PCOS Hastalarının Tedavisinde İnositolün Yeri
Özet
Referanslar
Stein, I. F. & Leventhal, M.L. Amenorrhea associated with bilateral polycystic ovaries, 1935 Gardner 2024, 6th Edition
Her Yönü ile PKOS, Prof. Dr. Gürkan BOZDAĞ, No- bel Tıp Kitabevleri, sy 89 Batuhan ASLAN, Yavuz Emre ŞÜKÜR
Wang Y, Zhao X, Zhao H, Ding H, Tan J, Chen J, Zhang R, Azziz R, Yang D. Risks for gestational diabetes melli- tus and pregnancy-induced hypertension are increased in polycystic ovary syndrome. Biomed Res Int. 2013; 2013:182582. doi: 10.1155/2013/182582. Epub 2013 Nov 25. PMID: 24371816; PMCID: PMC3859212
Stepto NK, Cassar S, Joham AE, Hutchison SK, Har- rison CL, Goldstein RF, Teede HJ. Women with poly- cystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Hum Reprod. 2013 Mar;28(3):777-84. doi: 10.1093/humrep/des463. Epub 2013 Jan 12. PMID: 23315061
DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndro- me using the homeostasis model assessment. Fertil Steril. 2005 May;83(5):1454-60. doi: 10.1016/j.fertns- tert.2004.11.070. PMID: 15866584
Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 1989 Sep;38(9):1165-74. doi: 10.2337/diab.38.9.1165. PMID: 2670645
Book CB, Dunaif A. Selective insulin resistance in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1999 Sep;84(9):3110-6. doi: 10.1210/jcem.84.9.6010. PMID: 10487672
Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Bioc- himie. 2013 Oct;95(10):1811-27. doi: 10.1016/j.bioc- hi.2013.05.011. Epub 2013 Jun 10. PMID: 23764390
Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network. Recommendations from the inter- national evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018 Aug;110(3):364-379. doi: 10.1016/j.fertns- tert.2018.05.004. Epub 2018 Jul 19. PMID: 30033227; PMCID: PMC6939856
Moran LJ, Tassone EC, Boyle J, Brennan L, Harrison CL, Hirschberg AL, Lim S, Marsh K, Misso ML, Redman L, Thondan M, Wijeyaratne C, Garad R, Stepto NK, Teede HJ. Evidence summaries and recommen- dations from the international evidence-based guide- line for the assessment and management of polycystic ovary syndrome: Lifestyle management. Obes Rev. 2020 Oct;21(10): e13046. doi: 10.1111/obr.13046. Epub
2020 May 26. PMID: 32452622
Brennan L, Teede H, Skouteris H, Linardon J, Hill B, Moran L. Lifestyle and Behavioral Management of Pol- ycystic Ovary Syndrome. J Womens Health (Larchmt). 2017 Aug;26(8):836-848. doi: 10.1089/jwh.2016.5792. Epub 2017 Jun 1. PMID: 28570835
Büttner J. Johann Jospeh von Scherer (1814-1869). Ein Beitrag zur frühen Geschichte der Klinischen Chemie [Johann Joseph von Scherer (1814-69). The early his- tory of clinical chemistry]. J Clin Chem Clin Biochem. 1978 Sep;16(9):478-83. German. PMID: 361923
Di Paolo G, De Camilli P. Phosphoinositides in cell re- gulation and membrane dynamics. Nature. 2006 Oct 12;443(7112):651-7. doi: 10.1038/nature05185. PMID: 17035995
Larner J. D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistan- ce. Int J Exp Diabetes Res. 2002;3(1):47-60. doi: 10.1080/15604280212528. PMID: 11900279; PMCID: PMC2478565
Uldry “Identification of a mammalian H+-myo-i- nositol symporter expressed predominantly in the brain” The EMBO Journal (2001) doi:10.1093/em- boj/20.16.4467
Laganà AS, Garzon S, Casarin J, Franchi M, Ghezzi
F. Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends Endocrinol Metab. 2018 Nov;29(11):768-780. doi: 10.1016/j.tem.2018.09.001. Epub 2018 Sep 27. PMID: 30270194
Warskulat ve ark. 1997Warskulat et al. “myo-Inositol is an osmolyte in rat liver macrophages (Kupffer cells) but not in RAW 264.7 mouse macrophages” Biochemical Journal (1997) doi:10.1042/bj3260289
Singh P, Biswal S, Verma SK. A prospective randomi- sed controlled study on the effects of myoinositol on ovarian functions and metabolic factors in women with polycystic ovarian syndrome. Int J Reprod Cont- racept Obstet Gynecol 2020; 9:4912-7
