Endometrial Siklus ve Reseptivite

Achache H, Revzel A. endometrial receptivity markers, the journey to successful embryo implantation. Human Reproduction Update, 2006;12(6):731–746. doi:10.1093/humupd/dml004

Blanco-Breindel MF, Singh M, Kahn J. endometrial Receptivity. StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.

Albayrak İG, Azhari F, Çolak EN, et al. endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization. Molecular Biology Reports, 2021;48(6):5075–5082. doi:10.1007/s11033-021-06502-x

Apparao KB, Murray MJ, Fritz MA, et al. Osteopontin and its receptor αvβ3 integrin are coexpressed in the human Endometrium during the window of implantation. Biology of Reproduction, 2001;64(3):897–904. doi.org/10.1095/biolreprod64.3.897

Lessey BA, Damjanovich L, Coutifaris C, et al. Integrin adhesion molecules in the human Endometrium. Correlation with the normal and abnormal menstrual cycle. The Journal of Clinical Investigation, 1992;90(1):188–195. doi:10.1172/JCI115835

Genbacev OD, Prakobphol A, Foulk RA, et al. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science, 2003;299:405–408. doi:10.1126/science.1079546

Defrère S, Van Langendonckt A, Vaessen MJ, et al. In vivo expression of ICAM-1, CD105, and VEGF in peritoneal endometriosis. Fertility and Sterility, 2005;84(3):695–703. doi:10.1016/j.fertnstert.2005.03.059

Tei C, Maruyama T, Kuji N, et al. Reduced expression of HOXA10 in the Endometrium of women with endometriosis: A possible cause of implantation failure. Fertility and Sterility, 2003;80(4):813–817. doi: 10.1016/S0015-0282(03)00982-8

Stewart CL. Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo. Molecular Reproduction and Development, 1994;39(2):233–238. doi:10.1002/mrd.1080390215

von Wolff M, Thaler CJ, Zepf C, et al. endometrial expression and secretion of interleukin-6 throughout the menstrual cycle. Gynecological Endocrinology, 2002;16(2):121–129. doi:10.1080/gye.16.2.121.129

Simon C, Moreno C, Remohí J, et al. Molecular interactions between embryo and uterus in the adhesion phase of implantation. Human Reproduction, 1998;13(Suppl 3):219–232. doi:10.1093/humrep/13.suppl_3.219

Arici A, Engin O, Attar E, et al. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human Endometrium. The Journal of Clinical Endocrinology & Metabolism, 1995;80(6):1908–1915. doi:10.1210/jcem.80.6.7775640

Taylor HS, Arici A, Olive D, et al. HOXA10 is expressed in response to sex steroids at the time of implantation in the human Endometrium. The Journal of Clinical Investigation, 1998;101(7):1379–1384. doi:10.1172/JCI1057

Daftary GS, Troy PJ, Bagot CN, et al. Direct regulation of β3-integrin subunit gene expression by HOXA10 in endometrial cells. Molecular Endocrinology, 2002;16(3):571–579. doi:10.1210/mend.16.3.0792

Kim JJ, Taylor HS. Regulation of HOXA10 and its role in endometrial receptivity. Seminars in Reproductive Medicine, 2007;25(6):445–451. doi: 10.1055/s-2007-991043

Shilpasree AS, Kulkarni VB, Shetty P, et al. Vitamin D deficiency reduces HOXA10 expression in PCOS Endometrium: a possible mechanism in implantation failure. Reproductive Biology and Endocrinology, 2022;20(1):82. doi:10.1186/s12958-022-00957-3

Koçer MG, Attar E. Endometriozis ve adenomiyozisin tekrarlayan implantasyon başarısızlığındaki yeri. Gürgan T (ed), IVF Tedavilerinde Tekrarlayan İmplantasyon Başarısızlıkları içinde. Ankara: Türkiye Klinikleri; 2021. p. 52-61.

