KR Endometritis Tanısı ve Tedavisi

Kimura F, Takebayashi A, Ishida M, Nakamura A, Kita- zawa J, Morimune A, et al. Review: Chronic endometritis and its effect on reproduction. Journal of Obstetrics and Gynaecology Research. 2019 May 6;45(5):951–60.

Kitaya K, Tada Y, Hayashi T, Taguchi S, Funabiki M, Nakamura Y. Comprehensive Endometrial Immunoglobulin Subclass Analysis in Infertile Women Suffering from Repeated Implantation Failure with or without Chronic Endometritis. American Journal of Reproduc- tive Immunology. 2014 Oct 5;72(4):386–91.

Di Pietro C, Cicinelli E, Guglielmino MR, Ragusa M, Farina M, Palumbo MA, et al. Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apop- totic Proteins in the Endometrium of Infertile Women with Chronic Endometritis. American Journal of Reproductive Immunology. 2013 May 28;69(5):509–17.

Yoshii N, Hamatani T, Inagaki N, Hosaka T, Inoue O, Yamada M, et al. Successful implantation after redu- cing matrix metalloproteinase activity in the uterine cavity. Reproductive Biology and Endocrinology. 2013 Dec 11;11(1):37.

Veiga EC de A, Soares Junior JM, Samama M, Ikeda F, Francisco LS, Sartor A, et al. Chronic endometritis and assisted reproduction: a systematic review and me- ta-analysis. Revista da Associação Médica Brasileira.

Michels TC. Chronic endometritis. Am Family Physician. 1995 Jul;52(1):217–22.

Greenwood SM, Moran JJ. Chronic endometritis: morphologic and clinical observations. Obstetrics and gynecology. 1981 Aug;58(2):176–84.

Katherine T Chen. Endometritis unrelated to preg- nancy. [Online] https://www.uptodate.com/contents/ endometritisunrelatedtopregnancysearch=CHRO- NIC20ENDOMETRITIS&source=search_result&- selectedTitle=1~150&usage_type=default&display_ rank=1#references

Cimadomo D, de los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, et al. ESHRE good practi- ce recommendations on recurrent implantation failure. Human Reproduction Open. 2023 Jun 1;2023(3).

Espinós JJ, Fabregues F, Fontes J, García-Velasco JA, Llácer J, Requena A, et al. Impact of chronic endomet- ritis in infertility: a SWOT analysis. Reproduction Bio- medicine Online. 2021 May;42(5):939–51.

Cicinelli E, Matteo M, Trojano G, Mitola PC, Tinelli R, Vitagliano A, et al. Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. Ame- rican Journal of Reproductive Immunology. 2018 Jan 14;79(1).

Li J, Wei J, Chen S, Wang X, Chen J, Zeng D, et al. Prevalence and risk factors for chronic endometritis in patients with adenomyosis and infertility: a retros- pective cohort study. BMC Womens Health. 2024 Jul 16;24(1):403.

Cimadomo D, Craciunas L, Vermeulen N, Vomstein K, Toth B. Definition, diagnostic and therapeutic options

in recurrent implantation failure: an international sur do A, Saccone G, Cicinelli E, et al. Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a sys- tematic review and meta-analysis. Fertil Steril. 2018 Jul;110(1):103-112.e1.

Ticconi C, Inversetti A, Marraffa S, Campagnolo L, Arthur J, Zambella E, et al. Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis. Frontiers in Immunology. 2024 Aug 16;15.

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Mon- fort M, Bau D, Vilella F, et al. The diagnosis of chronic endometritis in infertile asymptomatic women: a com- parative study of histology, microbial cultures, hyste- roscopy, and molecular microbiology. American Jour- nal of Obstetrics & Gynecology. 2018 Jun;218(6):602. e1-602.e16.

Liu H, Song J, Zhang F, Li J, Kong W, Lv S, et al. A New Hysteroscopic Scoring System for Diagnosing Chronic Endometritis. Journal of Minimally Invasive Gyneco- logy. 2020 Jul;27(5):1127–32.

Kitaya K, Nagai Y, Arai W, Sakuraba Y, Ishikawa T. Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Re- peated Implantation Failure. Mediators Inflammation. 2019 May 21;2019:1–10.

Kitaya K, Yasuo T, Yamaguchi T. Bridging the Diagnos- tic Gap between Histopathologic and Hysteroscopic Chronic Endometritis with Deep Learning Models. Medicina (B Aires). 2024 Jun 12;60(6):972.

Küçük T, Safali M. “Chromohysteroscopy” for evalua-

vey of clinicians and embryologists. Human Reproduc- tion. 2021 Jan 25;36(2):305–17.