Bevilacqua A, Bizzarri M. Inositols in Insulin Signaling and Glucose Metabolism. Int J Endocrinol. 2018 Nov 25; 2018:1968450. doi: 10.1155/2018/1968450. PMID: 30595691; PMCID: PMC6286734
Karadağ C, Sakinci M, Birge Ö, Bakır MS, Karadağ B, Sağnıç S. Comparison of metformin, myoinositol and metformin-myoinositol combined treatments for poly- cystic ovary syndrome. Turk J Obstet Gynecol. 2024 Jun 10;21(2):78-84. doi: 10.4274/tjod.galenos.2024.21456. PMID: 38853482; PMCID: PMC11589227
Pasta ve ark. 2016). Pasta et al. “A Randomized Pi- lot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women” Breast Cancer Basic and Clinical Research (2016) doi:10.4137/bcbcr.s 38408
C. (2022). Myoinositol supplementation in the tre- atment of gestational diabetes mellitus: effects on gl- ycaemic control and maternal-foetal outcomes. BMC Pregnancy and Childbirth, 22(1)
Garzon S, Laganà AS, Monastra G. Risk of reduced intestinal absorption of myo-inositol caused by D-chi- ro-inositol or by glucose transporter inhibitors. Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):697-703. doi: 10.1080/17425255.2019.1651839. Epub 2019 Aug 8. PMID: 31382802
Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, Nagar HD, Makwana L, Kshirsagar S, Kaul P, Ghosh AK, Pradhan S, Mehta A, Jaiswal A, Nakhate KT, Kam- di S. Efficacy of combination therapy of inositols, an- tioxidants and vitamins in obese and non-obese wo- men with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020 Jan;40(1):96-101. doi: 10.1080/01443615.2019.1604644. Epub 2019 Jul 24. PMID: 31339394
Gupta D, Khan S, Islam M, Malik BH, Rutkofsky IH. Myo-Inositol’s Role in Assisted Reproductive Techno- logy: Evidence for Improving the Quality of Oocytes and Embryos in Patients With Polycystic Ovary Synd- rome. Cureus. 2020 May 12;12(5): e8079. doi: 10.7759/ cureus.8079. PMID: 32542134; PMCID: PMC7292722
Atyaf Hasan, Al-Quraan Elena, Al-Quraan Ghassan, Tayseer Rimawi, Said Nasrallah. (2019). Melatonin and Myoinositol: A Foreword Step Toward IVF Success, a Prospective Clinical Trial. Journal of Gynecology and Obstetrics, 7(1), 17
Zhang T, Xi Q, Wang D, Li J, Wang M, Li D, Zhu L, Jin
L. Mitochondrial dysfunction and endoplasmic reticu- lum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes. J Ovari- an Res. 2019 Jun 8;12(1):53. doi: 10.1186/s13048-019- 0529-x. PMID: 31176373; PMCID: PMC6556043
Nazirudeen R, Sridhar S, Priyanka R, Sumathi B, Nata- rajan V, Subbiah E, Raghavan KS, Sangumani J. A ran- domized controlled trial comparing myoinositol with metformin versus metformin monotherapy in poly- cystic ovary syndrome. Clin Endocrinol (Oxf). 2023 Aug;99(2):198-205. doi: 10.1111/cen.14931. Epub 2023 Jun 2. PMID: 37265016
Pizzo A, Laganà AS, Barbaro L. Comparison between effects of myo-inositol and D-chiro-inositol on ova- rian function and metabolic factors in women with PCOS. Gynecol Endocrinol. 2014 Mar;30(3):205-8. doi: 10.3109/09513590.2013.860120. Epub 2013 Dec 19. PMID: 24351072
Regidor PA, Schindler AE. Myoinositol as a Safe and Al- ternative Approach in the Treatment of Infertile PCOS Women: A German Observational Study. Int J Endoc- rinol. 2016; 2016:9537632. doi: 10.1155/2016/9537632. Epub 2016 Aug 23. PMID: 27642297; PMCID: PMC5011528
Lesoine B, Regidor PA. Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Un- dergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality. Int J Endocrinol. 2016; 2016:4378507. doi: 10.1155/2016/4378507.
H. Matsubayashi, T. Takeuchi, S. Mizuta, T. Ishikawa. Myoinositol supplementation on intracytoplasmic sperm injection outcome in Japanese infertile polycys- tic ovarian syndrome women with non-obese less-and- rogenic phenotype: a prospective controlled observa- tional study. Clin. Exp. Obstet. Gynecol. 2019, 46(4), 549–552.
