PCOS’lu İnfertil Hastaların IVF/ICSI/IVM İle Yönetimi

Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril. 2023;120(4):767–93.

Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(12):4565–92.

Siristatidis CS, Papapanou M, Maheshwari A, Vaidakis D. In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction. Cochrane Database Syst Rev. 2025;2(2):CD006606.

Palomba S. Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper. Hum Reprod. 2021;36(9):2421–8.

Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687–708.

Xu YL, Guo W, Hao YX, Yang S, Li R, Zheng XY, et al. Outcomes of subsequent IVF cycles among women with PCOS after the first unstimulated IVM treatment: a single-center matched retrospective case-control study. J Matern Fetal Neonatal Med. 2024;37(1):2425756.

Mostinckx L, Goyens E, Mackens S, Roelens C, Boudry L, Uvin V, et al. Clinical outcomes from ART in predicted hyperresponders: in vitro maturation of oocytes versus conventional ovarian stimulation for IVF/ICSI. Hum Reprod. 2024;39(3):586–94.

Kotlyar AM, Seifer DB. Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes. Reprod Biol Endocrinol. 2023;21(1):70.

Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999;22(1):141–6.

Bailey AP, Hawkins LK, Missmer SA, Correia KF, Yanushpolsky EH. Effect of body mass index on in vitro fertilization outcomes in women with polycystic ovary syndrome. Am J Obstet Gynecol. 2014;211(2):163 e1–6.

Wei D, Shi Y, Li J, Wang Z, Zhang L, Sun Y, et al. Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome. Hum Reprod. 2017;32(2):354–61.

MacDougall MJ, Tan SL, Balen A, Jacobs HS. A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization. Hum Reprod. 1993;8(2):233–7.

Fertility problems: assessment and treatment London: National Institute for Health and Care Excellence (NICE); 2017 Sep. (NICE Clinical Guidelines, No. 156.) [Available from: https://www.ncbi.nlm.nih.gov/books/NBK554709/.

Yu HF, Chen HS, Rao DP, Gong J. Association between polycystic ovary syndrome and the risk of pregnancy complications: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2016;95(51):e4863.

Child TJ, Abdul-Jalil AK, Gulekli B, Tan SL. In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome. Fertil Steril. 2001;76(5):936–42.

Chian R-C, Gülekli B, Buckett William M, Tan S-L. Priming with Human Chorionic Gonadotropin before Retrieval of Immature Oocytes in Women with Infertility Due to the Polycystic Ovary Syndrome. New England Journal of Medicine. 1999;341(21):1624–6.

Tan SL, Child TJ, Gulekli B. In vitro maturation and fertilization of oocytes from unstimulated ovaries: predicting the number of immature oocytes retrieved by early follicular phase ultrasonography. Am J Obstet Gynecol. 2002;186(4):684–9.

Gilchrist RB, Ho TM, De Vos M, Sanchez F, Romero S, Ledger WL, et al. A fresh start for IVM: capacitating the oocyte for development using pre-IVM. Hum Reprod Update. 2024;30(1):3–25.

Whittemore AS. The risk of ovarian cancer after treatment for infertility. N Engl J Med. 1994;331(12):805–6.

Gulekli B, Kovali M, Aydiner F, Dogan S, Dogan SS. IVM is an alternative for patients with PCO after failed conventional IVF attempt. J Assist Reprod Genet. 2011;28(6):495–9.

Gulekli B, Kovali Sezer M, Gungor SS, Timur HT, Okyay RE, Idiman E. Safe and successful use of oocyte in-vitro maturation in two infertile women with multiple sclerosis. Reprod Biomed Online. 2020;41(2):154–6.

Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J. In vitro maturation for patients with repeated in vitro fertilization failure due to "oocyte maturation abnormalities". Fertil Steril. 2010;94(2):496–501.

Gulekli B, Olgan S, Aydiner F. In vitro oocyte maturation from unstimulated cycles: does it offer a realistic chance to overcome the problem of repeated oocyte maturation arrest in IVF? Arch Gynecol Obstet. 2011;283 Suppl 1:133–4.

Chian RC, Gulekli B, Buckett WM, Tan SL. Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome. N Engl J Med. 1999;341(21):1624, 6.

Gulekli B, Buckett WM, Chian RC, Child TJ, Abdul-Jalil AK, Tan SL. Randomized, controlled trial of priming with 10,000 IU versus 20,000 IU of human chorionic gonadotropin in women with polycystic ovary syndrome who are undergoing in vitro maturation. Fertil Steril. 2004;82(5):1458–9.

Lin Y, Zheng X, Ma C, Li X, Zhang X, Yang P, et al. Human Chorionic Gonadotropin Priming Does Not Improve Pregnancy Outcomes of PCOS-IVM Cycles. Front Endocrinol (Lausanne). 2020;11:279.

Vuong LN, Ho VNA, Le AH, Nguyen NT, Pham TD, Nguyen MHN, et al. Hormone-free vs. follicle-stimulating hormone-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial. Fertil Steril. 2025;123(2):253–61.

Buckett WM, Chian RC, Holzer H, Dean N, Usher R, Tan SL. Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection. Obstet Gynecol. 2007;110(4):885–91.

Child TJ, Phillips SJ, Abdul-Jalil AK, Gulekli B, Tan SL. A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries. Obstet Gynecol. 2002;100(4):665–70.

Agdi M, Zarei A, Al-Sannan B, Tulandi T, Tan SL. Effects of ovarian puncture for in vitro maturation on subsequent in vitro fertilization cycle in women with polycystic ovaries. Fertil Steril. 2010;94(1):381–3.

