IVF/ICSI Protokolleri Sırasında E2, P4 Ölçümleri Yararlı Mı, Masraflflı Mı?

Ghumman S. Principles and Practice of Controlled Ovarian Stimulation in ART. Ghumman S, editor. New Delhi: Springer India (2015). doi: 10.1007/978-81-322- 1686-5 2. Fatemi H, Bilger W, Denis D, Griesinger G, La Marca A, Longobardi S, et al. Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017). Reprod Biol Endocrinol (2021) 19:68. doi: 10.1186/S12958-021- 00744-X/TABLES/1

Racca A, Drakopoulos P, Neves AR, Polyzos NP. Current therapeutic options for controlled ovarian stimulation in assisted reproductive technology. Drugs (2020) 80:973–94. doi: 10.1007/S40265-020-01324-W/METRICS

Lunenfeld B, Bilger W, Longobardi S, Kirsten J, D’Hooghe T, Sunkara SK. Decision points for individualized hormonal stimulation with recombinant gonadotropins for treatment of women with infertility. Gynecol Endocrinol (2019) 35:1027–36. doi: 10.1080/09513590.2019.1650345

Humaidan P, Nelson SM, Devroey P, Coddington CC, Schwartz LB, Gordon K, et al. Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials. Hum Reprod (2016) 31:1997–2004. doi: 10.1093/HUMREP/ DEW149

ESHRE ART Factsheet. Available at: https://www.eshre.eu/Europe/Factsheetsand-infographics (Accessed November 18, 2022).

Martins WP, Vieira CVR, Teixeira DM, Barbosa MAP, Dassunção LA, Nastri CO. Ultrasound for monitoring controlled ovarian stimulation: a systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstetrics Gynecol (2014) 43:25–33. doi: 10.1002/UOG.12566

Kwan I, Bhattacharya S, Woolner A. Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI). Cochrane Database Systematic Rev (2021) 2021. doi: 10.1002/14651858.CD005289.PUB4/MEDIA/CDSR/CD005289/IMAGE_N/ NCD005289-CMP-001.04.SVG

Blood hormone monitoring in controlled ovarian stimulation - IVF-Worldwide . Available at: https://ivf-worldwide.com/survey/blood-hormone-monitoring-incontrolled-ovarian-stimulation.html (Accessed September 25, 2023).

Results - Blood hormone monitoring in controlled ovarian stimulation - IVFWorldwide. Available at: https://ivf-worldwide.com/survey/blood-hormonemonitoring-in-controlled-ovarian-stimulation/results-blood-hormone-monitoring-incontrolled-ovarian-stimulation.html (Accessed September 25, 2023).

Kwan I, Bhattacharya S, Kang A, Woolner A. Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI). Cochrane Database Systematic Rev (2014) 2014. doi: 10.1002/14651858.CD005289.PUB3/MEDIA/CDSR/CD005289/REL0003/ CD005289/IMAGE_N/NCD005289-CMP-001-04.PNG

Wiser A, Gonen O, Ghetler Y, Shavit T, Berkovitz A, Shulman A. Monitoring stimulated cycles during in vitro fertilization treatment with ultrasound only – preliminary results. Gynecol Endocrinol (2012) 28:429–31. doi: 10.3109/ 09513590.2011.633666

Polyzos NP, Popovic-Todorovic B. SAY NO to mild ovarian stimulation for all poor responders: it is time to realize that not all poor responders are the same. Hum Reprod (2020) 35:1964–71. doi: 10.1093/HUMREP/DEAA183

Kahyaoglu S, Yumusak OH, Ozgu-Erdinc AS, Yilmaz S, Kahyaoglu I, EnginUstun Y, et al. Can serum estradiol levels on the fourth day of IVF/ICSI cycle predict outcome in poor responder women? Syst Biol Reprod Med (2015) 61:233–7. doi: 10.3109/19396368.2015.1013645

El Maghraby HA, Mahdi M, El Arab MS, Mabrouk M, Ghi T, Farina A. Stimulation day-six serum estradiol: A predictive indicator for the probability of embryo cryopreservation in IVF/ICSI cycles. J Obstetrics Gynaecology Res (2009) 35:326–9. doi: 10.1111/J.1447-0756.2008.00940.X