Zheng X, Lin D, Zhang Y, Lin Y, Song J, Li S, Sun Y. Ino- sitol supplement improves clinical pregnancy rate in in- fertile women undergoing ovulation induction for ICSI or IVF-ET. Medicine (Baltimore). 2017 Dec;96(49): e8842. doi: 10.1097/MD.0000000000008842. PMID: 29245250; PMCID: PMC5728865
Sigue, R. J. L., & Decena, D. D. (2022). Efficacy of Myo-inositol in Improving Pregnancy Rate and Regu- lation of Menstrual Cycle for Patients With Polycystic Ovarian Syndrome: A Systematic Review and Meta-A- nalysis. Journal of Medicine, University of Santo Tomas, 6(2), 979–998.
Maffazioli GDN, Lopes CP, Heinrich-Oliveira V, Lobo RA, Hayashida SAY, Soares JM Jr, Maciel GAR, Bara- cat EC. Prevalence of metabolic disturbances among women with polycystic ovary syndrome in diffe- rent regions of Brazil. Int J Gynaecol Obstet. 2020 Dec;151(3):383-391. doi: 10.1002/ijgo.13374. Epub 2020 Oct 12. PMID: 32931592
Greff D, Váncsa S, Váradi A, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Horváth EM, Várbíró S. Myoinosi- tols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analy- sis of Randomized Controlled Trials. Nutrients. 2023 Sep 30;15(19):4224. doi: 10.3390/nu15194224. PMID: 37836508; PMCID: PMC10574514
Morgante G, Orvieto R, Di Sabatino A, Musacchio MC, De Leo V. The role of inositol supplementation in patients with polycystic ovary syndrome, with insu- lin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. Fertil Steril. 2011 Jun 30;95(8):2642-4. doi: 10.1016/j.fertnstert.2011.01.035. Epub 2011 Feb 5. PMID: 21300338
Zoltán, K., Ildikó, K., & Kolcsár, M. (2019). Current aspects of polycystic ovary syndrome ii: treatment of hyperandrogenism, insulin resistance and infertility. Bulletin of Medical Sciences, 92(2), 89-104.
Chirania, K., Misra, S., & Behera, S. (2017). A rando- mised clinical trial comparing myoinositol and met- formin in pcos. International Journal of Reproduction Contraception Obstetrics and Gynecology, 6(5), 1814.
Kamenov Z, Gateva A. Inositols in PCOS. Molecu- les. 2020 Nov 27;25(23):5566. doi: 10.3390/molecu- les25235566. PMID: 33260918; PMCID: PMC7729761
Unfer V, Carlomagno G, Papaleo E, Vailati S, Candiani M, Baillargeon JP. Hyperinsulinemia Alters Myoino- sitol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS. Reprod Sci. 2014 Jul;21(7):854- 858. doi: 10.1177/1933719113518985.
Modak R, Biswas DK, Pal A, Mandal TK. Prevalence and predictors of metabolic syndrome with compari- son of myoinositol and metformin in PCOS women. Int J Reprod Contracept Obstet Gynecol 2019; 8:570-5
U-Allah, I.; Sabeen, N.; Iqbal, Q.; Zulfiqar, S.; Wasim, T. Myoinositol in restoring spontaneous ovarian activity in patients with Polycystic Ovarian Syndrome (PCOS). Esculapio 2020, 16, 41–45
Gade, P., S, A., & Vazifdar, S. (2021). Myoinositol with Metformin and Myoinositol Alone in Infertile PCOS Women Undergoing Ovulation Induction Cycles: A Comparative Study.” Sumathi Publications, 2021
Ribas Filho, D., Nogueira-de-Almeida, C. A., & Zota- relli-Filho, I. J. (2022). Myo-inositol in polycystic ovary syndrome: a systematic review and positioning of its use. International Journal of Nutrology, 15(2).
Parveen, S., Iram, N., Saeed, B., Yaqub, U., & Niazi, N. (2023). Clomiphene supported ovulation induction in subfertile polycystic ovary syndrome women: role of different insulin sensitizers. Pakistan Armed Forces Medical Journal, 73(3), 810-13.
O.V. Clinical effect of the combination of myoinositol and D-chiroinositol in the ratio 5:1 with manganese and folic acid on female reproductive function in patients with anovulatory infertility in patients with ab- normal menstrual cycles and obesity // Gynecology.
