Adenomyosiste IUI/IVF/ICSI Yönetimi

Donnez J, Donnez O, Dolmans MM. Introduction: Uterine adenomyosis, another enigmatic disease of our time. Fertility and Sterility. 2018;3:369–370. doi:10.1016/j.fertnstert.2018.01.035

Vercellini P, Viganò P, Somigliana E, et al. Adenomyosis: Epidemiological factors. Best Practice & Research Clinical Obstetrics & Gynaecology. 2006;20:65–77. doi:10.1016/j.bpobgyn.2006.01.017

Puente JM, Fabris A, Patel J, et al. Adenomyosis in infertile women: Prevalence and the role of 3D ultrasound as a marker of severity of the disease. Reproductive Biology and Endocrinology. 2016;14:60. doi:10.1186/s12958-016-0185-6

Khan KN, Fujishita A, Mori T. Pathogenesis of human adenomyosis: Current understanding and its association with infertility. J Clin Med. 2022;11(14):4057. doi:10.3390/jcm11144057.4o

aKissler S, Hamscho N, Zangos S, et al. Uterotubal transport disorder in adenomyosis and endometriosis—a cause for infertility. BJOG: An International Journal of Obstetrics and Gynaecology. 2006;113:902–908. doi:10.1111/j.1471-0528.2006.00970.x

Cao Y, Yang D, Cai S, Li Y, Yin T, Diao L. Adenomyosis-associated infertility: an update of the immunological perspective. Reprod Biomed Online. 2025 May;50(5):104703. doi:10.1016/j.rbmo.2024.104703.

Vercellini P, Consonni D, Dridi D, et al. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Human Reproduction. 2014;29(5):964–977.

Campo S, Campo V, Benagiano G. Adenomyosis and infertility. Reprod Biomed Online. 2012 Jan;24(1):35-46.

Struble J, Reid S, Bedaiwy MA. Adenomyosis: A clinical review of a challenging gynecologic condition. Journal of Minimally Invasive Gynecology. 2016;23(2):164–185.

Tellum T, Nygaard S, Lieng M. Noninvasive diagnosis of adenomyosis: A structured review and meta-analysis of diagnostic accuracy in imaging. Journal of Minimally Invasive Gynecology. 2020;27:408–418. doi:10.1016/j.jmig.2019.11.001

Harmsen MJ, Van den Bosch T, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, Hehenkamp WJK, Groenman F, De Bruyn C, Rasmussen C, et al.Ultrasound Obstet Gynecol. 2022 Jul;60(1):118-131. doi: 10.1002/uog.24786.PMID: 34587658

Dason ES, Maxim M, Sanders A, et al. Guideline No. 437: Diagnosis and management of adenomyosis. Journal of Obstetrics and Gynaecology Canada. 2023;45(6):417–429.e1.

Etrusco A, Barra F, Chiantera V, et al. Current medical therapy for adenomyosis: from bench to bedside. Drugs. 2023. doi:10.1007/s40265-023-01883-3

Khan KN, Kitajima M, Hiraki K, et al. Cell proliferation effect of GnRH agonist on pathological lesions of women with endometriosis, adenomyosis and uterine myoma. Human Reproduction. 2010;25:2878–2890. doi:10.1093/humrep/deq240

Younes G, Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril. 2017 Sep;108(3):483-490.e3. doi: 10.1016/j.fertnstert.2017.06.025. PMID: 28865548.

Li G, Li Y, Zhou J, et al. Effect of different treatment protocols on in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) outcomes in adenomyosis women: a systematic review and meta-analysis. BMJ Open. 2024;14(7):e077025. doi:10.1136/bmjopen-2023-077025

Zhang Y, Liu X, Wang F, et al. Title not specified. Journal of Clinical Medicine. 2023;12(5):1740. doi:10.3390/jcm12051740

Wang X, Li D, Zhao L, et al. Fertility outcomes in adenomyosis patients undergoing FET vs fresh ET. Fertility and Sterility. 2023.

Liang Y, Zhang H, Chen Z, et al. Frozen embryo transfer improves live birth in adenomyosis: a meta-analysis. Human Reproduction Update. 2022.