Wei C-X, Zhang L, Qi Y-H, Zhang J-W. Effect of the trends of estradiol level on the outcome of in vitro fertilization-embryo transfer with antagonist regimens: a single center retrospective cohort study. Research Square [Preprint] (2021). doi: 10.21203/ RS.3.RS-1066884/V2

Practice Committee of the American Society for Reproductive Medicine. Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertil Steril (2016) 106:1634–47. doi: 10.1016/ J.FERTNSTERT.2016.08.048

Papanikolaou EG, Pozzobon C, Kolibianakis EM, Camus M, Tournaye H, Fatemi HM, et al. Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril (2006) 85:112–20. doi: 10.1016/J.FERTNSTERT.2005.07.1292

Liu M, Liu S, Li L, Wang P, Li H, Li Y. LH levels may be used as an indicator for the time of antagonist administration in GnRH antagonist protocols—a proof-ofconcept study. Front Endocrinol (Lausanne) (2019) 10:67/BIBTEX. doi: 10.3389/ FENDO.2019.00067/BIBTEX

Zhang W, Liu Z, Liu M, Li J, Guan Y. Is it necessary to monitor the serum luteinizing hormone (LH) concentration on the human chorionic gonadotropin (HCG) day among

young women during the follicular-phase long protocol? A retrospective cohort study. Reprod Biol Endocrinol (2022) 20:1–7. doi: 10.1186/S12958-022-00888-4/ FIGURES/2

Benmachiche A, Benbouhedja S, Zoghmar A, Humaidan P. Low LH level on the day of gnRH agonist trigger is associated with reduced ongoing pregnancy and live birth rates and increased early miscarriage rates following IVF/ICSI treatment and fresh embryo transfer. Front Endocrinol (Lausanne) (2019) 10:639. doi: 10.3389/ FENDO.2019.00639

Lawrenz B, Melado L, Fatemi H. Premature progesterone rise in ART-cycles. Reprod Biol (2018) 18:1–4. doi: 10.1016/J.REPBIO.2018.01.001

Neves AR, Santos-Ribeiro S, Garcıa-Mart ́ ınez S, Devesa M, Soares SR, Garc ́ ıa-́ Velasco JA, et al. The effect of late-follicular phase progesterone elevation on embryo ploidy and cumulative live birth rates. Reprod BioMed Online (2021) 43:1063–9. doi: 10.1016/j.rbmo.2021.07.019

Montoya-Botero P, Polyzos NP. The endometrium during and after ovarian hyperstimulation and the role of segmentation of infertility treatment. Best Pract Res Clin Endocrinol Metab (2019) 33:61–75. doi: 10.1016/J.BEEM.2018.09.003

Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update (2013) 19:433–57. doi: 10.1093/HUMUPD/ DMT014

Al-Azemi M, Kyrou D, Kolibianakis EM, Humaidan P, Van Vaerenbergh I, Devroey P, et al. Elevated progesterone during ovarian stimulation for IVF. Reprod BioMed Online (2012) 24:381–8. doi: 10.1016/j.rbmo.2012.01.010

Panaino TR, da Silva JB, de Lima MAT, Lira P, Arêas PCC, Mancebo ACA, et al. High Progesterone levels in the beginning of ICSI antagonist cycles and clinical pregnancy: still a concern? JBRA Assist Reprod (2017) 21:11. doi: 10.5935/1518- 0557.20170004

Papanikolaou EG, Pados G, Grimbizis G, Bili E, Kyriazi L, Polyzos NP, et al. GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Hum Reprod (2012) 27:1822–8. doi: 10.1093/HUMREP/ DES066

Xu B, Li Z, Zhang H, Jin L, Li Y, Ai J, et al. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Steril (2012) 97:1321–7. doi: 10.1016/ J.FERTNSTERT.2012.03.014

Devroey P, Polyzos NP, Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod (2011) 26:2593–7. doi: 10.1093/HUMREP/DER251