Manjula, S. and M., K. (2024). Clinicians perspectives on nutritional supplementation and polycystic ovary syndrome management in women in indian settings. International Journal of Reproduction Contraception Obstetrics and Gynecology, 13(11), 3268-3274.
Referanslar
Stein, I. F. & Leventhal, M.L. Amenorrhea associated with bilateral polycystic ovaries, 1935 Gardner 2024, 6th Edition
Her Yönü ile PKOS, Prof. Dr. Gürkan BOZDAĞ, No- bel Tıp Kitabevleri, sy 89 Batuhan ASLAN, Yavuz Emre ŞÜKÜR
Wang Y, Zhao X, Zhao H, Ding H, Tan J, Chen J, Zhang R, Azziz R, Yang D. Risks for gestational diabetes melli- tus and pregnancy-induced hypertension are increased in polycystic ovary syndrome. Biomed Res Int. 2013; 2013:182582. doi: 10.1155/2013/182582. Epub 2013 Nov 25. PMID: 24371816; PMCID: PMC3859212
Stepto NK, Cassar S, Joham AE, Hutchison SK, Har- rison CL, Goldstein RF, Teede HJ. Women with poly- cystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Hum Reprod. 2013 Mar;28(3):777-84. doi: 10.1093/humrep/des463. Epub 2013 Jan 12. PMID: 23315061
DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndro- me using the homeostasis model assessment. Fertil Steril. 2005 May;83(5):1454-60. doi: 10.1016/j.fertns- tert.2004.11.070. PMID: 15866584
Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 1989 Sep;38(9):1165-74. doi: 10.2337/diab.38.9.1165. PMID: 2670645
Book CB, Dunaif A. Selective insulin resistance in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1999 Sep;84(9):3110-6. doi: 10.1210/jcem.84.9.6010. PMID: 10487672
Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Bioc- himie. 2013 Oct;95(10):1811-27. doi: 10.1016/j.bioc- hi.2013.05.011. Epub 2013 Jun 10. PMID: 23764390
Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network. Recommendations from the inter- national evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018 Aug;110(3):364-379. doi: 10.1016/j.fertns- tert.2018.05.004. Epub 2018 Jul 19. PMID: 30033227; PMCID: PMC6939856
Moran LJ, Tassone EC, Boyle J, Brennan L, Harrison CL, Hirschberg AL, Lim S, Marsh K, Misso ML, Redman L, Thondan M, Wijeyaratne C, Garad R, Stepto NK, Teede HJ. Evidence summaries and recommen- dations from the international evidence-based guide- line for the assessment and management of polycystic ovary syndrome: Lifestyle management. Obes Rev. 2020 Oct;21(10): e13046. doi: 10.1111/obr.13046. Epub
2020 May 26. PMID: 32452622
Brennan L, Teede H, Skouteris H, Linardon J, Hill B, Moran L. Lifestyle and Behavioral Management of Pol- ycystic Ovary Syndrome. J Womens Health (Larchmt). 2017 Aug;26(8):836-848. doi: 10.1089/jwh.2016.5792. Epub 2017 Jun 1. PMID: 28570835
Büttner J. Johann Jospeh von Scherer (1814-1869). Ein Beitrag zur frühen Geschichte der Klinischen Chemie [Johann Joseph von Scherer (1814-69). The early his- tory of clinical chemistry]. J Clin Chem Clin Biochem. 1978 Sep;16(9):478-83. German. PMID: 361923
Di Paolo G, De Camilli P. Phosphoinositides in cell re- gulation and membrane dynamics. Nature. 2006 Oct 12;443(7112):651-7. doi: 10.1038/nature05185. PMID: 17035995
Larner J. D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistan- ce. Int J Exp Diabetes Res. 2002;3(1):47-60. doi: 10.1080/15604280212528. PMID: 11900279; PMCID: PMC2478565
Uldry “Identification of a mammalian H+-myo-i- nositol symporter expressed predominantly in the brain” The EMBO Journal (2001) doi:10.1093/em- boj/20.16.4467
Laganà AS, Garzon S, Casarin J, Franchi M, Ghezzi
F. Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends Endocrinol Metab. 2018 Nov;29(11):768-780. doi: 10.1016/j.tem.2018.09.001. Epub 2018 Sep 27. PMID: 30270194
Warskulat ve ark. 1997Warskulat et al. “myo-Inositol is an osmolyte in rat liver macrophages (Kupffer cells) but not in RAW 264.7 mouse macrophages” Biochemical Journal (1997) doi:10.1042/bj3260289
