Frozen-Thaw Sikluslarda Endometriumun Hazırlanması

Özet

Referanslar

Glujovsky D, Pesce R, Fiszbajn G, et al. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD006359.

Andersen AG, Als-Nielsen B, Hornnes PJ, et al. Time interval from human chorionic gonadotrophin (HCG) injection to follicular rupture. Hum Reprod. 1995 Dec;10(12):3202-3205.

Park SJ, Goldsmith LT, Skurnick JH, et al. Characteristics of the urinary luteinizing hormone surge in young ovulatory women. Fertil Steril. 2007 Sep;88(3):684-690.

Waldman IN, Racowsky C, Disler ER, et al. The clinical relevance of luteal phase progesterone support in true natural cycle cryopreserved blastocyst stage embryo transfers: a retrospective cohort study. Fertil Res Pract. 2021 Feb 9;7(1):4.

Fatemi HM, Kyrou D, Bourgain C, et al. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril. 2010 Nov;94(6):2054-2058.

Weissman A, Horowitz E, Ravhon A, et al. Spontaneous ovulation versus HCG triggering for timing natural-cycle frozen-thawed embryo transfer: a randomized study. Reprod Biomed Online. 2011 Oct;23(4):484-489.

Montagut M, Santos-Ribeiro S, De Vos M, et al. Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues. Hum Reprod. 2016 Dec;31(12):2803-2810.

Mackens S, Stubbe A, Santos-Ribeiro S, et al. To trigger or not to trigger ovulation in a natural cycle for frozen embryo transfer: a randomized controlled trial. Hum Reprod. 2020 May;35(5):1073-1081.

Fauser BC, de Jong D, Olivennes F, et al. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002 Feb;87(2):709-715.

Casper RF, Yanushpolsky EH. Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support. Fertil Steril. 2016 Apr;105(4):867-872.

Eftekhar M, Rahsepar M, Rahmani E. Effect of progesterone supplementation on natural frozen-thawed embryo transfer cycles: a randomized controlled trial. Int J Fertil Steril. 2013;7(1):13-20.

Mizrachi Y, Horowitz E, Ganer Herman HG, et al. Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Hum Reprod Update. 2021;27:643-650.

Groenewoud ER, Macklon NS, Cohlen BJ; ANTARCTICA Study Group. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles. Reprod Biomed Online. 2017 May;34(5):546-554.

Jahromi BN, Pourgholam F, Parsanezhad ME, et al. Role of estradiol level before progesterone start on outcomes of frozen embryo transfer; a systematic review and meta-analysis. Contracept Reprod Med. 2024 Dec;9(1):64.

Kalem Z, Kalem MN, Gürgan T. Methods for endometrial preparation in frozen-thawed embryo transfer cycles. J Turk Ger Gynecol Assoc. 2016 Sep;17(3):168-172.

Mackens S, Santos-Ribeiro S, van de Vijver A, et al. Frozen embryo transfer: a review on the optimal endometrial preparation and timing. Hum Reprod. 2017 Nov;32(11):2234-2242.

Yang X, Bu Z, Hu L. Live Birth Rate of Frozen-Thawed Single Blastocyst Transfer After 6 or 7 Days of Progesterone Administration in Hormone Replacement Therapy Cycles: A Propensity Score-Matched Cohort Study. Front Endocrinol (Lausanne). 2021 Aug 11;12:706427.

Franasiak JM, Ruiz-Alonso M, Scott RT, et al. Both slowly developing embryos and a variable pace of luteal endometrial progression may conspire to prevent normal birth in spite of a capable embryo. Fertil Steril. 2016 Apr;105(4):861-866.

El-Toukhy T, Coomarasamy A, Khairy M, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril. 2008 Apr;89(4):832-839.

Zhang J. Resurgence of minimal stimulation in vitro fertilization with a protocol consisting of GnRH-agonist trigger and vitrified-thawed embryo transfer. Int J Fertil Steril. 2016 Jul-Sep;10(2):148-153.

Navot D, Anderson TL, Droesch K, et al. Hormonal manipulation of endometrial maturation. J Clin Endocrinol Metab. 1989 Apr;68(4):801-807.

Leeton J, Rogers P, King C, et al. A comparison of pregnancy rates for 131 donor oocyte transfers using either a sequential or fixed regime of steroid replacement therapy. Hum Reprod. 1991 Feb;6(2):299-301.