Lawrenz B, Melado L, Fatemi HM. Frozen embryo transfers in a natural cycle: how to do it right. Curr Opin Obstet Gynecol (2023) 35:224–9. doi: 10.1097/ GCO.0000000000000862

Griesinger G, Weig M, Schroer A, Diedrich K, Kolibianakis EM. Mid-cycle serum levels of endogenous LH are not associated with the likelihood of pregnancy in artificial frozen-thawed embryo transfer cycles without pituitary suppression. Hum Reprod (2007) 22:2589–93. doi: 10.1093/HUMREP/DEM207

Niu Z, Feng Y, Sun Y, Zhang A, Zhang H. Estrogen level monitoring in artificial frozen-thawed embryo transfer cycles using step-up regime without pituitary suppression: is it necessary? J Exp Clin Assist Reprod (2008) 5. doi: 10.1186/1743- 1050-5-4

Li Q, Ruan L, Zhu L, Yang Z, Zhu M, Luo Y. Elevated estradiol levels in frozen embryo transfer have different effects on pregnancy outcomes depending on the stage of transferred embryos. Sci Rep (2022) 12. doi: 10.1038/S41598-022-09545-7

Melo P, Chung Y, Pickering O, Price MJ, Fishel S, Khairy M, et al. Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis. Fertil Steril (2021) 116:1534–56. doi: 10.1016/J.FERTNSTERT.2021.07.002

Á lvarez M, Gaggiotti-Marre S, Martınez F, Coll L, Garc ́ ıa S, Gonza ́ ́lez-Foruria I, et al. Individualized luteal phase support in artificially prepared frozen embryo transfer cycles based on serum progesterone levels: a prospective cohort study. Hum Reprod (2021) 36:1552–60. doi: 10.1093/HUMREP/DEAB031

Stavridis K, Kastora SL, Triantafyllidou O, Mavrelos D, Vlahos N. Effectiveness of progesterone rescue in women presenting low circulating progesterone levels around the day of embryo transfer: a systematic review and meta-analysis. Fertil Steril (2023) 119:954–63. doi: 10.1016/J.FERTNSTERT.2023.02.007

Ghumman S. Principles and Practice of Controlled Ovarian Stimulation in ART. Ghumman S, editor. New Delhi: Springer India (2015). doi: 10.1007/978-81-322- 1686-5 2. Fatemi H, Bilger W, Denis D, Griesinger G, La Marca A, Longobardi S, et al. Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017). Reprod Biol Endocrinol (2021) 19:68. doi: 10.1186/S12958-021- 00744-X/TABLES/1

Racca A, Drakopoulos P, Neves AR, Polyzos NP. Current therapeutic options for controlled ovarian stimulation in assisted reproductive technology. Drugs (2020) 80:973–94. doi: 10.1007/S40265-020-01324-W/METRICS

Lunenfeld B, Bilger W, Longobardi S, Kirsten J, D’Hooghe T, Sunkara SK. Decision points for individualized hormonal stimulation with recombinant gonadotropins for treatment of women with infertility. Gynecol Endocrinol (2019) 35:1027–36. doi: 10.1080/09513590.2019.1650345

Humaidan P, Nelson SM, Devroey P, Coddington CC, Schwartz LB, Gordon K, et al. Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials. Hum Reprod (2016) 31:1997–2004. doi: 10.1093/HUMREP/ DEW149

ESHRE ART Factsheet. Available at: https://www.eshre.eu/Europe/Factsheetsand-infographics (Accessed November 18, 2022).

Martins WP, Vieira CVR, Teixeira DM, Barbosa MAP, Dassunção LA, Nastri CO. Ultrasound for monitoring controlled ovarian stimulation: a systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstetrics Gynecol (2014) 43:25–33. doi: 10.1002/UOG.12566

Kwan I, Bhattacharya S, Woolner A. Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI). Cochrane Database Systematic Rev (2021) 2021. doi: 10.1002/14651858.CD005289.PUB4/MEDIA/CDSR/CD005289/IMAGE_N/ NCD005289-CMP-001.04.SVG

Blood hormone monitoring in controlled ovarian stimulation - IVF-Worldwide . Available at: https://ivf-worldwide.com/survey/blood-hormone-monitoring-incontrolled-ovarian-stimulation.html (Accessed September 25, 2023).