Humaidan P, Garcia Velasco JA, Cozzolino M. Local intraendometrial estrogen biosynthesis leading to progesterone resistance impacts implantation in adenomyosis and endometriosis. Fertility and Sterility. 2023;120:927. doi:10.1016/j.fertnstert.2023.06.004

Wu Y, Huang J, Zhong G, Lan J, Lin H, Zhang Q. Long-term GnRH agonist pretreatment before frozen embryo transfer improves pregnancy outcomes in women with adenomyosis. Reprod Biomed Online. (2022) 44(2):380–8. 10.1016/j.rbmo.2021.10.014

Moawad G, Youssef Y, Fruscalzo A, Khedhri S, Faysal H, Pirtea P, Guani B, Vallée A, Ayoubi JM, Feki A. Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis. Front Reprod Health. 2024 Dec 9;6:1484202. doi: 10.3389/frph.2024.1484202.

Chen L, Zhao Y, Wang Y, et al. GnRH agonist pretreatment in adenomyosis patients undergoing IVF. Reproductive Biomedicine Online. 2023.

Benaglia L, Somigliana E, Bermejo A, et al. GnRH agonist pretreatment improves IVF outcomes in adenomyosis. Journal of Assisted Reproduction and Genetics. 2022.

Galati G, Olivieri C, Cosentino M, et al. Medical treatment before in-vitro fertilization in patients with adenomyosis: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2025;42(2):381–388. doi:10.1007/s10815-024-03323-2

Younes G, Tulandi T. Conservative surgery for adenomyosis and results: A systematic review. Journal of Minimally Invasive Gynecology. 2018;25:265–276. doi:10.1016/j.jmig.2017.07.014

Fujishita A, Masuzaki H, Khan KN, et al. Modified reduction surgery for adenomyosis: A preliminary report of the transverse H incision technique. Gynecologic and Obstetric Investigation. 2004;57:132–138. doi:10.1159/000077755

Yoon SH, Lee GJB, Cho HJ, et al. Clinical efficacy of a novel method of fertility-preserving adenomyomectomy in infertile women with diffuse adenomyosis. Medicine (Baltimore). 2023;102:e33266. doi:10.1097/MD.0000000000033266

Zhou Y, Shen L, Wang Y, et al. Long-term pregnancy outcomes of patients with diffuse adenomyosis after double-flap adenomyomectomy. Journal of Clinical Medicine. 2022;11:3489. doi:10.3390/jcm11123489

Donnez J, Donnez O, Dolmans MM. Introduction: Uterine adenomyosis, another enigmatic disease of our time. Fertility and Sterility. 2018;3:369–370. doi:10.1016/j.fertnstert.2018.01.035

Vercellini P, Viganò P, Somigliana E, et al. Adenomyosis: Epidemiological factors. Best Practice & Research Clinical Obstetrics & Gynaecology. 2006;20:65–77. doi:10.1016/j.bpobgyn.2006.01.017

Puente JM, Fabris A, Patel J, et al. Adenomyosis in infertile women: Prevalence and the role of 3D ultrasound as a marker of severity of the disease. Reproductive Biology and Endocrinology. 2016;14:60. doi:10.1186/s12958-016-0185-6

Khan KN, Fujishita A, Mori T. Pathogenesis of human adenomyosis: Current understanding and its association with infertility. J Clin Med. 2022;11(14):4057. doi:10.3390/jcm11144057.4o

aKissler S, Hamscho N, Zangos S, et al. Uterotubal transport disorder in adenomyosis and endometriosis—a cause for infertility. BJOG: An International Journal of Obstetrics and Gynaecology. 2006;113:902–908. doi:10.1111/j.1471-0528.2006.00970.x

Cao Y, Yang D, Cai S, Li Y, Yin T, Diao L. Adenomyosis-associated infertility: an update of the immunological perspective. Reprod Biomed Online. 2025 May;50(5):104703. doi:10.1016/j.rbmo.2024.104703.

Vercellini P, Consonni D, Dridi D, et al. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Human Reproduction. 2014;29(5):964–977.

Campo S, Campo V, Benagiano G. Adenomyosis and infertility. Reprod Biomed Online. 2012 Jan;24(1):35-46.

Struble J, Reid S, Bedaiwy MA. Adenomyosis: A clinical review of a challenging gynecologic condition. Journal of Minimally Invasive Gynecology. 2016;23(2):164–185.