Li MQ, Wang Y, Chang KK, et al. Leukemia inhibitory factor and its receptor expression in patients with unexplained infertility. Molecular Medicine Reports, 2016;13(5):4241–4246. doi:10.3892/mmr.2016.5142

Brinsden PR, Gibbons NJ, Mahutte NG. Leukemia inhibitory factor: a cytokine modulating uterine receptivity and embryo implantation. Reproductive BioMedicine Online, 2009;19:43–51.

Adiguzel D, Celik-Ozenci C. FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy. Human Reproduction Update, 2021;27(3):570–583. doi:10.1093/humupd/dmaa060

Marquardt RM, Kim TH, Shin JH, et al. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? International Journal of Molecular Sciences, 2019;20(15):3822. doi:10.3390/ijms20153822

Chi RA, Wang T, Adams N, Wu SP, Young SL, Spencer TE, DeMayo F. Human endometrial transcriptome and progesterone receptor cistrome reveal important pathways and epithelial regulators. The Journal of Clinical Endocrinology & Metabolism, 2020;105(4):e1419–e1439. doi:10.1210/clinem/dgz117

Aplin JD, Meseguer M, Simon C, et al. MUC1, glycans and the cell-surface barrier to embryo implantation. Biochemical Society Transactions, 1998;26(2):173–177. doi: 10.1042/0300-5127:0290153

Meseguer M, Aplin JD, Caballero-Campo P, et al. Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biology of Reproduction, 2001;64:590–601. doi: 10.1095/biolreprod64.2.590.

Thathiah A, Carson DD. MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17. Biochemical Journal, 2004;382:363–373. doi: 10.1042/BJ20040513

Huang J, Ma KS, Wang LT, Chiang CH, Yang SF, Wang CH, Wang PH. Roles of mucins in embryo implantation and fertility. International Journal of Molecular Sciences, 2023;24(21):15896. doi:10.3390/ijms242115896

Wu F, Chen X, Liu Y, et al. Decreased MUC1 in Endometrium is an independent receptivity marker in recurrent implantation failure during implantation window. Reproductive Biology and Endocrinology, 2018;16(1):24. doi:10.1186/s12958-018-0379-1.

Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, Wang CC. Decreased MUC1 in Endometrium is an independent receptivity marker in recurrent implantation failure during implantation window. Reproductive Biology and Endocrinology, 2018;16:60. doi:10.1186/s12958-018-0379-1.

29. Gipson IK, Blalock TD, Tisdale AS, et al. MUC16 is lost from the uterodome (pinopode) surface of the receptive human Endometrium: in vitro evidence that MUC16 is a barrier to trophoblast adherence. Biology of Reproduction, 2008;78(1):134–142. doi:10.1095/biolreprod.107.062794

Rawlings TM, Makwana K, Tryfonos M, et al. Organoids to model the Endometrium: Implantation and beyond. Reproduction and Fertility, 2021;2(3):R85–R101. doi:10.1530/RAF-21-0023

Turco MY, Gardner L, et al. endometrial organoids as a tool for reproductive research and personalized medicine. Nature Reviews Endocrinology, 2023;19(7):420–436. doi:10.1038/s41574-023-00882-0

Boretto M, Vandenbempt V, De Vos K, et al. Human endometrial organoids interact with embryo-like structures and model implantation. Placenta, 2024;150:25–35. doi:10.1016/j.placenta.2024.03.004

Wagner A, Zhou Y, Zhang Y, et al. A human endometrial organoid platform to model the window of implantation. (10/04/2025 tarihinde https://elifesciences.org/reviewed-preprints/90729v2 adresinden ulaşılmıştır).

Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, et al. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertility and Sterility, 2013;100(3):818–824. doi: 10.1016/j.fertnstert.2013.05.004

Laird SM, Tuckerman EM, Li TC. Cytokine expression in the Endometrium of women with implantation failure and recurrent miscarriage. Reproductive BioMedicine Online, 2001;2(1):64–68. doi: 10.1016/S1472-6483(10)62011-1

Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF Journal of Assisted Reproduction and Genetics, 2003;19(10):426–433.