Results - Blood hormone monitoring in controlled ovarian stimulation - IVFWorldwide. Available at: https://ivf-worldwide.com/survey/blood-hormonemonitoring-in-controlled-ovarian-stimulation/results-blood-hormone-monitoring-incontrolled-ovarian-stimulation.html (Accessed September 25, 2023).

Kwan I, Bhattacharya S, Kang A, Woolner A. Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI). Cochrane Database Systematic Rev (2014) 2014. doi: 10.1002/14651858.CD005289.PUB3/MEDIA/CDSR/CD005289/REL0003/ CD005289/IMAGE_N/NCD005289-CMP-001-04.PNG

Wiser A, Gonen O, Ghetler Y, Shavit T, Berkovitz A, Shulman A. Monitoring stimulated cycles during in vitro fertilization treatment with ultrasound only – preliminary results. Gynecol Endocrinol (2012) 28:429–31. doi: 10.3109/ 09513590.2011.633666

Polyzos NP, Popovic-Todorovic B. SAY NO to mild ovarian stimulation for all poor responders: it is time to realize that not all poor responders are the same. Hum Reprod (2020) 35:1964–71. doi: 10.1093/HUMREP/DEAA183

Kahyaoglu S, Yumusak OH, Ozgu-Erdinc AS, Yilmaz S, Kahyaoglu I, EnginUstun Y, et al. Can serum estradiol levels on the fourth day of IVF/ICSI cycle predict outcome in poor responder women? Syst Biol Reprod Med (2015) 61:233–7. doi: 10.3109/19396368.2015.1013645

El Maghraby HA, Mahdi M, El Arab MS, Mabrouk M, Ghi T, Farina A. Stimulation day-six serum estradiol: A predictive indicator for the probability of embryo cryopreservation in IVF/ICSI cycles. J Obstetrics Gynaecology Res (2009) 35:326–9. doi: 10.1111/J.1447-0756.2008.00940.X

Wei C-X, Zhang L, Qi Y-H, Zhang J-W. Effect of the trends of estradiol level on the outcome of in vitro fertilization-embryo transfer with antagonist regimens: a single center retrospective cohort study. Research Square [Preprint] (2021). doi: 10.21203/ RS.3.RS-1066884/V2

Practice Committee of the American Society for Reproductive Medicine. Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertil Steril (2016) 106:1634–47. doi: 10.1016/ J.FERTNSTERT.2016.08.048

Papanikolaou EG, Pozzobon C, Kolibianakis EM, Camus M, Tournaye H, Fatemi HM, et al. Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril (2006) 85:112–20. doi: 10.1016/J.FERTNSTERT.2005.07.1292

Liu M, Liu S, Li L, Wang P, Li H, Li Y. LH levels may be used as an indicator for the time of antagonist administration in GnRH antagonist protocols—a proof-ofconcept study. Front Endocrinol (Lausanne) (2019) 10:67/BIBTEX. doi: 10.3389/ FENDO.2019.00067/BIBTEX

Zhang W, Liu Z, Liu M, Li J, Guan Y. Is it necessary to monitor the serum luteinizing hormone (LH) concentration on the human chorionic gonadotropin (HCG) day among

young women during the follicular-phase long protocol? A retrospective cohort study. Reprod Biol Endocrinol (2022) 20:1–7. doi: 10.1186/S12958-022-00888-4/ FIGURES/2

Benmachiche A, Benbouhedja S, Zoghmar A, Humaidan P. Low LH level on the day of gnRH agonist trigger is associated with reduced ongoing pregnancy and live birth rates and increased early miscarriage rates following IVF/ICSI treatment and fresh embryo transfer. Front Endocrinol (Lausanne) (2019) 10:639. doi: 10.3389/ FENDO.2019.00639

Lawrenz B, Melado L, Fatemi H. Premature progesterone rise in ART-cycles. Reprod Biol (2018) 18:1–4. doi: 10.1016/J.REPBIO.2018.01.001