Teede HJ, Tay CT, Laven J, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertil Steril. 2023;120(4):767–93.

Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(12):4565–92.

Siristatidis CS, Papapanou M, Maheshwari A, Vaidakis D. In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction. Cochrane Database Syst Rev. 2025;2(2):CD006606.

Palomba S. Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper. Hum Reprod. 2021;36(9):2421–8.

Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687–708.

Xu YL, Guo W, Hao YX, Yang S, Li R, Zheng XY, et al. Outcomes of subsequent IVF cycles among women with PCOS after the first unstimulated IVM treatment: a single-center matched retrospective case-control study. J Matern Fetal Neonatal Med. 2024;37(1):2425756.

Mostinckx L, Goyens E, Mackens S, Roelens C, Boudry L, Uvin V, et al. Clinical outcomes from ART in predicted hyperresponders: in vitro maturation of oocytes versus conventional ovarian stimulation for IVF/ICSI. Hum Reprod. 2024;39(3):586–94.

Kotlyar AM, Seifer DB. Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes. Reprod Biol Endocrinol. 2023;21(1):70.

Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999;22(1):141–6.

Bailey AP, Hawkins LK, Missmer SA, Correia KF, Yanushpolsky EH. Effect of body mass index on in vitro fertilization outcomes in women with polycystic ovary syndrome. Am J Obstet Gynecol. 2014;211(2):163 e1–6.

Wei D, Shi Y, Li J, Wang Z, Zhang L, Sun Y, et al. Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome. Hum Reprod. 2017;32(2):354–61.

MacDougall MJ, Tan SL, Balen A, Jacobs HS. A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization. Hum Reprod. 1993;8(2):233–7.

Fertility problems: assessment and treatment London: National Institute for Health and Care Excellence (NICE); 2017 Sep. (NICE Clinical Guidelines, No. 156.) [Available from: https://www.ncbi.nlm.nih.gov/books/NBK554709/.

Yu HF, Chen HS, Rao DP, Gong J. Association between polycystic ovary syndrome and the risk of pregnancy complications: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2016;95(51):e4863.

Child TJ, Abdul-Jalil AK, Gulekli B, Tan SL. In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome. Fertil Steril. 2001;76(5):936–42.

Chian R-C, Gülekli B, Buckett William M, Tan S-L. Priming with Human Chorionic Gonadotropin before Retrieval of Immature Oocytes in Women with Infertility Due to the Polycystic Ovary Syndrome. New England Journal of Medicine. 1999;341(21):1624–6.

Tan SL, Child TJ, Gulekli B. In vitro maturation and fertilization of oocytes from unstimulated ovaries: predicting the number of immature oocytes retrieved by early follicular phase ultrasonography. Am J Obstet Gynecol. 2002;186(4):684–9.

Gilchrist RB, Ho TM, De Vos M, Sanchez F, Romero S, Ledger WL, et al. A fresh start for IVM: capacitating the oocyte for development using pre-IVM. Hum Reprod Update. 2024;30(1):3–25.

Whittemore AS. The risk of ovarian cancer after treatment for infertility. N Engl J Med. 1994;331(12):805–6.

Gulekli B, Kovali M, Aydiner F, Dogan S, Dogan SS. IVM is an alternative for patients with PCO after failed conventional IVF attempt. J Assist Reprod Genet. 2011;28(6):495–9.

Gulekli B, Kovali Sezer M, Gungor SS, Timur HT, Okyay RE, Idiman E. Safe and successful use of oocyte in-vitro maturation in two infertile women with multiple sclerosis. Reprod Biomed Online. 2020;41(2):154–6.

Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J. In vitro maturation for patients with repeated in vitro fertilization failure due to "oocyte maturation abnormalities". Fertil Steril. 2010;94(2):496–501.

Gulekli B, Olgan S, Aydiner F. In vitro oocyte maturation from unstimulated cycles: does it offer a realistic chance to overcome the problem of repeated oocyte maturation arrest in IVF? Arch Gynecol Obstet. 2011;283 Suppl 1:133–4.

Chian RC, Gulekli B, Buckett WM, Tan SL. Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome. N Engl J Med. 1999;341(21):1624, 6.

Gulekli B, Buckett WM, Chian RC, Child TJ, Abdul-Jalil AK, Tan SL. Randomized, controlled trial of priming with 10,000 IU versus 20,000 IU of human chorionic gonadotropin in women with polycystic ovary syndrome who are undergoing in vitro maturation. Fertil Steril. 2004;82(5):1458–9.

Lin Y, Zheng X, Ma C, Li X, Zhang X, Yang P, et al. Human Chorionic Gonadotropin Priming Does Not Improve Pregnancy Outcomes of PCOS-IVM Cycles. Front Endocrinol (Lausanne). 2020;11:279.

Vuong LN, Ho VNA, Le AH, Nguyen NT, Pham TD, Nguyen MHN, et al. Hormone-free vs. follicle-stimulating hormone-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomized controlled trial. Fertil Steril. 2025;123(2):253–61.

Buckett WM, Chian RC, Holzer H, Dean N, Usher R, Tan SL. Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection. Obstet Gynecol. 2007;110(4):885–91.

Child TJ, Phillips SJ, Abdul-Jalil AK, Gulekli B, Tan SL. A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries. Obstet Gynecol. 2002;100(4):665–70.

Agdi M, Zarei A, Al-Sannan B, Tulandi T, Tan SL. Effects of ovarian puncture for in vitro maturation on subsequent in vitro fertilization cycle in women with polycystic ovaries. Fertil Steril. 2010;94(1):381–3.