Achache H, Revzel A. endometrial receptivity markers, the journey to successful embryo implantation. Human Reproduction Update, 2006;12(6):731–746. doi:10.1093/humupd/dml004

Blanco-Breindel MF, Singh M, Kahn J. endometrial Receptivity. StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.

Albayrak İG, Azhari F, Çolak EN, et al. endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization. Molecular Biology Reports, 2021;48(6):5075–5082. doi:10.1007/s11033-021-06502-x

Apparao KB, Murray MJ, Fritz MA, et al. Osteopontin and its receptor αvβ3 integrin are coexpressed in the human Endometrium during the window of implantation. Biology of Reproduction, 2001;64(3):897–904. doi.org/10.1095/biolreprod64.3.897

Lessey BA, Damjanovich L, Coutifaris C, et al. Integrin adhesion molecules in the human Endometrium. Correlation with the normal and abnormal menstrual cycle. The Journal of Clinical Investigation, 1992;90(1):188–195. doi:10.1172/JCI115835

Genbacev OD, Prakobphol A, Foulk RA, et al. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science, 2003;299:405–408. doi:10.1126/science.1079546

Defrère S, Van Langendonckt A, Vaessen MJ, et al. In vivo expression of ICAM-1, CD105, and VEGF in peritoneal endometriosis. Fertility and Sterility, 2005;84(3):695–703. doi:10.1016/j.fertnstert.2005.03.059

Tei C, Maruyama T, Kuji N, et al. Reduced expression of HOXA10 in the Endometrium of women with endometriosis: A possible cause of implantation failure. Fertility and Sterility, 2003;80(4):813–817. doi: 10.1016/S0015-0282(03)00982-8

Stewart CL. Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo. Molecular Reproduction and Development, 1994;39(2):233–238. doi:10.1002/mrd.1080390215

von Wolff M, Thaler CJ, Zepf C, et al. endometrial expression and secretion of interleukin-6 throughout the menstrual cycle. Gynecological Endocrinology, 2002;16(2):121–129. doi:10.1080/gye.16.2.121.129

Simon C, Moreno C, Remohí J, et al. Molecular interactions between embryo and uterus in the adhesion phase of implantation. Human Reproduction, 1998;13(Suppl 3):219–232. doi:10.1093/humrep/13.suppl_3.219

Arici A, Engin O, Attar E, et al. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human Endometrium. The Journal of Clinical Endocrinology & Metabolism, 1995;80(6):1908–1915. doi:10.1210/jcem.80.6.7775640

Taylor HS, Arici A, Olive D, et al. HOXA10 is expressed in response to sex steroids at the time of implantation in the human Endometrium. The Journal of Clinical Investigation, 1998;101(7):1379–1384. doi:10.1172/JCI1057

Daftary GS, Troy PJ, Bagot CN, et al. Direct regulation of β3-integrin subunit gene expression by HOXA10 in endometrial cells. Molecular Endocrinology, 2002;16(3):571–579. doi:10.1210/mend.16.3.0792

Kim JJ, Taylor HS. Regulation of HOXA10 and its role in endometrial receptivity. Seminars in Reproductive Medicine, 2007;25(6):445–451. doi: 10.1055/s-2007-991043

Shilpasree AS, Kulkarni VB, Shetty P, et al. Vitamin D deficiency reduces HOXA10 expression in PCOS Endometrium: a possible mechanism in implantation failure. Reproductive Biology and Endocrinology, 2022;20(1):82. doi:10.1186/s12958-022-00957-3

Koçer MG, Attar E. Endometriozis ve adenomiyozisin tekrarlayan implantasyon başarısızlığındaki yeri. Gürgan T (ed), IVF Tedavilerinde Tekrarlayan İmplantasyon Başarısızlıkları içinde. Ankara: Türkiye Klinikleri; 2021. p. 52-61.