Rodríguez-Varela C, Salvaleda-Mateu M, Labarta E. Duration of oestrogen exposure does not affect reproductive outcome in artificial cycles: a retrospective analysis of more than 7000 hormonal replacement therapy cycles for an embryo transfer. Front Endocrinol (Lausanne). 2023 Aug 1;14:1233685.

Wei C, Wu H, Yu Y, Li Y, Xiang S, Lian F. Effect of estrogen exposure on pregnancy outcomes in artificial frozen-thawed embryo transfer cycles. Gynecol Endocrinol. 2024 Dec;40(1):2352142.

Dal Prato L, Borini A, Cattoli M, et al. Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with GnRH agonist. Fertil Steril. 2002 May;77(5):956-960.

Van de Vijver A, Polyzos NP, Van Landuyt L, et al. Cryopreserved embryo transfer in an artificial cycle: is GnRH agonist down-regulation necessary? Reprod Biomed Online. 2014 Nov;29(5):588-594.

Yarali H, Polat M, Mumusoglu S, et al. Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis. J Assist Reprod Genet. 2016 Oct;33(10):1287-1304.

Xu B, Hou Z, Liu N, et al. Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth? J Ovarian Res. 2023 Sep;16(1):197.

Aghahoseini M, Alyasin A, Rashidi S, et al. The efficacy of GnRH agonist before frozen embryo transfer in improving pregnancy outcome and decreasing miscarriage rate in hyperandrogenic PCOS women: a randomized clinical trial. Minerva Ginecol. 2020 Aug;72(4):344-351.

Li X, Lin J, Zhang L, et al. Effects of GnRH agonist pretreatment on frozen embryo transfer outcomes in artificial cycles: a meta-analysis. Arch Gynecol Obstet. 2023 Sep;308(3):675-683.

Morozov V, Ruman J, Kenigsberg D, et al. Natural cycle cryo-thaw transfer may improve pregnancy outcome. J Assist Reprod Genet. 2007 Apr;24(4):119-123.

Satwik R, Majumdar A, Mittal Gupta S, et al. Natural cycle versus hormone replacement cycle for transferring vitrified-warmed embryos in eumenorrhoeic women: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2021 Aug;263:94-99.

Ghobara T, Gelbaya TA, Ayeleke RO. Cycle regimens for endometrial preparation prior to frozen embryo transfer. Cochrane Database Syst Rev. 2025 Jun;6(6):CD003414.

Kalem Z, Namlı Kalem M, Bakırarar B, et al. Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer. Saudi Med J. 2018 Nov;39(11):1102-1108.

Groenewoud ER, Cantineau AEP, Kollen BJ, et al. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update. 2013 Sep-Oct;19(5):458-470.

Jin Z, Shi H, Bu Z, et al. Live birth rates after natural cycle versus hormone replacement therapy for single euploid blastocyst transfers: a retrospective cohort study. Reprod Biomed Online. 2021 Dec;43(6):1002-1010.

Ginström Ernstad E, Wennerholm UB, Khatibi A, et al. Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles. Am J Obstet Gynecol. 2019 Aug;221(2):126.e1-8.

Khadem Ghaebi N, Mahmoudiniya M, Najaf Najafi M, Zohdi E, Attaran M. Comparison of letrozole with gonadotropin-releasing hormone agonist in frozen embryo transfer after recurrent implantation failure: An RCT. Int J Reprod Biomed. 2020 Feb 27;18(2):105-112.

Peeraer K, Couck I, Debrock S, et al. Frozen-thawed embryo transfer in a natural or mildly hormonally stimulated cycle in women with regular ovulatory cycles: a randomized controlled trial. Hum Reprod. 2015 Nov;30(11):2552-2562.

Wu H, Zhou P, Lin X, et al. Endometrial preparation for frozen-thawed embryo transfer cycles: a systematic review and network meta-analysis. J Assist Reprod Genet. 2021;38:2967-2982.

Zhang Y, Wu L, Li TC, et al. Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artificial cycle for endometrial preparation prior to frozen embryo transfer in women with PCOS. Reprod Biol Endocrinol. 2022 Apr;20(1):62.

Jiang Y, Wang L, Shen H, et al. The effect of progesterone supplementation for luteal phase support in natural cycle frozen embryo transfer: a systematic review and meta-analysis based on randomized controlled trials. Fertil Steril. 2023 Apr;119(4):597-605.

Roque M, Haahr T, Geber S, et al. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update. 2019 Jan;25(1):2-14.

Almohammadi A, Raveendran A, Black M, et al. The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review. Arch Gynecol Obstet. 2023 Aug;308(2):341-350.

