Zhao D, Wang J, Cui Y, Bao H. Assisted oocyte activation with calcium ionophore improves pregnancy outcomes and offspring safety in infertile patients: a systematic review and meta-analysis. Front Physiol 2021;12:751905.
Nikiforaki D, Vanden Meerschaut F, de Roo C, Lu Y, Ferrer-Buitrago M, de Sutter P, Heindryckx B. Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern. Fertil Steril 2016; 105:798–806.e2.
Li B, Zhou Y, Yan Z, Li M, Xue S, Cai R, Fu Y, Hong Q, Long H, Yin M et al. Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen-thawed embryo transfer: a 6-year population-based retrospective study. Arch Gynecol Obstet 2019a;300:1083–1092.
Long R, Wang M, Yang QY, Hu SQ, Zhu LX, Jin L. Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis. Reprod Biol Endocrinol 2020;18:123.
ESHRE Guideline Group on Female Fertility Preservation, Anderson RA, Amant F, Braat D, D'Angelo A, Chuva de Sousa Lopes SM, Demeestere I, Dwek S, Frith L, Lambertini M, Maslin C et al. ESHRE guideline: female fertility preservation. Hum Reprod Open 2020;2020:hoaa052.
Amer M, Metawae B, Hosny H, Raef A. Beneficial effect of adding pentoxifylline to processed semen samples on ICSI outcome in infertile males with mild and moderate asthenozoospermia: a randomized controlled prospective crossover study. Iran J Reprod Med 2013;11:939–944.
Ebner T, Tews G, Mayer RB, Ziehr S, Arzt W, Costamoling W, Shebl O. Pharmacological stimulation of sperm motility in frozen and thawed testicular sperm using the dimethylxanthine theophylline. Fertil Steril 2011;96:1331–1336.
Sandi-Monroy NL, Musanovic S, Zhu D, Szab o Z, Vogl A, Reeka N, Eibner K, Bundschu K, Gagsteiger F. Use of dimethylxanthine theophylline (SpermMobil(VR )) does not affect clinical, obstetric or perinatal outcomes. Arch Gynecol Obstet 2019;300:1435–1443.
Navas P, Paffoni A, Intra G, Gonz alez-Utor A, Clavero A, Gonzalvo MC, Dıaz R, Pena R, Restelli L, Somigliana E et al. Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa. Reprod Biomed Online 2017;34:414–421.
Lepine S, McDowell S, Searle LM, Kroon B, Glujovsky D, Yazdani A. Advanced sperm selection techniques for assisted reproduction. Cochrane Database Syst Rev 2019;7:CD010461.
Aydın Ş, Bulgan Kılıçdağ E, Çağlar Aytaç P, Çok T, Şimşek E, Haydardedeoğlu B. Prospective randomized controlled study of a microfluidic chip technology for sperm selection in male infertility patients. Andrologia 2022;54:e14415.
Yetkinel S, Kilicdag EB, Aytac PC, Haydardedeoglu B, Simsek E, Cok T. Effects of the microfluidic chip technique in sperm selection for intracytoplasmic sperm injection for unexplained infertility: a prospective, randomized controlled trial. J Assist Reprod Genet. 2019 Mar;36(3):403-409. doi: 10.1007/s10815-018-1375-2. Epub 2018 Dec 12. PMID: 30542782; PMCID: PMC6439003.
Teixeira DM, Hadyme Miyague A, Barbosa MA, Navarro PA, Raine-Fenning N, Nastri CO, Martins WP. Regular (ICSI) versus ultrahigh magnification (IMSI) sperm selection for assisted reproduction. Cochrane Database Syst Rev 2020;2:CD010167.
Hardy K, Spanos S. Growth factor expression and function in the human and mouse preimplantation embryo. J Endocrinol 2002; 172:221–236.
Armstrong S, MacKenzie J, Woodward B, Pacey A, Farquhar C. GMCSF (granulocyte macrophage colony-stimulating factor) supplementation in culture media for women undergoing assisted reproduction. Cochrane Database Syst Rev 2020;7:CD013497.
Lacey L, Hassan S, Franik S, Seif MW, Akhtar MA. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)). Cochrane Database Syst Rev 2021;3:CD001894.
Hviid KVR, Malchau SS, Pinborg A, Nielsen HS. Determinants of monozygotic twinning in ART: a systematic review and a metaanalysis. Hum Reprod Update 2018;24:468–483.
Fragouli E, Munne S, Wells D. The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies. Hum Reprod Update 2019;25:15–33.
van Montfoort A, Carvalho F, Coonen E, Kokkali G, Moutou C, Rubio C, Goossens V, De Rycke M. ESHRE PGT Consortium data collection XIX-XX: PGT analyses from 2016 to 2017. Hum Reprod Open 2021;2021:hoab024.
Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S. Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation.Cochrane Database Syst Rev 2020;9:CD005291.
Rubio C, Bellver J, Rodrigo L, Castill on G, Guill en A, Vidal C, Giles J, Ferrando M, Cabanillas S, Remoh ı J et al. In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril 2017;107:1122–1129.
Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, Sun X, Ling X, Li H, Hao C et al. Live birth with or without preimplantation genetic testing for aneuploidy. N Engl J Med 2021;385:2047–2058.
Verpoest W, Staessen C, Bossuyt PM, Goossens V, Altarescu G, Bonduelle M, Devesa M, Eldar-Geva T, Gianaroli L, Griesinger G et al. Preimplantation genetic testing for aneuploidy by microarray analysis of polar bodies in advanced maternal age: a randomized clinical trial. Hum Reprod 2018;33:1767–1776.
Rubio C, Bellver J, Rodrigo L, Castill on G, Guill en A, Vidal C, Giles J, Ferrando M, Cabanillas S, Remoh ı J et al. In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril 2017;107:1122–1129.
Natsuaki MN, Dimler LM. Pregnancy and child developmental outcomes after preimplantation genetic screening: a meta-analytic and systematic review. World J Pediatr 2018;14:555–569.
Hou W, Shi G, Ma Y, Liu Y, Lu M, Fan X, Sun Y. Impact of preimplantation genetic testing on obstetric and neonatal outcomes: a systematic review and meta-analysis. Fertil Steril 2021a; 116:990–1000.
Zheng W, Yang C, Yang S, Sun S, Mu M, Rao M, Zu R, Yan J, Ren B, Yang R et al. Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis. Hum Reprod Update 2021;27:989–1012.
Armstrong S, Bhide P, Jordan V, Pacey A, Marjoribanks J, Farquhar C. Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database Syst Rev 2019;5:CD011320.
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