Neves AR, Santos-Ribeiro S, Garcıa-Mart ́ ınez S, Devesa M, Soares SR, Garc ́ ıa-́ Velasco JA, et al. The effect of late-follicular phase progesterone elevation on embryo ploidy and cumulative live birth rates. Reprod BioMed Online (2021) 43:1063–9. doi: 10.1016/j.rbmo.2021.07.019

Montoya-Botero P, Polyzos NP. The endometrium during and after ovarian hyperstimulation and the role of segmentation of infertility treatment. Best Pract Res Clin Endocrinol Metab (2019) 33:61–75. doi: 10.1016/J.BEEM.2018.09.003

Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update (2013) 19:433–57. doi: 10.1093/HUMUPD/ DMT014

Al-Azemi M, Kyrou D, Kolibianakis EM, Humaidan P, Van Vaerenbergh I, Devroey P, et al. Elevated progesterone during ovarian stimulation for IVF. Reprod BioMed Online (2012) 24:381–8. doi: 10.1016/j.rbmo.2012.01.010

Panaino TR, da Silva JB, de Lima MAT, Lira P, Arêas PCC, Mancebo ACA, et al. High Progesterone levels in the beginning of ICSI antagonist cycles and clinical pregnancy: still a concern? JBRA Assist Reprod (2017) 21:11. doi: 10.5935/1518- 0557.20170004

Papanikolaou EG, Pados G, Grimbizis G, Bili E, Kyriazi L, Polyzos NP, et al. GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Hum Reprod (2012) 27:1822–8. doi: 10.1093/HUMREP/ DES066

Xu B, Li Z, Zhang H, Jin L, Li Y, Ai J, et al. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Steril (2012) 97:1321–7. doi: 10.1016/ J.FERTNSTERT.2012.03.014

Devroey P, Polyzos NP, Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod (2011) 26:2593–7. doi: 10.1093/HUMREP/DER251

Lawrenz B, Melado L, Fatemi HM. Frozen embryo transfers in a natural cycle: how to do it right. Curr Opin Obstet Gynecol (2023) 35:224–9. doi: 10.1097/ GCO.0000000000000862

Griesinger G, Weig M, Schroer A, Diedrich K, Kolibianakis EM. Mid-cycle serum levels of endogenous LH are not associated with the likelihood of pregnancy in artificial frozen-thawed embryo transfer cycles without pituitary suppression. Hum Reprod (2007) 22:2589–93. doi: 10.1093/HUMREP/DEM207

Niu Z, Feng Y, Sun Y, Zhang A, Zhang H. Estrogen level monitoring in artificial frozen-thawed embryo transfer cycles using step-up regime without pituitary suppression: is it necessary? J Exp Clin Assist Reprod (2008) 5. doi: 10.1186/1743- 1050-5-4

Li Q, Ruan L, Zhu L, Yang Z, Zhu M, Luo Y. Elevated estradiol levels in frozen embryo transfer have different effects on pregnancy outcomes depending on the stage of transferred embryos. Sci Rep (2022) 12. doi: 10.1038/S41598-022-09545-7

Melo P, Chung Y, Pickering O, Price MJ, Fishel S, Khairy M, et al. Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis. Fertil Steril (2021) 116:1534–56. doi: 10.1016/J.FERTNSTERT.2021.07.002

Á lvarez M, Gaggiotti-Marre S, Martınez F, Coll L, Garc ́ ıa S, Gonza ́ ́lez-Foruria I, et al. Individualized luteal phase support in artificially prepared frozen embryo transfer cycles based on serum progesterone levels: a prospective cohort study. Hum Reprod (2021) 36:1552–60. doi: 10.1093/HUMREP/DEAB031

Stavridis K, Kastora SL, Triantafyllidou O, Mavrelos D, Vlahos N. Effectiveness of progesterone rescue in women presenting low circulating progesterone levels around the day of embryo transfer: a systematic review and meta-analysis. Fertil Steril (2023) 119:954–63. doi: 10.1016/J.FERTNSTERT.2023.02.007