Tellum T, Nygaard S, Lieng M. Noninvasive diagnosis of adenomyosis: A structured review and meta-analysis of diagnostic accuracy in imaging. Journal of Minimally Invasive Gynecology. 2020;27:408–418. doi:10.1016/j.jmig.2019.11.001

Harmsen MJ, Van den Bosch T, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, Hehenkamp WJK, Groenman F, De Bruyn C, Rasmussen C, et al.Ultrasound Obstet Gynecol. 2022 Jul;60(1):118-131. doi: 10.1002/uog.24786.PMID: 34587658

Dason ES, Maxim M, Sanders A, et al. Guideline No. 437: Diagnosis and management of adenomyosis. Journal of Obstetrics and Gynaecology Canada. 2023;45(6):417–429.e1.

Etrusco A, Barra F, Chiantera V, et al. Current medical therapy for adenomyosis: from bench to bedside. Drugs. 2023. doi:10.1007/s40265-023-01883-3

Khan KN, Kitajima M, Hiraki K, et al. Cell proliferation effect of GnRH agonist on pathological lesions of women with endometriosis, adenomyosis and uterine myoma. Human Reproduction. 2010;25:2878–2890. doi:10.1093/humrep/deq240

Younes G, Tulandi T. Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril. 2017 Sep;108(3):483-490.e3. doi: 10.1016/j.fertnstert.2017.06.025. PMID: 28865548.

Li G, Li Y, Zhou J, et al. Effect of different treatment protocols on in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) outcomes in adenomyosis women: a systematic review and meta-analysis. BMJ Open. 2024;14(7):e077025. doi:10.1136/bmjopen-2023-077025

Zhang Y, Liu X, Wang F, et al. Title not specified. Journal of Clinical Medicine. 2023;12(5):1740. doi:10.3390/jcm12051740

Wang X, Li D, Zhao L, et al. Fertility outcomes in adenomyosis patients undergoing FET vs fresh ET. Fertility and Sterility. 2023.

Liang Y, Zhang H, Chen Z, et al. Frozen embryo transfer improves live birth in adenomyosis: a meta-analysis. Human Reproduction Update. 2022.

Humaidan P, Garcia Velasco JA, Cozzolino M. Local intraendometrial estrogen biosynthesis leading to progesterone resistance impacts implantation in adenomyosis and endometriosis. Fertility and Sterility. 2023;120:927. doi:10.1016/j.fertnstert.2023.06.004

Wu Y, Huang J, Zhong G, Lan J, Lin H, Zhang Q. Long-term GnRH agonist pretreatment before frozen embryo transfer improves pregnancy outcomes in women with adenomyosis. Reprod Biomed Online. (2022) 44(2):380–8. 10.1016/j.rbmo.2021.10.014

Moawad G, Youssef Y, Fruscalzo A, Khedhri S, Faysal H, Pirtea P, Guani B, Vallée A, Ayoubi JM, Feki A. Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis. Front Reprod Health. 2024 Dec 9;6:1484202. doi: 10.3389/frph.2024.1484202.

Chen L, Zhao Y, Wang Y, et al. GnRH agonist pretreatment in adenomyosis patients undergoing IVF. Reproductive Biomedicine Online. 2023.

Benaglia L, Somigliana E, Bermejo A, et al. GnRH agonist pretreatment improves IVF outcomes in adenomyosis. Journal of Assisted Reproduction and Genetics. 2022.

Galati G, Olivieri C, Cosentino M, et al. Medical treatment before in-vitro fertilization in patients with adenomyosis: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2025;42(2):381–388. doi:10.1007/s10815-024-03323-2

Younes G, Tulandi T. Conservative surgery for adenomyosis and results: A systematic review. Journal of Minimally Invasive Gynecology. 2018;25:265–276. doi:10.1016/j.jmig.2017.07.014

Fujishita A, Masuzaki H, Khan KN, et al. Modified reduction surgery for adenomyosis: A preliminary report of the transverse H incision technique. Gynecologic and Obstetric Investigation. 2004;57:132–138. doi:10.1159/000077755

Yoon SH, Lee GJB, Cho HJ, et al. Clinical efficacy of a novel method of fertility-preserving adenomyomectomy in infertile women with diffuse adenomyosis. Medicine (Baltimore). 2023;102:e33266. doi:10.1097/MD.0000000000033266

Zhou Y, Shen L, Wang Y, et al. Long-term pregnancy outcomes of patients with diffuse adenomyosis after double-flap adenomyomectomy. Journal of Clinical Medicine. 2022;11:3489. doi:10.3390/jcm11123489