Singh P, Biswal S, Verma SK. A prospective randomi- sed controlled study on the effects of myoinositol on ovarian functions and metabolic factors in women with polycystic ovarian syndrome. Int J Reprod Cont- racept Obstet Gynecol 2020; 9:4912-7
Bevilacqua A, Bizzarri M. Inositols in Insulin Signaling and Glucose Metabolism. Int J Endocrinol. 2018 Nov 25; 2018:1968450. doi: 10.1155/2018/1968450. PMID: 30595691; PMCID: PMC6286734
Karadağ C, Sakinci M, Birge Ö, Bakır MS, Karadağ B, Sağnıç S. Comparison of metformin, myoinositol and metformin-myoinositol combined treatments for poly- cystic ovary syndrome. Turk J Obstet Gynecol. 2024 Jun 10;21(2):78-84. doi: 10.4274/tjod.galenos.2024.21456. PMID: 38853482; PMCID: PMC11589227
Pasta ve ark. 2016). Pasta et al. “A Randomized Pi- lot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women” Breast Cancer Basic and Clinical Research (2016) doi:10.4137/bcbcr.s 38408
C. (2022). Myoinositol supplementation in the tre- atment of gestational diabetes mellitus: effects on gl- ycaemic control and maternal-foetal outcomes. BMC Pregnancy and Childbirth, 22(1)
Garzon S, Laganà AS, Monastra G. Risk of reduced intestinal absorption of myo-inositol caused by D-chi- ro-inositol or by glucose transporter inhibitors. Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):697-703. doi: 10.1080/17425255.2019.1651839. Epub 2019 Aug 8. PMID: 31382802
Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, Nagar HD, Makwana L, Kshirsagar S, Kaul P, Ghosh AK, Pradhan S, Mehta A, Jaiswal A, Nakhate KT, Kam- di S. Efficacy of combination therapy of inositols, an- tioxidants and vitamins in obese and non-obese wo- men with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020 Jan;40(1):96-101. doi: 10.1080/01443615.2019.1604644. Epub 2019 Jul 24. PMID: 31339394
Gupta D, Khan S, Islam M, Malik BH, Rutkofsky IH. Myo-Inositol’s Role in Assisted Reproductive Techno- logy: Evidence for Improving the Quality of Oocytes and Embryos in Patients With Polycystic Ovary Synd- rome. Cureus. 2020 May 12;12(5): e8079. doi: 10.7759/ cureus.8079. PMID: 32542134; PMCID: PMC7292722
Atyaf Hasan, Al-Quraan Elena, Al-Quraan Ghassan, Tayseer Rimawi, Said Nasrallah. (2019). Melatonin and Myoinositol: A Foreword Step Toward IVF Success, a Prospective Clinical Trial. Journal of Gynecology and Obstetrics, 7(1), 17
Zhang T, Xi Q, Wang D, Li J, Wang M, Li D, Zhu L, Jin
L. Mitochondrial dysfunction and endoplasmic reticu- lum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes. J Ovari- an Res. 2019 Jun 8;12(1):53. doi: 10.1186/s13048-019- 0529-x. PMID: 31176373; PMCID: PMC6556043
Nazirudeen R, Sridhar S, Priyanka R, Sumathi B, Nata- rajan V, Subbiah E, Raghavan KS, Sangumani J. A ran- domized controlled trial comparing myoinositol with metformin versus metformin monotherapy in poly- cystic ovary syndrome. Clin Endocrinol (Oxf). 2023 Aug;99(2):198-205. doi: 10.1111/cen.14931. Epub 2023 Jun 2. PMID: 37265016
Pizzo A, Laganà AS, Barbaro L. Comparison between effects of myo-inositol and D-chiro-inositol on ova- rian function and metabolic factors in women with PCOS. Gynecol Endocrinol. 2014 Mar;30(3):205-8. doi: 10.3109/09513590.2013.860120. Epub 2013 Dec 19. PMID: 24351072
Regidor PA, Schindler AE. Myoinositol as a Safe and Al- ternative Approach in the Treatment of Infertile PCOS Women: A German Observational Study. Int J Endoc- rinol. 2016; 2016:9537632. doi: 10.1155/2016/9537632. Epub 2016 Aug 23. PMID: 27642297; PMCID: PMC5011528
Lesoine B, Regidor PA. Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Un- dergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality. Int J Endocrinol. 2016; 2016:4378507. doi: 10.1155/2016/4378507.
