Endometrium Kanserinde Fertilite Koruyucu Yaklaşım

Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A. Cancer statistics, 2025. CA Cancer J Clin. 2025 Jan-Feb;75(1):10-45. doi: 10.3322/caac.21871. Epub 2025 Jan 16. PMID: 39817679; PMCID: PMC11745215.

Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I. Endometrial cancer. Lancet. 2005 Aug 6-12;366(9484):491-505. doi: 10.1016/S0140-6736(05)67063-8. PMID: 16084259.

Onstad MA, Schmandt RE, Lu KH. Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment. J Clin Oncol. 2016 Dec 10;34(35):4225-4230. doi: 10.1200/JCO.2016.69.4638. Epub 2016 Nov 7. PMID: 27903150; PMCID: PMC5455320. 2)2

Mourits MJ, De Vries EG, Willemse PH, Ten Hoor KA, Hollema H, Van der Zee AG. Tamoxifen treatment and gynecologic side effects: a review. Obstet Gynecol. 2001 May;97(5 Pt 2):855-66. doi: 10.1016/s0029-7844(00)01196-0. PMID: 11336777.

Gottschau M, Kjaer SK, Jensen A, Munk C, Mellemkjaer L. Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study. Gynecol Oncol. 2015 Jan;136(1):99-103. doi: 10.1016/j.ygyno.2014.11.012. Epub 2014 Nov 20. PMID: 25451694.

Lee NK, Cheung MK, Shin JY, Husain A, Teng NN, Berek JS, Kapp DS, Osann K, Chan JK. Prognostic factors for uterine cancer in reproductive-aged women. Obstet Gynecol. 2007 Mar;109(3):655-62. doi: 10.1097/01.AOG.0000255980.88205.15. PMID: 17329517.

Francoeur AA, Liao CI, Chang J, Johnson CR, Clair K, Tewari KS, Kapp DS, Chan JK, Bristow RE. Associated Trends in Obesity and Endometrioid Endometrial Cancer in the United States. Obstet Gynecol. 2025 Mar 1;145(3):e107-e116. doi: 10.1097/AOG.0000000000005814. Epub 2025 Jan 2. PMID: 39746203.

Abu-Rustum, N., Yashar, C., Arend, R., Barber, E., Bradley, K., Brooks, R., Campos, S. M., Chino, J., Chon, H. S., Chu, C., Crispens, M. A., Damast, S., Fisher, C. M., Frederick, P., Gaffney, D. K., Giuntoli, R., II, Han, E., Holmes, J., Howitt, B. E., Lea, J., Mariani, A., Mutch, D., Nagel, C., Nekhlyudov, L., Podoll, M., Salani, R., Schorge, J., Siedel, J., Sisodia, R., Soliman, P., Ueda, S., Urban, R., Wethington, S. L., Wyse, E., Zanotti, K., McMillian, N. R., & Aggarwal, S. (2023). Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 21(2), 181-209. Retrieved May 1, 2025, from https://doi.org/10.6004/jnccn.2023.0006

Walsh C, Holschneider C, Hoang Y, Tieu K, Karlan B, Cass I. Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol. 2005 Oct;106(4):693-9. doi: 10.1097/01.AOG.0000172423.64995.6f. PMID: 16199623.

Morrow CP, Bundy BN, Kurman RJ, Creasman WT, Heller P, Homesley HD, Graham JE. Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol. 1991 Jan;40(1):55-65. doi: 10.1016/0090-8258(91)90086-k. PMID: 1989916.

dos Reis R, Burzawa JK, Tsunoda AT, Hosaka M, Frumovitz M, Westin SN, Munsell MF, Ramirez PT. Lymphovascular Space Invasion Portends Poor Prognosis in Low-Risk Endometrial Cancer. Int J Gynecol Cancer. 2015 Sep;25(7):1292-9. doi: 10.1097/IGC.0000000000000490. PMID: 26067863; PMCID: PMC4549160.

Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF. TCGA Molecular Prognostic Groups of Endometrial Carcinoma: Current Knowledge and Future Perspectives. Int J Mol Sci. 2022 Oct 2;23(19):11684. doi: 10.3390/ijms231911684. PMID: 36232987; PMCID: PMC9569906.

Dijkhuizen FP, Mol BW, Brölmann HA, Heintz AP. The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia: a meta-analysis. Cancer. 2000 Oct 15;89(8):1765-72. PMID: 11042572.