Referanslar

Glujovsky D, Pesce R, Fiszbajn G, et al. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD006359.

Andersen AG, Als-Nielsen B, Hornnes PJ, et al. Time interval from human chorionic gonadotrophin (HCG) injection to follicular rupture. Hum Reprod. 1995 Dec;10(12):3202-3205.

Park SJ, Goldsmith LT, Skurnick JH, et al. Characteristics of the urinary luteinizing hormone surge in young ovulatory women. Fertil Steril. 2007 Sep;88(3):684-690.

Waldman IN, Racowsky C, Disler ER, et al. The clinical relevance of luteal phase progesterone support in true natural cycle cryopreserved blastocyst stage embryo transfers: a retrospective cohort study. Fertil Res Pract. 2021 Feb 9;7(1):4.

Fatemi HM, Kyrou D, Bourgain C, et al. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril. 2010 Nov;94(6):2054-2058.

Weissman A, Horowitz E, Ravhon A, et al. Spontaneous ovulation versus HCG triggering for timing natural-cycle frozen-thawed embryo transfer: a randomized study. Reprod Biomed Online. 2011 Oct;23(4):484-489.

Montagut M, Santos-Ribeiro S, De Vos M, et al. Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues. Hum Reprod. 2016 Dec;31(12):2803-2810.

Mackens S, Stubbe A, Santos-Ribeiro S, et al. To trigger or not to trigger ovulation in a natural cycle for frozen embryo transfer: a randomized controlled trial. Hum Reprod. 2020 May;35(5):1073-1081.

Fauser BC, de Jong D, Olivennes F, et al. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002 Feb;87(2):709-715.

Casper RF, Yanushpolsky EH. Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support. Fertil Steril. 2016 Apr;105(4):867-872.

Eftekhar M, Rahsepar M, Rahmani E. Effect of progesterone supplementation on natural frozen-thawed embryo transfer cycles: a randomized controlled trial. Int J Fertil Steril. 2013;7(1):13-20.

Mizrachi Y, Horowitz E, Ganer Herman HG, et al. Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Hum Reprod Update. 2021;27:643-650.

Groenewoud ER, Macklon NS, Cohlen BJ; ANTARCTICA Study Group. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles. Reprod Biomed Online. 2017 May;34(5):546-554.

Jahromi BN, Pourgholam F, Parsanezhad ME, et al. Role of estradiol level before progesterone start on outcomes of frozen embryo transfer; a systematic review and meta-analysis. Contracept Reprod Med. 2024 Dec;9(1):64.

Kalem Z, Kalem MN, Gürgan T. Methods for endometrial preparation in frozen-thawed embryo transfer cycles. J Turk Ger Gynecol Assoc. 2016 Sep;17(3):168-172.

Mackens S, Santos-Ribeiro S, van de Vijver A, et al. Frozen embryo transfer: a review on the optimal endometrial preparation and timing. Hum Reprod. 2017 Nov;32(11):2234-2242.

Yang X, Bu Z, Hu L. Live Birth Rate of Frozen-Thawed Single Blastocyst Transfer After 6 or 7 Days of Progesterone Administration in Hormone Replacement Therapy Cycles: A Propensity Score-Matched Cohort Study. Front Endocrinol (Lausanne). 2021 Aug 11;12:706427.

Franasiak JM, Ruiz-Alonso M, Scott RT, et al. Both slowly developing embryos and a variable pace of luteal endometrial progression may conspire to prevent normal birth in spite of a capable embryo. Fertil Steril. 2016 Apr;105(4):861-866.

El-Toukhy T, Coomarasamy A, Khairy M, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril. 2008 Apr;89(4):832-839.

Zhang J. Resurgence of minimal stimulation in vitro fertilization with a protocol consisting of GnRH-agonist trigger and vitrified-thawed embryo transfer. Int J Fertil Steril. 2016 Jul-Sep;10(2):148-153.

Navot D, Anderson TL, Droesch K, et al. Hormonal manipulation of endometrial maturation. J Clin Endocrinol Metab. 1989 Apr;68(4):801-807.

Leeton J, Rogers P, King C, et al. A comparison of pregnancy rates for 131 donor oocyte transfers using either a sequential or fixed regime of steroid replacement therapy. Hum Reprod. 1991 Feb;6(2):299-301.