H. Matsubayashi, T. Takeuchi, S. Mizuta, T. Ishikawa. Myoinositol supplementation on intracytoplasmic sperm injection outcome in Japanese infertile polycys- tic ovarian syndrome women with non-obese less-and- rogenic phenotype: a prospective controlled observa- tional study. Clin. Exp. Obstet. Gynecol. 2019, 46(4), 549–552.
Zheng X, Lin D, Zhang Y, Lin Y, Song J, Li S, Sun Y. Ino- sitol supplement improves clinical pregnancy rate in in- fertile women undergoing ovulation induction for ICSI or IVF-ET. Medicine (Baltimore). 2017 Dec;96(49): e8842. doi: 10.1097/MD.0000000000008842. PMID: 29245250; PMCID: PMC5728865
Sigue, R. J. L., & Decena, D. D. (2022). Efficacy of Myo-inositol in Improving Pregnancy Rate and Regu- lation of Menstrual Cycle for Patients With Polycystic Ovarian Syndrome: A Systematic Review and Meta-A- nalysis. Journal of Medicine, University of Santo Tomas, 6(2), 979–998.
Maffazioli GDN, Lopes CP, Heinrich-Oliveira V, Lobo RA, Hayashida SAY, Soares JM Jr, Maciel GAR, Bara- cat EC. Prevalence of metabolic disturbances among women with polycystic ovary syndrome in diffe- rent regions of Brazil. Int J Gynaecol Obstet. 2020 Dec;151(3):383-391. doi: 10.1002/ijgo.13374. Epub 2020 Oct 12. PMID: 32931592
Greff D, Váncsa S, Váradi A, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Horváth EM, Várbíró S. Myoinosi- tols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analy- sis of Randomized Controlled Trials. Nutrients. 2023 Sep 30;15(19):4224. doi: 10.3390/nu15194224. PMID: 37836508; PMCID: PMC10574514
Morgante G, Orvieto R, Di Sabatino A, Musacchio MC, De Leo V. The role of inositol supplementation in patients with polycystic ovary syndrome, with insu- lin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. Fertil Steril. 2011 Jun 30;95(8):2642-4. doi: 10.1016/j.fertnstert.2011.01.035. Epub 2011 Feb 5. PMID: 21300338
Zoltán, K., Ildikó, K., & Kolcsár, M. (2019). Current aspects of polycystic ovary syndrome ii: treatment of hyperandrogenism, insulin resistance and infertility. Bulletin of Medical Sciences, 92(2), 89-104.
Chirania, K., Misra, S., & Behera, S. (2017). A rando- mised clinical trial comparing myoinositol and met- formin in pcos. International Journal of Reproduction Contraception Obstetrics and Gynecology, 6(5), 1814.
Kamenov Z, Gateva A. Inositols in PCOS. Molecu- les. 2020 Nov 27;25(23):5566. doi: 10.3390/molecu- les25235566. PMID: 33260918; PMCID: PMC7729761
Unfer V, Carlomagno G, Papaleo E, Vailati S, Candiani M, Baillargeon JP. Hyperinsulinemia Alters Myoino- sitol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS. Reprod Sci. 2014 Jul;21(7):854- 858. doi: 10.1177/1933719113518985.
Modak R, Biswas DK, Pal A, Mandal TK. Prevalence and predictors of metabolic syndrome with compari- son of myoinositol and metformin in PCOS women. Int J Reprod Contracept Obstet Gynecol 2019; 8:570-5
U-Allah, I.; Sabeen, N.; Iqbal, Q.; Zulfiqar, S.; Wasim, T. Myoinositol in restoring spontaneous ovarian activity in patients with Polycystic Ovarian Syndrome (PCOS). Esculapio 2020, 16, 41–45
Gade, P., S, A., & Vazifdar, S. (2021). Myoinositol with Metformin and Myoinositol Alone in Infertile PCOS Women Undergoing Ovulation Induction Cycles: A Comparative Study.” Sumathi Publications, 2021
Ribas Filho, D., Nogueira-de-Almeida, C. A., & Zota- relli-Filho, I. J. (2022). Myo-inositol in polycystic ovary syndrome: a systematic review and positioning of its use. International Journal of Nutrology, 15(2).
Parveen, S., Iram, N., Saeed, B., Yaqub, U., & Niazi, N. (2023). Clomiphene supported ovulation induction in subfertile polycystic ovary syndrome women: role of different insulin sensitizers. Pakistan Armed Forces Medical Journal, 73(3), 810-13.
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