Akopians A, Pisarska M, Wang E. The Role of Inflamtion of endometrium in recurrent in vitro fertilization failure. Journal of Assisted Reproduction and Genetics. 2008 Mar 29;25(2–3):79–82.

Ozturk M, Ulubay M, Alanbay I, Keskin U, Karasahin E, Yenen MC. Using narrow-band imaging with conventional hysteroscopy increases the detection of ch- ronic endometritis in abnormal uterine bleeding and postmenopausal bleeding. Journal of Obstetrics and Gynaecology Research. 2016 Jan;42(1):67–71.

Cheng X, Huang Z, Xiao Z, Bai Y. Does antibiotic the- rapy for chronic endometritis improve clinical outco- mes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and me- ta-analysis. Journal of Assisted Reproduction and Gene- tics. 2022 Aug 13;39(8):1797–813.

Yasuo T, Kitaya K. Challenges in Clinical Diagnosis and Management of Chronic Endometritis. Diagnosti- cs. 2022 Nov 5;12(11):2711.

Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recom- mendations Report. 2021 Jul 23;70(4):1–187.

Kitaya K, Matsubayashi H, Takaya Y, Nishiyama R, Ya- maguchi K, Takeuchi T, et al. Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. American Journal of Reproductive Immunology. 2017 Nov 13;78(5).

Di Gennaro F, Guido G, Frallonardo L, Pennazzi L, Bevilacqua M, Locantore P, et al. Chronic Endometritis and Antimicrobial Resistance: Towards a Multid- rug-Resistant Endometritis? An Expert Opinion. Mic- roorganisms. 2025 Jan 17;13(1):197.

Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Human Repro- duction. 2015 Feb 1;30(2):323–30.

Vitagliano A, Laganà AS, De Ziegler D, Cicinelli R, Santarsiero CM, Buzzaccarini G, et al. Chronic Endometritis in Infertile Women: Impact of Untreated Dise- ase, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis. Diagnostics. 2022 Sep 18;12(9):2250.

Di Gennaro F, Guido G, Frallonardo L, Pennazzi L, Bevilacqua M, Locantore P, et al. Chronic Endometritis and Antimicrobial Resistance: Towards a Multid- rug-Resistant Endometritis? An Expert Opinion. Microorganisms. 2025 Jan 17;13(1):197.

Kimura F, Takebayashi A, Ishida M, Nakamura A, Kita- zawa J, Morimune A, et al. Review: Chronic endometritis and its effect on reproduction. Journal of Obstetrics and Gynaecology Research. 2019 May 6;45(5):951–60.

Kitaya K, Tada Y, Hayashi T, Taguchi S, Funabiki M, Nakamura Y. Comprehensive Endometrial Immunoglobulin Subclass Analysis in Infertile Women Suffering from Repeated Implantation Failure with or without Chronic Endometritis. American Journal of Reproduc- tive Immunology. 2014 Oct 5;72(4):386–91.

Di Pietro C, Cicinelli E, Guglielmino MR, Ragusa M, Farina M, Palumbo MA, et al. Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apop- totic Proteins in the Endometrium of Infertile Women with Chronic Endometritis. American Journal of Reproductive Immunology. 2013 May 28;69(5):509–17.

Yoshii N, Hamatani T, Inagaki N, Hosaka T, Inoue O, Yamada M, et al. Successful implantation after redu- cing matrix metalloproteinase activity in the uterine cavity. Reproductive Biology and Endocrinology. 2013 Dec 11;11(1):37.

Veiga EC de A, Soares Junior JM, Samama M, Ikeda F, Francisco LS, Sartor A, et al. Chronic endometritis and assisted reproduction: a systematic review and me- ta-analysis. Revista da Associação Médica Brasileira.

Michels TC. Chronic endometritis. Am Family Physician. 1995 Jul;52(1):217–22.

Greenwood SM, Moran JJ. Chronic endometritis: morphologic and clinical observations. Obstetrics and gynecology. 1981 Aug;58(2):176–84.

Katherine T Chen. Endometritis unrelated to preg- nancy. [Online] https://www.uptodate.com/contents/ endometritisunrelatedtopregnancysearch=CHRO- NIC20ENDOMETRITIS&source=search_result&- selectedTitle=1~150&usage_type=default&display_ rank=1#references

Cimadomo D, de los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, et al. ESHRE good practi- ce recommendations on recurrent implantation failure. Human Reproduction Open. 2023 Jun 1;2023(3).

Espinós JJ, Fabregues F, Fontes J, García-Velasco JA, Llácer J, Requena A, et al. Impact of chronic endomet- ritis in infertility: a SWOT analysis. Reproduction Bio- medicine Online. 2021 May;42(5):939–51.

