Diyabetes Mellitus ve Erkek İnfertilite İlişkisi

Rong J, Leng X, Jiang K, Tan J, Dong M, Tan J. Systemic impacts of diabetes on spermatogenesis and intervention strategies: multilayered mechanism analysis and cutting-edge therapeutic approaches. Reprod Biol Endocrinol. 2025;23(1):122. doi:10.1186/s12958-025-01454-4.

Graziani A, Scafa R, Grande G, Ferlin A. Diabetes and male fertility disorders. Mol Aspects Med. 2024;99:101303.

Dimakopoulou A, Jayasena CN, Radia UK, Algefari M, Minhas S, Oliver N, Dhillo WS. Animal models of diabetes-related male hypogonadism. Front Endocrinol (Lausanne). 2019;10:628.

Wagner IV, Klöting N, Savchuk I, Eifler L, Kulle A, Kralisch-Jäcklein S, Dötsch J, Hiort O, Svechnikov K, Söder O. Diabetes Type 1 negatively influences Leydig cell function in rats, which is partially reversible by insulin treatment. Endocrinology. 2021;162(4):bqab017. doi:10.1210/endocr/bqab017.

Griswold MD. 50 years of spermatogenesis: Sertoli cells and their interactions with germ cells. Biol Reprod. 2018;99(1):87–100. doi:10.1093/biolre/ioy027.

Alves MG, Martins AD, Cavaco JE, Socorro S, Oliveira PF. Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function. Tissue Barriers. 2013;1(2):e23992. doi:10.4161/tisb.23992.

Chen ZF, Shen YF, Gao DW, Lin DF, Ma WZ, Chang DG. Metabolic pathways and male fertility: exploring the role of Sertoli cells in energy homeostasis and spermatogenesis. Am J Physiol Endocrinol Metab. 2025;329(1):E160–E178. doi:10.1152/ajpendo.00074.2025.

Zhang W, Tong L, Jin B, Sun D. Diabetic testicular dysfunction and spermatogenesis impairment: mechanisms and therapeutic prospects. Front Endocrinol (Lausanne). 2025;16:1653975. doi:10.3389/fendo.2025.1653975.

Minas A, Camargo M, Alves MG, Bertolla RP. Effects of diabetes-induced hyperglycemia on epigenetic modifications and DNA packaging and methylation during spermatogenesis: a narrative review. Iran J Basic Med Sci. 2024;27(1):3–11. doi:10.22038/IJBMS.2023.69604.15173.

Long L, Qiu H, Cai B, Chen N, Lu X, Zheng S, Ye X, Li Y. Hyperglycemia induced testicular damage in type 2 diabetes mellitus rats exhibiting microcirculation impairments associated with vascular endothelial growth factor decreased via PI3K/Akt pathway. Oncotarget. 2018;9(4):5321–5336. doi:10.18632/oncotarget.23915.

Ghanbari E, Nejati V, Khazaei M. Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats. Int J Reprod BioMed. 2016;14(8):519.

Mo JY, Yan YS, Lin ZL, Liu R, Liu XQ, Wu HY, Yu JE, Huang YT, Sheng JZ, Huang HF. Gestational diabetes mellitus suppresses fetal testis development in mice. Biol Reprod. 2022;107(1):148–156. doi:10.1093/biolre/ioac138.

Pavlova E, Lakova E, Atanassova N. Evaluation of rat testicular cell populations in experimental condition of diabetes induced in early postnatal life. Preprints. 2025. doi:10.20944/preprints202508.0030.v1.

Cong J, Li Q, Li Y, et al. Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference. Cell Discov. 2025;11:74. doi:10.1038/s41421-025-00821-0.

Wu FJ, Lin TY, Sung LY, Chang WF, Wu PC, Luo CW. BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia. Sci Signal. 2017;10(477):eaal1910. doi:10.1126/scisignal.eaal1910.

Ramezani Tehrani F, Ghasemi V, Saei Ghare Naz M. A systematic review and meta-analysis of follicle-stimulating hormone levels among men with type 2 diabetes. Basic Clin Androl. 2025;35(1):11. doi:10.1186/s12610-025-00257-2.

Zenaw A, Chane E, Fetene G, Wondifraw H, Mekuanint A, Kinde Y, Kassie T, Demeke K, Fasil A, Worede A. Hypogonadism and its associated factors among adult male type 2 diabetes mellitus patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia 2024: a comparative cross-sectional study. PLoS One. 2025;20(8):e0329784. doi:10.1371/journal.pone.0329784.

Wang Y, Fu X, Li H. Mechanisms of oxidative stress-induced sperm dysfunction. Front Endocrinol (Lausanne). 2025;16:1520835.

Potiris A, Moustakli E, Trismpioti E, Drakaki E, Mavrogianni D, Matsas A, Zikopoulos A, Sfakianakis A, Tsakiridis I, Dagklis T, et al. From inflammation to infertility: how oxidative stress and infections disrupt male reproductive health. Metabolites. 2025;15(4):267. doi:10.3390/metabo15040267.

Yang Y, Zhao B, Wang Y, et al. Diabetic neuropathy: cutting-edge research and future directions. Sig Transduct Target Ther. 2025;10:132. doi:10.1038/s41392-025-02175-1.

Marrakchi M, Dhieb N, Ounaissa K, Achwak M, Boukhayatia F, Brahim AB, Amrouche C. Relationship between diabetic microangiopathy and sexual dysfunction in women with type 2 diabetes. Endocrine Abstracts. 2023;90.

Mostafa T, Abdel-Hamid IA. Ejaculatory dysfunction in men with diabetes mellitus. World J Diabetes. 2021;12(7):954–974. doi:10.4239/wjd.v12.i7.954.

Moustakli E, Christopoulos P, Potiris A, et al. Reductive stress and the role of antioxidants in male infertility: a narrative review. Arch Gynecol Obstet. 2025. doi:10.1007/s00404-025-08184-3.

Brannigan RE, Hermanson L, Kaczmarek J, Kim SK, Kirkby E, Tanrikut C. Updates to male infertility: AUA/ASRM guideline (2024). J Urol. 2024. doi:10.1097/JU.0000000000004180.

Huang R, Chen J, Guo B, et al. Diabetes-induced male infertility: potential mechanisms and treatment options. Mol Med. 2024;30:11. doi:10.1186/s10020-023-00771-x.