Leitao MM Jr, Kehoe S, Barakat RR, Alektiar K, Gattoc LP, Rabbitt C, Chi DS, Soslow RA, Abu-Rustum NR. Comparison of D&C and office endometrial biopsy accuracy in patients with FIGO grade 1 endometrial adenocarcinoma. Gynecol Oncol. 2009 Apr;113(1):105-8. doi: 10.1016/j.ygyno.2008.12.017. Epub 2009 Jan 23. PMID: 19167049.

Goldstein SR. Modern evaluation of the endometrium. Obstet Gynecol. 2010 Jul;116(1):168-176. doi: 10.1097/AOG.0b013e3181dfd557. PMID: 20567184.

Di Spiezio Sardo A, De Angelis MC, Della Corte L, Carugno J, Zizolfi B, Guadagno E, Gencarelli A, Cecchi E, Simoncini T, Bifulco G, Zullo F, Insabato L. Should endometrial biopsy under direct hysteroscopic visualization using the grasp technique become the new gold standard for the preoperative evaluation of the patient with endometrial cancer? Gynecol Oncol. 2020 Aug;158(2):347-353. doi: 10.1016/j.ygyno.2020.05.012. Epub 2020 May 25. PMID: 32467056.

Alcázar JL, Gastón B, Navarro B, Salas R, Aranda J, Guerriero S. Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with endometrial cancer: a systematic review and meta-analysis. J Gynecol Oncol. 2017 Nov;28(6):e86. doi: 10.3802/jgo.2017.28.e86. PMID: 29027404; PMCID: PMC5641536.

Herrera Cappelletti E, Humann J, Torrejón R, Gambadauro P. Chances of pregnancy and live birth among women undergoing conservative management of early-stage endometrial cancer: a systematic review and meta-analysis. Hum Reprod Update. 2022 Feb 28;28(2):282-295. doi: 10.1093/humupd/dmab041. PMID: 34935045; PMCID: PMC8888991.

Lancaster JM, Powell CB, Kauff ND, Cass I, Chen LM, Lu KH, Mutch DG, Berchuck A, Karlan BY, Herzog TJ; Society of Gynecologic Oncologists Education Committee. Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol. 2007 Nov;107(2):159-62. doi: 10.1016/j.ygyno.2007.09.031. PMID: 17950381.

Gunderson CC, Fader AN, Carson KA, Bristow RE. Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. Gynecol Oncol. 2012 May;125(2):477-82. doi: 10.1016/j.ygyno.2012.01.003. Epub 2012 Jan 11. PMID: 22245711.

Qin Y, Yu Z, Yang J, Cao D, Yu M, Wang Y, Shen K. Oral Progestin Treatment for Early-Stage Endometrial Cancer: A Systematic Review and Meta-analysis. Int J Gynecol Cancer. 2016 Jul;26(6):1081-91. doi: 10.1097/IGC.0000000000000723. PMID: 27177279.

Kim MK, Seong SJ, Kim YS, Song T, Kim ML, Yoon BS, Jun HS, Lee YH. Combined medroxyprogesterone acetate/levonorgestrel-intrauterine system treatment in young women with early-stage endometrial cancer. Am J Obstet Gynecol. 2013 Oct;209(4):358.e1-4. doi: 10.1016/j.ajog.2013.06.031. Epub 2013 Jun 19. PMID: 23791687.

Baker J, Obermair A, Gebski V, Janda M. Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: a meta-analysis and systematic review of the literature. Gynecol Oncol. 2012 Apr;125(1):263-70. doi: 10.1016/j.ygyno.2011.11.043. Epub 2011 Dec 3. PMID: 22196499.

Gallo A, Catena U, Saccone G, Di Spiezio Sardo A. Conservative Surgery in Endometrial Cancer. J Clin Med. 2021 Dec 29;11(1):183. doi: 10.3390/jcm11010183. PMID: 35011924; PMCID: PMC8745528.

Rodolakis A, Scambia G, Planchamp F, Acien M, Di Spiezio Sardo A, Farrugia M, Grynberg M, Pakiz M, Pavlakis K, Vermeulen N, Zannoni G, Zapardiel I, Macklon KLT. ESGO/ESHRE/ESGE Guidelines for the fertility-sparing treatment of patients with endometrial carcinoma. Hum Reprod Open. 2023 Feb 6;2023(1):hoac057. doi: 10.1093/hropen/hoac057. PMID: 36756380; PMCID: PMC9900425.