Cicinelli E, Matteo M, Trojano G, Mitola PC, Tinelli R, Vitagliano A, et al. Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. Ame- rican Journal of Reproductive Immunology. 2018 Jan 14;79(1).

Li J, Wei J, Chen S, Wang X, Chen J, Zeng D, et al. Prevalence and risk factors for chronic endometritis in patients with adenomyosis and infertility: a retros- pective cohort study. BMC Womens Health. 2024 Jul 16;24(1):403.

Cimadomo D, Craciunas L, Vermeulen N, Vomstein K, Toth B. Definition, diagnostic and therapeutic options

in recurrent implantation failure: an international sur do A, Saccone G, Cicinelli E, et al. Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a sys- tematic review and meta-analysis. Fertil Steril. 2018 Jul;110(1):103-112.e1.

Ticconi C, Inversetti A, Marraffa S, Campagnolo L, Arthur J, Zambella E, et al. Chronic endometritis and recurrent reproductive failure: a systematic review and meta-analysis. Frontiers in Immunology. 2024 Aug 16;15.

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Mon- fort M, Bau D, Vilella F, et al. The diagnosis of chronic endometritis in infertile asymptomatic women: a com- parative study of histology, microbial cultures, hyste- roscopy, and molecular microbiology. American Jour- nal of Obstetrics & Gynecology. 2018 Jun;218(6):602. e1-602.e16.

Liu H, Song J, Zhang F, Li J, Kong W, Lv S, et al. A New Hysteroscopic Scoring System for Diagnosing Chronic Endometritis. Journal of Minimally Invasive Gyneco- logy. 2020 Jul;27(5):1127–32.

Kitaya K, Nagai Y, Arai W, Sakuraba Y, Ishikawa T. Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Re- peated Implantation Failure. Mediators Inflammation. 2019 May 21;2019:1–10.

Kitaya K, Yasuo T, Yamaguchi T. Bridging the Diagnos- tic Gap between Histopathologic and Hysteroscopic Chronic Endometritis with Deep Learning Models. Medicina (B Aires). 2024 Jun 12;60(6):972.

Küçük T, Safali M. “Chromohysteroscopy” for evalua-

vey of clinicians and embryologists. Human Reproduc- tion. 2021 Jan 25;36(2):305–17.

Akopians A, Pisarska M, Wang E. The Role of Inflamtion of endometrium in recurrent in vitro fertilization failure. Journal of Assisted Reproduction and Genetics. 2008 Mar 29;25(2–3):79–82.

Ozturk M, Ulubay M, Alanbay I, Keskin U, Karasahin E, Yenen MC. Using narrow-band imaging with conventional hysteroscopy increases the detection of ch- ronic endometritis in abnormal uterine bleeding and postmenopausal bleeding. Journal of Obstetrics and Gynaecology Research. 2016 Jan;42(1):67–71.

Cheng X, Huang Z, Xiao Z, Bai Y. Does antibiotic the- rapy for chronic endometritis improve clinical outco- mes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and me- ta-analysis. Journal of Assisted Reproduction and Gene- tics. 2022 Aug 13;39(8):1797–813.

Yasuo T, Kitaya K. Challenges in Clinical Diagnosis and Management of Chronic Endometritis. Diagnosti- cs. 2022 Nov 5;12(11):2711.

Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recom- mendations Report. 2021 Jul 23;70(4):1–187.

Kitaya K, Matsubayashi H, Takaya Y, Nishiyama R, Ya- maguchi K, Takeuchi T, et al. Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. American Journal of Reproductive Immunology. 2017 Nov 13;78(5).

Di Gennaro F, Guido G, Frallonardo L, Pennazzi L, Bevilacqua M, Locantore P, et al. Chronic Endometritis and Antimicrobial Resistance: Towards a Multid- rug-Resistant Endometritis? An Expert Opinion. Mic- roorganisms. 2025 Jan 17;13(1):197.

Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Human Repro- duction. 2015 Feb 1;30(2):323–30.

Vitagliano A, Laganà AS, De Ziegler D, Cicinelli R, Santarsiero CM, Buzzaccarini G, et al. Chronic Endometritis in Infertile Women: Impact of Untreated Dise- ase, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis. Diagnostics. 2022 Sep 18;12(9):2250.

Di Gennaro F, Guido G, Frallonardo L, Pennazzi L, Bevilacqua M, Locantore P, et al. Chronic Endometritis and Antimicrobial Resistance: Towards a Multid- rug-Resistant Endometritis? An Expert Opinion. Microorganisms. 2025 Jan 17;13(1):197.