Rodríguez-Varela C, Salvaleda-Mateu M, Labarta E. Duration of oestrogen exposure does not affect reproductive outcome in artificial cycles: a retrospective analysis of more than 7000 hormonal replacement therapy cycles for an embryo transfer. Front Endocrinol (Lausanne). 2023 Aug 1;14:1233685.

Wei C, Wu H, Yu Y, Li Y, Xiang S, Lian F. Effect of estrogen exposure on pregnancy outcomes in artificial frozen-thawed embryo transfer cycles. Gynecol Endocrinol. 2024 Dec;40(1):2352142.

Dal Prato L, Borini A, Cattoli M, et al. Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with GnRH agonist. Fertil Steril. 2002 May;77(5):956-960.

Van de Vijver A, Polyzos NP, Van Landuyt L, et al. Cryopreserved embryo transfer in an artificial cycle: is GnRH agonist down-regulation necessary? Reprod Biomed Online. 2014 Nov;29(5):588-594.

Yarali H, Polat M, Mumusoglu S, et al. Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis. J Assist Reprod Genet. 2016 Oct;33(10):1287-1304.

Xu B, Hou Z, Liu N, et al. Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth? J Ovarian Res. 2023 Sep;16(1):197.

Aghahoseini M, Alyasin A, Rashidi S, et al. The efficacy of GnRH agonist before frozen embryo transfer in improving pregnancy outcome and decreasing miscarriage rate in hyperandrogenic PCOS women: a randomized clinical trial. Minerva Ginecol. 2020 Aug;72(4):344-351.

Li X, Lin J, Zhang L, et al. Effects of GnRH agonist pretreatment on frozen embryo transfer outcomes in artificial cycles: a meta-analysis. Arch Gynecol Obstet. 2023 Sep;308(3):675-683.

Morozov V, Ruman J, Kenigsberg D, et al. Natural cycle cryo-thaw transfer may improve pregnancy outcome. J Assist Reprod Genet. 2007 Apr;24(4):119-123.

Satwik R, Majumdar A, Mittal Gupta S, et al. Natural cycle versus hormone replacement cycle for transferring vitrified-warmed embryos in eumenorrhoeic women: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2021 Aug;263:94-99.

Ghobara T, Gelbaya TA, Ayeleke RO. Cycle regimens for endometrial preparation prior to frozen embryo transfer. Cochrane Database Syst Rev. 2025 Jun;6(6):CD003414.

Kalem Z, Namlı Kalem M, Bakırarar B, et al. Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer. Saudi Med J. 2018 Nov;39(11):1102-1108.

Groenewoud ER, Cantineau AEP, Kollen BJ, et al. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update. 2013 Sep-Oct;19(5):458-470.

Jin Z, Shi H, Bu Z, et al. Live birth rates after natural cycle versus hormone replacement therapy for single euploid blastocyst transfers: a retrospective cohort study. Reprod Biomed Online. 2021 Dec;43(6):1002-1010.

Ginström Ernstad E, Wennerholm UB, Khatibi A, et al. Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles. Am J Obstet Gynecol. 2019 Aug;221(2):126.e1-8.

Khadem Ghaebi N, Mahmoudiniya M, Najaf Najafi M, Zohdi E, Attaran M. Comparison of letrozole with gonadotropin-releasing hormone agonist in frozen embryo transfer after recurrent implantation failure: An RCT. Int J Reprod Biomed. 2020 Feb 27;18(2):105-112.

Peeraer K, Couck I, Debrock S, et al. Frozen-thawed embryo transfer in a natural or mildly hormonally stimulated cycle in women with regular ovulatory cycles: a randomized controlled trial. Hum Reprod. 2015 Nov;30(11):2552-2562.

Wu H, Zhou P, Lin X, et al. Endometrial preparation for frozen-thawed embryo transfer cycles: a systematic review and network meta-analysis. J Assist Reprod Genet. 2021;38:2967-2982.

Zhang Y, Wu L, Li TC, et al. Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artificial cycle for endometrial preparation prior to frozen embryo transfer in women with PCOS. Reprod Biol Endocrinol. 2022 Apr;20(1):62.

Jiang Y, Wang L, Shen H, et al. The effect of progesterone supplementation for luteal phase support in natural cycle frozen embryo transfer: a systematic review and meta-analysis based on randomized controlled trials. Fertil Steril. 2023 Apr;119(4):597-605.

Roque M, Haahr T, Geber S, et al. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update. 2019 Jan;25(1):2-14.

Almohammadi A, Raveendran A, Black M, et al. The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review. Arch Gynecol Obstet. 2023 Aug;308(2):341-350.

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