Anestezi Derinliği Monitörizasyonunun Doğru Yorumlanmasının Klinik Önemi: Lomber Stabilizasyon Cerrahisi Sırasında “Alpha Dropout” Gelişen Bir Olgu
Özet
Lomber disk hernisi ve instabilite nedeniyle L3-L5 seviyelerine posterior vida-rod stabilizasyonu planlanan 58 yaşındaki kadın hastaya, cerrahi sırasında nöromonitörizasyon uygulanacak olması nedeniyle total intravenöz anestezi (TİVA) ve anestezi derinliği monitörizasyonu ile anestezi yönetimi planlandı. Anestezi indüksiyonunun ardından propofol ve remifentanil infüzyonu ile anestezi idamesi sağlandı. Cerrahi insizyon sırasında EEG üzerinde alpha dropout (alfa kaybı) örüntüsünün geliştiği izlendi. Bu örüntü, yetersiz antinosiseptif yanıt göstergesi olarak değerlendirilerek remifentanil infüzyon dozu artırıldı ve kısa sürede EEG görüntüsünün normalize olduğu gözlendi. Yaklaşık 2.5 saat süren operasyonun ardından stabil hemodinamik ve EEG örüntüleri ile anestezi sonlandırıldı. Postoperatif dönemde düşük ağrı skorları, minimal opioid gereksinimi olan ve bilişsel fonksiyonlarda bozulma izlenmeyen hasta, postoperatif 3. gün komplikasyonsuz olarak taburcu edildi.
Referanslar
Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015;123(4):937-960. doi:10.1097/ALN.0000000000000841
Chan MTV, Hedrick TL, Egan TD, et al. American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on the Role of Neuromonitoring in Perioperative Outcomes: Electroencephalography. Anesthesia & Analgesia. 2020;130(5):1278. doi:10.1213/ANE.0000000000004502
Laferrière-Langlois P, Morisson L, Jeffries S, Duclos C, Espitalier F, Richebé P. Depth of Anesthesia and Nociception Monitoring: Current State and Vision For 2050. Anesthesia & Analgesia. 2024;138(2):295-307. doi:10.1213/ANE.0000000000006860
Dai Y, Shen C, Shi K, Liu Q, Qiu X, Sun J. Intraoperative Electroencephalogram Frontal Low Alpha Power for Predicting Postoperative Delirium in Elderly Patients after Orthopedic Surgery: A Prospective Cohort Study. Annali Italiani di Chirurgia. 2024;95(6):1134-1146. doi:10.62713/aic.3641
Guessous K, Touchard C, Glezerson B, et al. Intraoperative Electroencephalography Alpha-Band Power Is a Better Proxy for Preoperative Low MoCA Under Propofol Compared With Sevoflurane. Anesthesia & Analgesia. 2023;137(5):1084. doi:10.1213/ANE.0000000000006422
Radtke FM, Franck M, Lendner J, Krüger S, Wernecke KD, Spies CD. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. British Journal of Anaesthesia. 2013;110:i98-i105. doi:10.1093/bja/aet055
Obert DP, Schweizer C, Zinn S, et al. The influence of age on EEG-based anaesthesia indices. Journal of Clinical Anesthesia. 2021;73:110325. doi:10.1016/j.jclinane.2021.110325
Castellon-Larios K, Rosero BR, Niño-de Mejía MC, Bergese SD. The use of cerebral monitoring for intraoperative awareness. Colombian Journal of Anesthesiology. 2016;44(1):23-29. doi:10.1016/j.rcae.2015.09.005
Aldecoa C, Bettelli G, Bilotta F, et al. Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients. European Journal of Anaesthesiology. Published online August 31, 2023. doi:10.1097/EJA.0000000000001876
Pandit JJ, Cook TM. I. National Institute for Clinical Excellence guidance on measuring depth of anaesthesia: limitations of EEG-based technology. BJA: British Journal of Anaesthesia. 2013;110(3):325-328. doi:10.1093/bja/aet006
Mulvey DA, Klepsch P. Use of Processed Electroencephalography in the Clinical Setting. Curr Anesthesiol Rep. 2020;10(4):480-487. doi:10.1007/s40140-020-00424-3
Lee KH, Egan TD, Johnson KB. Raw and processed electroencephalography in modern anesthesia practice: a brief primer on select clinical applications. Korean J Anesthesiol. 2021;74(6):465-477. doi:10.4097/kja.21349
Hight DF, Gaskell AL, Kreuzer M, Voss LJ, García PS, Sleigh JW. Transient electroencephalographic alpha power loss during maintenance of general anaesthesia. British Journal of Anaesthesia. 2019;122(5):635-642. doi:10.1016/j.bja.2018.11.029
García PS, Kreuzer M, Hight D, Sleigh JW. Effects of noxious stimulation on the electroencephalogram during general anaesthesia: a narrative review and approach to analgesic titration. British Journal of Anaesthesia. 2021;126(2):445-457. doi:10.1016/j.bja.2020.10.036
Anders M, Anders B, Dreismickenbecker E, et al. EEG responses to standardised noxious stimulation during clinical anaesthesia: a pilot study. BJA Open. 2023;5:100118. doi:10.1016/j.bjao.2022.100118
Mackay EC, Sleigh JW, Voss LJ, Barnard JP. Episodic Waveforms in the Electroencephalogram during General Anaesthesia: A Study of Patterns of Response to Noxious Stimuli. Anaesth Intensive Care. 2010;38(1):102-112. doi:10.1177/0310057X1003800118
Mariappan R, Magar JT. Intense Noxious Stimulus during an Adequate Depth of General Anesthesia Produces a Transient Burst Suppression Pattern in a Density Spectral Array. J Neuroanaesth Crit Care. 2024;11(03):193-195. doi:10.1055/s-0044-1787977
Lobo FA, Vacas S, Naranjo M. Loss of spectral alpha power during spine surgery: what could be wrong? J Clin Monit Comput. 2021;35(6):1531-1533. doi:10.1007/s10877-021-00720-1
Lele AV, Furman M, Myers J, Kinney G, Sharma D, Hecker J. Inadvertent Burst Suppression During Total Intravenous Anesthesia in 112 Consecutive Patients Undergoing Spinal Instrumentation Surgery: A Retrospective Observational Quality Improvement Project. Journal of Neurosurgical Anesthesiology. 2022;34(3):300. doi:10.1097/ANA.0000000000000754
Meço BC, De Agua Reis AB, Berger-Estilita J, Jakobsen K, Alkış N, Radtke FM. Precision Anaesthesia: Advancing Patient-Centered Precision Care Through Repetitive Assessment of PROMs with the Safe Brain Initiative Approach. TJAR. 2023;51(5):374-379. doi:10.4274/TJAR.2023.231420