Li MQ, Wang Y, Chang KK, et al. Leukemia inhibitory factor and its receptor expression in patients with unexplained infertility. Molecular Medicine Reports, 2016;13(5):4241–4246. doi:10.3892/mmr.2016.5142

Brinsden PR, Gibbons NJ, Mahutte NG. Leukemia inhibitory factor: a cytokine modulating uterine receptivity and embryo implantation. Reproductive BioMedicine Online, 2009;19:43–51.

Adiguzel D, Celik-Ozenci C. FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy. Human Reproduction Update, 2021;27(3):570–583. doi:10.1093/humupd/dmaa060

Marquardt RM, Kim TH, Shin JH, et al. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? International Journal of Molecular Sciences, 2019;20(15):3822. doi:10.3390/ijms20153822

Chi RA, Wang T, Adams N, Wu SP, Young SL, Spencer TE, DeMayo F. Human endometrial transcriptome and progesterone receptor cistrome reveal important pathways and epithelial regulators. The Journal of Clinical Endocrinology & Metabolism, 2020;105(4):e1419–e1439. doi:10.1210/clinem/dgz117

Aplin JD, Meseguer M, Simon C, et al. MUC1, glycans and the cell-surface barrier to embryo implantation. Biochemical Society Transactions, 1998;26(2):173–177. doi: 10.1042/0300-5127:0290153

Meseguer M, Aplin JD, Caballero-Campo P, et al. Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biology of Reproduction, 2001;64:590–601. doi: 10.1095/biolreprod64.2.590.

Thathiah A, Carson DD. MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17. Biochemical Journal, 2004;382:363–373. doi: 10.1042/BJ20040513

Huang J, Ma KS, Wang LT, Chiang CH, Yang SF, Wang CH, Wang PH. Roles of mucins in embryo implantation and fertility. International Journal of Molecular Sciences, 2023;24(21):15896. doi:10.3390/ijms242115896

Wu F, Chen X, Liu Y, et al. Decreased MUC1 in Endometrium is an independent receptivity marker in recurrent implantation failure during implantation window. Reproductive Biology and Endocrinology, 2018;16(1):24. doi:10.1186/s12958-018-0379-1.

Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, Wang CC. Decreased MUC1 in Endometrium is an independent receptivity marker in recurrent implantation failure during implantation window. Reproductive Biology and Endocrinology, 2018;16:60. doi:10.1186/s12958-018-0379-1.

29. Gipson IK, Blalock TD, Tisdale AS, et al. MUC16 is lost from the uterodome (pinopode) surface of the receptive human Endometrium: in vitro evidence that MUC16 is a barrier to trophoblast adherence. Biology of Reproduction, 2008;78(1):134–142. doi:10.1095/biolreprod.107.062794

Rawlings TM, Makwana K, Tryfonos M, et al. Organoids to model the Endometrium: Implantation and beyond. Reproduction and Fertility, 2021;2(3):R85–R101. doi:10.1530/RAF-21-0023

Turco MY, Gardner L, et al. endometrial organoids as a tool for reproductive research and personalized medicine. Nature Reviews Endocrinology, 2023;19(7):420–436. doi:10.1038/s41574-023-00882-0

Boretto M, Vandenbempt V, De Vos K, et al. Human endometrial organoids interact with embryo-like structures and model implantation. Placenta, 2024;150:25–35. doi:10.1016/j.placenta.2024.03.004

Wagner A, Zhou Y, Zhang Y, et al. A human endometrial organoid platform to model the window of implantation. (10/04/2025 tarihinde https://elifesciences.org/reviewed-preprints/90729v2 adresinden ulaşılmıştır).

Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, et al. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertility and Sterility, 2013;100(3):818–824. doi: 10.1016/j.fertnstert.2013.05.004

Laird SM, Tuckerman EM, Li TC. Cytokine expression in the Endometrium of women with implantation failure and recurrent miscarriage. Reproductive BioMedicine Online, 2001;2(1):64–68. doi: 10.1016/S1472-6483(10)62011-1

Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF Journal of Assisted Reproduction and Genetics, 2003;19(10):426–433.